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The current mutation

ID: V3909
DNA: 1450G>A
Protein: E484K
Position: 23012








COV2Var annotation categories







Summary information of mutation (1450G>A)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp02
  Gene Name   S
  Gene Type   protein_coding
  Genome position   23012
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   missense_variant
  DNA Level   DNA Mutation: 1450G>A
  Ref Seq: G
  Mut Seq: A
  Protein Level   Protein 1-letter Mutation: E484K
  Protein 3-letter Mutation: Glu484Lys

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (1450G>A) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.351 425 144 3.39e-1
2020-10 B.1 425 106 2.49e-1
2020-10 P.2 425 95 2.24e-1
2020-11 B.1.351 952 405 4.25e-1
2020-11 P.2 952 329 3.46e-1
2020-11 B.1 952 73 7.67e-2
2020-12 B.1.351 2542 1217 4.79e-1
2020-12 P.2 2542 727 2.86e-1
2020-12 B.1 2542 142 5.59e-2
2020-02 B.1.351 2 2 1.00e+0
2020-03 B.1 7 2 2.86e-1
2020-03 B.1.525 7 2 2.86e-1
2020-03 B.1.1.306 7 1 1.43e-1
2020-04 P.1 13 4 3.08e-1
2020-04 P.2 13 2 1.54e-1
2020-04 A.2 13 1 7.69e-2
2020-05 B.1.620 70 35 5.00e-1
2020-05 B.1.525 70 9 1.29e-1
2020-05 B.1.619 70 7 1.00e-1
2020-06 B.1 9 2 2.22e-1
2020-06 B.1.351 9 2 2.22e-1
2020-06 B.1.486 9 2 2.22e-1
2020-07 B.1.1.515 22 6 2.73e-1
2020-07 B.1 22 4 1.82e-1
2020-07 B.1.555 22 2 9.09e-2
2020-08 B.1.351 37 10 2.70e-1
2020-08 B.1 37 8 2.16e-1
2020-08 B.1.1.515 37 4 1.08e-1
2020-09 B.1.351 129 72 5.58e-1
2020-09 B.1 129 21 1.63e-1
2020-09 P.2 129 9 6.98e-2
2021-01 B.1.351 7198 2360 3.28e-1
2021-01 P.2 7198 1833 2.55e-1
2021-01 R.1 7198 582 8.09e-2
2021-10 B.1.621 1438 207 1.44e-1
2021-10 P.1 1438 146 1.02e-1
2021-10 AZ.5 1438 138 9.60e-2
2021-11 B.1.621 864 72 8.33e-2
2021-11 AY.4 864 60 6.94e-2
2021-11 P.1 864 56 6.48e-2
2021-12 B.1.617.2 644 124 1.93e-1
2021-12 AY.43 644 64 9.94e-2
2021-12 AY.4.5 644 50 7.76e-2
2021-02 B.1.351 12854 3482 2.71e-1
2021-02 P.1 12854 1875 1.46e-1
2021-02 P.2 12854 1734 1.35e-1
2021-03 B.1.351 35608 7427 2.09e-1
2021-03 P.1 35608 6314 1.77e-1
2021-03 B.1.526 35608 6183 1.74e-1
2021-04 P.1 53288 14454 2.71e-1
2021-04 B.1.526 53288 9415 1.77e-1
2021-04 P.1.14 53288 6192 1.16e-1
2021-05 P.1 41333 14696 3.56e-1
2021-05 P.1.14 41333 4643 1.12e-1
2021-05 B.1.526 41333 3573 8.64e-2
2021-06 P.1 32335 13553 4.19e-1
2021-06 P.1.14 32335 2485 7.69e-2
2021-06 B.1.621 32335 2138 6.61e-2
2021-07 P.1 27333 10216 3.74e-1
2021-07 B.1.621 27333 3695 1.35e-1
2021-07 P.1.14 27333 1349 4.94e-2
2021-08 P.1 13259 4308 3.25e-1
2021-08 B.1.621 13259 2137 1.61e-1
2021-08 P.1.7 13259 1389 1.05e-1
2021-09 B.1.621 3990 886 2.22e-1
2021-09 P.1 3990 716 1.79e-1
2021-09 P.1.7 3990 473 1.19e-1
2022-01 BA.1.1 102 18 1.76e-1
2022-01 B.1.617.2 102 13 1.27e-1
2022-01 AY.43 102 9 8.82e-2
2022-10 CM.2 1802 767 4.26e-1
2022-10 BA.2.3.20 1802 461 2.56e-1
2022-10 CM.4 1802 124 6.88e-2
2022-11 CM.2 2297 764 3.33e-1
2022-11 BA.2.3.20 2297 523 2.28e-1
2022-11 CM.8.1 2297 124 5.40e-2
2022-12 CM.2 1914 559 2.92e-1
2022-12 BA.2.3.20 1914 356 1.86e-1
2022-12 CM.8.1 1914 308 1.61e-1
2022-02 BA.1.1 62 30 4.84e-1
2022-02 AY.125 62 3 4.84e-2
2022-02 B.1 62 3 4.84e-2
2022-03 BA.2 63 20 3.17e-1
2022-03 BA.1.1 63 7 1.11e-1
2022-03 BA.2.9 63 7 1.11e-1
2022-04 BA.2 47 16 3.40e-1
2022-04 BA.2.9 47 8 1.70e-1
2022-04 AY.103 47 3 6.38e-2
2022-05 B.1.621.1 82 36 4.39e-1
2022-05 BA.2 82 28 3.41e-1
2022-05 P.1 82 4 4.88e-2
2022-06 BA.2 31 6 1.94e-1
2022-06 B.1.1.528 31 3 9.68e-2
2022-06 BF.6 31 3 9.68e-2
2022-07 BA.2 33 5 1.52e-1
2022-07 BA.4.6 33 4 1.21e-1
2022-07 BA.5.1.6 33 3 9.09e-2
2022-08 BA.2.3.20 49 13 2.65e-1
2022-08 BA.4.6 49 6 1.22e-1
2022-08 CM.2 49 6 1.22e-1
2022-09 CM.2 746 279 3.74e-1
2022-09 BA.2.3.20 746 225 3.02e-1
2022-09 CM.4 746 56 7.51e-2
2023-01 CM.8.1 1020 306 3.00e-1
2023-01 BA.2.3.20 1020 160 1.57e-1
2023-01 CM.2 1020 130 1.27e-1
2023-02 CM.8.1 199 84 4.22e-1
2023-02 CM.12 199 23 1.16e-1
2023-02 BA.2.3.20 199 16 8.04e-2

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V3909 A.23 3.16e-2 3 2020-8-14 2021-3-5
V3909 A.23.1 6.54e-2 77 2020-9-21 2021-8-22
V3909 A.30 1.00e+0 4 2021-2-13 2021-5-15
V3909 AT.1 9.19e-1 158 2021-1-18 2021-8-3
V3909 AV.1 9.24e-1 145 2020-5-12 2021-7-5
V3909 AY.109 3.22e-2 125 2021-1-10 2022-2-21
V3909 AY.84 1.06e-2 20 2021-4-9 2022-1-24
V3909 AZ.1 9.70e-1 423 2021-1-22 2021-7-29
V3909 AZ.2 9.87e-1 1138 2021-2-5 2021-8-19
V3909 AZ.2.1 9.66e-1 113 2021-3-15 2021-6-26
V3909 AZ.3 9.78e-1 619 2021-2-8 2021-8-20
V3909 AZ.4 9.69e-1 316 2021-2-8 2021-8-14
V3909 AZ.5 9.49e-1 448 2021-2-9 2021-12-6
V3909 AZ.6 1.00e+0 86 2021-3-4 2021-6-14
V3909 B.1 1.89e-2 2014 2020-1-1 2023-1-20
V3909 B.1.1.10 1.40e-2 13 2020-3-1 2022-4-4
V3909 B.1.1.161 1.98e-2 4 2020-3-4 2022-12-30
V3909 B.1.1.207 3.56e-1 335 2020-4-14 2021-12-1
V3909 B.1.1.216 1.92e-2 19 2020-5-6 2022-7-9
V3909 B.1.1.217 3.47e-2 10 2020-4-13 2021-4-26
V3909 B.1.1.220 3.00e-1 97 2020-3-23 2021-5-26
V3909 B.1.1.232 1.12e-2 6 2020-3-28 2021-8-4
V3909 B.1.1.273 3.87e-2 6 2020-4-23 2021-5-3
V3909 B.1.1.28 1.29e-2 57 2020-3-5 2022-6-15
V3909 B.1.1.297 3.37e-2 14 2020-7-16 2021-9-20
V3909 B.1.1.306 7.98e-2 161 2020-3-1 2021-12-6
V3909 B.1.1.318 9.69e-1 3447 2020-5-14 2021-11-27
V3909 B.1.1.345 1.00e+0 24 2020-11-10 2021-3-7
V3909 B.1.1.393 7.50e-1 3 2020-11-4 2021-1-12
V3909 B.1.1.412 3.05e-2 4 2020-6-18 2021-6-7
V3909 B.1.1.515 2.00e-1 10 2020-3-16 2020-10-7
V3909 B.1.1.523 9.59e-1 567 2021-2-2 2022-3-23
V3909 B.1.1.525 9.05e-1 124 2021-1-5 2021-8-24
V3909 B.1.1.526 2.12e-1 28 2020-8-31 2021-9-23
V3909 B.1.1.528 2.48e-2 4 2020-12-7 2022-7-5
V3909 B.1.1.83 2.28e-1 99 2020-3-21 2021-12-18
V3909 B.1.110.3 2.51e-2 38 2020-3-15 2022-3-30
V3909 B.1.177.10 1.63e-2 18 2020-9-2 2021-5-4
V3909 B.1.177.88 1.00e+0 71 2020-12-26 2021-4-20
V3909 B.1.214.3 4.88e-2 6 2020-12-14 2021-7-8
V3909 B.1.237 2.16e-2 4 2020-4-24 2021-8-4
V3909 B.1.243.1 9.70e-1 32 2020-12-15 2021-5-4
V3909 B.1.281 1.58e-1 6 2020-4-8 2020-11-16
V3909 B.1.314 1.50e-2 2 2020-3-13 2021-4-7
V3909 B.1.351 8.74e-1 27334 2020-2-18 2022-10-26
V3909 B.1.351.1 7.50e-1 6 2021-1-19 2021-4-28
V3909 B.1.351.2 9.09e-1 3205 2020-11-3 2021-10-12
V3909 B.1.351.3 8.92e-1 1045 2021-1-24 2021-8-5
V3909 B.1.351.5 9.39e-1 1411 2020-5-10 2022-1-16
V3909 B.1.400.1 8.64e-1 51 2020-11-9 2021-4-29
V3909 B.1.415.1 7.67e-1 92 2021-5-7 2021-8-2
V3909 B.1.441 7.48e-2 8 2020-3-13 2021-11-5
V3909 B.1.486 2.22e-1 2 2020-4-28 2020-9-9
V3909 B.1.494 7.14e-2 4 2020-3-5 2021-8-23
V3909 B.1.525 9.83e-1 7448 2020-3-25 2021-11-29
V3909 B.1.526 5.53e-1 22246 2020-1-28 2022-5-19
V3909 B.1.538 1.28e-1 11 2020-5-16 2021-6-17
V3909 B.1.555 4.44e-2 2 2020-3-11 2020-10-30
V3909 B.1.575.2 9.86e-1 210 2021-5-7 2021-7-2
V3909 B.1.597 1.36e-2 2 2020-3-19 2021-5-11
V3909 B.1.618 9.90e-1 201 2020-10-26 2021-5-14
V3909 B.1.619 9.65e-1 1002 2020-3-10 2021-8-5
V3909 B.1.619.1 9.99e-1 1615 2021-2-22 2021-9-21
V3909 B.1.620 9.79e-1 1225 2020-4-5 2021-9-17
V3909 B.1.621 9.56e-1 10993 2020-5-7 2022-1-25
V3909 B.1.621.1 9.81e-1 1828 2021-4-9 2022-5-25
V3909 B.1.621.2 9.72e-1 614 2021-4-11 2021-12-22
V3909 B.1.625 9.89e-1 360 2020-11-16 2021-12-3
V3909 B.1.626 9.83e-1 238 2021-4-15 2021-10-14
V3909 B.1.630 1.62e-2 3 2021-3-17 2022-8-22
V3909 B.1.632 9.74e-1 147 2021-4-19 2021-9-22
V3909 B.1.634 9.55e-1 274 2021-3-2 2021-8-16
V3909 B.1.638 8.33e-1 10 2021-5-24 2021-6-10
V3909 B.1.639 9.63e-1 52 2021-1-19 2021-11-15
V3909 B.1.640.2 9.59e-1 47 2021-10-15 2022-1-10
V3909 BA.2.3.20 9.61e-1 1754 2022-8-12 2023-2-14
V3909 BB.2 9.43e-1 330 2021-4-20 2021-10-12
V3909 BF.7.13.2 1.10e-2 2 2022-9-9 2023-2-7
V3909 C.1 3.66e-2 14 2020-4-16 2021-11-12
V3909 C.1.2 8.76e-1 254 2021-3-18 2022-5-25
V3909 C.14 2.33e-2 7 2020-3-20 2022-4-27
V3909 C.22 1.54e-1 2 2020-4-3 2021-1-23
V3909 C.38 9.46e-1 105 2021-2-16 2021-8-20
V3909 C.40 1.00e-1 4 2021-2-2 2021-10-8
V3909 CM.1 9.62e-1 175 2022-8-23 2023-2-17
V3909 CM.10 7.91e-1 178 2022-9-5 2023-2-12
V3909 CM.11 9.42e-1 147 2022-9-5 2023-2-12
V3909 CM.12 9.92e-1 237 2022-10-6 2023-2-17
V3909 CM.2 9.66e-1 2522 2022-7-26 2023-2-20
V3909 CM.2.1 9.67e-1 29 2022-10-12 2023-1-29
V3909 CM.3 9.70e-1 193 2022-9-10 2023-2-1
V3909 CM.4 9.62e-1 432 2022-9-4 2023-2-11
V3909 CM.4.1 9.58e-1 161 2022-8-22 2023-2-6
V3909 CM.5 9.49e-1 258 2022-1-10 2023-2-7
V3909 CM.5.1 9.55e-1 42 2022-9-12 2023-2-3
V3909 CM.5.2 9.53e-1 161 2022-10-10 2023-1-24
V3909 CM.6 9.41e-1 32 2022-8-28 2023-2-6
V3909 CM.6.1 9.75e-1 39 2022-9-23 2023-2-2
V3909 CM.7 9.88e-1 80 2022-9-15 2023-2-10
V3909 CM.8 9.10e-1 172 2022-9-6 2023-2-5
V3909 CM.8.1 9.51e-1 827 2022-1-4 2023-2-22
V3909 CM.9 9.55e-1 63 2022-9-29 2023-1-6
V3909 N.10 1.00e+0 35 2020-12-29 2021-6-8
V3909 N.6 2.17e-2 3 2020-2-16 2021-10-24
V3909 N.9 9.55e-1 234 2020-9-25 2021-7-22
V3909 P.1 9.60e-1 67046 2020-4-7 2022-7-23
V3909 P.1.1 9.72e-1 2593 2020-4-30 2021-10-17
V3909 P.1.10 9.69e-1 3385 2021-2-10 2021-10-29
V3909 P.1.10.1 9.76e-1 82 2021-4-25 2021-7-13
V3909 P.1.10.2 9.17e-1 22 2021-5-17 2021-7-8
V3909 P.1.11 9.58e-1 137 2021-5-10 2021-10-1
V3909 P.1.12 8.86e-1 1107 2020-12-23 2021-12-23
V3909 P.1.12.1 1.00e+0 176 2021-7-17 2021-12-6
V3909 P.1.13 9.66e-1 974 2021-2-24 2021-9-8
V3909 P.1.14 9.61e-1 17568 2020-11-3 2022-6-23
V3909 P.1.15 9.36e-1 4396 2021-1-6 2021-12-22
V3909 P.1.16 9.79e-1 2247 2021-1-31 2021-11-29
V3909 P.1.17 9.25e-1 5683 2021-2-23 2021-11-19
V3909 P.1.17.1 9.92e-1 1133 2021-4-2 2021-8-16
V3909 P.1.2 9.57e-1 1090 2021-1-28 2021-11-17
V3909 P.1.3 1.00e+0 29 2021-3-12 2021-6-30
V3909 P.1.4 9.91e-1 1067 2021-3-19 2021-11-11
V3909 P.1.5 1.00e+0 12 2021-4-3 2021-7-2
V3909 P.1.6 9.88e-1 567 2021-3-26 2021-11-16
V3909 P.1.7 9.46e-1 4077 2021-3-15 2021-12-1
V3909 P.1.7.1 9.76e-1 785 2021-2-7 2022-1-10
V3909 P.1.8 9.29e-1 274 2021-5-3 2021-10-25
V3909 P.1.9 9.58e-1 298 2021-4-9 2021-12-7
V3909 P.2 9.67e-1 6170 2020-4-13 2022-6-8
V3909 P.3 9.43e-1 509 2021-1-8 2022-2-17
V3909 Q.1 8.04e-2 565 2021-1-8 2021-10-11
V3909 R.1 9.96e-1 10806 2020-10-24 2021-12-23
V3909 R.2 1.00e+0 67 2020-12-22 2021-5-5
V3909 XBB.1.3 9.57e-1 45 2022-9-14 2023-2-16
V3909 XBJ 9.51e-1 232 2022-9-2 2023-2-17
V3909 XH 1.91e-2 3 2021-12-30 2022-6-8






Examining mutation (1450G>A) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID
Odocoileus virginianus B.1.1 USA 2020-11-7 EPI_ISL_13610583
Felis catus P.1 Brazil 2021-5-1 EPI_ISL_4565991
Felis catus B.1.619.1 South Korea 2021-6-30 EPI_ISL_15775583
Felis catus B.1.619.1 South Korea 2021-8-1 EPI_ISL_15727693
Felis catus B.1.526 USA 2021-3-6 EPI_ISL_2930559
Nasua nasua P.2 Brazil 2021-2-18 EPI_ISL_8800460
Odocoileus virginianus P.1 USA 2021-11-24 EPI_ISL_9347709
Odocoileus virginianus P.1 USA 2021-11-28 EPI_ISL_16297221
Odocoileus virginianus P.1 USA 2021-11-22 EPI_ISL_16318399
Odocoileus virginianus P.1 USA 2021-11-22 EPI_ISL_16297305
Odocoileus virginianus P.1 USA 2021-11-22 EPI_ISL_16318397
Odocoileus virginianus P.1 USA 2021-11-22 EPI_ISL_16297313
Odocoileus virginianus P.1 USA 2021-11-28 EPI_ISL_16308828
Odocoileus virginianus P.1 USA 2021-11-23 EPI_ISL_16297249
Odocoileus virginianus P.1 USA 2021-10-30 EPI_ISL_13610615
Odocoileus virginianus P.1 USA 2021-11-9 EPI_ISL_13610663
Odocoileus virginianus P.1 USA 2021-10-27 EPI_ISL_13610611
Odocoileus virginianus P.1 USA 2021-11-7 EPI_ISL_13610655
Odocoileus virginianus P.1 USA 2021-11-2 EPI_ISL_13610626
Odocoileus virginianus P.1 USA 2021-11-9 EPI_ISL_13610664
Odocoileus virginianus P.1 USA 2021-10-31 EPI_ISL_13610619
Odocoileus virginianus P.1 USA 2021-11-3 EPI_ISL_13658787
Odocoileus virginianus P.1 USA 2021-11-5 EPI_ISL_13610633
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13610643
Odocoileus virginianus P.1 USA 2021-10-31 EPI_ISL_13610620
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13610644
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13610645
Odocoileus virginianus P.1 USA 2021-11-1 EPI_ISL_13610623
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13610649
Odocoileus virginianus P.1 USA 2021-11-3 EPI_ISL_13610632
Odocoileus virginianus P.1 USA 2021-11-5 EPI_ISL_13610637
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13658797
Odocoileus virginianus P.1 USA 2021-11-13 EPI_ISL_13610673
Odocoileus virginianus P.1 USA 2021-12-2 EPI_ISL_16297284
Canis lupus familiaris B.1.625 Colombia 2021-4-26 EPI_ISL_8422346
Canis lupus B.1.620 South Korea 2021-5-28 EPI_ISL_15775590
Canis lupus B.1.619.1 South Korea 2021-6-6 EPI_ISL_15775594
Canis lupus B.1.619.1 South Korea 2021-7-13 EPI_ISL_15727698
Canis lupus B.1.619.1 South Korea 2021-8-3 EPI_ISL_15727701
Canis lupus familiaris B.1.526 USA 2021-3-3 EPI_ISL_2930560
Mus musculus B.1.351 China 2021-5-1 EPI_ISL_16138137
Mus musculus B USA 2021-1-22 EPI_ISL_1666328
Panthera uncia B.1.621 USA 2021-7-22 EPI_ISL_5858432
Panthera uncia B.1.621 USA 2021-7-26 EPI_ISL_5858433
Panthera uncia B.1.621 USA 2021-7-27 EPI_ISL_3261746
Panthera uncia B.1.621 USA 2021-7-22 EPI_ISL_3261747
Mus musculus P.3 Hong Kong 2022-2-17 EPI_ISL_12996407




Association between mutation (1450G>A) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory 4.27e-1 1.40e-1 3.06e+0 2.23e-3 Increase
Deceased 3.07e-1 8.42e-2 3.65e+0 2.64e-4 Increase
Homebound -2.93e+0 3.32e-1 -8.81e+0 1.20e-18 Decrease
Hospitalized -7.63e-1 4.38e-2 -1.74e+1 6.09e-68 Decrease
Mild 7.18e-1 1.19e-1 6.03e+0 1.63e-9 Increase
Recovered 7.18e-1 4.57e-2 1.57e+1 1.14e-55 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 8.34e-2 2.15e-2 3.88e+0 1.03e-4 Increase
18-39 8.85e-2 1.11e-2 7.94e+0 2.10e-15 Increase
40-64 -9.09e-3 1.13e-2 -8.03e-1 4.22e-1 Decrease
65-84 -1.51e-1 1.66e-2 -9.14e+0 6.15e-20 Decrease
>=85 -1.92e-1 3.24e-2 -5.91e+0 3.38e-9 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male 5.47e-3 1.09e-2 5.00e-1 6.17e-1 Increase





Investigating natural selection at mutation (1450G>A) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method
S 21563 25384 1273 484 1.00e-2 BA.2.10.1 MEME
S 21563 25384 1273 484 0.00e+0 BA.2.3.20 MEME
S 21563 25384 1273 484 0.00e+0 BA.2.38 MEME
S 21563 25384 1273 484 3.00e-2 BA.2.56 MEME
S 21563 25384 1273 484 1.00e-2 XBB MEME
S 21563 25384 1273 484 4.00e-2 B.1.565 MEME
S 21563 25384 1273 484 4.00e-2 BA.1.1.18 MEME
S 21563 25384 1273 484 5.00e-2 BA.1.1.1 MEME
S 21563 25384 1273 484 2.00e-2 BA.1.15 MEME
S 21563 25384 1273 484 1.00e-2 BA.1.17 MEME
S 21563 25384 1273 484 3.00e-2 BA.1.20 MEME
S 21563 25384 1273 484 2.00e-2 BA.1 MEME
S 21563 25384 1273 484 0.00e+0 BA.2.3 MEME
S 21563 25384 1273 484 1.00e-2 BQ.1.23 MEME
S 21563 25384 1273 484 4.00e-2 AY.23 MEME
S 21563 25384 1273 484 3.00e-2 AY.36 MEME
S 21563 25384 1273 484 2.00e-2 CM.10 MEME
S 21563 25384 1273 484 3.00e-2 CM.8 MEME
S 21563 25384 1273 484 4.00e-2 XBJ MEME

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method
S 21563 25384 1273 484 0.00 27.15 4.00e-2 BA.1.13 FEL
S 21563 25384 1273 484 0.00 26.23 2.00e-2 BA.2.10.1 FEL
S 21563 25384 1273 484 0.00 44.61 4.00e-2 AY.45 FEL
S 21563 25384 1273 484 0.00 40.26 3.00e-2 BA.1.1.18 FEL
S 21563 25384 1273 484 0.00 18.83 3.00e-2 BA.1.1.1 FEL
S 21563 25384 1273 484 0.00 30.05 1.00e-2 BA.1.15 FEL
S 21563 25384 1273 484 0.00 37.52 1.00e-2 BA.1.17 FEL
S 21563 25384 1273 484 0.00 33.71 2.00e-2 BA.1.20 FEL
S 21563 25384 1273 484 0.00 24.38 1.00e-2 BA.1 FEL
S 21563 25384 1273 484 0.00 34.16 2.00e-2 AY.23 FEL
S 21563 25384 1273 484 0.00 61.74 2.00e-2 AY.36 FEL

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.1.1.10 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.1.11 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.1.1.13 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.1.1.16 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.13 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.1.14.2 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.1.15.2 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.1.7 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.1.19 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.1.21 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.2.10.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.2.12 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.2.13.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.2.3.15 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.2.3.20 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.2.38 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.2.39 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.2.44 FUBAR
S 21563 25384 1273 484 1.00e-2 9.50e-1 BA.2.56 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.2.5 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.2.75 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.2.7 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.2.9.3 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.4.1.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.4.4 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.4.6.5 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.5.1.19 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.1.24 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.1.30 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.5.1.4 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.5.1.6 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.2.16 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.5.2.18 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.5.2.21 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.2.24 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.2.26 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.5.2.27 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.2.34 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.5.2.3 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BA.5.2.48 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.5.2.8 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.3.1 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.5.3 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.5.6.2 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BE.1.4 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BE.2 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BE.3 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BE.9 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BF.11 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BF.25 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BF.27 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BF.28 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BF.4 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BF.6 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BF.7.4 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BG.5 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BK.1 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BM.1.1.3 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BN.1.5 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BQ.1.1.10 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BQ.1.1.11 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BQ.1.13 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BQ.1.1.5 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BQ.1.1.7 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BQ.1.3 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BQ.1.5 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BQ.1.8 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BU.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 C.37 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 CH.1.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 CM.2 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 CM.8.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 P.1.10 FUBAR
S 21563 25384 1273 484 0.00e+0 9.70e-1 P.1.12 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 P.1.15 FUBAR
S 21563 25384 1273 484 1.00e-2 9.50e-1 P.1.16 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 P.1.17 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 P.1.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 XB FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 A.23.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.106 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.108 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 AY.109 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.111 FUBAR
S 21563 25384 1273 484 0.00e+0 9.70e-1 AY.131 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 AY.16 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 AY.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.24 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 AY.30 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.35 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 AY.37 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.45 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 AY.5.4 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 AY.70 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.84 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.85 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 AY.91 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.92 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 AY.99 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 B.1.1.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 B.1.1.28 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 B.1.311 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 B.1.36 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 B.1.525 FUBAR
S 21563 25384 1273 484 0.00e+0 9.70e-1 B.1.619 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 B.1.623 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 B FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 B.1.2 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 B.1.351 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 B.1.526 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 B.1.621 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.1.1.14 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.1.1.15 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.1.1.18 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.1.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.1.1.2 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.1.14 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.1.15.1 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.1.15 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.17.2 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.1.17 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.18 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.1.1 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.1.20 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 BA.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.2.18 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.2.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.2.36 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.2.3 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.2.9 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.4.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.70e-1 BA.4.6 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.4 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.5.1.10 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.5.1.22 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.1.23 FUBAR
S 21563 25384 1273 484 1.00e-2 9.50e-1 BA.5.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BA.5.2.20 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BA.5.2.9 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BA.5.5 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BA.5.6 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BE.1.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 BE.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BF.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 BF.21 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BF.26 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 BQ.1.12 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 BQ.1.23 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 P.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 XBB.1 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.102 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 AY.112 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 AY.120 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.122 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.127 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 AY.20 FUBAR
S 21563 25384 1273 484 0.00e+0 1.00e+0 AY.23 FUBAR
S 21563 25384 1273 484 0.00e+0 9.90e-1 AY.36 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.43 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.4.5 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 AY.4.6 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 AY.98.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 B.1.177 FUBAR
S 21563 25384 1273 484 1.00e-2 9.80e-1 B.1.1 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 B.1.221 FUBAR
S 21563 25384 1273 484 0.00e+0 9.60e-1 B.1.237 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.2.3.21 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 BA.2.34 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BA.5.5.3 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BE.1.4.2 FUBAR
S 21563 25384 1273 484 2.00e-2 9.60e-1 BJ.1 FUBAR
S 21563 25384 1273 484 1.00e-2 9.70e-1 BM.2 FUBAR
S 21563 25384 1273 484 0.00e+0 9.80e-1 CM.10 FUBAR
S 21563 25384 1273 484 1.00e-2 9.60e-1 CM.5.1 FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 XAM FUBAR
S 21563 25384 1273 484 2.00e-2 9.50e-1 XBB.1.4 FUBAR




Alterations in protein physicochemical properties induced by mutation (1450G>A)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY
Mutation S 141177.53 6.41 146460 84.67 -0.079
Reference S 141178.47 6.24 146460 84.67 -0.079




Alterations in protein stability induced by mutation (1450G>A)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition
E484K S Point 484 -0.85 Decrease 7 25 Environment
E484K S Point 484 -0.76 Decrease 7.4 37 Internal




Impact on protein function induced by mutation (1450G>A)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms
E484K S Point 0.333 Loss of Loop (Pr = 0.28 | P = 0.02)
Gain of Strand (Pr = 0.26 | P = 0.05)
Gain of Disulfide_linkage at C480 (Pr = 0.26 | P = 4.2e-03)
Altered Cytoplasmic_loop (Pr = 0.11 | P = 0.03)
Loss of GPI-anchor_amidation at N481 (Pr = 0.02 | P = 0.02)




Exploring mutation (1450G>A) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (1450G>A)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites
E484K S 23012 LysC NGVKGFNCYF (pos: 484)
 NA
E484K S 23012 Pepsin (pH1.3) NA
 VEGFNCYFPL (pos: 486)
E484K S 23012 Proteinase K NA
 NGVEGFNCYF (pos: 484)
E484K S 23012 LysN CNGVKGFNCY (pos: 483)
 NA
E484K S 23012 Pepsin (pH>2) NA
 VEGFNCYFPL (pos: 486)
E484K S 23012 Staphylococcal peptidase I NA
 NGVEGFNCYF (pos: 484)
E484K S 23012 Asp-N endopeptidase + N-terminal Glu NA
 CNGVEGFNCY (pos: 483)
E484K S 23012 Glutamyl endopeptidase NA
 NGVEGFNCYF (pos: 484)
E484K S 23012 Trypsin NGVKGFNCYF (pos: 484)
 NA




Impact of spike protein mutation (1450G>A) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score
Mutation S RBD 0.5197 -0.3049
Reference S RBD 0.5197 0.00265




Impact of mutation (1450G>A) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

;
Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image
E484K S RBD 484 9.01e+0 8.77e+0 2.41e-1 1.78e-1 Image Description


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

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        Show interface residues:





Impact of mutation (1450G>A) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score
E484K COV2-2196 antibody class 1 2020 3.01e-2 2.41e-2
E484K COV2-2130 antibody class 3 2020 9.66e-4 1.20e-3
E484K COV2-2955 antibody class 2 2021 9.93e-1 8.49e-1
E484K CR3022 antibody class 4 2020 1.73e-2 5.92e-3
E484K COV2-2677 antibody class 4 2020 6.29e-4 6.67e-4
E484K COV2-2082 antibody class 4 2020 3.03e-3 2.88e-3
E484K COV2-2094 antibody class 4 2020 1.77e-3 1.61e-3
E484K COV2-2165 antibody class 1 2020 2.03e-3 1.84e-3
E484K COV2-2832 antibody class 1 2020 3.01e-2 2.88e-2
E484K COV2-2479 antibody class 2 2020 3.10e-2 2.37e-2
E484K COV2-2050 antibody class 2 2020 2.28e-1 2.16e-1
E484K COV2-2096 antibody class 2 2020 1.26e-1 4.10e-2
E484K COV2-2499 antibody class 3 2020 2.06e-3 5.54e-3
E484K subject A (day 21) serum convalescent serum 2020 5.62e-3 2.92e-2
E484K subject A (day 120) serum convalescent serum 2020 6.26e-2 1.60e-1
E484K subject A (day 45) serum convalescent serum 2020 1.26e-2 4.72e-2
E484K subject B (day 26) serum convalescent serum 2020 3.46e-2 1.09e-1
E484K subject B (day 113) serum convalescent serum 2020 1.18e-1 1.59e-1
E484K subject C (day 32) serum convalescent serum 2020 3.37e-4 1.02e-1
E484K subject C (day 104) serum convalescent serum 2020 5.95e-4 3.92e-2
E484K subject D (day 33) serum convalescent serum 2020 5.99e-3 3.24e-2
E484K subject D (day 76) serum convalescent serum 2020 2.50e-4 1.68e-3
E484K subject E (day 28) serum convalescent serum 2020 1.61e-1 2.67e-1
E484K subject E (day 104) serum convalescent serum 2020 2.06e-1 4.49e-1
E484K subject F (day 48) serum convalescent serum 2020 1.26e-2 2.18e-1
E484K subject F (day 115) serum convalescent serum 2020 5.06e-2 2.62e-1
E484K subject G (day 18) serum convalescent serum 2020 4.26e-3 1.47e-1
E484K subject G (day 94) serum convalescent serum 2020 6.00e-2 7.06e-2
E484K subject H (day 61) serum convalescent serum 2020 4.31e-2 8.22e-2
E484K subject H (day 152) serum convalescent serum 2020 1.43e-1 1.58e-1
E484K subject I (day 26) serum convalescent serum 2020 2.45e-1 2.88e-1
E484K subject I (day 102) serum convalescent serum 2020 3.08e-1 3.86e-1
E484K subject J (day 15) serum convalescent serum 2020 1.03e-2 2.87e-2
E484K subject J (day 121) serum convalescent serum 2020 3.70e-2 6.22e-2
E484K subject K (day 29) serum convalescent serum 2020 9.83e-4 6.01e-3
E484K subject K (day 103) serum convalescent serum 2020 1.12e-3 1.32e-2
E484K M01 (day 119) serum Moderna vaccine serum 2020 8.64e-3 4.39e-2
E484K M02 (day 119) serum Moderna vaccine serum 2020 1.90e-3 1.40e-2
E484K M03 (day 119) serum Moderna vaccine serum 2020 6.00e-3 6.07e-2
E484K M04 (day 119) serum Moderna vaccine serum 2020 2.26e-4 9.66e-4
E484K M05 (day 119) serum Moderna vaccine serum 2020 9.65e-4 9.16e-3
E484K M06 (day 119) serum Moderna vaccine serum 2020 3.37e-3 5.97e-2
E484K M07 (day 119) serum Moderna vaccine serum 2020 4.28e-2 9.30e-2
E484K M08 (day 119) serum Moderna vaccine serum 2020 1.13e-2 3.72e-2
E484K M09 (day 119) serum Moderna vaccine serum 2020 1.53e-4 1.82e-3
E484K M10 (day 119) serum Moderna vaccine serum 2020 5.02e-3 6.80e-2
E484K M11 (day 119) serum Moderna vaccine serum 2020 2.54e-3 6.24e-2
E484K M12 (day 119) serum Moderna vaccine serum 2020 4.72e-3 3.21e-3
E484K M13 (day 119) serum Moderna vaccine serum 2020 1.62e-4 4.09e-3
E484K M14 (day 119) serum Moderna vaccine serum 2020 1.58e-4 6.10e-4
E484K M16 (day 119) serum Moderna vaccine serum 2020 6.08e-2 7.90e-2
E484K M17 (day 119) serum Moderna vaccine serum 2020 3.60e-3 9.74e-3
E484K M18 (day 119) serum Moderna vaccine serum 2020 5.73e-3 2.29e-2
E484K M19 (day 119) serum Moderna vaccine serum 2020 6.27e-3 3.11e-2
E484K M20 (day 119) serum Moderna vaccine serum 2020 2.51e-4 1.37e-3
E484K M21 (day 119) serum Moderna vaccine serum 2020 2.90e-3 1.61e-2
E484K M22 (day 119) serum Moderna vaccine serum 2020 6.18e-4 1.31e-3
E484K M23 (day 119) serum Moderna vaccine serum 2020 2.39e-4 1.70e-3
E484K M02 (day 36) serum Moderna vaccine serum 2020 2.24e-3 3.86e-3
E484K M05 (day 36) serum Moderna vaccine serum 2020 1.75e-3 6.34e-4
E484K M08 (day 36) serum Moderna vaccine serum 2020 1.41e-3 1.62e-3
E484K M10 (day 36) serum Moderna vaccine serum 2020 1.43e-4 4.28e-3
E484K M12 (day 36) serum Moderna vaccine serum 2020 2.74e-4 4.06e-4
E484K COV-021 serum convalescent serum 2020 5.58e-2 1.23e-1
E484K COV-047 serum convalescent serum 2020 8.08e-2 1.61e-1
E484K COV-057 serum convalescent serum 2020 3.08e-2 2.59e-1
E484K COV-072 serum convalescent serum 2020 1.00e-2 1.12e-1
E484K COV-107 serum convalescent serum 2020 6.23e-2 1.44e-1
E484K C002 antibody class 2 2020 9.83e-1 9.23e-1
E484K C105 antibody class 1 2020 1.07e-3 1.18e-3
E484K C110 antibody class 3 2020 1.51e-3 3.78e-3
E484K C121 antibody class 2 2020 1.00e+0 9.04e-1
E484K C135 antibody class 3 2020 1.62e-3 1.97e-3
E484K C144 antibody class 2 2020 9.66e-1 9.71e-1
E484K LY-CoV555 antibody class 2 2020 9.70e-1 8.85e-1
E484K REGN10933 antibody class 1 2020 8.03e-3 1.60e-1
E484K REGN10987 antibody class 3 2020 2.08e-3 2.07e-3
E484K LY-CoV016 antibody class 1 2020 1.09e-3 4.93e-2
E484K S309 antibody class 3 2021 3.37e-2 4.16e-2
E484K S2H97 antibody class 4 2021 3.95e-3 4.15e-3
E484K S304 antibody class 4 2021 9.32e-3 1.99e-2
E484K S2X35 antibody class 4 2021 4.75e-2 4.87e-2
E484K S2E12 antibody class 1 2021 9.82e-2 2.74e-1
E484K S2X16 antibody class 2 2021 9.87e-1 9.66e-1
E484K S2H58 antibody class 2 2021 9.88e-1 9.87e-1
E484K S2H13 antibody class 2 2021 8.68e-1 9.03e-1
E484K S2D106 antibody class 2 2021 1.00e+0 6.01e-1
E484K S2X58 antibody class 2 2021 9.82e-1 7.60e-1
E484K S2H14 antibody class 1 2021 1.57e-3 3.66e-2
E484K S2X227 antibody class 3 2021 1.92e-3 1.94e-3
E484K S2X259 antibody class 4 2021 1.60e-3 1.68e-3
E484K BD30-196 antibody class 2 2022 1.78e-1 1.77e-1
E484K BD30-254 antibody class 2 2022 4.45e-1 2.60e-1
E484K BD30-362 antibody class 2 2022 3.22e-1 1.96e-1
E484K BD30-368 antibody class 2 2022 7.00e-1 3.91e-1
E484K BD30-397 antibody class 2 2022 5.12e-1 4.78e-1
E484K BD30-403 antibody class 2 2022 3.90e-1 2.98e-1
E484K BD30-417 antibody class 1 2022 2.95e-1 1.45e-1
E484K BD30-504 antibody class 1 2022 1.02e-1 6.13e-2
E484K BD30-515 antibody class 1 2022 6.56e-3 2.69e-2
E484K BD30-536 antibody class 2 2022 4.92e-1 3.89e-1
E484K BD30-566 antibody class 1 2022 2.37e-2 3.35e-2
E484K BD30-593 antibody class 2 2022 5.67e-1 5.10e-1
E484K REGN10933 antibody class 1 2022 2.59e-2 5.95e-2
E484K P2B-2F6 antibody class 3 2022 4.04e-1 3.61e-1
E484K LY-CoV555 antibody class 2 2022 7.99e-1 5.02e-1
E484K S2M11 antibody class 2 2022 6.51e-1 4.11e-1
E484K S2H14 antibody class 4 2022 2.10e-2 3.37e-2
E484K S2H13 antibody class 2 2022 3.61e-1 2.97e-1
E484K P2C-1A3 antibody class 2 2022 5.18e-1 4.64e-1
E484K H4 antibody class 2 2022 4.39e-1 4.39e-1
E484K DH1041 antibody class 2 2022 5.03e-1 4.07e-1
E484K CV07-270 antibody class 3 2022 4.95e-1 3.16e-1
E484K COVOX-40 antibody class 1 2022 6.38e-3 3.02e-2
E484K COVOX-384 antibody class 2 2022 7.32e-1 5.96e-1
E484K COVOX-316 antibody class 2 2022 7.00e-1 4.90e-1
E484K COVOX-269 antibody class 1 2022 2.53e-1 1.44e-1
E484K COVA2-39 antibody class 1 2022 5.16e-1 3.80e-1
E484K C144 antibody class 2 2022 2.94e-1 2.33e-1
E484K C121 antibody class 2 2022 6.68e-1 3.29e-1
E484K C002 antibody class 2 2022 7.00e-1 4.24e-1
E484K BG10-19 antibody class 3 2022 2.11e-1 1.13e-1
E484K BG1-24 antibody class 1 2022 6.15e-1 3.92e-1
E484K 2��15�� antibody class 2 2022 3.05e-1 2.32e-1
E484K 15033 antibody class 1 2022 1.00e-1 7.62e-2
E484K 2H2 antibody class 1 2022 1.06e-2 3.30e-2
E484K CV05-163 antibody class 1 2022 3.09e-1 2.30e-1
E484K CV38-142 antibody class 3 2022 1.07e-1 6.27e-2
E484K FC08 antibody class 3 2022 3.06e-2 2.80e-2
E484K P17 antibody class 2 2022 3.22e-1 1.95e-1
E484K C058 antibody class 2 2022 5.57e-1 3.14e-1
E484K C083 antibody class 2 2022 4.91e-1 1.03e-1
E484K C516 antibody class 2 2022 4.64e-1 3.41e-1
E484K C578 antibody class 1 2022 1.29e-1 1.15e-1
E484K C591 antibody class 2 2022 3.83e-1 3.29e-1
E484K CM32 antibody class 2 2022 3.51e-1 2.72e-1
E484K BG7-20 antibody class 1 2022 4.15e-1 2.10e-1
E484K DH1043 antibody class 2 2022 6.17e-1 2.27e-1
E484K DH1042 antibody class 2 2022 3.22e-1 1.87e-1
E484K DH1184 antibody class 2 2022 4.79e-1 1.81e-1
E484K DH1186 antibody class 2 2022 8.40e-1 3.54e-1
E484K DH1173 antibody class 2 2022 4.89e-1 3.73e-1
E484K DH1154 antibody class 1 2022 6.78e-2 5.12e-2
E484K DH1111 antibody class 2 2022 4.07e-1 3.82e-1
E484K DH1082 antibody class 2 2022 4.31e-1 3.68e-1
E484K DH1159-2 antibody class 2 2022 6.93e-1 3.69e-1
E484K DH1196 antibody class 2 2022 6.32e-1 3.37e-1
E484K DH1214 antibody class 2 2022 4.92e-1 2.76e-1
E484K CV07-200 antibody class 2 2022 3.02e-1 2.02e-1
E484K CV07-222 antibody class 2 2022 4.57e-1 2.81e-1
E484K CV07-255 antibody class 2 2022 5.41e-1 3.48e-1
E484K CV07-262 antibody class 2 2022 4.46e-1 2.43e-1
E484K CV07-283 antibody class 2 2022 3.20e-1 1.95e-1
E484K CV07-287 antibody class 1 2022 1.93e-2 1.89e-2
E484K CV07-315 antibody class 2 2022 3.46e-1 2.53e-1
E484K CV-X2-106 antibody class 1 2022 1.19e-1 5.73e-2
E484K COV2-2098 antibody class 1 2022 1.45e-1 6.95e-2
E484K COV2-2504 antibody class 2 2022 6.03e-1 3.43e-1
E484K COV2-2064 antibody class 2 2022 1.47e-1 1.17e-1
E484K COV2-2539 antibody class 2 2022 2.16e-1 1.01e-1
E484K COV2-2819 antibody class 2 2022 1.31e-2 5.24e-2
E484K COV2-2693 antibody class 3 2022 2.70e-1 2.61e-1
E484K COV2-2479 antibody class 2 2022 6.72e-1 1.48e-1
E484K COV2-2955 antibody class 2 2022 2.53e-1 1.43e-1
E484K COV2-2678 antibody class 4 2022 3.88e-2 2.94e-2
E484K BD55-13 antibody class 3 2022 1.26e-1 1.78e-1
E484K BD55-40 antibody class 2 2022 5.68e-1 4.86e-1
E484K BD55-83 antibody class 3 2022 1.01e-1 8.37e-2
E484K BD55-121 antibody class 4 2022 2.70e-1 1.84e-1
E484K BD55-137 antibody class 1 2022 2.56e-1 1.67e-1
E484K BD55-141 antibody class 1 2022 5.07e-2 9.39e-2
E484K BD55-160 antibody class 2 2022 6.29e-1 4.12e-1
E484K BD55-161 antibody class 2 2022 6.22e-1 4.43e-1
E484K BD55-175 antibody class 1 2022 2.68e-1 1.57e-1
E484K BD55-183 antibody class 1 2022 8.01e-3 1.09e-2
E484K BD55-196 antibody class 3 2022 1.69e-1 4.42e-2
E484K BD55-205 antibody class 2 2022 4.49e-1 3.43e-1
E484K BD55-240 antibody class 2 2022 5.16e-1 4.27e-1
E484K BD55-267 antibody class 2 2022 4.64e-1 1.70e-1
E484K BD55-270 antibody class 2 2022 6.19e-1 3.43e-1
E484K BD55-271 antibody class 3 2022 2.81e-2 1.60e-2
E484K BD55-272 antibody class 4 2022 2.56e-1 1.01e-1
E484K BD55-276 antibody class 2 2022 7.83e-1 3.86e-1
E484K BD55-285 antibody class 1 2022 1.19e-2 2.44e-2
E484K BD55-288 antibody class 3 2022 1.79e-1 5.14e-2
E484K BD55-292 antibody class 1 2022 4.21e-3 1.16e-2
E484K BD55-311 antibody class 3 2022 2.61e-2 2.38e-2
E484K BD55-600 antibody class 1 2022 1.04e-1 1.13e-1
E484K BD55-1039 antibody class 3 2022 3.20e-1 1.38e-1
E484K BD55-1049 antibody class 2 2022 5.25e-1 4.23e-1
E484K BD55-1051 antibody class 2 2022 2.81e-1 2.85e-1
E484K BD55-1065 antibody class 2 2022 5.72e-1 4.48e-1
E484K BD55-1078 antibody class 2 2022 2.26e-2 1.15e-1
E484K BD55-1171 antibody class 2 2022 5.22e-1 1.91e-1
E484K BD55-1223 antibody class 2 2022 5.88e-1 5.15e-1
E484K BD55-1225 antibody class 4 2022 7.49e-3 3.10e-2
E484K BD55-1226 antibody class 4 2022 1.29e-1 7.60e-2
E484K BD55-1256 antibody class 2 2022 6.04e-1 2.85e-1
E484K BD55-1266 antibody class 3 2022 9.86e-3 1.88e-2
E484K BD55-1274 antibody class 3 2022 1.88e-1 1.04e-1
E484K BD55-1312 antibody class 3 2022 1.18e-1 3.05e-2
E484K BD55-1432 antibody class 3 2022 9.78e-2 4.59e-2
E484K BD55-1435 antibody class 2 2022 3.72e-1 2.79e-1
E484K BD55-1558 antibody class 2 2022 2.92e-1 2.53e-1
E484K BD55-1576 antibody class 2 2022 9.57e-3 1.85e-1
E484K BD55-1579 antibody class 2 2022 4.47e-1 2.43e-1
E484K BD55-1694 antibody class 2 2022 3.85e-1 3.42e-1
E484K BD55-1706 antibody class 3 2022 6.34e-2 3.34e-2
E484K BD55-1779 antibody class 3 2022 1.19e-1 3.04e-2
E484K BD55-1809 antibody class 1 2022 7.32e-1 5.08e-1
E484K BD55-3304 antibody class 4 2022 2.72e-2 2.68e-2
E484K BD55-3546 antibody class 3 2022 5.78e-3 1.33e-2
E484K BD55-4351 antibody class 2 2022 6.15e-1 4.48e-1
E484K BD55-4382 antibody class 2 2022 5.94e-1 4.16e-1
E484K BD55-4397 antibody class 2 2022 4.82e-1 4.75e-1
E484K BD55-5251 antibody class 3 2022 2.54e-2 5.91e-2
E484K BD55-5399 antibody class 1 2022 1.32e-2 4.46e-2
E484K BD55-5404 antibody class 4 2022 5.93e-3 4.20e-2
E484K BD55-5634 antibody class 2 2022 1.26e-1 2.59e-1
E484K BD55-5655 antibody class 1 2022 3.66e-1 3.40e-1
E484K BD55-5743 antibody class 1 2022 8.10e-2 1.06e-1
E484K BD55-5747 antibody class 2 2022 5.50e-1 4.62e-1
E484K BD55-5774 antibody class 1 2022 7.66e-3 1.96e-2
E484K BD55-5811 antibody class 1 2022 3.56e-1 4.46e-1
E484K BD55-5854 antibody class 2 2022 5.08e-1 2.50e-1
E484K BD55-5966 antibody class 1 2022 4.81e-1 2.10e-1
E484K BD55-6222 antibody class 4 2022 8.17e-3 1.81e-2
E484K BD55-6382 antibody class 1 2022 9.16e-2 1.55e-1
E484K BD55-6383 antibody class 1 2022 2.33e-1 1.13e-1
E484K BD55-6413 antibody class 1 2022 2.11e-1 2.10e-1
E484K OC220225-GC0005 antibody class 2 2022 4.74e-1 2.13e-1
E484K OC220225-GC0010 antibody class 2 2022 2.53e-1 5.01e-2
E484K OC220225-GC0012 antibody class 1 2022 2.12e-2 3.68e-2
E484K OC220225-GC0015 antibody class 3 2022 8.71e-2 1.63e-1
E484K OC220225-GC0017 antibody class 2 2022 7.40e-1 4.19e-1
E484K OC220225-GC0020 antibody class 3 2022 3.64e-1 4.30e-1
E484K OC220225-GC0022 antibody class 1 2022 5.22e-1 2.55e-1
E484K OC220225-GC0026 antibody class 3 2022 3.52e-3 3.34e-3
E484K OC220225-GC0030 antibody class 3 2022 7.34e-3 4.14e-2
E484K OC220225-GC0043 antibody class 2 2022 6.43e-1 2.93e-1
E484K OC220225-GC0047 antibody class 2 2022 5.50e-1 3.02e-1
E484K OC220225-GC0049 antibody class 1 2022 8.05e-3 2.23e-2
E484K OC220225-GC0051 antibody class 3 2022 2.89e-2 1.58e-1
E484K OC220225-GC0054 antibody class 2 2022 9.38e-3 1.48e-1
E484K OC220225-GC0077 antibody class 2 2022 3.08e-1 3.54e-1
E484K OC220225-GC0078 antibody class 3 2022 3.49e-1 1.49e-1
E484K OC220225-SN0003 antibody class 1 2022 3.83e-1 2.67e-1
E484K OC220225-SN0059 antibody class 2 2022 7.07e-1 3.09e-1
E484K OC220225-SN0083 antibody class 3 2022 3.38e-3 1.89e-3
E484K OC220225-SN0108 antibody class 3 2022 7.94e-2 1.37e-2
E484K OC220225-SN0112 antibody class 3 2022 3.39e-2 4.04e-2
E484K OC220225-SN0118 antibody class 3 2022 5.96e-2 2.37e-2
E484K OC220225-SN0163 antibody class 3 2022 2.87e-3 8.74e-3
E484K OC220225-SN0233 antibody class 2 2022 8.48e-2 2.79e-1
E484K OC220302-SN0410 antibody class 3 2022 5.22e-2 2.78e-2
E484K OC220302-SN0420 antibody class 3 2022 1.35e-1 1.51e-1
E484K OC220302-SN0430 antibody class 3 2022 6.97e-2 4.57e-2
E484K OC220302-SN0431 antibody class 1 2022 4.20e-3 5.68e-3
E484K OC220302-SN0433 antibody class 2 2022 2.97e-1 4.23e-1
E484K OC220302-SN0436 antibody class 3 2022 1.88e-2 3.55e-2
E484K OC220302-SN0461 antibody class 3 2022 1.70e-1 3.48e-1
E484K OC220302-SN0468 antibody class 3 2022 2.70e-2 2.62e-2
E484K OC220302-SN0475 antibody class 3 2022 3.24e-1 3.66e-1
E484K OC220302-SN0477 antibody class 2 2022 5.13e-1 2.51e-1
E484K OC220302-SN0480 antibody class 2 2022 1.33e-1 1.67e-1
E484K OC220302-SN0486 antibody class 3 2022 2.41e-2 4.23e-2
E484K OC220302-SN0488 antibody class 3 2022 2.69e-3 2.19e-2
E484K OC220302-SN0493 antibody class 2 2022 8.18e-1 1.32e-1
E484K OC220302-SN0506 antibody class 1 2022 1.28e-2 3.00e-2
E484K OC220302-SN0520 antibody class 2 2022 6.28e-3 4.78e-2
E484K OC220302-SN0528 antibody class 3 2022 3.51e-2 9.42e-3
E484K OC220302-SN0558 antibody class 3 2022 1.29e-1 4.64e-2
E484K OC220302-SN0566 antibody class 3 2022 2.24e-2 4.88e-2
E484K OC220302-SN0576 antibody class 4 2022 2.18e-2 4.33e-2
E484K OC220302-SN0592 antibody class 3 2022 6.03e-2 5.09e-2
E484K OC220302-SN0618 antibody class 3 2022 6.47e-2 4.99e-2
E484K OC220302-SN0638 antibody class 3 2022 9.74e-3 1.97e-2
E484K WIBP-2B11 antibody class 1 2022 4.11e-2 2.98e-2
E484K XG2v-039 antibody class 1 2022 3.52e-2 1.89e-1
E484K XG2v-045 antibody class 2 2022 5.05e-1 4.25e-1
E484K XG2v-098 antibody class 1 2022 2.70e-2 4.13e-2
E484K XGv-003 antibody class 2 2022 8.16e-1 1.96e-1
E484K XGv-047 antibody class 3 2022 3.37e-2 4.82e-2
E484K XGv-051 antibody class 2 2022 1.31e-1 5.31e-2
E484K XGv-052 antibody class 2 2022 7.94e-3 4.08e-2
E484K XGv-094 antibody class 3 2022 2.13e-1 2.10e-1
E484K XGv-097 antibody class 2 2022 6.39e-1 4.74e-1
E484K XGv-152 antibody class 2 2022 4.91e-1 3.64e-1
E484K XGv-155 antibody class 2 2022 7.75e-1 3.82e-1
E484K XGv-172 antibody class 2 2022 4.31e-1 4.54e-1
E484K XGv-191 antibody class 3 2022 1.57e-1 1.93e-1
E484K XGv-198 antibody class 3 2022 6.36e-2 5.84e-2
E484K XGv-208 antibody class 1 2022 7.58e-3 1.90e-2
E484K XGv-214 antibody class 3 2022 3.38e-3 2.71e-3
E484K XGv-232 antibody class 2 2022 6.96e-1 4.97e-1
E484K XGv-251 antibody class 3 2022 2.48e-2 5.19e-2
E484K XGv-279 antibody class 1 2022 6.12e-2 9.10e-2
E484K XGv-324 antibody class 2 2022 4.22e-1 2.58e-1
E484K XGv-405 antibody class 1 2022 7.89e-3 1.06e-2
E484K COVOX-150 antibody class 1 2021 8.54e-3 1.07e-2
E484K C1A-B12 antibody class 1 2021 2.94e-3 9.08e-2
E484K C578 antibody class 1 2021 6.36e-3 7.99e-2
E484K BD-504 antibody class 1 2021 4.70e-2 5.55e-2
E484K COVOX-222 antibody class 1 2021 4.49e-3 6.11e-3
E484K DXP-604 antibody class 1 2021 3.71e-3 3.66e-3
E484K REGN10933 antibody class 1 2021 9.86e-2 2.09e-1
E484K BD-319 antibody class 1 2021 2.52e-2 7.32e-2
E484K 15033 antibody class 1 2021 4.74e-2 3.75e-2
E484K BD-417 antibody class 1 2021 4.12e-1 1.92e-1
E484K BD55-1508 antibody class 1 2021 8.99e-3 8.54e-2
E484K BG1-24 antibody class 1 2021 6.18e-1 3.66e-1
E484K C083 antibody class 1 2021 5.45e-1 8.58e-2
E484K BG10-19 antibody class 2 2021 8.31e-1 2.29e-1
E484K BD55-1274 antibody class 2 2021 1.96e-1 6.85e-2
E484K BD55-1694 antibody class 2 2021 3.84e-1 4.30e-1
E484K C002 antibody class 2 2021 7.09e-1 3.62e-1
E484K P17 antibody class 2 2021 3.29e-1 2.48e-1
E484K 2��15�� antibody class 2 2021 4.13e-1 2.19e-1
E484K BD-254 antibody class 2 2021 4.42e-1 2.56e-1
E484K BD-362 antibody class 2 2021 4.24e-1 2.48e-1
E484K BD-368 antibody class 2 2021 7.10e-1 2.85e-1
E484K BD-397 antibody class 2 2021 5.82e-1 4.71e-1
E484K BD-403 antibody class 2 2021 3.99e-1 3.01e-1
E484K DXP-593 antibody class 2 2021 6.60e-1 7.02e-1
E484K BD55-1579 antibody class 2 2021 9.06e-1 4.31e-1
E484K BD-791 antibody class 2 2021 6.16e-1 4.15e-1
E484K BD-870 antibody class 2 2021 6.01e-1 5.72e-1
E484K BD55-4382 antibody class 2 2021 6.36e-1 4.23e-1
E484K BG7-20 antibody class 2 2021 3.74e-1 1.67e-1
E484K C591 antibody class 2 2021 3.91e-1 3.59e-1
E484K CM32 antibody class 2 2021 3.56e-1 2.86e-1
E484K COV2-2064 antibody class 2 2021 1.70e-1 4.71e-2
E484K COV2-2504 antibody class 2 2021 6.72e-1 3.48e-1
E484K COV2-2539 antibody class 2 2021 1.96e-1 7.51e-2
E484K COVA2-39 antibody class 2 2021 5.86e-1 4.72e-1
E484K COVOX-316 antibody class 2 2021 1.01e+0 7.26e-1
E484K COVOX-384 antibody class 2 2021 8.02e-1 6.71e-1
E484K CV05-163 antibody class 2 2021 3.81e-1 1.30e-1
E484K CV07-255 antibody class 2 2021 6.42e-1 3.89e-1
E484K DH1173 antibody class 2 2021 5.42e-1 3.90e-1
E484K DH1184 antibody class 2 2021 5.80e-1 1.76e-1
E484K H4 antibody class 2 2021 4.39e-1 4.39e-1
E484K P2B-2F6 antibody class 2 2021 5.54e-1 3.74e-1
E484K P2C-1A3 antibody class 2 2021 8.38e-1 5.92e-1
E484K S2H13 antibody class 2 2021 3.66e-1 3.78e-1
E484K S2M11 antibody class 2 2021 6.12e-1 4.08e-1
E484K BD-790 antibody class 2 2021 7.47e-1 4.49e-1
E484K C058 antibody class 2 2021 6.36e-1 4.34e-1
E484K COV2-2479 antibody class 2 2021 5.91e-1 9.03e-2
E484K COV2-2955 antibody class 2 2021 3.95e-1 1.69e-1
E484K CV07-200 antibody class 2 2021 2.78e-1 2.31e-1
E484K CV07-222 antibody class 2 2021 5.34e-1 2.81e-1
E484K CV07-262 antibody class 2 2021 4.66e-1 2.78e-1
E484K CV07-283 antibody class 2 2021 3.30e-1 1.48e-1
E484K CV07-315 antibody class 2 2021 3.46e-1 2.78e-1
E484K DH1041 antibody class 2 2021 5.88e-1 4.14e-1
E484K DH1042 antibody class 2 2021 6.70e-1 2.81e-1
E484K DH1043 antibody class 2 2021 8.57e-1 2.95e-1
E484K DH1111 antibody class 2 2021 4.07e-1 2.86e-1
E484K DH1159-2 antibody class 2 2021 6.93e-1 3.69e-1
E484K DH1186 antibody class 2 2021 8.37e-1 3.00e-1
E484K DH1214 antibody class 2 2021 5.13e-1 2.89e-1
E484K LY-CoV555 antibody class 2 2021 8.41e-1 7.02e-1
E484K BD-536 antibody class 2 2021 4.97e-1 3.70e-1
E484K BD-900 antibody class 2 2021 8.49e-1 3.79e-1
E484K C121 antibody class 2 2021 9.88e-1 6.36e-1
E484K BD55-1962 antibody class 2 2021 4.72e-3 2.50e-2
E484K C119 antibody class 3 2021 1.61e-2 1.13e-1
E484K BD-643 antibody class 3 2021 1.38e-1 2.04e-1
E484K BD55-3304 antibody class 4 2021 2.80e-2 3.23e-2
E484K AZD7442 (AZD8895 + AZD1061) antibody AZD8895:class 1 + AZD1061:class 2 2020 1.08e-2 2.07e-2
E484K AZD1061 antibody class 2 2020 9.66e-4 1.20e-3
E484K AZD8895 antibody class 1 2020 3.01e-2 2.41e-2
E484K P02 serum 2x BNT162b2 2021 6.90e-3 5.35e-3
E484K P03 serum 2x BNT162b2 2021 1.26e-3 3.36e-3
E484K P04 serum 2x BNT162b2 2021 2.56e-3 5.57e-3
E484K P05 serum 2x BNT162b2 2021 2.47e-3 7.19e-3
E484K P08 serum 2x BNT162b2 2021 3.81e-3 3.37e-2
E484K P09 serum 2x BNT162b2 2021 1.93e-3 4.89e-3
E484K P12 serum 2x BNT162b2 2021 4.23e-3 9.32e-3
E484K P14 serum 2x BNT162b2 2021 1.56e-3 3.17e-3
E484K M02-day-119 serum 2x mRNA-1273 2021 1.90e-3 1.40e-2
E484K M05-day-119 serum 2x mRNA-1273 2021 9.65e-4 9.16e-3
E484K M08-day-119 serum 2x mRNA-1273 2021 1.13e-2 3.72e-2
E484K M10-day-119 serum 2x mRNA-1273 2021 5.02e-3 6.80e-2
E484K M12-day-119 serum 2x mRNA-1273 2021 4.72e-3 3.21e-3
E484K M16-day-119 serum 2x mRNA-1273 2021 6.08e-2 7.90e-2
E484K M17-day-119 serum 2x mRNA-1273 2021 3.60e-3 9.74e-3
E484K M18-day-119 serum 2x mRNA-1273 2021 5.73e-3 2.29e-2
E484K M19-day-119 serum 2x mRNA-1273 2021 6.27e-3 3.11e-2
E484K M03-day-119 serum 2x mRNA-1273 2021 6.00e-3 6.07e-2
E484K M04-day-119 serum 2x mRNA-1273 2021 2.26e-4 9.66e-4
E484K M06-day-119 serum 2x mRNA-1273 2021 3.37e-3 5.97e-2
E484K M07-day-119 serum 2x mRNA-1273 2021 4.28e-2 9.30e-2
E484K M09-day-119 serum 2x mRNA-1273 2021 1.53e-4 1.82e-3
E484K M11-day-119 serum 2x mRNA-1273 2021 2.54e-3 6.24e-2
E484K M13-day-119 serum 2x mRNA-1273 2021 1.62e-4 3.66e-3
E484K M14-day-119 serum 2x mRNA-1273 2021 1.58e-4 6.10e-4
E484K M20-day-119 serum 2x mRNA-1273 2021 2.51e-4 1.37e-3
E484K M21-day-119 serum 2x mRNA-1273 2021 2.90e-3 1.61e-2
E484K M22-day-119 serum 2x mRNA-1273 2021 6.18e-4 1.31e-3
E484K M23-day-119 serum 2x mRNA-1273 2021 2.39e-4 1.70e-3
E484K 267C serum Delta breakthrough 2021 2.98e-3 7.73e-2
E484K 268C serum Delta breakthrough 2021 1.08e-2 6.75e-2
E484K 273C serum Delta breakthrough 2021 4.98e-2 1.17e-1
E484K 274C serum Delta breakthrough 2021 2.57e-2 9.72e-2
E484K 276C serum Delta breakthrough 2021 1.14e-1 2.27e-1
E484K 277C serum Delta breakthrough 2021 5.66e-3 3.57e-2
E484K 278C serum Delta breakthrough 2021 2.68e-2 8.83e-2
E484K 279C serum Delta breakthrough 2021 1.48e-2 7.60e-2
E484K Delta 1 serum primary Delta infection 2021 2.19e-3 3.54e-2
E484K Delta 3 serum primary Delta infection 2021 1.37e-2 6.78e-2
E484K Delta 4 serum primary Delta infection 2021 2.48e-2 1.15e-1
E484K Delta 6 serum primary Delta infection 2021 7.99e-3 1.10e-1
E484K Delta 7 serum primary Delta infection 2021 1.91e-3 2.38e-2
E484K Delta 8 serum primary Delta infection 2021 2.35e-2 8.25e-2
E484K Delta 10 serum primary Delta infection 2021 2.62e-3 2.43e-2
E484K Delta 11 serum primary Delta infection 2021 1.13e-2 8.96e-2




Investigating the co-mutation patterns of mutation (1450G>A) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V7289 10740C>T synonymous_variant ORF1ab_pp1a H3580H 1.00e+0 BA.1.1.18
V1288 5141T>C missense_variant ORF1ab_pp1a I1714T 7.48e-1 BA.2.3
V1549 6505A>G missense_variant ORF1ab_pp1a M2169V 7.64e-1 BA.2.3
V1550 6521C>T missense_variant ORF1ab_pp1a T2174I 7.65e-1 BA.2.3
V1746 7943C>T missense_variant ORF1ab_pp1a T2648I 6.80e-1 BA.2.3
V2271 11765A>G missense_variant ORF1ab_pp1a Q3922R 7.76e-1 BA.2.3
V3679 492T>G missense_variant S N164K 7.62e-1 BA.2.3
V3762 733C>A missense_variant S H245N 6.74e-1 BA.2.3
V3785 770G>A missense_variant S G257D 7.10e-1 BA.2.3
V3870 1331A>G missense_variant S K444R 6.21e-1 BA.2.3
V3882 1348A>G missense_variant S N450D 7.76e-1 BA.2.3
V3891 1380T>G missense_variant S N460K 8.09e-1 BA.2.3
V3912 1451A>G missense_variant S E484G 9.54e-1 BA.2.3
V6035 1206C>T synonymous_variant ORF1ab_pp1a R402R 7.41e-1 BA.2.3
V697 2180C>T missense_variant ORF1ab_pp1a T727I 6.66e-1 BA.2.3
V7191 9924C>T synonymous_variant ORF1ab_pp1a T3308T 7.01e-1 BA.2.3
V9618 277C>A synonymous_variant N R93R 7.86e-1 BA.2.3
V6873 7539T>C synonymous_variant ORF1ab_pp1a Y2513Y 7.07e-1 BA.4.1
V3927 1501A>T missense_variant S N501Y 8.63e-1 P.1
V294 550C>T missense_variant ORF1ab_pp1a R184C 6.42e-1 AY.125
V4954 250C>T missense_variant ORF7a P84S 6.38e-1 AY.125
V5150 192G>T missense_variant ORF8 E64D 8.63e-1 AY.125
V8304 18552G>A synonymous_variant ORF1ab_pp1ab L6184L 8.98e-1 AY.125
V8601 21042C>T synonymous_variant ORF1ab_pp1ab R7014R 8.03e-1 AY.125
V2080 10581G>T missense_variant ORF1ab_pp1a M3527I 6.81e-1 AY.20
V7194 9939T>C synonymous_variant ORF1ab_pp1a L3313L 8.63e-1 AY.20
V7238 10317C>T synonymous_variant ORF1ab_pp1a D3439D 8.12e-1 AY.20
V8144 17412C>T synonymous_variant ORF1ab_pp1ab I5804I 6.55e-1 AY.20
V3642 431A>C missense_variant S Y144S 7.07e-1 AY.47
V3645 433T>A missense_variant S Y145N 7.07e-1 AY.47
V8337 18771T>C synonymous_variant ORF1ab_pp1ab I6257I 7.07e-1 AY.47
V861 2908C>A missense_variant ORF1ab_pp1a Q970K 7.07e-1 AY.47
V4008 2018G>C missense_variant S S673T 7.19e-1 B.1.617.2
V8984 2772C>T synonymous_variant S A924A 6.85e-1 B.1.617.2
V8467 19899A>G synonymous_variant ORF1ab_pp1ab K6633K 6.20e-1 BF.5
V1215 4675C>T missense_variant ORF1ab_pp1a L1559F 7.97e-1 A.23.1
V1350 5570C>T missense_variant ORF1ab_pp1a S1857L 1.00e+0 A.2.5.2
V1459 6184C>T missense_variant ORF1ab_pp1a L2062F 8.65e-1 A.27
V1832 8537C>T missense_variant ORF1ab_pp1a T2846I 7.49e-1 A.27
V374 916G>T missense_variant ORF1ab_pp1a V306F 8.65e-1 A.27
V7042 8853C>T synonymous_variant ORF1ab_pp1a D2951D 8.65e-1 A.27
V854 2887G>T missense_variant ORF1ab_pp1a G963C 8.65e-1 A.27
V6430 4080C>T synonymous_variant ORF1ab_pp1a I1360I 1.00e+0 A.2
V9254 804G>T synonymous_variant ORF3a T268T 1.00e+0 A.2
V4248 3604G>C missense_variant S E1202Q 7.07e-1 AE.8
V1575 6731T>C missense_variant ORF1ab_pp1a I2244T 7.07e-1 A
V2076 10553C>T missense_variant ORF1ab_pp1a A3518V 7.07e-1 A
V2765 15942G>T missense_variant ORF1ab_pp1ab E5314D 7.07e-1 A
V4008 2018G>C missense_variant S S673T 6.45e-1 AY.102
V8984 2772C>T synonymous_variant S A924A 6.08e-1 AY.102
V1758 8053C>A missense_variant ORF1ab_pp1a P2685T 6.70e-1 AY.106
V5011 7G>T stop_gained ORF7b E3* 8.66e-1 AY.106
V6774 6676C>T synonymous_variant ORF1ab_pp1a L2226L 8.66e-1 AY.106
V8394 19251A>G synonymous_variant ORF1ab_pp1ab R6417R 8.66e-1 AY.106
V3744 646C>T missense_variant S L216F 7.07e-1 AY.107
V4012 2027C>T missense_variant S T676I 7.07e-1 AY.107
V4111 2576C>A missense_variant S T859N 8.66e-1 AY.107
V6684 6003C>T synonymous_variant ORF1ab_pp1a A2001A 7.07e-1 AY.107
V2206 11246C>T missense_variant ORF1ab_pp1a T3749I 8.30e-1 AY.109
V4374 125C>T missense_variant ORF3a P42L 9.19e-1 AY.109
V5534 760G>T missense_variant N A254S 8.65e-1 AY.109
V8318 18630C>T synonymous_variant ORF1ab_pp1ab C6210C 9.23e-1 AY.109
V8799 1296C>T synonymous_variant S C432C 9.23e-1 AY.109
V9155 114A>G synonymous_variant ORF3a Q38Q 8.10e-1 AY.109
V4008 2018G>C missense_variant S S673T 1.00e+0 AY.110
V4103 2537C>T missense_variant S A846V 7.07e-1 AY.110
V538 1578G>T missense_variant ORF1ab_pp1a Q526H 7.07e-1 AY.110
V8032 16584C>T synonymous_variant ORF1ab_pp1ab D5528D 7.07e-1 AY.110
V8984 2772C>T synonymous_variant S A924A 1.00e+0 AY.110
V8593 20994A>G synonymous_variant ORF1ab_pp1ab S6998S 8.29e-1 AY.113
V3868 1320T>G missense_variant S N440K 8.66e-1 AY.114
V8983 2763A>G synonymous_variant S K921K 7.50e-1 AY.114
V3599 239A>C missense_variant S D80A 1.00e+0 AY.118
V3927 1501A>T missense_variant S N501Y 1.00e+0 AY.118
V7482 12279A>G synonymous_variant ORF1ab_pp1a S4093S 1.00e+0 AY.118
V9406 93C>T synonymous_variant ORF6 Y31Y 1.00e+0 AY.119.2
V216 304G>A missense_variant ORF1ab_pp1a E102K 8.16e-1 AY.119
V3739 643G>C missense_variant S D215H 6.67e-1 AY.119
V3826 1038A>C missense_variant S R346S 8.16e-1 AY.119
V3927 1501A>T missense_variant S N501Y 6.67e-1 AY.119
V3973 1861C>T missense_variant S P621S 6.67e-1 AY.119
V5924 468T>C synonymous_variant ORF1ab_pp1a D156D 8.16e-1 AY.119
V7086 9177C>T synonymous_variant ORF1ab_pp1a C3059C 6.67e-1 AY.119
V8054 16743T>C synonymous_variant ORF1ab_pp1ab N5581N 8.16e-1 AY.119
V1999 9923C>T missense_variant ORF1ab_pp1a T3308I 1.00e+0 AY.120.2
V5256 19C>A missense_variant N Q7K 1.00e+0 AY.120.2
V5904 348G>A synonymous_variant ORF1ab_pp1a V116V 1.00e+0 AY.120.2
V8927 2334C>T synonymous_variant S T778T 1.00e+0 AY.120.2
V9722 822C>T synonymous_variant N F274F 7.07e-1 AY.120.2
V5204 328G>T stop_gained ORF8 E110* 6.30e-1 AY.121
V700 2183G>A missense_variant ORF1ab_pp1a G728D 6.30e-1 AY.121
V7464 12135C>T synonymous_variant ORF1ab_pp1a L4045L 1.00e+0 AY.123
V6513 4710G>T synonymous_variant ORF1ab_pp1a V1570V 6.71e-1 AY.127
V7103 9300C>T synonymous_variant ORF1ab_pp1a F3100F 1.00e+0 AY.131
V9350 390C>T synonymous_variant M T130T 1.00e+0 AY.131
V1949 9413T>C missense_variant ORF1ab_pp1a F3138S 1.00e+0 AY.13
V3921 1469T>C missense_variant S F490S 8.66e-1 AY.13
V3927 1501A>T missense_variant S N501Y 1.00e+0 AY.13
V6846 7299C>T synonymous_variant ORF1ab_pp1a S2433S 8.66e-1 AY.13
V8451 19752C>T synonymous_variant ORF1ab_pp1ab D6584D 1.00e+0 AY.13
V9454 207C>T synonymous_variant ORF7a D69D 8.66e-1 AY.13
V1057 3637C>T missense_variant ORF1ab_pp1a P1213S 7.07e-1 AY.1
V2194 11186A>G missense_variant ORF1ab_pp1a Q3729R 7.07e-1 AY.1
V221 328C>T missense_variant ORF1ab_pp1a H110Y 7.07e-1 AY.1
V2925 17227C>T missense_variant ORF1ab_pp1ab P5743S 1.00e+0 AY.1
V4022 2042C>A missense_variant S P681H 7.07e-1 AY.1
V4624 766_769delGTTA frameshift_variant ORF3a V256fs 7.07e-1 AY.1
V4702 -31A>T upstream_gene_variant M None 7.07e-1 AY.1
V511 1420G>T missense_variant ORF1ab_pp1a A474S 1.00e+0 AY.1
V5243 -2A>T upstream_gene_variant N None 7.07e-1 AY.1
V6477 4419T>C synonymous_variant ORF1ab_pp1a A1473A 7.07e-1 AY.1
V6656 5772C>T synonymous_variant ORF1ab_pp1a S1924S 7.07e-1 AY.1
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 7.07e-1 AY.1
V8466 19884C>T synonymous_variant ORF1ab_pp1ab F6628F 7.07e-1 AY.1
V933 3163A>G missense_variant ORF1ab_pp1a T1055A 7.07e-1 AY.1
V3080 18244C>T missense_variant ORF1ab_pp1ab L6082F 1.00e+0 AY.25.3
V3896 1430G>A missense_variant S S477N 1.00e+0 AY.25.3
V6094 1644C>T synonymous_variant ORF1ab_pp1a F548F 1.00e+0 AY.25.3
V6723 6198G>T synonymous_variant ORF1ab_pp1a V2066V 1.00e+0 AY.25.3
V3495 21108G>T missense_variant ORF1ab_pp1ab Q7036H 1.00e+0 AY.28
V8676 333T>C synonymous_variant S D111D 1.00e+0 AY.28
V1165 4394A>G missense_variant ORF1ab_pp1a Y1465C 7.07e-1 AY.32
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 7.07e-1 AY.32
V3761 732A>T missense_variant S L244F 7.07e-1 AY.32
V6463 4321C>T synonymous_variant ORF1ab_pp1a L1441L 7.07e-1 AY.32
V6548 4929G>T synonymous_variant ORF1ab_pp1a L1643L 7.07e-1 AY.32
V3855 1224A>T missense_variant S R408S 7.94e-1 AY.33
V479 1325G>A missense_variant ORF1ab_pp1a G442D 6.99e-1 AY.33
V3927 1501A>T missense_variant S N501Y 1.00e+0 AY.34.1.1
V1348 5561C>T missense_variant ORF1ab_pp1a T1854I 6.73e-1 AY.34
V5124 135G>T missense_variant ORF8 W45C 8.25e-1 AY.34
V7018 8640C>T synonymous_variant ORF1ab_pp1a D2880D 9.35e-1 AY.34
V7344 11298C>T synonymous_variant ORF1ab_pp1a C3766C 6.03e-1 AY.34
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 8.75e-1 AY.34
V8611 21153A>G synonymous_variant ORF1ab_pp1ab K7051K 9.04e-1 AY.34
V1458 6181G>T missense_variant ORF1ab_pp1a V2061F 6.32e-1 AY.36.1
V4008 2018G>C missense_variant S S673T 1.00e+0 AY.36.1
V6461 4317C>T synonymous_variant ORF1ab_pp1a N1439N 6.20e-1 AY.36.1
V8984 2772C>T synonymous_variant S A924A 8.94e-1 AY.36.1
V3927 1501A>T missense_variant S N501Y 1.00e+0 AY.37
V5461 608G>A missense_variant N R203K 1.00e+0 AY.37
V3042 18014T>C missense_variant ORF1ab_pp1ab I6005T 1.00e+0 AY.39.1.2
V7218 10167C>T synonymous_variant ORF1ab_pp1a Y3389Y 1.00e+0 AY.39.1.2
V1840 8570T>C missense_variant ORF1ab_pp1a V2857A 7.07e-1 AY.39.1.4
V2251 11570C>T missense_variant ORF1ab_pp1a T3857I 1.00e+0 AY.39.1.4
V2387 12567G>T missense_variant ORF1ab_pp1a Q4189H 1.00e+0 AY.39.1.4
V2625 14491C>T missense_variant ORF1ab_pp1ab H4831Y 1.00e+0 AY.39.1.4
V4008 2018G>C missense_variant S S673T 1.00e+0 AY.39.1.4
V4171 3218A>C missense_variant S K1073T 7.07e-1 AY.39.1.4
V5948 600C>T synonymous_variant ORF1ab_pp1a C200C 1.00e+0 AY.39.1.4
V6461 4317C>T synonymous_variant ORF1ab_pp1a N1439N 7.07e-1 AY.39.1.4
V8984 2772C>T synonymous_variant S A924A 1.00e+0 AY.39.1.4
V1268 4965G>T missense_variant ORF1ab_pp1a K1655N 1.00e+0 AY.39.2
V2083 10610A>G missense_variant ORF1ab_pp1a N3537S 1.00e+0 AY.39.2
V3682 526C>T missense_variant S L176F 1.00e+0 AY.39.2
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 1.00e+0 AY.39.2
V3783 767C>T missense_variant S S256L 8.16e-1 AY.39.2
V4850 13C>A missense_variant ORF7a L5I 1.00e+0 AY.39.2
V8358 18921C>T synonymous_variant ORF1ab_pp1ab C6307C 1.00e+0 AY.39.2
V362 883G>A missense_variant ORF1ab_pp1a G295S 6.54e-1 AY.4.2.1
V3080 18244C>T missense_variant ORF1ab_pp1ab L6082F 7.07e-1 AY.43.8
V3987 1919C>T missense_variant S S640F 1.00e+0 AY.43.8
V4480 316C>T missense_variant ORF3a L106F 7.07e-1 AY.43.8
V6216 2433T>C synonymous_variant ORF1ab_pp1a N811N 1.00e+0 AY.43.8
V6850 7335C>T synonymous_variant ORF1ab_pp1a C2445C 1.00e+0 AY.43.8
V1262 4918C>T missense_variant ORF1ab_pp1a P1640S 6.81e-1 AY.4.5
V3953 1715C>T missense_variant S T572I 7.55e-1 AY.4.5
V7328 11151C>T synonymous_variant ORF1ab_pp1a L3717L 8.88e-1 AY.4.5
V3152 18743C>T missense_variant ORF1ab_pp1ab A6248V 8.82e-1 AY.46.5
V1592 6782C>T missense_variant ORF1ab_pp1a S2261F 7.07e-1 AY.46.6
V2740 15661C>T missense_variant ORF1ab_pp1ab L5221F 1.00e+0 AY.46.6
V3827 1038A>T missense_variant S R346S 1.00e+0 AY.46.6
V8283 18417C>T synonymous_variant ORF1ab_pp1ab A6139A 7.07e-1 AY.46.6
V9155 114A>G synonymous_variant ORF3a Q38Q 7.07e-1 AY.46.6
V9583 108A>C synonymous_variant N R36R 1.00e+0 AY.46.6
V240 360G>T missense_variant ORF1ab_pp1a K120N 7.07e-1 AY.5.4
V3751 725_733delTTGCTTTAC disruptive_inframe_deletion S L242_L244del 7.07e-1 AY.5.4
V5933 540G>A synonymous_variant ORF1ab_pp1a G180G 8.16e-1 AY.57
V1511 6368C>T missense_variant ORF1ab_pp1a A2123V 7.46e-1 AY.69
V2211 11256G>T missense_variant ORF1ab_pp1a M3752I 7.46e-1 AY.69
V3868 1320T>G missense_variant S N440K 8.53e-1 AY.69
V3900 1433C>A missense_variant S T478K -6.28e-1 AY.69
V4129 2806G>A missense_variant S D936N 7.27e-1 AY.69
V4134 2816C>T missense_variant S S939F 6.36e-1 AY.69
V4337 77C>T missense_variant ORF3a S26L -7.52e-1 AY.69
V4872 66G>T missense_variant ORF7a E22D 6.84e-1 AY.69
V6167 2142G>A synonymous_variant ORF1ab_pp1a K714K 8.04e-1 AY.69
V7549 12849T>C synonymous_variant ORF1ab_pp1a Y4283Y 7.03e-1 AY.69
V7717 14139C>T synonymous_variant ORF1ab_pp1ab F4713F 7.46e-1 AY.69
V8582 20949A>G synonymous_variant ORF1ab_pp1ab G6983G 8.53e-1 AY.69
V8971 2632T>C synonymous_variant S L878L 7.27e-1 AY.69
V9622 327T>C synonymous_variant N Y109Y 8.04e-1 AY.69
V3118 18524C>T missense_variant ORF1ab_pp1ab T6175I 6.32e-1 AY.72
V3907 1447G>T missense_variant S V483F 7.07e-1 AY.72
V4669 61C>T missense_variant E L21F 1.00e+0 AY.72
V6533 4833T>C synonymous_variant ORF1ab_pp1a N1611N 7.07e-1 AY.72
V735 2320G>T missense_variant ORF1ab_pp1a V774F 7.07e-1 AY.72
V8944 2461C>T synonymous_variant S L821L 1.00e+0 AY.72
V1567 6629G>T missense_variant ORF1ab_pp1a C2210F 7.07e-1 AY.77
V217 316G>A missense_variant ORF1ab_pp1a V106I 7.07e-1 AY.77
V3100 18387G>T missense_variant ORF1ab_pp1ab E6129D 7.07e-1 AY.77
V418 1082C>T missense_variant ORF1ab_pp1a P361L 7.07e-1 AY.77
V6978 8361C>T synonymous_variant ORF1ab_pp1a F2787F 7.07e-1 AY.77
V8984 2772C>T synonymous_variant S A924A 7.07e-1 AY.77
V3577 200C>T missense_variant S A67V 7.07e-1 AY.78
V9647 444C>T synonymous_variant N T148T 1.00e+0 AY.78
V3847 1151C>T missense_variant S P384L 1.00e+0 AY.79
V5421 539G>A missense_variant N S180N 1.00e+0 AY.79
V5677 -3C>T upstream_gene_variant ORF10 None 7.07e-1 AY.79
V619 1841C>T missense_variant ORF1ab_pp1a T614I 1.00e+0 AY.79
V7644 13596C>T synonymous_variant ORF1ab_pp1ab D4532D 7.07e-1 AY.79
V8332 18747C>T synonymous_variant ORF1ab_pp1ab D6249D 1.00e+0 AY.79
V4844 -4G>T upstream_gene_variant ORF7a None 7.36e-1 AY.84
V6886 7644A>G synonymous_variant ORF1ab_pp1a K2548K 8.59e-1 AY.84
V693 2167T>C missense_variant ORF1ab_pp1a S723P 1.00e+0 AY.84
V7496 12468C>T synonymous_variant ORF1ab_pp1a A4156A 1.00e+0 AY.84
V8592 20991G>T synonymous_variant ORF1ab_pp1ab A6997A 9.76e-1 AY.84
V1169 4418C>T missense_variant ORF1ab_pp1a A1473V 9.35e-1 AY.85
V1228 4750G>A missense_variant ORF1ab_pp1a V1584M 9.35e-1 AY.85
V1532 6436C>T missense_variant ORF1ab_pp1a L2146F 6.61e-1 AY.85
V5891 276C>T synonymous_variant ORF1ab_pp1a L92L 9.35e-1 AY.85
V7538 12754C>T synonymous_variant ORF1ab_pp1a L4252L 7.90e-1 AY.85
V8710 624G>A synonymous_variant S T208T 8.75e-1 AY.85
V9395 9T>C synonymous_variant ORF6 H3H 7.07e-1 AY.85
V3599 239A>C missense_variant S D80A 7.07e-1 AY.91
V3629 422_430delTGGGTGTTT disruptive_inframe_deletion S L141_V143del 7.07e-1 AY.91
V3885 1355T>A missense_variant S L452Q 7.07e-1 AY.91
V4219 3450G>T missense_variant S E1150D 7.07e-1 AY.91
V4428 207G>T missense_variant ORF3a W69C 7.07e-1 AY.91
V7574 12999C>T synonymous_variant ORF1ab_pp1a H4333H 7.07e-1 AY.91
V1533 6439A>G missense_variant ORF1ab_pp1a N2147D 1.00e+0 AY.92
V1885 8855C>T missense_variant ORF1ab_pp1a T2952I 1.00e+0 AY.92
V2194 11186A>G missense_variant ORF1ab_pp1a Q3729R 1.00e+0 AY.92
V2925 17227C>T missense_variant ORF1ab_pp1ab P5743S 7.07e-1 AY.92
V3927 1501A>T missense_variant S N501Y 7.07e-1 AY.92
V4022 2042C>A missense_variant S P681H 7.07e-1 AY.92
V4625 766G>A missense_variant ORF3a V256I 1.00e+0 AY.92
V4630 769A>T missense_variant ORF3a N257Y 1.00e+0 AY.92
V4633 775G>T missense_variant ORF3a V259L 1.00e+0 AY.92
V5080 32C>A missense_variant ORF8 T11K 1.00e+0 AY.92
V5114 112C>T missense_variant ORF8 P38S 7.07e-1 AY.92
V5787 *4364T>C downstream_gene_variant S None 1.00e+0 AY.92
V6656 5772C>T synonymous_variant ORF1ab_pp1a S1924S 1.00e+0 AY.92
V8466 19884C>T synonymous_variant ORF1ab_pp1ab F6628F 7.07e-1 AY.92
V3670 466_471delGAGTTC conservative_inframe_deletion S E156_F157del 1.00e+0 AY.95
V9557 360C>T synonymous_variant ORF8 F120F 1.00e+0 AY.95
V3761 732A>T missense_variant S L244F 7.07e-1 AY.98.1
V6796 6828C>T synonymous_variant ORF1ab_pp1a V2276V 7.07e-1 AY.98.1
V3927 1501A>T missense_variant S N501Y 7.22e-1 AY.99.2
V6688 6018T>C synonymous_variant ORF1ab_pp1a N2006N 9.73e-1 B.1.110.3
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 9.19e-1 B.1.1.10
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 9.19e-1 B.1.1.10
V3663 455G>T missense_variant S W152L 9.19e-1 B.1.1.10
V4067 2306G>T missense_variant S G769V 8.79e-1 B.1.1.10
V4256 3656G>T missense_variant S G1219V 6.77e-1 B.1.1.10
V4604 686C>T missense_variant ORF3a T229I 6.17e-1 B.1.1.10
V4731 82T>C missense_variant M F28L 9.19e-1 B.1.1.10
V4897 124G>A missense_variant ORF7a G42S 6.77e-1 B.1.1.10
V5237 1delA frameshift_variant&start_lost N M1fs 9.60e-1 B.1.1.10
V5329 118C>T missense_variant N R40C 6.17e-1 B.1.1.10
V5432 560C>T missense_variant N S187L 9.19e-1 B.1.1.10
V5657 1254G>T missense_variant N Q418H 9.19e-1 B.1.1.10
V6088 1617G>A synonymous_variant ORF1ab_pp1a E539E 6.77e-1 B.1.1.10
V7107 9333C>T synonymous_variant ORF1ab_pp1a Y3111Y 6.77e-1 B.1.1.10
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 9.19e-1 B.1.1.10
V7974 16113G>T synonymous_variant ORF1ab_pp1ab P5371P 6.77e-1 B.1.1.10
V8213 17916G>A synonymous_variant ORF1ab_pp1ab K5972K 6.17e-1 B.1.1.10
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 8.79e-1 B.1.1.10
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 9.19e-1 B.1.1.10
V8429 19575T>C synonymous_variant ORF1ab_pp1ab N6525N 8.44e-1 B.1.1.10
V8724 702C>T synonymous_variant S N234N 6.77e-1 B.1.1.10
V9396 12C>T synonymous_variant ORF6 L4L 9.19e-1 B.1.1.10
V201 256G>T missense_variant ORF1ab_pp1a V86F 7.74e-1 B.1.111
V2927 17254C>T missense_variant ORF1ab_pp1ab L5752F 7.74e-1 B.1.111
V8323 18678T>C synonymous_variant ORF1ab_pp1ab D6226D 7.74e-1 B.1.111
V1601 6821C>T missense_variant ORF1ab_pp1a T2274I 7.06e-1 B.1.1.141
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 1.00e+0 B.1.1.141
V8946 2472C>T synonymous_variant S N824N 7.06e-1 B.1.1.141
V1675 7526G>A missense_variant ORF1ab_pp1a G2509D 1.00e+0 B.1.1.189
V5074 23G>A missense_variant ORF8 G8E 1.00e+0 B.1.1.189
V9485 348C>T synonymous_variant ORF7a L116L 7.07e-1 B.1.1.189
V1308 5305A>G missense_variant ORF1ab_pp1a M1769V 7.07e-1 B.1.1.192
V5060 -5C>T upstream_gene_variant ORF8 None 7.07e-1 B.1.1.192
V5241 -3A>T upstream_gene_variant N None 7.07e-1 B.1.1.192
V5621 1136C>T missense_variant N T379I 7.07e-1 B.1.1.192
V8705 558C>T synonymous_variant S F186F 7.07e-1 B.1.1.192
V9531 186G>T synonymous_variant ORF8 V62V 7.07e-1 B.1.1.192
V4516 427G>T missense_variant ORF3a A143S 9.64e-1 B.1.1.207
V4573 604G>T missense_variant ORF3a V202L 8.15e-1 B.1.1.207
V467 1282A>G missense_variant ORF1ab_pp1a S428G 9.68e-1 B.1.1.207
V2084 10615A>G missense_variant ORF1ab_pp1a M3539V 7.22e-1 B.1.1.216
V6833 7155C>T synonymous_variant ORF1ab_pp1a I2385I 7.22e-1 B.1.1.216
V8261 18237C>T synonymous_variant ORF1ab_pp1ab Y6079Y 6.85e-1 B.1.1.216
V2789 16202C>T missense_variant ORF1ab_pp1ab P5401L 6.76e-1 B.1.1.232
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 8.15e-1 B.1.1.232
V4117 2635G>T missense_variant S A879S 7.35e-1 B.1.1.232
V4695 217C>T missense_variant E L73F 7.35e-1 B.1.1.232
V5243 -2A>T upstream_gene_variant N None 7.03e-1 B.1.1.232
V1951 9428C>T missense_variant ORF1ab_pp1a A3143V 6.32e-1 B.1.1.25
V2760 15899C>T missense_variant ORF1ab_pp1ab T5300I 6.32e-1 B.1.1.25
V3352 20143T>C missense_variant ORF1ab_pp1ab F6715L 6.32e-1 B.1.1.25
V4177 3233C>T missense_variant S A1078V 6.32e-1 B.1.1.25
V4990 329T>C missense_variant ORF7a I110T 6.32e-1 B.1.1.25
V6291 2985G>A synonymous_variant ORF1ab_pp1a E995E 6.32e-1 B.1.1.25
V9567 48G>A synonymous_variant N T16T 6.32e-1 B.1.1.25
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 1.00e+0 B.1.1.263
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 1.00e+0 B.1.1.263
V3204 19102C>T missense_variant ORF1ab_pp1ab P6368S 1.00e+0 B.1.1.263
V3663 455G>T missense_variant S W152L 1.00e+0 B.1.1.263
V4067 2306G>T missense_variant S G769V 1.00e+0 B.1.1.263
V4731 82T>C missense_variant M F28L 1.00e+0 B.1.1.263
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.1.263
V5432 560C>T missense_variant N S187L 1.00e+0 B.1.1.263
V5657 1254G>T missense_variant N Q418H 1.00e+0 B.1.1.263
V5783 *4361G>T downstream_gene_variant S None 7.07e-1 B.1.1.263
V5886 264G>T synonymous_variant ORF1ab_pp1a L88L 1.00e+0 B.1.1.263
V7628 13416C>T synonymous_variant ORF1ab_pp1ab Y4472Y 1.00e+0 B.1.1.263
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 7.07e-1 B.1.1.263
V7781 14541C>T synonymous_variant ORF1ab_pp1ab Y4847Y 1.00e+0 B.1.1.263
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 1.00e+0 B.1.1.263
V8429 19575T>C synonymous_variant ORF1ab_pp1ab N6525N 1.00e+0 B.1.1.263
V9235 684T>C synonymous_variant ORF3a V228V 1.00e+0 B.1.1.263
V1348 5561C>T missense_variant ORF1ab_pp1a T1854I 1.00e+0 B.1.126
V1717 7813C>T missense_variant ORF1ab_pp1a P2605S 1.00e+0 B.1.126
V3830 1060A>G missense_variant S N354D 1.00e+0 B.1.126
V4043 2102C>T missense_variant S A701V 7.07e-1 B.1.126
V5031 61G>T missense_variant ORF7b V21F 1.00e+0 B.1.126
V5469 614C>T missense_variant N T205I 7.07e-1 B.1.126
V5776 *4358G>A downstream_gene_variant S None 1.00e+0 B.1.126
V5834 *4484G>A downstream_gene_variant S None 1.00e+0 B.1.126
V5988 861G>A synonymous_variant ORF1ab_pp1a R287R 1.00e+0 B.1.126
V6940 8028C>T synonymous_variant ORF1ab_pp1a T2676T 7.07e-1 B.1.126
V1278 5045C>T missense_variant ORF1ab_pp1a T1682I 7.07e-1 B.1.1.277
V1870 8717C>T missense_variant ORF1ab_pp1a T2906I 7.07e-1 B.1.1.277
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 7.07e-1 B.1.1.277
V2163 11023_11031delTCTGGTTTT conservative_inframe_deletion ORF1ab_pp1a S3675_F3677del 1.00e+0 B.1.1.277
V2167 11026G>A missense_variant ORF1ab_pp1a G3676S 7.07e-1 B.1.1.277
V2169 11031T>G missense_variant ORF1ab_pp1a F3677L 7.07e-1 B.1.1.277
V2410 12794C>T missense_variant ORF1ab_pp1a T4265I 7.07e-1 B.1.1.277
V2616 14357C>T missense_variant ORF1ab_pp1ab T4786M 7.07e-1 B.1.1.277
V2791 16210A>G missense_variant ORF1ab_pp1ab S5404G 7.07e-1 B.1.1.277
V2868 16802A>G missense_variant ORF1ab_pp1ab Y5601C 7.07e-1 B.1.1.277
V3682 526C>T missense_variant S L176F 7.07e-1 B.1.1.277
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 7.07e-1 B.1.1.277
V3870 1331A>G missense_variant S K444R 7.07e-1 B.1.1.277
V3884 1354C>A missense_variant S L452M 7.07e-1 B.1.1.277
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.1.277
V4111 2576C>A missense_variant S T859N 1.00e+0 B.1.1.277
V4619 760G>A missense_variant ORF3a G254R 7.07e-1 B.1.1.277
V4760 245T>C missense_variant M I82T 1.00e+0 B.1.1.277
V5237 1delA frameshift_variant&start_lost N M1fs 7.07e-1 B.1.1.277
V5354 250A>G missense_variant N I84V 1.00e+0 B.1.1.277
V8403 19320T>C synonymous_variant ORF1ab_pp1ab D6440D 7.07e-1 B.1.1.277
V9475 291C>T synonymous_variant ORF7a Y97Y 1.00e+0 B.1.1.277
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 8.16e-1 B.1.1.291
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 8.16e-1 B.1.1.291
V4731 82T>C missense_variant M F28L 8.16e-1 B.1.1.291
V5657 1254G>T missense_variant N Q418H 8.16e-1 B.1.1.291
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 8.16e-1 B.1.1.291
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 6.66e-1 B.1.1.291
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 8.16e-1 B.1.1.291
V1982 9764C>T missense_variant ORF1ab_pp1a T3255I 6.65e-1 B.1.1.294
V2908 17072C>T missense_variant ORF1ab_pp1ab T5691I 8.16e-1 B.1.1.294
V3887 1358A>T missense_variant S Y453F 8.16e-1 B.1.1.294
V4048 2147C>T missense_variant S T716I 8.16e-1 B.1.1.294
V4742 187G>A missense_variant M A63T 8.16e-1 B.1.1.294
V5081 32C>T missense_variant ORF8 T11I 8.65e-1 B.1.1.294
V5274 38C>T missense_variant N P13L 8.16e-1 B.1.1.294
V5451 595C>T missense_variant N P199S 7.74e-1 B.1.1.294
V6676 5931C>T synonymous_variant ORF1ab_pp1a P1977P 8.16e-1 B.1.1.294
V1898 8939A>G missense_variant ORF1ab_pp1a D2980G 7.07e-1 B.1.1.298
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 7.07e-1 B.1.1.298
V2907 17069C>T missense_variant ORF1ab_pp1ab T5690M 7.07e-1 B.1.1.298
V3837 1099G>T missense_variant S V367F 7.07e-1 B.1.1.298
V4111 2576C>A missense_variant S T859N 7.07e-1 B.1.1.298
V5076 26T>C missense_variant ORF8 I9T 7.07e-1 B.1.1.298
V5240 -3A>G upstream_gene_variant N None 7.07e-1 B.1.1.298
V5403 469A>G missense_variant N I157V 7.07e-1 B.1.1.298
V5975 777G>A synonymous_variant ORF1ab_pp1a L259L 7.07e-1 B.1.1.298
V6320 3207A>G synonymous_variant ORF1ab_pp1a G1069G 7.07e-1 B.1.1.298
V7447 11988C>T synonymous_variant ORF1ab_pp1a A3996A 1.00e+0 B.1.1.298
V8411 19392G>A synonymous_variant ORF1ab_pp1ab K6464K 7.07e-1 B.1.1.298
V9314 213C>T synonymous_variant M Y71Y 7.07e-1 B.1.1.298
V2803 16352C>A missense_variant ORF1ab_pp1ab T5451N 9.56e-1 B.1.1.306
V3530 52C>T missense_variant S L18F 6.43e-1 B.1.1.306
V3555 79G>T missense_variant S A27S 8.37e-1 B.1.1.306
V4010 2025G>C missense_variant S Q675H 7.48e-1 B.1.1.306
V5249 7G>T missense_variant N D3Y 8.33e-1 B.1.1.306
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 8.73e-1 B.1.1.306
V8707 594T>C synonymous_variant S D198D 9.46e-1 B.1.1.306
V5734 *4321G>T downstream_gene_variant S None 6.32e-1 B.1.1.316
V9085 3486A>G synonymous_variant S P1162P 7.74e-1 B.1.1.316
V2728 15584C>T missense_variant ORF1ab_pp1ab T5195I 7.62e-1 B.1.1.317
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 9.46e-1 B.1.1.317
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 8.88e-1 B.1.1.317
V3663 455G>T missense_variant S W152L 6.06e-1 B.1.1.317
V4067 2306G>T missense_variant S G769V 7.22e-1 B.1.1.317
V4731 82T>C missense_variant M F28L 9.46e-1 B.1.1.317
V5237 1delA frameshift_variant&start_lost N M1fs 8.71e-1 B.1.1.317
V5432 560C>T missense_variant N S187L 9.46e-1 B.1.1.317
V5657 1254G>T missense_variant N Q418H 9.46e-1 B.1.1.317
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 9.46e-1 B.1.1.317
V8183 17694C>T synonymous_variant ORF1ab_pp1ab C5898C 7.94e-1 B.1.1.317
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 9.19e-1 B.1.1.317
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 9.46e-1 B.1.1.317
V9396 12C>T synonymous_variant ORF6 L4L 8.30e-1 B.1.1.317
V1116 3936G>T missense_variant ORF1ab_pp1a M1312I 1.00e+0 B.1.1.326
V2038 10184C>T missense_variant ORF1ab_pp1a P3395L 8.16e-1 B.1.1.326
V5285 59C>T missense_variant N P20L 1.00e+0 B.1.1.326
V6026 1155C>T synonymous_variant ORF1ab_pp1a A385A 1.00e+0 B.1.1.326
V6849 7329C>T synonymous_variant ORF1ab_pp1a G2443G 1.00e+0 B.1.1.326
V7892 15474C>T synonymous_variant ORF1ab_pp1ab F5158F 1.00e+0 B.1.1.326
V8662 249C>T synonymous_variant S V83V 1.00e+0 B.1.1.326
V9406 93C>T synonymous_variant ORF6 Y31Y 7.06e-1 B.1.1.326
V9539 228C>T synonymous_variant ORF8 I76I 8.16e-1 B.1.1.326
V5042 98A>C missense_variant ORF7b E33A 8.03e-1 B.1.1.33
V6010 999G>T synonymous_variant ORF1ab_pp1a T333T 8.03e-1 B.1.1.33
V6850 7335C>T synonymous_variant ORF1ab_pp1a C2445C 6.35e-1 B.1.1.33
V786 2614G>A missense_variant ORF1ab_pp1a A872T 7.46e-1 B.1.1.33
V8816 1474T>C synonymous_variant S L492L 7.38e-1 B.1.1.33
V6937 8013T>C synonymous_variant ORF1ab_pp1a N2671N 1.00e+0 B.1.1.348
V7344 11298C>T synonymous_variant ORF1ab_pp1a C3766C 1.00e+0 B.1.1.348
V1262 4918C>T missense_variant ORF1ab_pp1a P1640S 8.16e-1 B.1.1.372
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 6.32e-1 B.1.1.372
V216 304G>A missense_variant ORF1ab_pp1a E102K 1.00e+0 B.1.1.372
V2478 13403C>T missense_variant ORF1ab_pp1ab T4468I 7.07e-1 B.1.1.372
V3246 19454C>T missense_variant ORF1ab_pp1ab T6485I 7.07e-1 B.1.1.372
V3525 26C>T missense_variant S P9L 1.00e+0 B.1.1.372
V3550 74C>T missense_variant S P25L 1.00e+0 B.1.1.372
V3662 454T>C missense_variant S W152R 7.07e-1 B.1.1.372
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 7.07e-1 B.1.1.372
V3881 1345T>C missense_variant S Y449H 1.00e+0 B.1.1.372
V3900 1433C>A missense_variant S T478K 8.16e-1 B.1.1.372
V3927 1501A>T missense_variant S N501Y 7.07e-1 B.1.1.372
V4018 2037T>A missense_variant S N679K 7.07e-1 B.1.1.372
V4048 2147C>T missense_variant S T716I 1.00e+0 B.1.1.372
V4111 2576C>A missense_variant S T859N 7.07e-1 B.1.1.372
V4116 2635G>A missense_variant S A879T 7.07e-1 B.1.1.372
V4188 3303C>A missense_variant S H1101Q 7.07e-1 B.1.1.372
V4603 686C>A missense_variant ORF3a T229N 7.07e-1 B.1.1.372
V4606 712G>T missense_variant ORF3a D238Y 7.07e-1 B.1.1.372
V4622 766_768delGTT conservative_inframe_deletion ORF3a V256del 1.00e+0 B.1.1.372
V4668 61C>A missense_variant E L21I 1.00e+0 B.1.1.372
V4689 202T>C missense_variant E S68P 7.07e-1 B.1.1.372
V4732 85C>T missense_variant M L29F 7.07e-1 B.1.1.372
V4760 245T>C missense_variant M I82T 1.00e+0 B.1.1.372
V4781 463C>T missense_variant M H155Y 7.07e-1 B.1.1.372
V4860 32C>T missense_variant ORF7a T11I 7.07e-1 B.1.1.372
V5085 46T>C missense_variant ORF8 F16L 7.07e-1 B.1.1.372
V5274 38C>T missense_variant N P13L 7.07e-1 B.1.1.372
V5352 239C>G missense_variant N P80R 7.07e-1 B.1.1.372
V5629 1152G>T missense_variant N Q384H 1.00e+0 B.1.1.372
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 8.16e-1 B.1.1.372
V6862 7434A>G synonymous_variant ORF1ab_pp1a K2478K 1.00e+0 B.1.1.372
V6869 7500C>T synonymous_variant ORF1ab_pp1a S2500S 7.07e-1 B.1.1.372
V688 2123C>T missense_variant ORF1ab_pp1a T708I 7.07e-1 B.1.1.372
V7538 12754C>T synonymous_variant ORF1ab_pp1a L4252L 8.16e-1 B.1.1.372
V7941 15828C>T synonymous_variant ORF1ab_pp1ab Y5276Y 7.07e-1 B.1.1.372
V8293 18483C>T synonymous_variant ORF1ab_pp1ab V6161V 1.00e+0 B.1.1.372
V8338 18789T>C synonymous_variant ORF1ab_pp1ab I6263I 1.00e+0 B.1.1.372
V8671 297C>T synonymous_variant S N99N 7.07e-1 B.1.1.372
V8716 648C>T synonymous_variant S L216L 7.07e-1 B.1.1.372
V8929 2367C>T synonymous_variant S Y789Y 7.07e-1 B.1.1.372
V9338 351C>T synonymous_variant M N117N 7.07e-1 B.1.1.372
V9612 243T>C synonymous_variant N D81D 1.00e+0 B.1.1.372
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 1.00e+0 B.1.1.420
V4155 3059C>T missense_variant S A1020V 1.00e+0 B.1.1.420
V2167 11026G>A missense_variant ORF1ab_pp1a G3676S 7.07e-1 B.1.1.434
V2169 11031T>G missense_variant ORF1ab_pp1a F3677L 7.07e-1 B.1.1.434
V4374 125C>T missense_variant ORF3a P42L 7.07e-1 B.1.1.434
V3924 1480T>C missense_variant S S494P 8.94e-1 B.1.1.523
V1252 4883G>T missense_variant ORF1ab_pp1a R1628L 1.00e+0 B.1.1.70
V2329 12194C>T missense_variant ORF1ab_pp1a T4065I 9.73e-1 B.1.177.10
V3801 815C>T missense_variant S P272L 7.26e-1 B.1.177.10
V3953 1715C>T missense_variant S T572I 1.00e+0 B.1.177.10
V4163 3189G>T missense_variant S L1063F 1.00e+0 B.1.177.10
V6040 1248C>T synonymous_variant ORF1ab_pp1a C416C 7.57e-1 B.1.177.10
V7368 11482C>T synonymous_variant ORF1ab_pp1a L3828L 7.70e-1 B.1.177.10
V7388 11601C>T synonymous_variant ORF1ab_pp1a C3867C 9.12e-1 B.1.177.10
V8158 17481C>T synonymous_variant ORF1ab_pp1ab N5827N 6.20e-1 B.1.177.10
V9076 3438C>T synonymous_variant S D1146D 7.70e-1 B.1.177.10
V9391 621C>T synonymous_variant M N207N 7.70e-1 B.1.177.10
V9429 91T>C synonymous_variant ORF7a L31L 9.12e-1 B.1.177.10
V1423 6077A>C missense_variant ORF1ab_pp1a D2026A 1.00e+0 B.1.177.17
V163 184C>T missense_variant ORF1ab_pp1a P62S 1.00e+0 B.1.177.17
V2120 10844C>T missense_variant ORF1ab_pp1a A3615V 7.07e-1 B.1.177.17
V2920 17176C>T missense_variant ORF1ab_pp1ab P5726S 1.00e+0 B.1.177.17
V3658 448A>G missense_variant S K150E 1.00e+0 B.1.177.17
V3907 1447G>T missense_variant S V483F 1.00e+0 B.1.177.17
V3961 1749G>C missense_variant S E583D 1.00e+0 B.1.177.17
V5346 209A>G missense_variant N Q70R 1.00e+0 B.1.177.17
V5653 1240G>T missense_variant N A414S 1.00e+0 B.1.177.17
V702 2188C>T missense_variant ORF1ab_pp1a L730F 1.00e+0 B.1.177.17
V9152 108G>A synonymous_variant ORF3a P36P 1.00e+0 B.1.177.17
V2036 10183C>T missense_variant ORF1ab_pp1a P3395S 9.25e-1 B.1.177.32
V4337 77C>T missense_variant ORF3a S26L 9.25e-1 B.1.177.32
V7675 13851C>T synonymous_variant ORF1ab_pp1ab T4617T 9.49e-1 B.1.177.4
V3539 62G>C missense_variant S R21T 7.07e-1 B.1.177.60
V8289 18450C>T synonymous_variant ORF1ab_pp1ab A6150A 7.07e-1 B.1.177.60
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 1.00e+0 B.1.177.81
V3751 725_733delTTGCTTTAC disruptive_inframe_deletion S L242_L244del 1.00e+0 B.1.177.81
V1921 9173C>T missense_variant ORF1ab_pp1a T3058I 6.87e-1 B.1.177.86
V3780 758A>G missense_variant S D253G 7.07e-1 B.1.214.2
V4381 131G>T missense_variant ORF3a G44V 6.73e-1 B.1.221
V5239 -3A>C upstream_gene_variant N None 7.14e-1 B.1.221
V5353 241G>T missense_variant N D81Y 6.12e-1 B.1.221
V8115 17172C>T synonymous_variant ORF1ab_pp1ab G5724G 6.74e-1 B.1.234
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 7.07e-1 B.1.241
V2189 11153T>C missense_variant ORF1ab_pp1a V3718A 7.07e-1 B.1.241
V3572 190T>C missense_variant S W64R 7.07e-1 B.1.241
V3722 629_631delTTA disruptive_inframe_deletion S I210del 7.07e-1 B.1.241
V3849 1181A>G missense_variant S N394S 7.07e-1 B.1.241
V4111 2576C>A missense_variant S T859N 7.07e-1 B.1.241
V5469 614C>T missense_variant N T205I 7.07e-1 B.1.241
V6690 6045C>T synonymous_variant ORF1ab_pp1a S2015S 7.07e-1 B.1.241
V889 2996C>T missense_variant ORF1ab_pp1a T999I 7.07e-1 B.1.241
V1121 3965C>T missense_variant ORF1ab_pp1a T1322I 1.00e+0 B.1.258.17
V1263 4919C>T missense_variant ORF1ab_pp1a P1640L 7.07e-1 B.1.258.17
V2373 12496G>A missense_variant ORF1ab_pp1a D4166N 1.00e+0 B.1.258.17
V4546 524C>T missense_variant ORF3a T175I 1.00e+0 B.1.258.17
V710 2229G>T missense_variant ORF1ab_pp1a E743D 7.07e-1 B.1.258.17
V6830 7128G>T synonymous_variant ORF1ab_pp1a P2376P 6.31e-1 B.1.265
V865 2914G>A missense_variant ORF1ab_pp1a E972K 7.74e-1 B.1.265
V5441 578G>T missense_variant N S193I 7.07e-1 B.1.279
V7920 15687C>T synonymous_variant ORF1ab_pp1ab I5229I 7.07e-1 B.1.279
V2038 10184C>T missense_variant ORF1ab_pp1a P3395L 7.07e-1 B.1.320
V2325 12145A>G missense_variant ORF1ab_pp1a I4049V 7.07e-1 B.1.320
V2759 15894G>T missense_variant ORF1ab_pp1ab M5298I 7.07e-1 B.1.320
V3078 18227C>T missense_variant ORF1ab_pp1ab P6076L 7.07e-1 B.1.320
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 7.07e-1 B.1.320
V364 884G>T missense_variant ORF1ab_pp1a G295V 7.07e-1 B.1.320
V3861 1251G>T missense_variant S K417N 1.00e+0 B.1.320
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.320
V3962 1749G>T missense_variant S E583D 1.00e+0 B.1.320
V5025 42A>T missense_variant ORF7b L14F 7.07e-1 B.1.320
V5145 185T>C missense_variant ORF8 V62A 7.07e-1 B.1.320
V5492 641_646delGCGGTG disruptive_inframe_deletion N G214_G215del 7.07e-1 B.1.320
V7079 9126C>T synonymous_variant ORF1ab_pp1a D3042D 7.07e-1 B.1.320
V7297 10821T>C synonymous_variant ORF1ab_pp1a Y3607Y 7.07e-1 B.1.320
V7921 15688C>T synonymous_variant ORF1ab_pp1ab L5230L 1.00e+0 B.1.320
V2113 10810T>C missense_variant ORF1ab_pp1a F3604L 1.00e+0 B.1.324
V5236 -5C>T upstream_gene_variant N None 7.07e-1 B.1.349
V3861 1251G>T missense_variant S K417N 7.98e-1 B.1.351.2
V3927 1501A>T missense_variant S N501Y 9.48e-1 B.1.351.2
V3861 1251G>T missense_variant S K417N 7.05e-1 B.1.351.3
V3927 1501A>T missense_variant S N501Y 8.63e-1 B.1.351.3
V3861 1251G>T missense_variant S K417N 7.52e-1 B.1.351.5
V3927 1501A>T missense_variant S N501Y 8.93e-1 B.1.351.5
V3927 1501A>T missense_variant S N501Y 8.45e-1 B.1.351
V1259 4913C>A missense_variant ORF1ab_pp1a T1638N 7.07e-1 B.1.36.17
V1607 6848C>T missense_variant ORF1ab_pp1a T2283I 7.07e-1 B.1.36.17
V1888 8888A>G missense_variant ORF1ab_pp1a Q2963R 1.00e+0 B.1.36.17
V1944 9350C>T missense_variant ORF1ab_pp1a T3117I 1.00e+0 B.1.36.17
V216 304G>A missense_variant ORF1ab_pp1a E102K 1.00e+0 B.1.36.17
V2267 11743C>T missense_variant ORF1ab_pp1a L3915F 1.00e+0 B.1.36.17
V3258 19595C>T missense_variant ORF1ab_pp1ab A6532V 1.00e+0 B.1.36.17
V3525 26C>T missense_variant S P9L 1.00e+0 B.1.36.17
V3578 204_209delACATGT disruptive_inframe_deletion S H69_V70del 1.00e+0 B.1.36.17
V3945 1668C>A missense_variant S N556K 1.00e+0 B.1.36.17
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.36.17
V4143 2848G>A missense_variant S D950N 7.07e-1 B.1.36.17
V5239 -3A>C upstream_gene_variant N None 7.07e-1 B.1.36.17
V5354 250A>G missense_variant N I84V 1.00e+0 B.1.36.17
V6632 5568C>T synonymous_variant ORF1ab_pp1a S1856S 7.07e-1 B.1.36.17
V1486 6267G>T missense_variant ORF1ab_pp1a E2089D 1.00e+0 B.1.36.18
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 7.07e-1 B.1.36.18
V4035 2066G>T missense_variant S S689I 1.00e+0 B.1.36.18
V9051 3252T>C synonymous_variant S D1084D 1.00e+0 B.1.36.18
V9730 849A>G synonymous_variant N Q283Q 1.00e+0 B.1.36.18
V6842 7263C>T synonymous_variant ORF1ab_pp1a V2421V 8.16e-1 B.1.361
V7351 11379C>T synonymous_variant ORF1ab_pp1a Y3793Y 8.16e-1 B.1.361
V8358 18921C>T synonymous_variant ORF1ab_pp1ab C6307C 6.66e-1 B.1.361
V9303 123C>T synonymous_variant M N41N 8.16e-1 B.1.361
V9409 118T>C synonymous_variant ORF6 L40L 8.16e-1 B.1.361
V4294 3788C>T missense_variant S P1263L 1.00e+0 B.1.36.31
V7827 14952C>T synonymous_variant ORF1ab_pp1ab S4984S 1.00e+0 B.1.36.31
V254 412G>A missense_variant ORF1ab_pp1a A138T 6.05e-1 B.1.369
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 6.23e-1 B.1.369
V3636 425G>T missense_variant S G142V 6.12e-1 B.1.36
V1184 4544C>T missense_variant ORF1ab_pp1a S1515F 1.00e+0 B.1.391
V1935 9261G>T missense_variant ORF1ab_pp1a M3087I 1.00e+0 B.1.391
V24 -161G>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 B.1.391
V2868 16802A>G missense_variant ORF1ab_pp1ab Y5601C 1.00e+0 B.1.391
V3641 432_437delTTACCA disruptive_inframe_deletion S Y145_H146del 1.00e+0 B.1.391
V4015 2031G>T missense_variant S Q677H 1.00e+0 B.1.391
V4503 384G>T missense_variant ORF3a W128C 1.00e+0 B.1.391
V4521 452C>T missense_variant ORF3a T151I 1.00e+0 B.1.391
V4647 803C>T missense_variant ORF3a T268M 7.07e-1 B.1.391
V4965 277G>T missense_variant ORF7a V93F 1.00e+0 B.1.391
V5041 97G>T stop_gained ORF7b E33* 1.00e+0 B.1.391
V5100 86A>T missense_variant ORF8 Q29L 1.00e+0 B.1.391
V5116 116T>C missense_variant ORF8 I39T 1.00e+0 B.1.391
V5279 52G>A missense_variant N G18S 1.00e+0 B.1.391
V5370 355G>T missense_variant N A119S 1.00e+0 B.1.391
V5499 649G>T missense_variant N A217S 1.00e+0 B.1.391
V5513 702G>T missense_variant N M234I 1.00e+0 B.1.391
V5946 588C>T synonymous_variant ORF1ab_pp1a Y196Y 1.00e+0 B.1.391
V6064 1419C>T synonymous_variant ORF1ab_pp1a I473I 1.00e+0 B.1.391
V6558 4998T>C synonymous_variant ORF1ab_pp1a S1666S 1.00e+0 B.1.391
V6833 7155C>T synonymous_variant ORF1ab_pp1a I2385I 1.00e+0 B.1.391
V7549 12849T>C synonymous_variant ORF1ab_pp1a Y4283Y 1.00e+0 B.1.391
V8101 17070G>T synonymous_variant ORF1ab_pp1ab T5690T 7.07e-1 B.1.391
V8887 1995C>T synonymous_variant S P665P 1.00e+0 B.1.391
V9078 3444C>T synonymous_variant S F1148F 1.00e+0 B.1.391
V9093 3522T>C synonymous_variant S A1174A 1.00e+0 B.1.391
V9341 363C>T synonymous_variant M N121N 1.00e+0 B.1.391
V9349 387G>T synonymous_variant M L129L 1.00e+0 B.1.391
V1241 4790C>T missense_variant ORF1ab_pp1a T1597I 8.16e-1 B.1.396
V6913 7827C>T synonymous_variant ORF1ab_pp1a L2609L 6.66e-1 B.1.396
V8634 120C>T synonymous_variant S D40D 8.16e-1 B.1.396
V2339 12260C>T missense_variant ORF1ab_pp1a T4087I 7.06e-1 B.1.398
V5843 72C>T synonymous_variant ORF1ab_pp1a R24R 7.06e-1 B.1.398
V935 3166G>A missense_variant ORF1ab_pp1a V1056M 7.06e-1 B.1.398
V9531 186G>T synonymous_variant ORF8 V62V 7.06e-1 B.1.398
V2730 15593C>T missense_variant ORF1ab_pp1ab T5198I 7.07e-1 B.1.400
V1532 6436C>T missense_variant ORF1ab_pp1a L2146F 7.94e-1 B.1.438.1
V2123 10852A>G missense_variant ORF1ab_pp1a I3618V 8.70e-1 B.1.438.1
V4488 334G>T missense_variant ORF3a V112F 8.05e-1 B.1.438.1
V9126 3762C>T synonymous_variant S C1254C 8.70e-1 B.1.438.1
V1174 4490C>T missense_variant ORF1ab_pp1a P1497L 7.07e-1 B.1.466.2
V1769 8106G>T missense_variant ORF1ab_pp1a Q2702H 7.07e-1 B.1.466.2
V2853 16744A>G missense_variant ORF1ab_pp1ab I5582V 7.07e-1 B.1.466.2
V3067 18167C>T missense_variant ORF1ab_pp1ab T6056I 7.07e-1 B.1.466.2
V35 -119C>T upstream_gene_variant ORF1ab_pp1a None 7.07e-1 B.1.466.2
V3634 425_433delGTGTTTATT disruptive_inframe_deletion S G142_Y145delinsD 7.07e-1 B.1.466.2
V3757 727G>C missense_variant S A243P 7.07e-1 B.1.466.2
V3831 1062C>A missense_variant S N354K 7.07e-1 B.1.466.2
V4720 8A>G missense_variant M D3G 7.07e-1 B.1.466.2
V5243 -2A>T upstream_gene_variant N None 7.07e-1 B.1.466.2
V5385 417G>T missense_variant N L139F 7.07e-1 B.1.466.2
V6835 7164A>G synonymous_variant ORF1ab_pp1a A2388A 7.07e-1 B.1.466.2
V9060 3342C>T synonymous_variant S I1114I 7.07e-1 B.1.466.2
V4143 2848G>A missense_variant S D950N 6.53e-1 B.1.470
V2163 11023_11031delTCTGGTTTT conservative_inframe_deletion ORF1ab_pp1a S3675_F3677del 7.07e-1 B.1.499
V2167 11026G>A missense_variant ORF1ab_pp1a G3676S 7.07e-1 B.1.499
V2169 11031T>G missense_variant ORF1ab_pp1a F3677L 7.07e-1 B.1.499
V3600 239A>G missense_variant S D80G 7.07e-1 B.1.499
V3636 425G>T missense_variant S G142V 7.07e-1 B.1.499
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 7.07e-1 B.1.499
V3640 430T>A missense_variant S Y144N 7.07e-1 B.1.499
V3886 1355T>G missense_variant S L452R 7.07e-1 B.1.499
V4483 322C>T missense_variant ORF3a L108F 7.07e-1 B.1.499
V772 2521A>G missense_variant ORF1ab_pp1a I841V 7.07e-1 B.1.499
V7740 14307C>T synonymous_variant ORF1ab_pp1ab D4769D 7.07e-1 B.1.499
V908 3055G>A missense_variant ORF1ab_pp1a V1019I 7.07e-1 B.1.499
V1414 6047C>T missense_variant ORF1ab_pp1a T2016I 7.07e-1 B.1.517
V2688 15142G>T missense_variant ORF1ab_pp1ab A5048S 7.07e-1 B.1.517
V3577 200C>T missense_variant S A67V 7.07e-1 B.1.517
V4690 203C>T missense_variant E S68F 7.07e-1 B.1.517
V4775 373C>T missense_variant M H125Y 7.07e-1 B.1.517
V1841 8576C>T missense_variant ORF1ab_pp1a T2859I 1.00e+0 B.1.524
V3608 284C>T missense_variant S T95I 1.00e+0 B.1.524
V4023 2042C>G missense_variant S P681R 1.00e+0 B.1.524
V4143 2848G>A missense_variant S D950N 1.00e+0 B.1.524
V5239 -3A>C upstream_gene_variant N None 1.00e+0 B.1.524
V5493 640G>T missense_variant N G214C 1.00e+0 B.1.524
V5919 438C>T synonymous_variant ORF1ab_pp1a G146G 7.07e-1 B.1.524
V7158 9714C>T synonymous_variant ORF1ab_pp1a L3238L 7.07e-1 B.1.524
V9180 246C>T synonymous_variant ORF3a N82N 7.07e-1 B.1.524
V1386 5836G>A missense_variant ORF1ab_pp1a G1946S -8.03e-1 B.1.526
V3896 1430G>A missense_variant S S477N -8.69e-1 B.1.526
V4043 2102C>T missense_variant S A701V 7.31e-1 B.1.526
V4994 346C>T missense_variant ORF7a L116F -7.07e-1 B.1.526
V5274 38C>T missense_variant N P13L -7.38e-1 B.1.526
V5452 596C>T missense_variant N P199L 7.48e-1 B.1.526
V5511 702G>A missense_variant N M234I 7.47e-1 B.1.526
V6810 6936A>G synonymous_variant ORF1ab_pp1a S2312S -7.86e-1 B.1.526
V7000 8544C>T synonymous_variant ORF1ab_pp1a D2848D -7.27e-1 B.1.526
V9216 576A>G synonymous_variant ORF3a K192K -7.44e-1 B.1.526
V4842 -5C>T upstream_gene_variant ORF7a None 8.66e-1 B.1.560
V4916 182C>T missense_variant ORF7a T61I 8.66e-1 B.1.560
V7761 14430C>T synonymous_variant ORF1ab_pp1ab D4810D 8.94e-1 B.1.560
V9470 261C>T synonymous_variant ORF7a F87F 7.55e-1 B.1.560
V1162 4390C>T missense_variant ORF1ab_pp1a R1464W 7.07e-1 B.1.561
V1709 7775A>G missense_variant ORF1ab_pp1a D2592G 7.07e-1 B.1.561
V3896 1430G>A missense_variant S S477N 7.07e-1 B.1.561
V4006 2015C>T missense_variant S A672V 7.07e-1 B.1.561
V4200 3352G>T missense_variant S D1118Y 1.00e+0 B.1.561
V4663 26C>T missense_variant E T9I 8.16e-1 B.1.561
V4728 49C>T missense_variant M L17F 1.00e+0 B.1.561
V4780 442C>T missense_variant M H148Y 7.07e-1 B.1.561
V5255 17C>T missense_variant N P6L 7.07e-1 B.1.561
V5776 *4358G>A downstream_gene_variant S None 7.07e-1 B.1.561
V579 1693G>A missense_variant ORF1ab_pp1a A565T 7.07e-1 B.1.561
V6636 5604C>T synonymous_variant ORF1ab_pp1a Y1868Y 7.07e-1 B.1.561
V7270 10590A>G synonymous_variant ORF1ab_pp1a S3530S 1.00e+0 B.1.561
V7613 13290C>T synonymous_variant ORF1ab_pp1ab Y4430Y 1.00e+0 B.1.561
V7759 14418T>C synonymous_variant ORF1ab_pp1ab N4806N 7.07e-1 B.1.561
V8132 17286C>T synonymous_variant ORF1ab_pp1ab L5762L 7.07e-1 B.1.561
V8840 1668C>T synonymous_variant S N556N 1.00e+0 B.1.561
V8896 2040T>C synonymous_variant S S680S 7.07e-1 B.1.561
V9741 894C>T synonymous_variant N Y298Y 7.07e-1 B.1.561
V1499 6308C>T missense_variant ORF1ab_pp1a S2103F 7.07e-1 B.1.565
V2875 16871C>T missense_variant ORF1ab_pp1ab P5624L 6.66e-1 B.1.565
V9589 123G>T synonymous_variant N R41R 6.12e-1 B.1.565
V2190 11165A>G missense_variant ORF1ab_pp1a Y3722C 9.49e-1 B.1.575
V5274 38C>T missense_variant N P13L 6.89e-1 B.1.575
V9315 228C>T synonymous_variant M I76I 8.36e-1 B.1.575
V992 3373G>T missense_variant ORF1ab_pp1a G1125C 9.49e-1 B.1.575
V3898 1431C>A missense_variant S S477R 7.74e-1 B.1.577
V4849 8T>C missense_variant ORF7a I3T 7.74e-1 B.1.577
V5656 1250C>T missense_variant N T417I 6.32e-1 B.1.577
V2616 14357C>T missense_variant ORF1ab_pp1ab T4786M 7.07e-1 B.1.582
V3411 20495C>T missense_variant ORF1ab_pp1ab A6832V 7.07e-1 B.1.582
V3751 725_733delTTGCTTTAC disruptive_inframe_deletion S L242_L244del 7.07e-1 B.1.582
V3896 1430G>A missense_variant S S477N 7.07e-1 B.1.582
V6850 7335C>T synonymous_variant ORF1ab_pp1a C2445C 7.07e-1 B.1.582
V987 3355G>A missense_variant ORF1ab_pp1a G1119S 7.07e-1 B.1.582
V1548 6497C>T missense_variant ORF1ab_pp1a T2166I 7.07e-1 B.1.596
V3535 59C>A missense_variant S T20N 1.00e+0 B.1.596
V3551 76C>T missense_variant S P26S 7.07e-1 B.1.596
V3628 412G>T missense_variant S D138Y 1.00e+0 B.1.596
V377 925C>T missense_variant ORF1ab_pp1a P309S 7.07e-1 B.1.596
V5352 239C>G missense_variant N P80R 7.07e-1 B.1.596
V6730 6276C>T synonymous_variant ORF1ab_pp1a H2092H 1.00e+0 B.1.596
V6736 6348A>G synonymous_variant ORF1ab_pp1a V2116V 1.00e+0 B.1.596
V7644 13596C>T synonymous_variant ORF1ab_pp1ab D4532D 7.07e-1 B.1.596
V3886 1355T>G missense_variant S L452R -1.00e+0 B.1.619.1
V3900 1433C>A missense_variant S T478K -1.00e+0 B.1.619.1
V1268 4965G>T missense_variant ORF1ab_pp1a K1655N -6.16e-1 B.1.620
V1286 5123C>A missense_variant ORF1ab_pp1a A1708D -6.82e-1 B.1.620
V3742 644A>G missense_variant S D215G -7.03e-1 B.1.620
V3861 1251G>T missense_variant S K417N -6.16e-1 B.1.620
V3896 1430G>A missense_variant S S477N 9.81e-1 B.1.620
V3927 1501A>T missense_variant S N501Y -6.18e-1 B.1.620
V4048 2147C>T missense_variant S T716I -6.82e-1 B.1.620
V4692 212C>T missense_variant E P71L -7.03e-1 B.1.620
V48 -92G>T upstream_gene_variant ORF1ab_pp1a None -6.77e-1 B.1.620
V6214 2427A>T synonymous_variant ORF1ab_pp1a T809T -6.76e-1 B.1.620
V6651 5721C>T synonymous_variant ORF1ab_pp1a F1907F -6.53e-1 B.1.620
V7840 15060C>T synonymous_variant ORF1ab_pp1ab N5020N 6.32e-1 B.1.620
V8865 1854A>T synonymous_variant S T618T 7.05e-1 B.1.620
V9557 360C>T synonymous_variant ORF8 F120F -6.12e-1 B.1.620
V3927 1501A>T missense_variant S N501Y 8.10e-1 B.1.621.1
V3880 1345T>A missense_variant S Y449N 8.61e-1 B.1.621.2
V3927 1501A>T missense_variant S N501Y 8.81e-1 B.1.621.2
V3927 1501A>T missense_variant S N501Y 8.95e-1 B.1.621
V2829 16588G>T missense_variant ORF1ab_pp1ab G5530C 6.32e-1 B.1.623
V7027 8721C>T synonymous_variant ORF1ab_pp1a D2907D 6.32e-1 B.1.623
V808 2680G>A missense_variant ORF1ab_pp1a G894S 6.32e-1 B.1.623
V1073 3690G>T missense_variant ORF1ab_pp1a K1230N 1.00e+0 B.1.640.1
V1657 7379C>T missense_variant ORF1ab_pp1a A2460V 1.00e+0 B.1.640.1
V1976 9664G>A missense_variant ORF1ab_pp1a D3222N 1.00e+0 B.1.640.1
V1982 9764C>T missense_variant ORF1ab_pp1a T3255I -1.00e+0 B.1.640.1
V2069 10510C>T missense_variant ORF1ab_pp1a P3504S 8.16e-1 B.1.640.1
V2163 11023_11031delTCTGGTTTT conservative_inframe_deletion ORF1ab_pp1a S3675_F3677del 1.00e+0 B.1.640.1
V258 416A>G missense_variant ORF1ab_pp1a D139G 1.00e+0 B.1.640.1
V3608 284C>T missense_variant S T95I 1.00e+0 B.1.640.1
V3921 1469T>C missense_variant S F490S 1.00e+0 B.1.640.1
V3926 1493A>G missense_variant S Q498R 1.00e+0 B.1.640.1
V4210 3415G>C missense_variant S D1139H 1.00e+0 B.1.640.1
V4245 3598C>T missense_variant S L1200F 1.00e+0 B.1.640.1
V4535 512C>T missense_variant ORF3a S171L 8.16e-1 B.1.640.1
V522 1493C>T missense_variant ORF1ab_pp1a A498V 1.00e+0 B.1.640.1
V6629 5541C>T synonymous_variant ORF1ab_pp1a C1847C 1.00e+0 B.1.640.1
V7234 10296T>C synonymous_variant ORF1ab_pp1a T3432T 1.00e+0 B.1.640.1
V7792 14649C>T synonymous_variant ORF1ab_pp1ab N4883N 1.00e+0 B.1.640.1
V876 2965G>T missense_variant ORF1ab_pp1a G989C 1.00e+0 B.1.640.1
V3809 920C>T missense_variant S T307I 1.00e+0 BA.1.1.11
V2917 17138C>T missense_variant ORF1ab_pp1ab A5713V 8.16e-1 BA.1.20
V3912 1451A>G missense_variant S E484G 8.66e-1 BA.2.10.1
V5294 73G>T missense_variant N G25C 1.00e+0 BA.2.24
V1288 5141T>C missense_variant ORF1ab_pp1a I1714T 1.00e+0 BA.2.3.11
V1549 6505A>G missense_variant ORF1ab_pp1a M2169V 1.00e+0 BA.2.3.11
V1550 6521C>T missense_variant ORF1ab_pp1a T2174I 1.00e+0 BA.2.3.11
V1746 7943C>T missense_variant ORF1ab_pp1a T2648I 1.00e+0 BA.2.3.11
V2271 11765A>G missense_variant ORF1ab_pp1a Q3922R 1.00e+0 BA.2.3.11
V2951 17414C>T missense_variant ORF1ab_pp1ab T5805M 7.07e-1 BA.2.3.11
V3665 458T>C missense_variant S M153T 1.00e+0 BA.2.3.11
V3679 492T>G missense_variant S N164K 1.00e+0 BA.2.3.11
V3762 733C>A missense_variant S H245N 1.00e+0 BA.2.3.11
V3785 770G>A missense_variant S G257D 1.00e+0 BA.2.3.11
V3870 1331A>G missense_variant S K444R 1.00e+0 BA.2.3.11
V3882 1348A>G missense_variant S N450D 1.00e+0 BA.2.3.11
V3884 1354C>A missense_variant S L452M 1.00e+0 BA.2.3.11
V3891 1380T>G missense_variant S N460K 1.00e+0 BA.2.3.11
V3912 1451A>G missense_variant S E484G 1.00e+0 BA.2.3.11
V4222 3484C>T missense_variant S P1162S 7.07e-1 BA.2.3.11
V4248 3604G>C missense_variant S E1202Q 7.07e-1 BA.2.3.11
V4279 3749G>T missense_variant S C1250F 1.00e+0 BA.2.3.11
V6035 1206C>T synonymous_variant ORF1ab_pp1a R402R 1.00e+0 BA.2.3.11
V6616 5400G>A synonymous_variant ORF1ab_pp1a Q1800Q 1.00e+0 BA.2.3.11
V697 2180C>T missense_variant ORF1ab_pp1a T727I 1.00e+0 BA.2.3.11
V7191 9924C>T synonymous_variant ORF1ab_pp1a T3308T 1.00e+0 BA.2.3.11
V8219 17988C>T synonymous_variant ORF1ab_pp1ab N5996N 7.07e-1 BA.2.3.11
V8946 2472C>T synonymous_variant S N824N 1.00e+0 BA.2.3.11
V9618 277C>A synonymous_variant N R93R 1.00e+0 BA.2.3.11
V3882 1348A>G missense_variant S N450D 6.52e-1 BA.2.3.20
V3884 1354C>A missense_variant S L452M 6.76e-1 BA.2.3.20
V3891 1380T>G missense_variant S N460K 7.41e-1 BA.2.3.20
V3896 1430G>A missense_variant S S477N 8.38e-1 BA.2.3.20
V3900 1433C>A missense_variant S T478K 8.76e-1 BA.2.3.20
V3912 1451A>G missense_variant S E484G 9.93e-1 BA.2.3.20
V3926 1493A>G missense_variant S Q498R 8.45e-1 BA.2.3.20
V3927 1501A>T missense_variant S N501Y 8.52e-1 BA.2.3.20
V3930 1513T>C missense_variant S Y505H 7.92e-1 BA.2.3.20
V2526 13693C>T missense_variant ORF1ab_pp1ab R4565C 7.07e-1 BA.2.36
V6598 5283C>T synonymous_variant ORF1ab_pp1a T1761T 7.07e-1 BA.2.36
V6838 7179A>G synonymous_variant ORF1ab_pp1a V2393V 8.16e-1 BA.2.36
V9596 150G>T synonymous_variant N A50A 7.07e-1 BA.2.36
V2395 12646G>A missense_variant ORF1ab_pp1a V4216I 8.16e-1 BA.2.38
V7797 14667C>T synonymous_variant ORF1ab_pp1ab N4889N 7.07e-1 BA.2.38
V8149 17439C>T synonymous_variant ORF1ab_pp1ab N5813N 7.07e-1 BA.2.38
V2814 16462C>T missense_variant ORF1ab_pp1ab H5488Y 1.00e+0 BA.2.40.1
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 7.07e-1 BA.2.52
V2156 11007G>T missense_variant ORF1ab_pp1a M3669I 7.07e-1 BA.2.56
V8412 19398C>T synonymous_variant ORF1ab_pp1ab H6466H 7.07e-1 BA.2.56
V7044 8868C>T synonymous_variant ORF1ab_pp1a L2956L 1.00e+0 BA.2.62
V7836 15015C>T synonymous_variant ORF1ab_pp1ab H5005H 7.07e-1 BA.2.62
V9491 39T>C synonymous_variant ORF7b F13F 1.00e+0 BA.2.62
V2012 10012C>T missense_variant ORF1ab_pp1a L3338F 7.07e-1 BA.5.1.19
V5810 *4389G>T downstream_gene_variant S None 1.00e+0 BA.5.1.2
V4803 17A>G missense_variant ORF6 D6G 6.54e-1 BA.5.1.6
V6197 2328T>C synonymous_variant ORF1ab_pp1a A776A 1.00e+0 BA.5.1.6
V7943 15847C>T synonymous_variant ORF1ab_pp1ab L5283L 1.00e+0 BA.5.1.6
V5078 29T>C missense_variant ORF8 I10T 1.00e+0 BA.5.2.18
V5678 -1G>T upstream_gene_variant ORF10 None 1.00e+0 BA.5.2.3
V5093 74G>T missense_variant ORF8 C25F 7.07e-1 BA.5.2.48
V7691 13956C>T synonymous_variant ORF1ab_pp1ab D4652D 1.00e+0 BA.5.2.48
V9300 99T>C synonymous_variant M C33C 1.00e+0 BA.5.2.9
V5590 1048G>T missense_variant N V350F 1.00e+0 BE.3
V1416 6053C>T missense_variant ORF1ab_pp1a P2018L 8.16e-1 BE.9
V798 2645C>T missense_variant ORF1ab_pp1a T882I 6.54e-1 BF.28
V619 1841C>T missense_variant ORF1ab_pp1a T614I 1.00e+0 BF.6
V8300 18540C>T synonymous_variant ORF1ab_pp1ab S6180S 1.00e+0 BF.6
V5967 696T>C synonymous_variant ORF1ab_pp1a R232R 1.00e+0 BF.7.14
V5979 807A>G synonymous_variant ORF1ab_pp1a E269E 1.00e+0 BW.1.1
V7408 11740C>T synonymous_variant ORF1ab_pp1a L3914L 1.00e+0 BW.1.1
V1101 3848C>T missense_variant ORF1ab_pp1a A1283V 7.07e-1 C.16
V2304 11937G>T missense_variant ORF1ab_pp1a K3979N 7.07e-1 C.16
V342 794C>T missense_variant ORF1ab_pp1a T265I 7.07e-1 C.16
V3599 239A>C missense_variant S D80A 7.07e-1 C.16
V3889 1379A>G missense_variant S N460S 7.07e-1 C.16
V3927 1501A>T missense_variant S N501Y 7.07e-1 C.16
V3954 1718C>T missense_variant S T573I 7.07e-1 C.16
V5244 -1A>T upstream_gene_variant N None 7.07e-1 C.16
V629 1879G>A missense_variant ORF1ab_pp1a V627I 7.07e-1 C.16
V713 2243C>T missense_variant ORF1ab_pp1a P748L 7.07e-1 C.16
V7622 13356C>T synonymous_variant ORF1ab_pp1ab D4452D 7.07e-1 C.16
V8949 2499C>T synonymous_variant S F833F 7.07e-1 C.16
V9259 819G>T synonymous_variant ORF3a V273V 7.07e-1 C.16
V1268 4965G>T missense_variant ORF1ab_pp1a K1655N 1.00e+0 C.36
V1288 5141T>C missense_variant ORF1ab_pp1a I1714T 1.00e+0 C.36
V202 257T>A missense_variant ORF1ab_pp1a V86D 1.00e+0 C.36
V3530 52C>T missense_variant S L18F 1.00e+0 C.36
V4043 2102C>T missense_variant S A701V 1.00e+0 C.36
V6214 2427A>T synonymous_variant ORF1ab_pp1a T809T 1.00e+0 C.36
V7807 14760C>T synonymous_variant ORF1ab_pp1ab F4920F 1.00e+0 C.36
V3509 21224A>G missense_variant ORF1ab_pp1ab K7075R 7.25e-1 C.37
V3894 1424C>T missense_variant S A475V 6.91e-1 C.37
V3997 1963C>T missense_variant S H655Y 6.69e-1 C.37
V3882 1348A>G missense_variant S N450D 6.48e-1 CM.2
V3884 1354C>A missense_variant S L452M 6.73e-1 CM.2
V3891 1380T>G missense_variant S N460K 6.78e-1 CM.2
V3896 1430G>A missense_variant S S477N 8.31e-1 CM.2
V3900 1433C>A missense_variant S T478K 8.86e-1 CM.2
V3912 1451A>G missense_variant S E484G 9.89e-1 CM.2
V3926 1493A>G missense_variant S Q498R 9.09e-1 CM.2
V3927 1501A>T missense_variant S N501Y 8.97e-1 CM.2
V3930 1513T>C missense_variant S Y505H 8.52e-1 CM.2
V3891 1380T>G missense_variant S N460K 6.32e-1 CM.8.1
V3896 1430G>A missense_variant S S477N 8.64e-1 CM.8.1
V3900 1433C>A missense_variant S T478K 8.94e-1 CM.8.1
V3912 1451A>G missense_variant S E484G 9.75e-1 CM.8.1
V3917 1457T>C missense_variant S F486S 9.11e-1 CM.8.1
V3926 1493A>G missense_variant S Q498R 7.54e-1 CM.8.1
V3927 1501A>T missense_variant S N501Y 7.24e-1 CM.8.1
V3930 1513T>C missense_variant S Y505H 7.24e-1 CM.8.1
V3927 1501A>T missense_variant S N501Y 7.07e-1 N.5
V6080 1560C>T synonymous_variant ORF1ab_pp1a A520A 7.07e-1 N.5
V6621 5451G>A synonymous_variant ORF1ab_pp1a K1817K 7.07e-1 N.5
V6736 6348A>G synonymous_variant ORF1ab_pp1a V2116V 7.07e-1 N.5
V6924 7890A>G synonymous_variant ORF1ab_pp1a L2630L 7.07e-1 N.5
V3927 1501A>T missense_variant S N501Y 7.98e-1 P.1.10
V3927 1501A>T missense_variant S N501Y 8.85e-1 P.1.12
V3927 1501A>T missense_variant S N501Y 9.70e-1 P.1.13
V3927 1501A>T missense_variant S N501Y 8.24e-1 P.1.14
V8859 1818C>T synonymous_variant S N606N 6.45e-1 P.1.14
V3927 1501A>T missense_variant S N501Y 9.22e-1 P.1.15
V8206 17865C>T synonymous_variant ORF1ab_pp1ab D5955D 6.61e-1 P.1.15
V3927 1501A>T missense_variant S N501Y 8.68e-1 P.1.16
V3927 1501A>T missense_variant S N501Y 7.54e-1 P.1.17.1
V3927 1501A>T missense_variant S N501Y 9.01e-1 P.1.17
V3927 1501A>T missense_variant S N501Y 9.13e-1 P.1.2
V3860 1250A>C missense_variant S K417T 7.05e-1 P.1.4
V3927 1501A>T missense_variant S N501Y 8.99e-1 P.1.4
V3927 1501A>T missense_variant S N501Y 1.00e+0 P.1.6
V3927 1501A>T missense_variant S N501Y 8.69e-1 P.1.7.1
V3927 1501A>T missense_variant S N501Y 9.04e-1 P.1.7
V3927 1501A>T missense_variant S N501Y 9.12e-1 P.3
V2550 13856C>T missense_variant ORF1ab_pp1ab P4619L 8.36e-1 Q.1
V3209 19126C>T missense_variant ORF1ab_pp1ab P6376S 8.56e-1 Q.1
V3668 460G>C missense_variant S E154Q 8.48e-1 Q.1
V4839 181G>C missense_variant ORF6 D61H 8.73e-1 Q.1
V4841 182A>T missense_variant ORF6 D61V 8.78e-1 Q.1
V4953 248C>T missense_variant ORF7a S83L 7.83e-1 Q.1
V5162 202A>T stop_gained ORF8 K68* 7.10e-1 Q.1
V5724 *4301T>G downstream_gene_variant S None 8.91e-1 Q.1
V6123 1845C>T synonymous_variant ORF1ab_pp1a N615N 8.09e-1 Q.1
V7238 10317C>T synonymous_variant ORF1ab_pp1a D3439D 9.10e-1 Q.1
V9418 183T>C synonymous_variant ORF6 D61D 8.68e-1 Q.1
V1198 4613C>T missense_variant ORF1ab_pp1a T1538I 1.00e+0 Q.3
V2194 11186A>G missense_variant ORF1ab_pp1a Q3729R 1.00e+0 Q.3
V2645 14738A>G missense_variant ORF1ab_pp1ab Y4913C 1.00e+0 Q.3
V2857 16755G>T missense_variant ORF1ab_pp1ab E5585D 1.00e+0 Q.3
V2925 17227C>T missense_variant ORF1ab_pp1ab P5743S 1.00e+0 Q.3
V3639 429_430insACT conservative_inframe_insertion S V143_Y144insT 1.00e+0 Q.3
V3642 431A>C missense_variant S Y144S 7.07e-1 Q.3
V4143 2848G>A missense_variant S D950N 7.07e-1 Q.3
V4264 3687G>T missense_variant S M1229I 1.00e+0 Q.3
V4702 -31A>T upstream_gene_variant M None 1.00e+0 Q.3
V5080 32C>A missense_variant ORF8 T11K 1.00e+0 Q.3
V5114 112C>T missense_variant ORF8 P38S 7.07e-1 Q.3
V5243 -2A>T upstream_gene_variant N None 7.07e-1 Q.3
V6656 5772C>T synonymous_variant ORF1ab_pp1a S1924S 7.07e-1 Q.3
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 1.00e+0 Q.3
V8337 18771T>C synonymous_variant ORF1ab_pp1ab I6257I 1.00e+0 Q.3
V8518 20406G>A synonymous_variant ORF1ab_pp1ab A6802A 1.00e+0 Q.3
V3876 1334T>C missense_variant S V445A 6.31e-1 Q.7
V8943 2460T>C synonymous_variant S D820D 7.74e-1 Q.7
V2290 11854C>T missense_variant ORF1ab_pp1a P3952S 7.07e-1 XBB.2
V2351 12379A>G missense_variant ORF1ab_pp1a I4127V 7.07e-1 XBB.2
V8969 2619C>T synonymous_variant S Y873Y 1.00e+0 XBB.2
V3912 1451A>G missense_variant S E484G 1.00e+0 XBB
V7771 14496C>T synonymous_variant ORF1ab_pp1ab F4832F 1.00e+0 XBF
V9736 871C>T synonymous_variant N L291L 8.16e-1 XBF
V5053 125_127delACG disruptive_inframe_deletion ORF7b H42_A43delinsP 7.07e-1 XBK
V5057 128C>T missense_variant ORF7b A43V 7.07e-1 XBK
V6229 2523C>T synonymous_variant ORF1ab_pp1a I841I 1.00e+0 XBK
V8607 21117C>T synonymous_variant ORF1ab_pp1ab S7039S 7.07e-1 XBK
V184 245_253delGTCATGTTA disruptive_inframe_deletion ORF1ab_pp1a G82_M85delinsV 1.00e+0 A.18
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 1.00e+0 A.18
V2163 11023_11031delTCTGGTTTT conservative_inframe_deletion ORF1ab_pp1a S3675_F3677del 1.00e+0 A.18
V2169 11031T>G missense_variant ORF1ab_pp1a F3677L 1.00e+0 A.18
V3023 17912C>T missense_variant ORF1ab_pp1ab P5971L 1.00e+0 A.18
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 6.97e-1 A.18
V371 905C>T missense_variant ORF1ab_pp1a S302F 1.00e+0 A.18
V5241 -3A>T upstream_gene_variant N None 1.00e+0 A.18
V6237 2577C>T synonymous_variant ORF1ab_pp1a A859A 1.00e+0 A.18
V6621 5451G>A synonymous_variant ORF1ab_pp1a K1817K 1.00e+0 A.18
V6866 7467C>T synonymous_variant ORF1ab_pp1a Y2489Y 1.00e+0 A.18
V7427 11850C>T synonymous_variant ORF1ab_pp1a S3950S 1.00e+0 A.18
V7476 12208C>T synonymous_variant ORF1ab_pp1a L4070L 1.00e+0 A.18
V842 2831C>T missense_variant ORF1ab_pp1a S944L 1.00e+0 A.18
V9788 1104T>C synonymous_variant N P368P 1.00e+0 A.18
V1938 9296C>T missense_variant ORF1ab_pp1a S3099L 1.00e+0 A.23
V2400 12659C>T missense_variant ORF1ab_pp1a P4220L 1.00e+0 A.23
V3927 1501A>T missense_variant S N501Y 1.00e+0 A.23
V3608 284C>T missense_variant S T95I 7.03e-1 AE.1
V3623 394G>C missense_variant S E132Q 1.00e+0 AE.1
V3727 632_634delATT disruptive_inframe_deletion S N211_L212delinsI 1.00e+0 AE.1
V3927 1501A>T missense_variant S N501Y 1.00e+0 AE.1
V4158 3080C>T missense_variant S T1027I 1.00e+0 AE.1
V4663 26C>T missense_variant E T9I 1.00e+0 AE.1
V4732 85C>T missense_variant M L29F 7.03e-1 AE.1
V5026 43G>A missense_variant ORF7b A15T 1.00e+0 AE.1
V5243 -2A>T upstream_gene_variant N None 1.00e+0 AE.1
V9396 12C>T synonymous_variant ORF6 L4L 1.00e+0 AE.1
V2580 14026G>T missense_variant ORF1ab_pp1ab D4676Y 1.00e+0 AE.5
V3530 52C>T missense_variant S L18F 1.00e+0 AE.5
V3555 79G>T missense_variant S A27S 1.00e+0 AE.5
V4010 2025G>C missense_variant S Q675H 1.00e+0 AE.5
V4573 604G>T missense_variant ORF3a V202L 1.00e+0 AE.5
V5024 41T>C missense_variant ORF7b L14S 1.00e+0 AE.5
V5164 206C>T missense_variant ORF8 S69L 1.00e+0 AE.5
V5249 7G>T missense_variant N D3Y 1.00e+0 AE.5
V5841 48C>T synonymous_variant ORF1ab_pp1a L16L -6.98e-1 AE.5
V6002 948C>T synonymous_variant ORF1ab_pp1a C316C -1.00e+0 AE.5
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 1.00e+0 AE.5
V8152 17457G>T synonymous_variant ORF1ab_pp1ab V5819V 1.00e+0 AE.5
V8707 594T>C synonymous_variant S D198D 1.00e+0 AE.5
V9582 105G>T synonymous_variant N A35A 1.00e+0 AE.5
V97 -25C>T upstream_gene_variant ORF1ab_pp1a None -6.98e-1 AE.5
V1890 8900C>T missense_variant ORF1ab_pp1a T2967I 1.00e+0 AH.3
V1982 9764C>T missense_variant ORF1ab_pp1a T3255I 7.06e-1 AH.3
V4546 524C>T missense_variant ORF3a T175I 7.06e-1 AH.3
V964 3277A>G missense_variant ORF1ab_pp1a T1093A 6.37e-1 AT.1
V3896 1430G>A missense_variant S S477N 1.00e+0 AY.25.1.2
V9159 129C>T synonymous_variant ORF3a F43F 7.06e-1 AY.25.1.2
V3608 284C>T missense_variant S T95I 7.01e-1 AZ.2.1
V8848 1725T>C synonymous_variant S A575A 7.01e-1 AZ.2.1
V5387 424C>T missense_variant N P142S 1.00e+0 B.1.1.115
V97 -25C>T upstream_gene_variant ORF1ab_pp1a None -1.00e+0 B.1.1.115
V2907 17069C>T missense_variant ORF1ab_pp1ab T5690M 1.00e+0 B.1.1.171
V3454 20873A>G missense_variant ORF1ab_pp1ab K6958R 1.00e+0 B.1.1.171
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 1.00e+0 B.1.1.171
V3631 422T>A stop_gained S L141* 7.06e-1 B.1.1.171
V3643 431A>T missense_variant S Y144F 7.06e-1 B.1.1.171
V4103 2537C>T missense_variant S A846V 1.00e+0 B.1.1.171
V7787 14613C>T synonymous_variant ORF1ab_pp1ab Y4871Y 1.00e+0 B.1.1.171
V9418 183T>C synonymous_variant ORF6 D61D 7.04e-1 B.1.1.171
V1821 8468C>T missense_variant ORF1ab_pp1a T2823I 1.00e+0 B.1.1.217
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 1.00e+0 B.1.1.217
V3087 18282G>A missense_variant ORF1ab_pp1ab M6094I 1.00e+0 B.1.1.217
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 1.00e+0 B.1.1.217
V3663 455G>T missense_variant S W152L 1.00e+0 B.1.1.217
V3764 737G>A missense_variant S R246K 1.00e+0 B.1.1.217
V3782 764C>T missense_variant S S255F 1.00e+0 B.1.1.217
V379 926C>T missense_variant ORF1ab_pp1a P309L 1.00e+0 B.1.1.217
V4067 2306G>T missense_variant S G769V 8.15e-1 B.1.1.217
V4731 82T>C missense_variant M F28L 1.00e+0 B.1.1.217
V522 1493C>T missense_variant ORF1ab_pp1a A498V 1.00e+0 B.1.1.217
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.1.217
V5432 560C>T missense_variant N S187L 1.00e+0 B.1.1.217
V5657 1254G>T missense_variant N Q418H 1.00e+0 B.1.1.217
V6677 5946A>G synonymous_variant ORF1ab_pp1a G1982G -6.94e-1 B.1.1.217
V7005 8562T>C synonymous_variant ORF1ab_pp1a I2854I 1.00e+0 B.1.1.217
V7133 9588T>C synonymous_variant ORF1ab_pp1a D3196D 1.00e+0 B.1.1.217
V7321 11100G>A synonymous_variant ORF1ab_pp1a V3700V 1.00e+0 B.1.1.217
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 1.00e+0 B.1.1.217
V7999 16305A>G synonymous_variant ORF1ab_pp1ab T5435T 1.00e+0 B.1.1.217
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 1.00e+0 B.1.1.217
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 1.00e+0 B.1.1.217
V8391 19224C>T synonymous_variant ORF1ab_pp1ab V6408V -6.59e-1 B.1.1.217
V9396 12C>T synonymous_variant ORF6 L4L 1.00e+0 B.1.1.217
V9699 696C>T synonymous_variant N S232S 1.00e+0 B.1.1.217
V975 3304A>G missense_variant ORF1ab_pp1a S1102G -6.15e-1 B.1.1.217
V1540 6469G>A missense_variant ORF1ab_pp1a V2157I 8.76e-1 B.1.1.220
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 1.00e+0 B.1.1.220
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 1.00e+0 B.1.1.220
V3663 455G>T missense_variant S W152L 9.41e-1 B.1.1.220
V4067 2306G>T missense_variant S G769V 1.00e+0 B.1.1.220
V4731 82T>C missense_variant M F28L 1.00e+0 B.1.1.220
V5237 1delA frameshift_variant&start_lost N M1fs 9.71e-1 B.1.1.220
V5432 560C>T missense_variant N S187L 1.00e+0 B.1.1.220
V5657 1254G>T missense_variant N Q418H 1.00e+0 B.1.1.220
V5783 *4361G>T downstream_gene_variant S None 9.27e-1 B.1.1.220
V5886 264G>T synonymous_variant ORF1ab_pp1a L88L 9.27e-1 B.1.1.220
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 1.00e+0 B.1.1.220
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 1.00e+0 B.1.1.220
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 1.00e+0 B.1.1.220
V9235 684T>C synonymous_variant ORF3a V228V 9.27e-1 B.1.1.220
V9396 12C>T synonymous_variant ORF6 L4L 1.00e+0 B.1.1.220
V1907 9079C>T missense_variant ORF1ab_pp1a L3027F 1.00e+0 B.1.1.228
V1945 9369A>T missense_variant ORF1ab_pp1a L3123F 1.00e+0 B.1.1.228
V2289 11851C>T missense_variant ORF1ab_pp1a L3951F 7.06e-1 B.1.1.228
V7920 15687C>T synonymous_variant ORF1ab_pp1ab I5229I 7.06e-1 B.1.1.228
V8402 19308C>T synonymous_variant ORF1ab_pp1ab Y6436Y 1.00e+0 B.1.1.228
V4721 11C>T missense_variant M S4F 1.00e+0 B.1.1.239
V7101 9276C>T synonymous_variant ORF1ab_pp1a L3092L 1.00e+0 B.1.1.239
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 1.00e+0 B.1.1.289
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 1.00e+0 B.1.1.289
V3663 455G>T missense_variant S W152L 1.00e+0 B.1.1.289
V4731 82T>C missense_variant M F28L 1.00e+0 B.1.1.289
V4872 66G>T missense_variant ORF7a E22D 1.00e+0 B.1.1.289
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.1.289
V5432 560C>T missense_variant N S187L 1.00e+0 B.1.1.289
V5657 1254G>T missense_variant N Q418H 1.00e+0 B.1.1.289
V7057 8925G>T synonymous_variant ORF1ab_pp1a V2975V 1.00e+0 B.1.1.289
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 1.00e+0 B.1.1.289
V8127 17238C>T synonymous_variant ORF1ab_pp1ab F5746F 1.00e+0 B.1.1.289
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 7.06e-1 B.1.1.289
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 1.00e+0 B.1.1.289
V9396 12C>T synonymous_variant ORF6 L4L 1.00e+0 B.1.1.289
V1601 6821C>T missense_variant ORF1ab_pp1a T2274I 8.41e-1 B.1.1.297
V2694 15187G>A missense_variant ORF1ab_pp1ab G5063S 8.83e-1 B.1.1.297
V3073 18193C>T missense_variant ORF1ab_pp1ab P6065S 8.83e-1 B.1.1.297
V3098 18383C>A missense_variant ORF1ab_pp1ab P6128H 8.83e-1 B.1.1.297
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 9.24e-1 B.1.1.297
V3631 422T>A stop_gained S L141* 6.48e-1 B.1.1.297
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 8.86e-1 B.1.1.297
V4865 38C>T missense_variant ORF7a A13V 8.83e-1 B.1.1.297
V552 1624C>T missense_variant ORF1ab_pp1a R542C 8.22e-1 B.1.1.297
V6245 2616C>T synonymous_variant ORF1ab_pp1a A872A 8.83e-1 B.1.1.297
V1013 3463G>T missense_variant ORF1ab_pp1a G1155C 7.04e-1 B.1.1.322
V1414 6047C>T missense_variant ORF1ab_pp1a T2016I 1.00e+0 B.1.1.322
V2334 12223C>T missense_variant ORF1ab_pp1a P4075S 1.00e+0 B.1.1.322
V241 364C>T missense_variant ORF1ab_pp1a L122F 1.00e+0 B.1.1.322
V2431 13064C>T missense_variant ORF1ab_pp1a T4355I 1.00e+0 B.1.1.322
V2789 16202C>T missense_variant ORF1ab_pp1ab P5401L 1.00e+0 B.1.1.322
V3437 20741C>T missense_variant ORF1ab_pp1ab A6914V 1.00e+0 B.1.1.322
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 1.00e+0 B.1.1.322
V3757 727G>C missense_variant S A243P 1.00e+0 B.1.1.322
V5241 -3A>T upstream_gene_variant N None 1.00e+0 B.1.1.322
V5382 404C>T missense_variant N T135I 1.00e+0 B.1.1.322
V7128 9540G>T synonymous_variant ORF1ab_pp1a L3180L 1.00e+0 B.1.1.322
V5239 -3A>C upstream_gene_variant N None 7.02e-1 B.1.1.34
V4239 3565G>A missense_variant S V1189I 1.00e+0 B.1.134
V5179 241G>T missense_variant ORF8 V81F 1.00e+0 B.1.134
V8296 18492G>T synonymous_variant ORF1ab_pp1ab P6164P 1.00e+0 B.1.134
V1499 6308C>T missense_variant ORF1ab_pp1a S2103F 1.00e+0 B.1.1.393
V1682 7586C>T missense_variant ORF1ab_pp1a A2529V 1.00e+0 B.1.1.393
V1951 9428C>T missense_variant ORF1ab_pp1a A3143V -1.00e+0 B.1.1.393
V3043 18017G>A missense_variant ORF1ab_pp1ab R6006K -1.00e+0 B.1.1.393
V3234 19392G>T missense_variant ORF1ab_pp1ab K6464N 1.00e+0 B.1.1.393
V5042 98A>C missense_variant ORF7b E33A 1.00e+0 B.1.1.393
V5207 340G>A missense_variant ORF8 V114I 1.00e+0 B.1.1.393
V5556 875T>C missense_variant N I292T 1.00e+0 B.1.1.393
V8407 19338C>T synonymous_variant ORF1ab_pp1ab N6446N 1.00e+0 B.1.1.393
V9325 300C>T synonymous_variant M F100F -1.00e+0 B.1.1.393
V9352 402A>G synonymous_variant M L134L -1.00e+0 B.1.1.393
V9557 360C>T synonymous_variant ORF8 F120F -1.00e+0 B.1.1.393
V1045 3608T>C missense_variant ORF1ab_pp1a I1203T 1.00e+0 B.1.1.397
V3632 423G>T missense_variant S L141F 1.00e+0 B.1.1.397
V3924 1480T>C missense_variant S S494P 1.00e+0 B.1.1.397
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.1.397
V641 1924C>T missense_variant ORF1ab_pp1a L642F 1.00e+0 B.1.1.397
V8082 16908C>T synonymous_variant ORF1ab_pp1ab A5636A 1.00e+0 B.1.1.397
V2366 12476C>T missense_variant ORF1ab_pp1a T4159I 7.06e-1 B.1.1.398
V2890 16947G>T missense_variant ORF1ab_pp1ab L5649F 7.05e-1 B.1.1.398
V3154 18745G>T missense_variant ORF1ab_pp1ab D6249Y 1.00e+0 B.1.1.398
V3392 20347C>T missense_variant ORF1ab_pp1ab L6783F 7.06e-1 B.1.1.398
V5144 184G>T missense_variant ORF8 V62L 1.00e+0 B.1.1.398
V5378 382G>T missense_variant N D128Y 1.00e+0 B.1.1.398
V737 2324A>G missense_variant ORF1ab_pp1a E775G 1.00e+0 B.1.1.398
V7764 14448G>T synonymous_variant ORF1ab_pp1ab V4816V 7.06e-1 B.1.1.398
V7921 15688C>T synonymous_variant ORF1ab_pp1ab L5230L 1.00e+0 B.1.1.398
V1272 4994C>T missense_variant ORF1ab_pp1a T1665I 1.00e+0 B.1.1.402
V1369 5761C>T missense_variant ORF1ab_pp1a P1921S 1.00e+0 B.1.1.402
V1520 6394A>G missense_variant ORF1ab_pp1a S2132G 1.00e+0 B.1.1.402
V1731 7862C>T missense_variant ORF1ab_pp1a A2621V 1.00e+0 B.1.1.402
V2116 10818G>T missense_variant ORF1ab_pp1a L3606F 1.00e+0 B.1.1.402
V2489 13456C>T missense_variant ORF1ab_pp1ab P4486S 1.00e+0 B.1.1.402
V2908 17072C>T missense_variant ORF1ab_pp1ab T5691I 1.00e+0 B.1.1.402
V2951 17414C>T missense_variant ORF1ab_pp1ab T5805M 1.00e+0 B.1.1.402
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.1.402
V4721 11C>T missense_variant M S4F 1.00e+0 B.1.1.402
V5711 83C>T missense_variant ORF10 A28V 1.00e+0 B.1.1.402
V6394 3804C>T synonymous_variant ORF1ab_pp1a A1268A 1.00e+0 B.1.1.402
V6538 4879C>T synonymous_variant ORF1ab_pp1a L1627L 1.00e+0 B.1.1.402
V7203 10014C>T synonymous_variant ORF1ab_pp1a L3338L 1.00e+0 B.1.1.402
V7209 10104C>T synonymous_variant ORF1ab_pp1a R3368R 1.00e+0 B.1.1.402
V7609 13269A>G synonymous_variant ORF1ab_pp1ab V4423V 1.00e+0 B.1.1.402
V7762 14433C>T synonymous_variant ORF1ab_pp1ab F4811F 1.00e+0 B.1.1.402
V8433 19608G>T synonymous_variant ORF1ab_pp1ab V6536V 1.00e+0 B.1.1.402
V1890 8900C>T missense_variant ORF1ab_pp1a T2967I 1.00e+0 B.1.1.412
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 1.00e+0 B.1.1.412
V2095 10717A>G missense_variant ORF1ab_pp1a K3573E 1.00e+0 B.1.1.412
V2789 16202C>T missense_variant ORF1ab_pp1ab P5401L 1.00e+0 B.1.1.412
V3242 19420G>T missense_variant ORF1ab_pp1ab V6474L 8.63e-1 B.1.1.412
V3785 770G>A missense_variant S G257D 8.63e-1 B.1.1.412
V4111 2576C>A missense_variant S T859N 1.00e+0 B.1.1.412
V5237 1delA frameshift_variant&start_lost N M1fs 8.63e-1 B.1.1.412
V5505 659C>T missense_variant N A220V 1.00e+0 B.1.1.412
V5706 70C>T missense_variant ORF10 R24C 8.91e-1 B.1.1.412
V2371 12491C>T missense_variant ORF1ab_pp1a T4164I 8.07e-1 B.1.1.515
V5022 38T>C missense_variant ORF7b F13S 7.50e-1 B.1.1.515
V5577 995C>T missense_variant N T332I 6.12e-1 B.1.1.515
V6538 4879C>T synonymous_variant ORF1ab_pp1a L1627L 8.75e-1 B.1.1.515
V8219 17988C>T synonymous_variant ORF1ab_pp1ab N5996N 6.61e-1 B.1.1.525
V5087 52C>T stop_gained ORF8 Q18* 8.38e-1 B.1.1.526
V66 -63C>T upstream_gene_variant ORF1ab_pp1a None 8.38e-1 B.1.1.526
V9729 846C>T synonymous_variant N T282T 9.78e-1 B.1.1.526
V1512 6371C>T missense_variant ORF1ab_pp1a T2124I 1.00e+0 B.1.1.528
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 1.00e+0 B.1.1.528
V2595 14144C>T missense_variant ORF1ab_pp1ab P4715L -8.92e-1 B.1.1.528
V3411 20495C>T missense_variant ORF1ab_pp1ab A6832V 1.00e+0 B.1.1.528
V3534 56C>T missense_variant S T19I 8.63e-1 B.1.1.528
V3544 71_79delTACCCCCTG disruptive_inframe_deletion S L24_A27delinsS 8.63e-1 B.1.1.528
V3635 425G>A missense_variant S G142D 1.00e+0 B.1.1.528
V3667 459G>T missense_variant S M153I 1.00e+0 B.1.1.528
V3735 638T>G missense_variant S V213G 1.00e+0 B.1.1.528
V3807 896C>T missense_variant S T299I 1.00e+0 B.1.1.528
V3820 1016G>A missense_variant S G339D 1.00e+0 B.1.1.528
V3823 1037G>A missense_variant S R346K 1.00e+0 B.1.1.528
V3838 1102C>A missense_variant S L368I 1.00e+0 B.1.1.528
V3840 1112C>T missense_variant S S371F 1.00e+0 B.1.1.528
V3841 1117T>C missense_variant S S373P 1.00e+0 B.1.1.528
V3843 1124C>T missense_variant S S375F 1.00e+0 B.1.1.528
V3844 1126A>G missense_variant S T376A 1.00e+0 B.1.1.528
V3851 1213G>A missense_variant S D405N 1.00e+0 B.1.1.528
V3854 1224A>C missense_variant S R408S 1.00e+0 B.1.1.528
V3861 1251G>T missense_variant S K417N 1.00e+0 B.1.1.528
V3868 1320T>G missense_variant S N440K 1.00e+0 B.1.1.528
V3896 1430G>A missense_variant S S477N 1.00e+0 B.1.1.528
V3900 1433C>A missense_variant S T478K 1.00e+0 B.1.1.528
V3926 1493A>G missense_variant S Q498R 1.00e+0 B.1.1.528
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.1.528
V3930 1513T>C missense_variant S Y505H 1.00e+0 B.1.1.528
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.1.528
V4019 2037T>G missense_variant S N679K 1.00e+0 B.1.1.528
V4022 2042C>A missense_variant S P681H 1.00e+0 B.1.1.528
V4023 2042C>G missense_variant S P681R -6.20e-1 B.1.1.528
V4063 2292C>A missense_variant S N764K 1.00e+0 B.1.1.528
V4079 2386G>T missense_variant S D796Y 8.92e-1 B.1.1.528
V4144 2862A>T missense_variant S Q954H 1.00e+0 B.1.1.528
V4146 2907T>A missense_variant S N969K 1.00e+0 B.1.1.528
V4255 3655G>T missense_variant S G1219C 1.00e+0 B.1.1.528
V443 1184C>T missense_variant ORF1ab_pp1a T395I -8.11e-1 B.1.1.528
V4732 85C>T missense_variant M L29F 8.63e-1 B.1.1.528
V619 1841C>T missense_variant ORF1ab_pp1a T614I 1.00e+0 B.1.1.528
V7360 11439C>T synonymous_variant ORF1ab_pp1a Y3813Y 1.00e+0 B.1.1.528
V7968 16068C>T synonymous_variant ORF1ab_pp1ab D5356D 1.00e+0 B.1.1.528
V9095 3534C>T synonymous_variant S N1178N 1.00e+0 B.1.1.528
V9184 273C>T synonymous_variant ORF3a Y91Y 1.00e+0 B.1.1.528
V9515 87A>G synonymous_variant ORF8 Q29Q 1.00e+0 B.1.1.528
V9765 987G>A synonymous_variant N T329T 1.00e+0 B.1.1.528
V9811 1236C>T synonymous_variant N S412S 1.00e+0 B.1.1.528
V1036 3563C>T missense_variant ORF1ab_pp1a S1188L 1.00e+0 B.1.153
V2897 16995G>T missense_variant ORF1ab_pp1ab E5665D 1.00e+0 B.1.153
V3485 21040C>T missense_variant ORF1ab_pp1ab R7014C 7.02e-1 B.1.153
V3628 412G>T missense_variant S D138Y 1.00e+0 B.1.153
V3860 1250A>C missense_variant S K417T 1.00e+0 B.1.153
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.153
V5187 274G>A missense_variant ORF8 E92K 1.00e+0 B.1.153
V5924 468T>C synonymous_variant ORF1ab_pp1a D156D 1.00e+0 B.1.153
V6224 2484C>T synonymous_variant ORF1ab_pp1a D828D 1.00e+0 B.1.153
V6691 6054A>G synonymous_variant ORF1ab_pp1a P2018P 1.00e+0 B.1.153
V6736 6348A>G synonymous_variant ORF1ab_pp1a V2116V 1.00e+0 B.1.153
V7644 13596C>T synonymous_variant ORF1ab_pp1ab D4532D 1.00e+0 B.1.153
V8553 20688A>T synonymous_variant ORF1ab_pp1ab S6896S 1.00e+0 B.1.153
V1151 4283A>G missense_variant ORF1ab_pp1a K1428R 1.00e+0 B.1.160.25
V1898 8939A>G missense_variant ORF1ab_pp1a D2980G 1.00e+0 B.1.160.25
V2951 17414C>T missense_variant ORF1ab_pp1ab T5805M 1.00e+0 B.1.160.25
V3608 284C>T missense_variant S T95I 1.00e+0 B.1.160.25
V3912 1451A>G missense_variant S E484G 1.00e+0 B.1.160.25
V3997 1963C>T missense_variant S H655Y 7.03e-1 B.1.160.25
V4366 119C>T missense_variant ORF3a S40L 1.00e+0 B.1.160.25
V5242 -2A>G upstream_gene_variant N None 1.00e+0 B.1.160.25
V7502 12504G>T synonymous_variant ORF1ab_pp1a A4168A 1.00e+0 B.1.160.25
V8232 18084C>T synonymous_variant ORF1ab_pp1ab T6028T 1.00e+0 B.1.160.25
V2789 16202C>T missense_variant ORF1ab_pp1ab P5401L 1.00e+0 B.1.160.26
V3629 422_430delTGGGTGTTT disruptive_inframe_deletion S L141_V143del 1.00e+0 B.1.160.26
V5081 32C>T missense_variant ORF8 T11I 7.05e-1 B.1.177.33
V3371 20216C>T missense_variant ORF1ab_pp1ab S6739L 1.00e+0 B.1.177.40
V4458 289G>A missense_variant ORF3a V97I 1.00e+0 B.1.177.51
V4717 5C>T missense_variant M A2V 1.00e+0 B.1.177.51
V1168 4414C>T missense_variant ORF1ab_pp1a P1472S 1.00e+0 B.1.177.85
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 1.00e+0 B.1.177.85
V6830 7128G>T synonymous_variant ORF1ab_pp1a P2376P 1.00e+0 B.1.177.85
V1119 3961C>T missense_variant ORF1ab_pp1a P1321S 7.06e-1 B.1.179
V1260 4913C>T missense_variant ORF1ab_pp1a T1638I 7.06e-1 B.1.179
V1371 5762C>T missense_variant ORF1ab_pp1a P1921L 7.06e-1 B.1.179
V1491 6278C>T missense_variant ORF1ab_pp1a T2093I 7.06e-1 B.1.179
V1773 8143G>A missense_variant ORF1ab_pp1a V2715I 7.06e-1 B.1.179
V2277 11788C>T missense_variant ORF1ab_pp1a L3930F 7.06e-1 B.1.179
V2843 16682C>T missense_variant ORF1ab_pp1ab A5561V 7.06e-1 B.1.179
V2925 17227C>T missense_variant ORF1ab_pp1ab P5743S 7.06e-1 B.1.179
V2952 17422G>T missense_variant ORF1ab_pp1ab V5808F 7.06e-1 B.1.179
V3823 1037G>A missense_variant S R346K 7.06e-1 B.1.179
V4413 179C>T missense_variant ORF3a S60F 7.06e-1 B.1.179
V5370 355G>T missense_variant N A119S 7.06e-1 B.1.179
V5426 548C>A missense_variant N S183Y 7.06e-1 B.1.179
V5749 *4340C>T downstream_gene_variant S None 7.06e-1 B.1.179
V6265 2772C>T synonymous_variant ORF1ab_pp1a F924F -7.06e-1 B.1.179
V6921 7875C>T synonymous_variant ORF1ab_pp1a S2625S 7.06e-1 B.1.179
V7448 12003G>A synonymous_variant ORF1ab_pp1a L4001L 7.06e-1 B.1.179
V7462 12129T>C synonymous_variant ORF1ab_pp1a D4043D 7.06e-1 B.1.179
V758 2411C>T missense_variant ORF1ab_pp1a P804L 7.06e-1 B.1.179
V8446 19698G>T synonymous_variant ORF1ab_pp1ab T6566T 7.06e-1 B.1.179
V8461 19830A>G synonymous_variant ORF1ab_pp1ab K6610K 7.06e-1 B.1.179
V8474 20004A>G synonymous_variant ORF1ab_pp1ab L6668L 7.06e-1 B.1.179
V9283 225C>T synonymous_variant E V75V 7.06e-1 B.1.179
V2005 9968G>T missense_variant ORF1ab_pp1a R3323L 9.67e-1 B.1.1.83
V2366 12476C>T missense_variant ORF1ab_pp1a T4159I 9.67e-1 B.1.1.83
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 9.93e-1 B.1.1.83
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 9.93e-1 B.1.1.83
V3218 19231C>T missense_variant ORF1ab_pp1ab H6411Y 8.88e-1 B.1.1.83
V3663 455G>T missense_variant S W152L 9.47e-1 B.1.1.83
V4067 2306G>T missense_variant S G769V 9.93e-1 B.1.1.83
V4450 268G>T missense_variant ORF3a V90F 7.01e-1 B.1.1.83
V4731 82T>C missense_variant M F28L 9.93e-1 B.1.1.83
V5237 1delA frameshift_variant&start_lost N M1fs 9.67e-1 B.1.1.83
V5432 560C>T missense_variant N S187L 9.93e-1 B.1.1.83
V5657 1254G>T missense_variant N Q418H 9.93e-1 B.1.1.83
V5712 85C>T stop_gained ORF10 Q29* 9.67e-1 B.1.1.83
V5783 *4361G>T downstream_gene_variant S None 9.67e-1 B.1.1.83
V5886 264G>T synonymous_variant ORF1ab_pp1a L88L 9.61e-1 B.1.1.83
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 9.93e-1 B.1.1.83
V7869 15279G>T synonymous_variant ORF1ab_pp1ab T5093T 6.02e-1 B.1.1.83
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 9.80e-1 B.1.1.83
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 9.80e-1 B.1.1.83
V8429 19575T>C synonymous_variant ORF1ab_pp1ab N6525N 9.93e-1 B.1.1.83
V9235 684T>C synonymous_variant ORF3a V228V 9.67e-1 B.1.1.83
V9396 12C>T synonymous_variant ORF6 L4L 9.93e-1 B.1.1.83
V2932 17287G>A missense_variant ORF1ab_pp1ab G5763R 1.00e+0 B.1.1.8
V3197 19010C>A missense_variant ORF1ab_pp1ab P6337H 1.00e+0 B.1.1.8
V3530 52C>T missense_variant S L18F 1.00e+0 B.1.1.8
V3663 455G>T missense_variant S W152L 7.06e-1 B.1.1.8
V4067 2306G>T missense_variant S G769V 1.00e+0 B.1.1.8
V4731 82T>C missense_variant M F28L 1.00e+0 B.1.1.8
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.1.8
V5432 560C>T missense_variant N S187L 1.00e+0 B.1.1.8
V5657 1254G>T missense_variant N Q418H 1.00e+0 B.1.1.8
V5783 *4361G>T downstream_gene_variant S None 1.00e+0 B.1.1.8
V5886 264G>T synonymous_variant ORF1ab_pp1a L88L 1.00e+0 B.1.1.8
V7628 13416C>T synonymous_variant ORF1ab_pp1ab Y4472Y 1.00e+0 B.1.1.8
V7706 14076C>T synonymous_variant ORF1ab_pp1ab N4692N 1.00e+0 B.1.1.8
V7781 14541C>T synonymous_variant ORF1ab_pp1ab Y4847Y 1.00e+0 B.1.1.8
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 1.00e+0 B.1.1.8
V8355 18903A>G synonymous_variant ORF1ab_pp1ab K6301K 1.00e+0 B.1.1.8
V8429 19575T>C synonymous_variant ORF1ab_pp1ab N6525N 1.00e+0 B.1.1.8
V9235 684T>C synonymous_variant ORF3a V228V 1.00e+0 B.1.1.8
V9396 12C>T synonymous_variant ORF6 L4L 7.06e-1 B.1.1.8
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.1.99
V5114 112C>T missense_variant ORF8 P38S -6.97e-1 B.1.1.99
V5457 604A>T missense_variant N S202C 1.00e+0 B.1.1.99
V5459 605G>C missense_variant N S202T 1.00e+0 B.1.1.99
V6224 2484C>T synonymous_variant ORF1ab_pp1a D828D 1.00e+0 B.1.1.99
V3166 18822G>T missense_variant ORF1ab_pp1ab K6274N 1.00e+0 B.1.214.3
V7829 14973C>T synonymous_variant ORF1ab_pp1ab H4991H 7.23e-1 B.1.214.3
V2952 17422G>T missense_variant ORF1ab_pp1ab V5808F 7.03e-1 B.1.237
V5443 581C>T missense_variant N S194L 6.96e-1 B.1.243.1
V1045 3608T>C missense_variant ORF1ab_pp1a I1203T 7.92e-1 B.1.281
V3673 468G>T missense_variant S E156D 8.99e-1 B.1.281
V4839 181G>C missense_variant ORF6 D61H 7.92e-1 B.1.281
V4841 182A>T missense_variant ORF6 D61V 7.92e-1 B.1.281
V5441 578G>T missense_variant N S193I 7.92e-1 B.1.281
V5673 -6A>G upstream_gene_variant ORF10 None 7.92e-1 B.1.281
V6424 4029G>A synonymous_variant ORF1ab_pp1a K1343K 7.92e-1 B.1.281
V7893 15492T>C synonymous_variant ORF1ab_pp1ab S5164S 1.00e+0 B.1.281
V9195 318C>T synonymous_variant ORF3a L106L 1.00e+0 B.1.281
V9418 183T>C synonymous_variant ORF6 D61D 6.85e-1 B.1.281
V1184 4544C>T missense_variant ORF1ab_pp1a S1515F 1.00e+0 B.1.314
V24 -161G>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 B.1.314
V2868 16802A>G missense_variant ORF1ab_pp1ab Y5601C 1.00e+0 B.1.314
V342 794C>T missense_variant ORF1ab_pp1a T265I -1.00e+0 B.1.314
V3641 432_437delTTACCA disruptive_inframe_deletion S Y145_H146del 1.00e+0 B.1.314
V3794 784G>T missense_variant S A262S 1.00e+0 B.1.314
V4406 171G>T missense_variant ORF3a Q57H -1.00e+0 B.1.314
V4521 452C>T missense_variant ORF3a T151I 1.00e+0 B.1.314
V4700 -35T>C upstream_gene_variant M None 1.00e+0 B.1.314
V4883 100C>T missense_variant ORF7a P34S 1.00e+0 B.1.314
V5041 97G>T stop_gained ORF7b E33* 1.00e+0 B.1.314
V5100 86A>T missense_variant ORF8 Q29L 1.00e+0 B.1.314
V5279 52G>A missense_variant N G18S 1.00e+0 B.1.314
V5370 355G>T missense_variant N A119S 1.00e+0 B.1.314
V5499 649G>T missense_variant N A217S 8.13e-1 B.1.314
V5513 702G>T missense_variant N M234I 1.00e+0 B.1.314
V5603 1099G>C missense_variant N E367Q 1.00e+0 B.1.314
V5946 588C>T synonymous_variant ORF1ab_pp1a Y196Y 1.00e+0 B.1.314
V6064 1419C>T synonymous_variant ORF1ab_pp1a I473I 1.00e+0 B.1.314
V619 1841C>T missense_variant ORF1ab_pp1a T614I 1.00e+0 B.1.314
V636 1891C>T missense_variant ORF1ab_pp1a L631F 1.00e+0 B.1.314
V6558 4998T>C synonymous_variant ORF1ab_pp1a S1666S 1.00e+0 B.1.314
V8302 18549T>C synonymous_variant ORF1ab_pp1ab D6183D 7.04e-1 B.1.314
V9093 3522T>C synonymous_variant S A1174A 1.00e+0 B.1.314
V9145 81T>C synonymous_variant ORF3a D27D 1.00e+0 B.1.314
V9341 363C>T synonymous_variant M N121N 1.00e+0 B.1.314
V9349 387G>T synonymous_variant M L129L 1.00e+0 B.1.314
V3861 1251G>T missense_variant S K417N 6.55e-1 B.1.351.1
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.351.1
V4488 334G>T missense_variant ORF3a V112F -6.55e-1 B.1.351.1
V4560 555G>T missense_variant ORF3a Q185H -6.55e-1 B.1.351.1
V4863 37G>A missense_variant ORF7a A13T -6.55e-1 B.1.351.1
V5033 73C>T missense_variant ORF7b L25F -6.55e-1 B.1.351.1
V5677 -3C>T upstream_gene_variant ORF10 None -6.55e-1 B.1.351.1
V5775 *4357C>T downstream_gene_variant S None -6.55e-1 B.1.351.1
V7844 15102T>C synonymous_variant ORF1ab_pp1ab H5034H 7.06e-1 B.1.411
V3823 1037G>A missense_variant S R346K 6.71e-1 B.1.415.1
V3928 1502A>C missense_variant S N501T 9.53e-1 B.1.415.1
V2478 13403C>T missense_variant ORF1ab_pp1ab T4468I 1.00e+0 B.1.417
V2820 16492C>T missense_variant ORF1ab_pp1ab P5498S 1.00e+0 B.1.417
V3229 19346C>T missense_variant ORF1ab_pp1ab T6449I 1.00e+0 B.1.417
V3608 284C>T missense_variant S T95I 1.00e+0 B.1.417
V3751 725_733delTTGCTTTAC disruptive_inframe_deletion S L242_L244del 1.00e+0 B.1.417
V7158 9714C>T synonymous_variant ORF1ab_pp1a L3238L 1.00e+0 B.1.417
V7622 13356C>T synonymous_variant ORF1ab_pp1ab D4452D 1.00e+0 B.1.417
V9744 906G>T synonymous_variant N P302P 1.00e+0 B.1.417
V3629 422_430delTGGGTGTTT disruptive_inframe_deletion S L141_V143del 1.00e+0 B.1.433
V1397 5948C>T missense_variant ORF1ab_pp1a A1983V 9.31e-1 B.1.441
V1406 6020C>T missense_variant ORF1ab_pp1a T2007I 8.65e-1 B.1.441
V3456 20881C>T missense_variant ORF1ab_pp1ab L6961F 8.57e-1 B.1.441
V3563 145C>T missense_variant S H49Y 7.79e-1 B.1.441
V4340 80A>G missense_variant ORF3a D27G 8.57e-1 B.1.441
V4380 131G>A missense_variant ORF3a G44E 8.57e-1 B.1.441
V8737 807T>C synonymous_variant S Y269Y 9.31e-1 B.1.441
V1348 5561C>T missense_variant ORF1ab_pp1a T1854I 1.00e+0 B.1.494
V1667 7491G>T missense_variant ORF1ab_pp1a K2497N 1.00e+0 B.1.494
V2086 10624C>T missense_variant ORF1ab_pp1a R3542C 1.00e+0 B.1.494
V2257 11651C>T missense_variant ORF1ab_pp1a S3884L -8.01e-1 B.1.494
V2513 13598C>T missense_variant ORF1ab_pp1ab T4533I 6.94e-1 B.1.494
V273 448G>A missense_variant ORF1ab_pp1a G150S 6.94e-1 B.1.494
V3928 1502A>C missense_variant S N501T 1.00e+0 B.1.494
V4022 2042C>A missense_variant S P681H 6.94e-1 B.1.494
V4023 2042C>G missense_variant S P681R 6.94e-1 B.1.494
V4182 3253G>A missense_variant S G1085R 6.94e-1 B.1.494
V4535 512C>T missense_variant ORF3a S171L 1.00e+0 B.1.494
V5201 318A>C missense_variant ORF8 E106D 1.00e+0 B.1.494
V5249 7G>T missense_variant N D3Y 1.00e+0 B.1.494
V5469 614C>T missense_variant N T205I 1.00e+0 B.1.494
V5642 1195G>T missense_variant N D399Y 6.94e-1 B.1.494
V687 2116G>T missense_variant ORF1ab_pp1a G706C 6.94e-1 B.1.494
V688 2123C>T missense_variant ORF1ab_pp1a T708I 6.94e-1 B.1.494
V7001 8553C>T synonymous_variant ORF1ab_pp1a C2851C 1.00e+0 B.1.494
V7060 8949C>T synonymous_variant ORF1ab_pp1a Y2983Y 1.00e+0 B.1.494
V7184 9888T>C synonymous_variant ORF1ab_pp1a D3296D 1.00e+0 B.1.494
V7541 12786C>T synonymous_variant ORF1ab_pp1a A4262A 6.94e-1 B.1.494
V9173 195C>T synonymous_variant ORF3a L65L 6.94e-1 B.1.494
V9205 429C>T synonymous_variant ORF3a A143A 1.00e+0 B.1.494
V929 3146C>T missense_variant ORF1ab_pp1a A1049V 1.00e+0 B.1.494
V9304 159C>T synonymous_variant M F53F 6.94e-1 B.1.494
V9801 1176G>T synonymous_variant N V392V 1.00e+0 B.1.494
V1192 4586A>G missense_variant ORF1ab_pp1a K1529R 1.00e+0 B.1.530
V2240 11478G>T missense_variant ORF1ab_pp1a Q3826H 1.00e+0 B.1.530
V2740 15661C>T missense_variant ORF1ab_pp1ab L5221F 1.00e+0 B.1.530
V2840 16671G>T missense_variant ORF1ab_pp1ab M5557I -1.00e+0 B.1.530
V3525 26C>T missense_variant S P9L 1.00e+0 B.1.530
V3599 239A>C missense_variant S D80A 1.00e+0 B.1.530
V3742 644A>G missense_variant S D215G 1.00e+0 B.1.530
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.530
V4187 3301C>T missense_variant S H1101Y 1.00e+0 B.1.530
V4232 3526G>T missense_variant S V1176F 1.00e+0 B.1.530
V4535 512C>T missense_variant ORF3a S171L 1.00e+0 B.1.530
V4692 212C>T missense_variant E P71L 1.00e+0 B.1.530
V5237 1delA frameshift_variant&start_lost N M1fs 1.00e+0 B.1.530
V5635 1172C>T missense_variant N T391I 1.00e+0 B.1.530
V5749 *4340C>T downstream_gene_variant S None 1.00e+0 B.1.530
V608 1796C>T missense_variant ORF1ab_pp1a A599V 1.00e+0 B.1.530
V7380 11547C>A synonymous_variant ORF1ab_pp1a G3849G 1.00e+0 B.1.530
V895 3026A>G missense_variant ORF1ab_pp1a Q1009R -1.00e+0 B.1.530
V2803 16352C>A missense_variant ORF1ab_pp1ab T5451N 7.74e-1 B.1.538
V3555 79G>T missense_variant S A27S 6.50e-1 B.1.538
V4010 2025G>C missense_variant S Q675H 6.84e-1 B.1.538
V5249 7G>T missense_variant N D3Y 7.72e-1 B.1.538
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 8.01e-1 B.1.538
V8707 594T>C synonymous_variant S D198D 8.68e-1 B.1.538
V201 256G>T missense_variant ORF1ab_pp1a V86F 1.00e+0 B.1.555
V2076 10553C>T missense_variant ORF1ab_pp1a A3518V 1.00e+0 B.1.555
V254 412G>A missense_variant ORF1ab_pp1a A138T 1.00e+0 B.1.555
V342 794C>T missense_variant ORF1ab_pp1a T265I 8.07e-1 B.1.555
V3571 190T>A missense_variant S W64R 1.00e+0 B.1.555
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 1.00e+0 B.1.555
V3643 431A>T missense_variant S Y144F 6.99e-1 B.1.555
V4406 171G>T missense_variant ORF3a Q57H 1.00e+0 B.1.555
V4637 779T>A missense_variant ORF3a M260K 1.00e+0 B.1.555
V5529 740C>T missense_variant N T247I 1.00e+0 B.1.555
V757 2410C>T missense_variant ORF1ab_pp1a P804S 1.00e+0 B.1.555
V7607 13251C>T synonymous_variant ORF1ab_pp1ab G4417G 1.00e+0 B.1.555
V9465 243A>G synonymous_variant ORF7a S81S 1.00e+0 B.1.555
V9600 162C>T synonymous_variant N T54T 1.00e+0 B.1.555
V2897 16995G>T missense_variant ORF1ab_pp1ab E5665D 1.00e+0 B.1.566
V3535 59C>A missense_variant S T20N 7.01e-1 B.1.566
V3551 76C>T missense_variant S P26S 7.01e-1 B.1.566
V3997 1963C>T missense_variant S H655Y 1.00e+0 B.1.566
V7503 12513C>T synonymous_variant ORF1ab_pp1a Y4171Y 1.00e+0 B.1.566
V3924 1480T>C missense_variant S S494P 1.00e+0 B.1.575.2
V1018 3473C>T missense_variant ORF1ab_pp1a P1158L 7.05e-1 B.1.597
V1231 4760C>T missense_variant ORF1ab_pp1a S1587L 7.05e-1 B.1.597
V2290 11854C>T missense_variant ORF1ab_pp1a P3952S 1.00e+0 B.1.597
V2854 16745T>C missense_variant ORF1ab_pp1ab I5582T 7.05e-1 B.1.597
V3350 20140C>T missense_variant ORF1ab_pp1ab P6714S 7.05e-1 B.1.597
V3561 98C>T missense_variant S T33I 7.05e-1 B.1.597
V4129 2806G>A missense_variant S D936N 7.05e-1 B.1.597
V4592 664G>T missense_variant ORF3a D222Y 1.00e+0 B.1.597
V6422 4011C>T synonymous_variant ORF1ab_pp1a Y1337Y 7.05e-1 B.1.597
V6425 4035G>T synonymous_variant ORF1ab_pp1a V1345V 7.05e-1 B.1.597
V6836 7170T>C synonymous_variant ORF1ab_pp1a F2390F 7.05e-1 B.1.597
V7046 8883T>C synonymous_variant ORF1ab_pp1a I2961I 7.05e-1 B.1.597
V8356 18906C>T synonymous_variant ORF1ab_pp1ab F6302F 1.00e+0 B.1.597
V9645 435C>T synonymous_variant N H145H 7.05e-1 B.1.597
V5443 581C>T missense_variant N S194L 1.00e+0 B.1.617.3
V5357 268G>T missense_variant N A90S -7.05e-1 B.1.618
V5499 649G>T missense_variant N A217S 7.05e-1 B.1.618
V3064 18148G>T missense_variant ORF1ab_pp1ab V6050F -8.64e-1 B.1.626
V5743 *4331G>T downstream_gene_variant S None -7.46e-1 B.1.626
V7220 10185C>T synonymous_variant ORF1ab_pp1a P3395P -8.64e-1 B.1.626
V1085 3737C>T missense_variant ORF1ab_pp1a T1246I 8.14e-1 B.1.630
V1262 4918C>T missense_variant ORF1ab_pp1a P1640S 1.00e+0 B.1.630
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 8.14e-1 B.1.630
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V -6.61e-1 B.1.630
V1986 9832G>A missense_variant ORF1ab_pp1a G3278S 8.14e-1 B.1.630
V216 304G>A missense_variant ORF1ab_pp1a E102K 8.14e-1 B.1.630
V3550 74C>T missense_variant S P25L 8.14e-1 B.1.630
V3717 570G>T missense_variant S R190S 8.14e-1 B.1.630
V3742 644A>G missense_variant S D215G 8.14e-1 B.1.630
V3881 1345T>C missense_variant S Y449H 8.14e-1 B.1.630
V3900 1433C>A missense_variant S T478K 8.64e-1 B.1.630
V3901 1433C>G missense_variant S T478R -6.04e-1 B.1.630
V3910 1450G>C missense_variant S E484Q -6.04e-1 B.1.630
V3927 1501A>T missense_variant S N501Y 8.14e-1 B.1.630
V4018 2037T>A missense_variant S N679K 8.14e-1 B.1.630
V4048 2147C>T missense_variant S T716I 8.14e-1 B.1.630
V4111 2576C>A missense_variant S T859N 1.00e+0 B.1.630
V4188 3303C>A missense_variant S H1101Q 8.14e-1 B.1.630
V4603 686C>A missense_variant ORF3a T229N 8.14e-1 B.1.630
V4622 766_768delGTT conservative_inframe_deletion ORF3a V256del 8.14e-1 B.1.630
V4668 61C>A missense_variant E L21I 8.14e-1 B.1.630
V4732 85C>T missense_variant M L29F 8.14e-1 B.1.630
V4760 245T>C missense_variant M I82T 6.61e-1 B.1.630
V4860 32C>T missense_variant ORF7a T11I 8.14e-1 B.1.630
V5020 40_41delTT frameshift_variant ORF7b L14fs 8.14e-1 B.1.630
V5242 -2A>G upstream_gene_variant N None -8.14e-1 B.1.630
V5243 -2A>T upstream_gene_variant N None 8.14e-1 B.1.630
V5274 38C>T missense_variant N P13L 8.14e-1 B.1.630
V5629 1152G>T missense_variant N Q384H 8.14e-1 B.1.630
V616 1826C>T missense_variant ORF1ab_pp1a T609I 8.14e-1 B.1.630
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 8.14e-1 B.1.630
V6862 7434A>G synonymous_variant ORF1ab_pp1a K2478K 8.14e-1 B.1.630
V6869 7500C>T synonymous_variant ORF1ab_pp1a S2500S 8.14e-1 B.1.630
V7610 13272C>T synonymous_variant ORF1ab_pp1ab Y4424Y 8.14e-1 B.1.630
V8293 18483C>T synonymous_variant ORF1ab_pp1ab V6161V 8.14e-1 B.1.630
V8338 18789T>C synonymous_variant ORF1ab_pp1ab I6263I 8.14e-1 B.1.630
V8466 19884C>T synonymous_variant ORF1ab_pp1ab F6628F 8.14e-1 B.1.630
V8716 648C>T synonymous_variant S L216L 8.14e-1 B.1.630
V8911 2169C>T synonymous_variant S T723T 8.14e-1 B.1.630
V8929 2367C>T synonymous_variant S Y789Y 8.14e-1 B.1.630
V9612 243T>C synonymous_variant N D81D 6.61e-1 B.1.630
V3896 1430G>A missense_variant S S477N 6.61e-1 B.1.632
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 6.32e-1 B.1.638
V3629 422_430delTGGGTGTTT disruptive_inframe_deletion S L141_V143del 6.32e-1 B.1.638
V3662 454T>C missense_variant S W152R 6.32e-1 B.1.638
V4751 208G>T missense_variant M V70F -6.74e-1 B.1.638
V97 -25C>T upstream_gene_variant ORF1ab_pp1a None 6.74e-1 B.1.638
V2856 16750G>T missense_variant ORF1ab_pp1ab D5584Y -7.00e-1 B.1.639
V3886 1355T>G missense_variant S L452R -7.00e-1 B.1.639
V3969 1841A>G missense_variant S D614G 7.00e-1 B.1.639
V5403 469A>G missense_variant N I157V 7.00e-1 B.1.639
V5777 *4358G>T downstream_gene_variant S None -7.00e-1 B.1.639
V6265 2772C>T synonymous_variant ORF1ab_pp1a F924F 7.00e-1 B.1.639
V3849 1181A>G missense_variant S N394S 6.92e-1 B.1.640.2
V3921 1469T>C missense_variant S F490S 1.00e+0 B.1.640.2
V4022 2042C>A missense_variant S P681H 7.00e-1 B.1.640.2
V3927 1501A>T missense_variant S N501Y 1.00e+0 B.1.91
V5825 *4450T>A downstream_gene_variant S None 1.00e+0 B.1.91
V6224 2484C>T synonymous_variant ORF1ab_pp1a D828D 1.00e+0 B.1.91
V6736 6348A>G synonymous_variant ORF1ab_pp1a V2116V 1.00e+0 B.1.91
V10 -200C>T upstream_gene_variant ORF1ab_pp1a None 7.06e-1 BA.5.2.10
V155 146G>A missense_variant ORF1ab_pp1a G49D 8.15e-1 BA.5.2.10
V3785 770G>A missense_variant S G257D 1.00e+0 BA.5.2.10
V7538 12754C>T synonymous_variant ORF1ab_pp1a L4252L 7.06e-1 BA.5.2.10
V9283 225C>T synonymous_variant E V75V 7.06e-1 BA.5.2.10
V3927 1501A>T missense_variant S N501Y 6.15e-1 BB.2
V6866 7467C>T synonymous_variant ORF1ab_pp1a Y2489Y 1.00e+0 BF.7.13.2
V7507 12550C>T synonymous_variant ORF1ab_pp1a L4184L 1.00e+0 BF.7.13.2
V3881 1345T>C missense_variant S Y449H 7.78e-1 C.1.2
V3927 1501A>T missense_variant S N501Y 8.90e-1 C.1.2
V1314 5356C>T missense_variant ORF1ab_pp1a P1786S 9.24e-1 C.14
V1507 6344G>T missense_variant ORF1ab_pp1a R2115I 9.24e-1 C.14
V1888 8888A>G missense_variant ORF1ab_pp1a Q2963R 9.24e-1 C.14
V1969 9601C>T missense_variant ORF1ab_pp1a L3201F 8.54e-1 C.14
V216 304G>A missense_variant ORF1ab_pp1a E102K 1.00e+0 C.14
V3249 19471G>T missense_variant ORF1ab_pp1ab D6491Y 9.24e-1 C.14
V347 812C>T missense_variant ORF1ab_pp1a P271L 9.24e-1 C.14
V3608 284C>T missense_variant S T95I 6.70e-1 C.14
V3663 455G>T missense_variant S W152L 9.24e-1 C.14
V3677 474A>C missense_variant S R158S 9.24e-1 C.14
V3868 1320T>G missense_variant S N440K 8.42e-1 C.14
V390 986C>T missense_variant ORF1ab_pp1a T329I 9.24e-1 C.14
V4013 2030A>G missense_variant S Q677R 9.24e-1 C.14
V5191 285G>T missense_variant ORF8 L95F 9.24e-1 C.14
V5224 358T>G missense_variant ORF8 F120V 9.24e-1 C.14
V5230 361A>C missense_variant ORF8 I121L 8.54e-1 C.14
V5237 1delA frameshift_variant&start_lost N M1fs 9.24e-1 C.14
V5513 702G>T missense_variant N M234I 8.54e-1 C.14
V6193 2271C>T synonymous_variant ORF1ab_pp1a V757V 6.70e-1 C.14
V6546 4927C>T synonymous_variant ORF1ab_pp1a L1643L 8.54e-1 C.14
V7266 10537C>T synonymous_variant ORF1ab_pp1a L3513L 7.52e-1 C.14
V7798 14668C>T synonymous_variant ORF1ab_pp1ab L4890L 8.54e-1 C.14
V7920 15687C>T synonymous_variant ORF1ab_pp1ab I5229I 7.09e-1 C.14
V7925 15696C>T synonymous_variant ORF1ab_pp1ab A5232A 7.52e-1 C.14
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 9.24e-1 C.14
V8806 1359T>C synonymous_variant S Y453Y 9.24e-1 C.14
V9169 180C>T synonymous_variant ORF3a S60S 9.24e-1 C.14
V9772 1008C>T synonymous_variant N A336A 9.24e-1 C.14
V9828 75C>T synonymous_variant ORF10 N25N 9.24e-1 C.14
V1258 4910C>T missense_variant ORF1ab_pp1a T1637I 7.00e-1 C.1
V1970 9602T>C missense_variant ORF1ab_pp1a L3201P 6.48e-1 C.1
V216 304G>A missense_variant ORF1ab_pp1a E102K 8.83e-1 C.1
V3525 26C>T missense_variant S P9L 9.23e-1 C.1
V3626 407G>T missense_variant S C136F 6.48e-1 C.1
V3881 1345T>C missense_variant S Y449H 9.23e-1 C.1
V3927 1501A>T missense_variant S N501Y 9.23e-1 C.1
V3997 1963C>T missense_variant S H655Y 9.62e-1 C.1
V4018 2037T>A missense_variant S N679K 9.23e-1 C.1
V4048 2147C>T missense_variant S T716I 9.23e-1 C.1
V4111 2576C>A missense_variant S T859N 7.00e-1 C.1
V4668 61C>A missense_variant E L21I 7.50e-1 C.1
V4760 245T>C missense_variant M I82T 7.53e-1 C.1
V5243 -2A>T upstream_gene_variant N None 8.43e-1 C.1
V5274 38C>T missense_variant N P13L 8.83e-1 C.1
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 7.01e-1 C.1
V6862 7434A>G synonymous_variant ORF1ab_pp1a K2478K 6.80e-1 C.1
V7538 12754C>T synonymous_variant ORF1ab_pp1a L4252L 7.00e-1 C.1
V8338 18789T>C synonymous_variant ORF1ab_pp1ab I6263I 7.50e-1 C.1
V9612 243T>C synonymous_variant N D81D 8.83e-1 C.1
V3987 1919C>T missense_variant S S640F 1.00e+0 C.2.1
V1262 4918C>T missense_variant ORF1ab_pp1a P1640S 1.00e+0 C.37.1
V216 304G>A missense_variant ORF1ab_pp1a E102K 1.00e+0 C.37.1
V3525 26C>T missense_variant S P9L 1.00e+0 C.37.1
V3550 74C>T missense_variant S P25L 1.00e+0 C.37.1
V3881 1345T>C missense_variant S Y449H 1.00e+0 C.37.1
V3900 1433C>A missense_variant S T478K 1.00e+0 C.37.1
V3927 1501A>T missense_variant S N501Y 1.00e+0 C.37.1
V3997 1963C>T missense_variant S H655Y 1.00e+0 C.37.1
V4018 2037T>A missense_variant S N679K 1.00e+0 C.37.1
V4048 2147C>T missense_variant S T716I 1.00e+0 C.37.1
V4188 3303C>A missense_variant S H1101Q 1.00e+0 C.37.1
V4428 207G>T missense_variant ORF3a W69C 7.06e-1 C.37.1
V4603 686C>A missense_variant ORF3a T229N 1.00e+0 C.37.1
V4622 766_768delGTT conservative_inframe_deletion ORF3a V256del 1.00e+0 C.37.1
V4668 61C>A missense_variant E L21I 1.00e+0 C.37.1
V4732 85C>T missense_variant M L29F 1.00e+0 C.37.1
V4760 245T>C missense_variant M I82T 1.00e+0 C.37.1
V4860 32C>T missense_variant ORF7a T11I 7.06e-1 C.37.1
V5020 40_41delTT frameshift_variant ORF7b L14fs 1.00e+0 C.37.1
V5243 -2A>T upstream_gene_variant N None 1.00e+0 C.37.1
V5352 239C>G missense_variant N P80R 1.00e+0 C.37.1
V5629 1152G>T missense_variant N Q384H 1.00e+0 C.37.1
V616 1826C>T missense_variant ORF1ab_pp1a T609I 1.00e+0 C.37.1
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 1.00e+0 C.37.1
V6862 7434A>G synonymous_variant ORF1ab_pp1a K2478K 1.00e+0 C.37.1
V6869 7500C>T synonymous_variant ORF1ab_pp1a S2500S 7.06e-1 C.37.1
V7814 14844C>T synonymous_variant ORF1ab_pp1ab T4948T 1.00e+0 C.37.1
V8293 18483C>T synonymous_variant ORF1ab_pp1ab V6161V 1.00e+0 C.37.1
V8338 18789T>C synonymous_variant ORF1ab_pp1ab I6263I 1.00e+0 C.37.1
V8466 19884C>T synonymous_variant ORF1ab_pp1ab F6628F 1.00e+0 C.37.1
V8929 2367C>T synonymous_variant S Y789Y 1.00e+0 C.37.1
V9612 243T>C synonymous_variant N D81D 1.00e+0 C.37.1
V9811 1236C>T synonymous_variant N S412S 1.00e+0 C.37.1
V3882 1348A>G missense_variant S N450D 6.68e-1 CM.10
V3884 1354C>A missense_variant S L452M 7.30e-1 CM.10
V3891 1380T>G missense_variant S N460K 8.04e-1 CM.10
V3896 1430G>A missense_variant S S477N 9.73e-1 CM.10
V3912 1451A>G missense_variant S E484G 9.87e-1 CM.10
V3926 1493A>G missense_variant S Q498R 7.92e-1 CM.10
V3927 1501A>T missense_variant S N501Y 7.78e-1 CM.10
V3930 1513T>C missense_variant S Y505H 7.49e-1 CM.10
V3868 1320T>G missense_variant S N440K 7.54e-1 CM.11
V3870 1331A>G missense_variant S K444R 6.92e-1 CM.11
V3882 1348A>G missense_variant S N450D 7.54e-1 CM.11
V3884 1354C>A missense_variant S L452M 7.91e-1 CM.11
V3891 1380T>G missense_variant S N460K 8.33e-1 CM.11
V3896 1430G>A missense_variant S S477N 9.45e-1 CM.11
V3900 1433C>A missense_variant S T478K 1.00e+0 CM.11
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.11
V3926 1493A>G missense_variant S Q498R 9.40e-1 CM.11
V3927 1501A>T missense_variant S N501Y 9.40e-1 CM.11
V3930 1513T>C missense_variant S Y505H 9.40e-1 CM.11
V2951 17414C>T missense_variant ORF1ab_pp1ab T5805M 7.06e-1 CM.12
V3868 1320T>G missense_variant S N440K 1.00e+0 CM.12
V3882 1348A>G missense_variant S N450D 7.06e-1 CM.12
V3884 1354C>A missense_variant S L452M 7.06e-1 CM.12
V3891 1380T>G missense_variant S N460K 7.06e-1 CM.12
V3896 1430G>A missense_variant S S477N 7.06e-1 CM.12
V3900 1433C>A missense_variant S T478K 7.06e-1 CM.12
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.12
V3926 1493A>G missense_variant S Q498R 7.06e-1 CM.12
V3927 1501A>T missense_variant S N501Y 7.06e-1 CM.12
V3930 1513T>C missense_variant S Y505H 7.06e-1 CM.12
V8358 18921C>T synonymous_variant ORF1ab_pp1ab C6307C -7.06e-1 CM.12
V9401 58A>C synonymous_variant ORF6 R20R 7.06e-1 CM.12
V3851 1213G>A missense_variant S D405N 7.21e-1 CM.1
V3861 1251G>T missense_variant S K417N 6.04e-1 CM.1
V3868 1320T>G missense_variant S N440K 6.67e-1 CM.1
V3882 1348A>G missense_variant S N450D 7.21e-1 CM.1
V3884 1354C>A missense_variant S L452M 7.21e-1 CM.1
V3891 1380T>G missense_variant S N460K 7.21e-1 CM.1
V3896 1430G>A missense_variant S S477N 8.29e-1 CM.1
V3900 1433C>A missense_variant S T478K 8.29e-1 CM.1
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.1
V3926 1493A>G missense_variant S Q498R 6.66e-1 CM.1
V3927 1501A>T missense_variant S N501Y 6.66e-1 CM.1
V249 405T>G missense_variant ORF1ab_pp1a S135R 1.00e+0 CM.2.1
V2918 17146C>T missense_variant ORF1ab_pp1ab R5716C 6.95e-1 CM.2.1
V3635 425G>A missense_variant S G142D 6.95e-1 CM.2.1
V3665 458T>C missense_variant S M153T 6.95e-1 CM.2.1
V3679 492T>G missense_variant S N164K 6.95e-1 CM.2.1
V3735 638T>G missense_variant S V213G 6.95e-1 CM.2.1
V3762 733C>A missense_variant S H245N 6.95e-1 CM.2.1
V3785 770G>A missense_variant S G257D 6.95e-1 CM.2.1
V3820 1016G>A missense_variant S G339D 6.95e-1 CM.2.1
V3840 1112C>T missense_variant S S371F 6.95e-1 CM.2.1
V3843 1124C>T missense_variant S S375F 6.95e-1 CM.2.1
V3844 1126A>G missense_variant S T376A 6.95e-1 CM.2.1
V3851 1213G>A missense_variant S D405N 6.95e-1 CM.2.1
V3854 1224A>C missense_variant S R408S 6.95e-1 CM.2.1
V3861 1251G>T missense_variant S K417N 6.95e-1 CM.2.1
V3868 1320T>G missense_variant S N440K 1.00e+0 CM.2.1
V3870 1331A>G missense_variant S K444R 1.00e+0 CM.2.1
V3882 1348A>G missense_variant S N450D 1.00e+0 CM.2.1
V3884 1354C>A missense_variant S L452M 1.00e+0 CM.2.1
V3891 1380T>G missense_variant S N460K 1.00e+0 CM.2.1
V3896 1430G>A missense_variant S S477N 1.00e+0 CM.2.1
V3900 1433C>A missense_variant S T478K 1.00e+0 CM.2.1
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.2.1
V3917 1457T>C missense_variant S F486S 1.00e+0 CM.2.1
V4144 2862A>T missense_variant S Q954H 6.95e-1 CM.2.1
V4146 2907T>A missense_variant S N969K 6.95e-1 CM.2.1
V4729 55C>G missense_variant M Q19E 6.95e-1 CM.2.1
V5241 -3A>T upstream_gene_variant N None 6.95e-1 CM.2.1
V5461 608G>A missense_variant N R203K 1.00e+0 CM.2.1
V5465 610G>C missense_variant N G204R 1.00e+0 CM.2.1
V5651 1237A>C missense_variant N S413R 6.95e-1 CM.2.1
V5960 669C>T synonymous_variant ORF1ab_pp1a D223D -6.95e-1 CM.2.1
V697 2180C>T missense_variant ORF1ab_pp1a T727I 6.95e-1 CM.2.1
V7191 9924C>T synonymous_variant ORF1ab_pp1a T3308T 6.95e-1 CM.2.1
V7193 9933C>T synonymous_variant ORF1ab_pp1a D3311D 6.95e-1 CM.2.1
V9076 3438C>T synonymous_variant S D1146D 6.95e-1 CM.2.1
V9109 3609T>C synonymous_variant S L1203L 6.95e-1 CM.2.1
V9496 52C>T synonymous_variant ORF7b L18L 1.00e+0 CM.2.1
V9682 609G>A synonymous_variant N R203R 1.00e+0 CM.2.1
V3868 1320T>G missense_variant S N440K 6.69e-1 CM.3
V3870 1331A>G missense_variant S K444R 6.32e-1 CM.3
V3882 1348A>G missense_variant S N450D 7.64e-1 CM.3
V3884 1354C>A missense_variant S L452M 7.64e-1 CM.3
V3891 1380T>G missense_variant S N460K 7.64e-1 CM.3
V3896 1430G>A missense_variant S S477N 9.11e-1 CM.3
V3900 1433C>A missense_variant S T478K 9.11e-1 CM.3
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.3
V3913 1454G>A missense_variant S G485D 7.29e-1 CM.3
V3926 1493A>G missense_variant S Q498R 8.12e-1 CM.3
V3927 1501A>T missense_variant S N501Y 8.12e-1 CM.3
V3930 1513T>C missense_variant S Y505H 8.12e-1 CM.3
V3665 458T>C missense_variant S M153T 6.36e-1 CM.4.1
V3785 770G>A missense_variant S G257D 6.09e-1 CM.4.1
V3868 1320T>G missense_variant S N440K 6.43e-1 CM.4.1
V3870 1331A>G missense_variant S K444R 6.43e-1 CM.4.1
V3882 1348A>G missense_variant S N450D 7.20e-1 CM.4.1
V3884 1354C>A missense_variant S L452M 7.20e-1 CM.4.1
V3891 1380T>G missense_variant S N460K 7.20e-1 CM.4.1
V3896 1430G>A missense_variant S S477N 1.00e+0 CM.4.1
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.4.1
V3926 1493A>G missense_variant S Q498R 8.40e-1 CM.4.1
V3927 1501A>T missense_variant S N501Y 8.40e-1 CM.4.1
V3930 1513T>C missense_variant S Y505H 8.40e-1 CM.4.1
V3882 1348A>G missense_variant S N450D 6.71e-1 CM.4
V3884 1354C>A missense_variant S L452M 6.82e-1 CM.4
V3891 1380T>G missense_variant S N460K 7.69e-1 CM.4
V3896 1430G>A missense_variant S S477N 8.54e-1 CM.4
V3900 1433C>A missense_variant S T478K 8.00e-1 CM.4
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.4
V3926 1493A>G missense_variant S Q498R 8.43e-1 CM.4
V3927 1501A>T missense_variant S N501Y 7.70e-1 CM.4
V3930 1513T>C missense_variant S Y505H 7.42e-1 CM.4
V3840 1112C>T missense_variant S S371F 6.06e-1 CM.5.2
V3841 1117T>C missense_variant S S373P 6.06e-1 CM.5.2
V3882 1348A>G missense_variant S N450D 6.67e-1 CM.5.2
V3884 1354C>A missense_variant S L452M 6.67e-1 CM.5.2
V3891 1380T>G missense_variant S N460K 6.67e-1 CM.5.2
V3896 1430G>A missense_variant S S477N 1.00e+0 CM.5.2
V3900 1433C>A missense_variant S T478K 1.00e+0 CM.5.2
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.5.2
V3913 1454G>A missense_variant S G485D 7.42e-1 CM.5.2
V3926 1493A>G missense_variant S Q498R 8.61e-1 CM.5.2
V3927 1501A>T missense_variant S N501Y 7.83e-1 CM.5.2
V3930 1513T>C missense_variant S Y505H 7.83e-1 CM.5.2
V3882 1348A>G missense_variant S N450D 7.60e-1 CM.5
V3884 1354C>A missense_variant S L452M 6.79e-1 CM.5
V3891 1380T>G missense_variant S N460K 8.49e-1 CM.5
V3896 1430G>A missense_variant S S477N 9.22e-1 CM.5
V3900 1433C>A missense_variant S T478K 8.18e-1 CM.5
V3912 1451A>G missense_variant S E484G 9.62e-1 CM.5
V3926 1493A>G missense_variant S Q498R 7.50e-1 CM.5
V3927 1501A>T missense_variant S N501Y 7.50e-1 CM.5
V3930 1513T>C missense_variant S Y505H 6.62e-1 CM.5
V3843 1124C>T missense_variant S S375F 1.00e+0 CM.7
V3844 1126A>G missense_variant S T376A 1.00e+0 CM.7
V3851 1213G>A missense_variant S D405N 7.03e-1 CM.7
V3861 1251G>T missense_variant S K417N 7.03e-1 CM.7
V3891 1380T>G missense_variant S N460K 1.00e+0 CM.7
V3896 1430G>A missense_variant S S477N 1.00e+0 CM.7
V3900 1433C>A missense_variant S T478K 1.00e+0 CM.7
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.7
V3926 1493A>G missense_variant S Q498R 1.00e+0 CM.7
V3927 1501A>T missense_variant S N501Y 1.00e+0 CM.7
V3930 1513T>C missense_variant S Y505H 1.00e+0 CM.7
V3973 1861C>T missense_variant S P621S -7.03e-1 CM.7
V4047 2117C>T missense_variant S A706V -1.00e+0 CM.7
V5274 38C>T missense_variant N P13L 1.00e+0 CM.7
V3891 1380T>G missense_variant S N460K 6.17e-1 CM.8
V3896 1430G>A missense_variant S S477N 8.89e-1 CM.8
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.8
V3926 1493A>G missense_variant S Q498R 6.77e-1 CM.8
V3927 1501A>T missense_variant S N501Y 7.12e-1 CM.8
V3930 1513T>C missense_variant S Y505H 6.24e-1 CM.8
V7750 14358G>A synonymous_variant ORF1ab_pp1ab T4786T -6.80e-1 CM.8
V1937 9269C>T missense_variant ORF1ab_pp1a T3090I 7.62e-1 CM.9
V3868 1320T>G missense_variant S N440K 6.34e-1 CM.9
V3870 1331A>G missense_variant S K444R 6.34e-1 CM.9
V3882 1348A>G missense_variant S N450D 6.90e-1 CM.9
V3884 1354C>A missense_variant S L452M 6.90e-1 CM.9
V3891 1380T>G missense_variant S N460K 7.62e-1 CM.9
V3896 1430G>A missense_variant S S477N 1.00e+0 CM.9
V3900 1433C>A missense_variant S T478K 1.00e+0 CM.9
V3912 1451A>G missense_variant S E484G 1.00e+0 CM.9
V3926 1493A>G missense_variant S Q498R 1.00e+0 CM.9
V3927 1501A>T missense_variant S N501Y 8.10e-1 CM.9
V3930 1513T>C missense_variant S Y505H 8.10e-1 CM.9
V194 252_254delTAT disruptive_inframe_deletion ORF1ab_pp1a M85del 1.00e+0 L.3
V196 253A>G missense_variant ORF1ab_pp1a M85V 1.00e+0 L.3
V1203 4628C>T missense_variant ORF1ab_pp1a T1543I 1.00e+0 N.4
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 1.00e+0 N.4
V3674 470T>C missense_variant S F157S 1.00e+0 N.4
V4033 2062G>T missense_variant S A688S 1.00e+0 N.4
V4537 514G>T missense_variant ORF3a G172C 1.00e+0 N.4
V4627 767_769delTTA disruptive_inframe_deletion ORF3a V256_N257delinsD 1.00e+0 N.4
V4823 98T>C missense_variant ORF6 I33T -7.06e-1 N.4
V4915 182C>G missense_variant ORF7a T61S 1.00e+0 N.4
V5060 -5C>T upstream_gene_variant ORF8 None 1.00e+0 N.4
V5247 5C>T missense_variant N S2F 1.00e+0 N.4
V5544 812C>T missense_variant N T271I 1.00e+0 N.4
V7346 11310C>T synonymous_variant ORF1ab_pp1a F3770F 1.00e+0 N.4
V8056 16746C>T synonymous_variant ORF1ab_pp1ab I5582I 7.06e-1 N.4
V9438 120C>T synonymous_variant ORF7a Y40Y 7.06e-1 N.4
V9631 378C>T synonymous_variant N N126N 1.00e+0 N.4
V9722 822C>T synonymous_variant N F274F 1.00e+0 N.4
V1693 7661C>T missense_variant ORF1ab_pp1a A2554V 8.13e-1 N.6
V1758 8053C>A missense_variant ORF1ab_pp1a P2685T 1.00e+0 N.6
V316 641C>T missense_variant ORF1ab_pp1a T214I 8.13e-1 N.6
V4500 379C>T missense_variant ORF3a L127F 1.00e+0 N.6
V5042 98A>C missense_variant ORF7b E33A 1.00e+0 N.6
V5256 19C>A missense_variant N Q7K 8.13e-1 N.6
V6010 999G>T synonymous_variant ORF1ab_pp1a T333T 1.00e+0 N.6
V6629 5541C>T synonymous_variant ORF1ab_pp1a C1847C 8.13e-1 N.6
V6835 7164A>G synonymous_variant ORF1ab_pp1a A2388A 8.13e-1 N.6
V6850 7335C>T synonymous_variant ORF1ab_pp1a C2445C 8.13e-1 N.6
V6920 7872G>T synonymous_variant ORF1ab_pp1a V2624V -6.99e-1 N.6
V7381 11547C>T synonymous_variant ORF1ab_pp1a G3849G 8.13e-1 N.6
V786 2614G>A missense_variant ORF1ab_pp1a A872T 1.00e+0 N.6
V8816 1474T>C synonymous_variant S L492L 1.00e+0 N.6
V9764 981G>T synonymous_variant N S327S 8.13e-1 N.6
V9771 999C>T synonymous_variant N Y333Y 1.00e+0 N.6
V1319 5383A>C missense_variant ORF1ab_pp1a K1795Q 6.98e-1 P.1.10.1
V1564 6619G>A missense_variant ORF1ab_pp1a G2207S -7.03e-1 P.1.10.1
V1571 6689T>C missense_variant ORF1ab_pp1a I2230T -7.03e-1 P.1.10.1
V2116 10818G>T missense_variant ORF1ab_pp1a L3606F -7.03e-1 P.1.10.1
V2322 12109C>T missense_variant ORF1ab_pp1a L4037F -7.03e-1 P.1.10.1
V438 1162C>T missense_variant ORF1ab_pp1a H388Y 7.03e-1 P.1.10.1
V6224 2484C>T synonymous_variant ORF1ab_pp1a D828D 8.12e-1 P.1.10.1
V6691 6054A>G synonymous_variant ORF1ab_pp1a P2018P 8.12e-1 P.1.10.1
V779 2576C>T missense_variant ORF1ab_pp1a A859V 1.00e+0 P.1.10.1
V89 -39G>A upstream_gene_variant ORF1ab_pp1a None -7.03e-1 P.1.10.1
V3927 1501A>T missense_variant S N501Y 1.00e+0 P.1.11
V3892 1409C>A missense_variant S T470N 9.49e-1 P.1.8
V3927 1501A>T missense_variant S N501Y 8.90e-1 P.1.8
V3927 1501A>T missense_variant S N501Y 9.28e-1 P.1.9
V2193 11185C>A missense_variant ORF1ab_pp1a Q3729K -1.00e+0 P.4
V2513 13598C>T missense_variant ORF1ab_pp1ab T4533I 1.00e+0 P.4
V3717 570G>T missense_variant S R190S 1.00e+0 P.4
V3886 1355T>G missense_variant S L452R -7.06e-1 P.4
V5924 468T>C synonymous_variant ORF1ab_pp1a D156D 1.00e+0 P.4
V6224 2484C>T synonymous_variant ORF1ab_pp1a D828D 1.00e+0 P.4
V6736 6348A>G synonymous_variant ORF1ab_pp1a V2116V 7.06e-1 P.4
V2485 13448A>G missense_variant ORF1ab_pp1ab K4483R 1.00e+0 XAM
V9181 250C>T synonymous_variant ORF3a L84L 1.00e+0 XAM
V3616 293C>T missense_variant S S98F -6.99e-1 XBB.1.3
V3891 1380T>G missense_variant S N460K 8.07e-1 XBB.1.3
V3896 1430G>A missense_variant S S477N 1.00e+0 XBB.1.3
V3900 1433C>A missense_variant S T478K 1.00e+0 XBB.1.3
V3911 1451A>C missense_variant S E484A 1.00e+0 XBB.1.3
V3917 1457T>C missense_variant S F486S 6.91e-1 XBB.1.3
V3921 1469T>C missense_variant S F490S 1.00e+0 XBB.1.3
V3926 1493A>G missense_variant S Q498R 1.00e+0 XBB.1.3
V3927 1501A>T missense_variant S N501Y 1.00e+0 XBB.1.3
V3930 1513T>C missense_variant S Y505H 1.00e+0 XBB.1.3
V3868 1320T>G missense_variant S N440K 6.74e-1 XBJ
V3870 1331A>G missense_variant S K444R 7.12e-1 XBJ
V3882 1348A>G missense_variant S N450D 7.82e-1 XBJ
V3884 1354C>A missense_variant S L452M 7.82e-1 XBJ
V3891 1380T>G missense_variant S N460K 7.82e-1 XBJ
V3896 1430G>A missense_variant S S477N 9.59e-1 XBJ
V3900 1433C>A missense_variant S T478K 9.22e-1 XBJ
V3912 1451A>G missense_variant S E484G 1.00e+0 XBJ
V3926 1493A>G missense_variant S Q498R 8.64e-1 XBJ
V3927 1501A>T missense_variant S N501Y 8.64e-1 XBJ
V3930 1513T>C missense_variant S Y505H 8.64e-1 XBJ
V6029 1176C>T synonymous_variant ORF1ab_pp1a G392G 7.00e-1 XH
V9722 822C>T synonymous_variant N F274F 6.46e-1 XH





Manual curation of mutation (1450G>A)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID
1450G>A E484K 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro bioRxiv 2021 33619479
1450G>A E484K 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab?in vitro MAbs 2021 34074219
1450G>A E484K A 48-Year-Old Immunocompetent Female Resident of Southern Florida with Confirmed Reinfection with P.1 (Gamma) Variant of SARS-CoV-2 Am J Case Rep 2022 35041639
1450G>A E484K A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its Variants Front Immunol 2021 34630410
1450G>A E484K A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo J Virol 2021 34495697
1450G>A E484K A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels Sci Rep 2021 34531417
1450G>A E484K A bivalent recombinant vaccine targeting the S1 protein induces neutralizing antibodies against both SARS-CoV-2 variants and wild-type of the virus MedComm (2020) 2021 34226895
1450G>A E484K A case of reinfection with a different variant of SARS-CoV-2: case report Egypt J Intern Med 2023 36785595
1450G>A E484K A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera Antiviral Res 2022 35772601
1450G>A E484K A Conservative Replacement in the Transmembrane Domain of SARS-CoV-2 ORF7a as a Putative Risk Factor in COVID-19 Biology (Basel) 2021 34943191
1450G>A E484K Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants Infect Drug Resist 2021 34880635
1450G>A E484K A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations. Front Immunol 2022 35222380
1450G>A E484K A discernable increase in the severe acute respiratory syndrome coronavirus 2 R.1 lineage carrying an E484K spike protein mutation in Japan Infect Genet Evol 2021 34352360
1450G>A E484K Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift J Med Virol 2022 35032057
1450G>A E484K Allosteric Cross-Talk among Spike's Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor J Phys Chem Lett 2021 34161095
1450G>A E484K An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants Sci Rep 2021 34140558
1450G>A E484K Analysis of BNT162b2- and CVnCoV-elicited sera and of convalescent sera toward SARS-CoV-2 viruses Allergy 2022 34820854
1450G>A E484K Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review Int J Mol Sci 2021 35008446
1450G>A E484K Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species Immunity 2021 34166623
1450G>A E484K An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021. Trop Med Infect Dis 2021 34449757
1450G>A E484K A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations Emerg Microbes Infect 2021 33977858
1450G>A E484K A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology Microbiol Spectr 2021 34787499
1450G>A E484K An overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future Expert Opin Drug Discov 2021 34304682
1450G>A E484K Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants Virol Sin 2021 34224110
1450G>A E484K Antibody evasion by the P.1 strain of SARS-CoV-2 Cell 2021 33852911
1450G>A E484K Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 bioRxiv 2021 33532778
1450G>A E484K Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 Nature 2021 33684923
1450G>A E484K Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro Front Pharmacol 2021 35126106
1450G>A E484K Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes Viruses 2022 35062348
1450G>A E484K Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures Glycobiology 2023 36136750
1450G>A E484K An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern Clin Infect Dis 2022 34272947
1450G>A E484K A one-step real-time RT-PCR assay for simultaneous typing of SARS-CoV-2 mutations associated with the E484K and N501Y spike protein amino-acid substitutions J Virol Methods 2021 34274369
1450G>A E484K A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants Front Immunol 2021 34966387
1450G>A E484K A potent, broadly protective vaccine against SARS-CoV-2 variants of concern. NPJ Vaccines 2022 36371432
1450G>A E484K A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil Viruses 2021 33919314
1450G>A E484K A Rapid Method for Generating Infectious SARS-CoV-2 and Variants Using Mutagenesis and Circular Polymerase Extension Cloning Microbiol Spectr 2023 36877070
1450G>A E484K Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan Front Cardiovasc Med 2021 34869681
1450G>A E484K A Sanger-based approach for scaling up screening of SARS-CoV-2 variants of interest and concern Infect Genet Evol 2021 33975021
1450G>A E484K A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assay J Virol Methods 2022 35271889
1450G>A E484K A short plus long-amplicon based sequencing approach improves genomic coverage and variant detection in the SARS-CoV-2 genome PLoS One 2022 35025877
1450G>A E484K A Simple Reverse Transcriptase PCR Melting-Temperature Assay To Rapidly Screen for Widely Circulating SARS-CoV-2 Variants J Clin Microbiol 2021 34288729
1450G>A E484K A Simple RT-PCR Melting temperature Assay to Rapidly Screen for Widely Circulating SARS-CoV-2 Variants medRxiv 2021 33758892
1450G>A E484K Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants J Pharm Anal 2022 34545316
1450G>A E484K Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021. Clin Infect Dis 2022 34473242
1450G>A E484K A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain). Emerg Microbes Infect 2022 34842496
1450G>A E484K B.1.526 SARS-CoV-2 variants identified in New York City are neutralized by vaccine-elicited and therapeutic monoclonal antibodies bioRxiv 2021 33791698
1450G>A E484K B.1.526 SARS-CoV-2 Variants Identified in New York City are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies mBio 2021 34311587
1450G>A E484K Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding Front Mol Biosci 2022 35677879
1450G>A E484K Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern Sci Transl Med 2021 34519517
1450G>A E484K BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in systemic lupus erythematosus Ann Rheum Dis 2022 34607791
1450G>A E484K Breakthrough Infections of E484K-Harboring SARS-CoV-2 Delta Variant, Lombardy, Italy. Emerg Infect Dis 2021 34499599
1450G>A E484K Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine EBioMedicine 2023 37148585
1450G>A E484K But Mouse, You Are Not Alone: On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice. ILAR J 2021 35022734
1450G>A E484K CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In Vitro Front Immunol 2021 34367128
1450G>A E484K Case Report: A 29-Year-Old Pregnant Woman at 24 Weeks of Gestation Presenting with Laryngotracheitis and COVID-19 Due to the R.1 Variant of SARS-CoV-2 Am J Case Rep 2022 36253963
1450G>A E484K Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. mBio 2022 35266815
1450G>A E484K Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein Infect Dis Poverty 2021 34419160
1450G>A E484K Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2 Infect Genet Evol 2021 34403832
1450G>A E484K Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection J Infect Dis 2022 35176774
1450G>A E484K Coding-Complete Genome Sequences and Mutation Profiles of Nine SARS-CoV-2 Strains Detected from COVID-19 Patients in Bangladesh Microbiol Resour Announc 2021 33707329
1450G>A E484K Combination of Isothermal Recombinase-Aided Amplification and CRISPR-Cas12a-Mediated Assay for Rapid Detection of Major Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern Front Microbiol 2022 35836420
1450G>A E484K Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells. Sci Rep 2021 34773067
1450G>A E484K Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern J Allergy Clin Immunol 2022 35093484
1450G>A E484K Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates Open Forum Infect Dis 2021 34254040
1450G>A E484K Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania bioRxiv 2021 33907751
1450G>A E484K Comparative Analysis of Five Multiplex RT-PCR Assays in the Screening of SARS-CoV-2 Variants Microorganisms 2022 35208761
1450G>A E484K Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 bioRxiv 2021 33655250
1450G>A E484K Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 Cell Rep Med 2021 33842902
1450G>A E484K Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants Genome Med 2021 34649620
1450G>A E484K Computational decomposition reveals reshaping of the SARS-CoV-2-ACE2 interface among viral variants expressing the N501Y mutation J Cell Biochem 2021 34516024
1450G>A E484K Controversy surrounding the Sputnik V vaccine Respir Med 2021 34399368
1450G>A E484K Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes mBio 2021 34060334
1450G>A E484K Convergent Evolution of Multiple Mutations Improves the Viral Fitness of SARS-CoV-2 Variants by Balancing Positive and Negative Selection Biochemistry 2022 35511584
1450G>A E484K Corilagin and 1,3,6-Tri-O-galloy-β-D-glucose: potential inhibitors of SARS-CoV-2 variants. Phys Chem Chem Phys 2021 34223589
1450G>A E484K COVID-19 and mutations a threat level assessment Nepal J Epidemiol 2021 33868743
1450G>A E484K COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants Sci Rep 2022 35505068
1450G>A E484K Covid-19: The E484K mutation and the risks it poses BMJ 2021 33547053
1450G>A E484K COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme J Clin Microbiol 2022 35766492
1450G>A E484K CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern Microbiol Spectr 2021 34787487
1450G>A E484K CRISPR-Cas12a-Based Detection of SARS-CoV-2 Harboring the E484K Mutation ACS Synth Biol 2021 34783536
1450G>A E484K Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host Nat Commun 2022 35538074
1450G>A E484K D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2 Comput Biol Med 2022 36327885
1450G>A E484K Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset Front Immunol 2021 34220870
1450G>A E484K Decreased and Heterogeneous Neutralizing Antibody Responses Against RBD of SARS-CoV-2 Variants After mRNA Vaccination Front Immunol 2022 35464418
1450G>A E484K Decreased neutralization of SARS-CoV-2 global variants by therapeutic anti-spike protein monoclonal antibodies bioRxiv 2021 33619484
1450G>A E484K De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients Transpl Infect Dis 2022 35899968
1450G>A E484K De novo emergence of the mutation E484K in a SARS-CoV-2 B.1.1.7 lineage variant Enferm Infecc Microbiol Clin (Engl Ed) 2021 34400021
1450G>A E484K De novo emergence of the mutation E484K in a SARS-CoV-2 B.1.1.7 lineage variant Enferm Infecc Microbiol Clin (Engl Ed) 2022 35729053
1450G>A E484K Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York bioRxiv 2021 33907745
1450G>A E484K Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York Nat Commun 2021 34373458
1450G>A E484K Detection and isolation of SARS-CoV-2 Eta variant from the international travelers and local residents of India J Med Virol 2022 35211985
1450G>A E484K Detection of a SARS-CoV-2 variant of concern in South Africa Nature 2021 33690265
1450G>A E484K Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan PLoS Pathog 2021 34097716
1450G>A E484K Detection of Representative Mutant Strains and a Case of Prolonged Infection by SARS-CoV-2 with Spike 69/70 Deletion in Japan Infect Drug Resist 2021 34267528
1450G>A E484K Detection of SARS-CoV-2 VOC-Omicron using commercial sample-to-answer real-time RT-PCR platforms and melting curve-based SNP assays J Clin Virol Plus 2022 35761832
1450G>A E484K Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization Microorganisms 2022 35889075
1450G>A E484K Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutations PLoS One 2021 34905589
1450G>A E484K Development of antibody resistance in emerging mutant strains of SARS CoV-2: Impediment for COVID-19 vaccines Rev Med Virol 2022 35416390
1450G>A E484K Development, Validation, and Utilization of a Luminex-Based SARS-CoV-2 Multiplex Serology Assay. Microbiol Spectr 2023 36927068
1450G>A E484K Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern bioRxiv 2021 34341794
1450G>A E484K Discovery of a SARS-CoV-2 variant from the P.1 lineage harboring K417T/E484K/N501Y mutations in Kofu, Japan. J Infect 2021 33766552
1450G>A E484K Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors Viruses 2023 37112982
1450G>A E484K Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater Sci Total Environ 2021 34371414
1450G>A E484K Dynamics of SARS-CoV-2 variants of concern (VOC) in Bangladesh during the first half of 2021 Virology 2022 34700068
1450G>A E484K Dynamics of Viral Infection and Evolution of SARS-CoV-2 Variants in the Calabria Area of Southern Italy Front Microbiol 2022 35966675
1450G>A E484K E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody Int Immunopharmacol 2022 34915409
1450G>A E484K E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil Infect Genet Evol 2021 34044192
1450G>A E484K E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies J Mol Graph Model 2021 34562851
1450G>A E484K Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design study. BMJ 2021 34417165
1450G>A E484K Effect of Double Mutation (L452R and E484Q) on the Binding Affinity of Monoclonal Antibodies (mAbs) against the RBD-A Target for Vaccine Development Vaccines (Basel) 2022 36679867
1450G>A E484K Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity. bioRxiv 2021 33758838
1450G>A E484K Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science 2021 34168071
1450G>A E484K Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics. Elife 2021 34435953
1450G>A E484K Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil Nat Commun 2021 34615860
1450G>A E484K Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines bioRxiv 2021 33758839
1450G>A E484K Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York Nature 2021 34428777
1450G>A E484K Emergence and Expansion of the SARS-CoV-2 Variant B.1.526 Identified in New York medRxiv 2021 33655278
1450G>A E484K Emergence and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient Diagn Microbiol Infect Dis 2022 35231807
1450G>A E484K Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions Nat Commun 2021 34599175
1450G>A E484K Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein Arch Virol 2022 35178586
1450G>A E484K Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India. J Infect Public Health 2022 34896696
1450G>A E484K Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon Int J Infect Dis 2022 34742926
1450G>A E484K Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2 Viruses 2021 34452507
1450G>A E484K Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment mSphere 2021 34431691
1450G>A E484K Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal Sci Rep 2021 34880295
1450G>A E484K Emergence of SARS-CoV-2 resistance mutations in a patient who received anti-SARS-COV2 spike protein monoclonal antibodies: a case report BMC Infect Dis 2021 34876033
1450G>A E484K Emergence of SARS-CoV-2 Variant B.1.575.2, Containing the E484K Mutation in the Spike Protein, in Pamplona, Spain, May to June 2021. J Clin Microbiol 2021 34495709
1450G>A E484K Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany Lancet Reg Health Eur 2021 34278371
1450G>A E484K Emergence of the E484K Mutation in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lineage B.1.1.345 in Upstate New York Clin Infect Dis 2022 34086878
1450G>A E484K Emergency SARS-CoV-2 Variants of Concern: Novel Multiplex Real-Time RT-PCR Assay for Rapid Detection and Surveillance Microbiol Spectr 2022 35196812
1450G>A E484K Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape: The Case of a Long-Term Patient Life (Basel) 2021 34833135
1450G>A E484K Emerging vaccine-breakthrough SARS-CoV-2 variants ArXiv 2021 34518803
1450G>A E484K Emerging Vaccine-Breakthrough SARS-CoV-2 Variants ACS Infect Dis 2022 35133792
1450G>A E484K Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against Coronavirus (COVID-19) StatPearls Publishing 2023 34033342
1450G>A E484K Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection J Extracell Vesicles 2022 34982509
1450G>A E484K Enhancing the Immunogenicity of RBD Protein Variants through Amino Acid E484 Mutation in SARS-CoV-2 Viruses 2022 36146826
1450G>A E484K Environmental genomic surveillance of SARS-CoV-2 in wastewater in Rio de Janeiro, Brazil. J Water Health 2023 37254912
1450G>A E484K Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid Chembiochem 2022 34890095
1450G>A E484K Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid and Potential Utility for SARS-CoV-2 Detection bioRxiv 2021 34494022
1450G>A E484K Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern Front Immunol 2021 34149735
1450G>A E484K Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern iScience 2021 34430803
1450G>A E484K Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma Nature 2021 33780970
1450G>A E484K Establishment of a Rapid Typing Method for Coronavirus Disease 2019 Mutant Strains Based on PARMS Technology Micromachines (Basel) 2022 35208270
1450G>A E484K Evaluation of Analytical and Clinical Performance and Usefulness in a Real-Life Hospital Setting of Two in-House Real-Time RT-PCR Assays to Track SARS-CoV-2 Variants of Concern Viruses 2023 37243201
1450G>A E484K Evaluation of a Rapid and Accessible Reverse Transcription-Quantitative PCR Approach for SARS-CoV-2 Variant of Concern Identification J Clin Microbiol 2022 35465708
1450G>A E484K Evaluation of the Analytical Performance of the Fully Automated Gene Analyzer µTASWako g1 for the Detection of SARS-CoV-2 Clin Lab 2023 36787563
1450G>A E484K Evaluation of the clinical and analytical performance of the Seegene allplex�?SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI) J Clin Virol 2021 34628158
1450G>A E484K Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy mBio 2022 35467423
1450G>A E484K Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV-2 variants in serum of COVID-19 mRNA vaccine recipients EBioMedicine 2021 34688034
1450G>A E484K Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera Cell 2021 33730597
1450G>A E484K Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants. mBio 2021 34465019
1450G>A E484K E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces PeerJ 2022 35341044
1450G>A E484K Evolving strategy for an evolving virus: Development of real-time PCR assays for detecting all SARS-CoV-2 variants of concern J Virol Methods 2022 35644262
1450G>A E484K Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants J Mol Biol 2021 34023401
1450G>A E484K Exploring the immune evasion of SARS-CoV-2 variant harboring E484K by molecular dynamics simulations Brief Bioinform 2022 34553217
1450G>A E484K Exploring the Interaction between E484K and N501Y Substitutions of SARS-CoV-2 in Shaping the Transmission Advantage of COVID-19 in Brazil: A Modeling Study Am J Trop Med Hyg 2021 34583340
1450G>A E484K Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Cell 2021 33667349
1450G>A E484K First importations of SARS-CoV-2 P.1 and P.2 variants from Brazil to Spain and early community transmission Enferm Infecc Microbiol Clin 2022 34099945
1450G>A E484K First importations of SARS-CoV-2 P.1 and P.2 variants from Brazil to Spain and early community transmission Enferm Infecc Microbiol Clin (Engl Ed) 2022 35577445
1450G>A E484K FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip Elife 2021 34106048
1450G>A E484K Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties J Biol Chem 2022 35337800
1450G>A E484K Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity Viruses 2022 35458533
1450G>A E484K Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women. Breastfeed Med 2022 34809492
1450G>A E484K Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants Front Immunol 2021 34691078
1450G>A E484K GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2 Biomed Pharmacother 2021 34388530
1450G>A E484K Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail bioRxiv 2021 33532768
1450G>A E484K Genomic characterization of the dominating Beta, V2 variant carrying vaccinated (Oxford-AstraZeneca) and nonvaccinated COVID-19 patient samples in Bangladesh: A metagenomics and whole-genome approach. J Med Virol 2022 34939673
1450G>A E484K Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey mBio 2022 35997285
1450G>A E484K Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil. BMC Genomics 2021 34016042
1450G>A E484K Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis 2021 33605869
1450G>A E484K Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil J Med Virol 2021 34241897
1450G>A E484K Genomic reconstruction of the SARS-CoV-2 epidemic in England Nature 2021 34649268
1450G>A E484K Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil. medRxiv 2021 33688664
1450G>A E484K [Genomics and epidemiology of SARS-CoV-2 lineage] Uirusu 2021 35526991
1450G>A E484K Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science 2021 33853970
1450G>A E484K Genomic Sequencing of SARS-CoV-2 E484K Variant B.1.243.1, Arizona, USA. Emerg Infect Dis 2021 34545803
1450G>A E484K Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019-2022. PLoS One 2022 35913920
1450G>A E484K Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil PLoS Negl Trop Dis 2021 34644287
1450G>A E484K Genomic surveillance of severe acute respiratory syndrome coronavirus 2 in Burundi, from May 2021 to January 2022. BMC Genomics 2023 37301830
1450G>A E484K Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein Viruses 2021 34696404
1450G>A E484K Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2 Front Immunol 2022 35784352
1450G>A E484K Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data. J Cell Physiol 2021 33755190
1450G>A E484K High-Throughput Adaptable SARS-CoV-2 Screening for Rapid Identification of Dominant and Emerging Regional Variants Am J Clin Pathol 2022 34999740
1450G>A E484K Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases Front Cell Infect Microbiol 2021 34760721
1450G>A E484K Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants Hum Vaccin Immunother 2022 34228597
1450G>A E484K Human-to-dog transmission of SARS-CoV-2, Colombia. Sci Rep 2022 35551247
1450G>A E484K Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines Cell Res 2021 34021265
1450G>A E484K Identification of anti-SARS-CoV-2 agents based on flavor/fragrance compositions that inhibit the interaction between the virus receptor binding domain and human angiotensin converting enzyme 2 PLoS One 2022 36534650
1450G>A E484K Identification of conserved linear epitopes in the SARS-CoV-2 receptor-binding region using monoclonal antibodies Heliyon 2023 37292282
1450G>A E484K Identification of E484K and other novel SARS-COV-2 variants from the Kingdom of Bahrain Microb Pathog 2021 34058304
1450G>A E484K Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization Cell Host Microbe 2021 33535027
1450G>A E484K Identifying SARS-CoV-2 Variants of Concern through saliva-based RT-qPCR by targeting recurrent mutation sites medRxiv 2022 35262087
1450G>A E484K Identifying SARS-CoV-2 Variants of Concern through Saliva-Based RT-qPCR by Targeting Recurrent Mutation Sites Microbiol Spectr 2022 35546574
1450G>A E484K Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far? Viruses 2021 34206453
1450G>A E484K Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module Sci Rep 2022 35181735
1450G>A E484K Immune transcriptomes from hospitalized patients infected with the SARS-CoV-2 variants B.1.1.7 and B.1.1.7 carrying the E484K escape mutation medRxiv 2021 34100027
1450G>A E484K Impact of BNT162b first vaccination on the immune transcriptome of elderly patients infected with the B.1.351 SARS-CoV-2 variant medRxiv 2021 34013280
1450G>A E484K Impact of BNT162b First Vaccination on the Immune Transcriptome of Elderly Patients Infected with the B.1.351 SARS-CoV-2 Variant Res Sq 2021 34100009
1450G>A E484K Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity Nature 2021 34634791
1450G>A E484K Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan Epidemiol Infect 2021 33908339
1450G>A E484K Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells Biomolecules 2022 36139010
1450G>A E484K Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant-Associated Receptor Binding Domain (RBD) Mutations on the Susceptibility to Serum Antibodies Elicited by Coronavirus Disease 2019 (COVID-19) Infection or Vaccination Clin Infect Dis 2022 34309648
1450G>A E484K Implication of SARS-CoV-2 Immune Escape Spike Variants on Secondary and Vaccine Breakthrough Infections Front Immunol 2021 34804022
1450G>A E484K Inadequate design of mutation detection panels prevents interpretation of variants of concern: results of an external quality assessment for SARS-CoV-2 variant detection Clin Chem Lab Med 2022 34751522
1450G>A E484K Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization Res Sq 2021 33532763
1450G>A E484K Influence of treatment with neutralizing monoclonal antibodies on the SARS-CoV-2 nasopharyngeal load and quasispecies Clin Microbiol Infect 2022 34537363
1450G>A E484K Insights into SARS-CoV-2's Mutations for Evading Human Antibodies: Sacrifice and Survival J Med Chem 2022 33834772
1450G>A E484K Insights into the Binding of Receptor-Binding Domain (RBD) of SARS-CoV-2 Wild Type and B.1.620 Variant with hACE2 Using Molecular Docking and Simulation Approaches Biology (Basel) 2021 34943225
1450G>A E484K In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape Infect Genet Evol 2022 35149224
1450G>A E484K In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization Molecules 2022 36014415
1450G>A E484K In Silico Evaluation of SARS-CoV-2 K417N, L452R, and E484K Detection Assays Against Omicron Variants. New Microbiol 2023 37247233
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1450G>A E484K In silico investigations of heparin binding to SARS-CoV-2 variants with a focus at the RBD/ACE2 interface Process Biochem 2022 35194375
1450G>A E484K Introduction and rapid dissemination of SARS-CoV-2 Gamma Variant of Concern in Venezuela Infect Genet Evol 2021 34800714
1450G>A E484K Investigation on the interaction mechanism of different SARS-CoV-2 spike variants with hACE2: insights from molecular dynamics simulations Phys Chem Chem Phys 2023 36597957
1450G>A E484K In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion Allergy 2022 34453338
1450G>A E484K In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four Mutants Pharmaceuticals (Basel) 2021 34681279
1450G>A E484K In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains Res Sq 2021 34013259
1450G>A E484K In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential Cell Rep 2021 34648735
1450G>A E484K Key Interacting Residues between RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics Simulation and Density Functional Calculation J Chem Inf Model 2021 34428371
1450G>A E484K Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2: a molecular dynamics study Nanoscale 2021 33999091
1450G>A E484K Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects. J Virol 2022 34668774
1450G>A E484K Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization bioRxiv 2021 33442690
1450G>A E484K Limited Neutralization of Authentic Severe Acute Respiratory Syndrome Coronavirus 2 Variants Carrying E484K In Vitro J Infect Dis 2021 34223909
1450G>A E484K Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France. Arch Virol 2022 35083577
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1450G>A E484K LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants bioRxiv 2022 33972947
1450G>A E484K Machine Learning Reveals the Critical Interactions for SARS-CoV-2 Spike Protein Binding to ACE2 J Phys Chem Lett 2021 34086459
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1450G>A E484K Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 Receptor Molecules 2022 35408761
1450G>A E484K Molecular Epidemiology of SARS-CoV-2 during Five COVID-19 Waves and the Significance of Low-Frequency Lineages Viruses 2023 37243279
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1450G>A E484K Molecular insights into the interaction of eighteen different variants of SARS-CoV-2 spike proteins with sixteen therapeutically important phytocompounds: in silico approach J Biomol Struct Dyn 2023 36690609
1450G>A E484K Molecular strategies for antibody binding and escape of SARS-CoV-2 and its mutations Sci Rep 2021 34741079
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1450G>A E484K Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern EBioMedicine 2022 35078012
1450G>A E484K mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2 Med 2022 35584653
1450G>A E484K mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants bioRxiv 2021 33501442
1450G>A E484K mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants bioRxiv 2021 33501451
1450G>A E484K mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants Nature 2021 33567448
1450G>A E484K Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient Swiss Med Wkly 2022 35748061
1450G>A E484K Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants bioRxiv 2021 33688659
1450G>A E484K Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity Cell 2021 33743213
1450G>A E484K Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity medRxiv 2021 33619506
1450G>A E484K Multiplexed Lab-on-a-Chip Bioassays for Testing Antibodies against SARS-CoV-2 and Its Variants in Multiple Individuals Anal Chem 2022 35080377
1450G>A E484K Multiplex SARS-CoV-2 Genotyping Reverse Transcriptase PCR for Population-Level Variant Screening and Epidemiologic Surveillance J Clin Microbiol 2021 34037430
1450G>A E484K Mutational Effect of Some Major COVID-19 Variants on Binding of the S Protein to ACE2 Biomolecules 2022 35454161
1450G>A E484K Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates J Biomol Struct Dyn 2022 34633892
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1450G>A E484K Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants ACS Omega 2021 34805715
1450G>A E484K Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia Infect Genet Evol 2022 34933126
1450G>A E484K Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern Microorganisms 2021 33925854
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1450G>A E484K Mutations in the receptor-binding domain of human SARS CoV-2 spike protein increases its affinity to bind human ACE-2 receptor J Biomol Struct Dyn 2023 35109768
1450G>A E484K Mutations of SARS-CoV-2 RBD May Alter Its Molecular Structure to Improve Its Infection Efficiency Biomolecules 2021 34572486
1450G>A E484K Mutation-Specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation J Clin Microbiol 2021 34011523
1450G>A E484K Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein. J Biomol Struct Dyn 2022 34463219
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1450G>A E484K Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677H mBio 2021 34607452
1450G>A E484K Neutralization of viruses with European, South African, and United States SARS-CoV-2 variant spike proteins by convalescent sera and BNT162b2 mRNA vaccine-elicited antibodies. bioRxiv 2021 33564768
1450G>A E484K Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants medRxiv 2021 33821288
1450G>A E484K Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants Nat Commun 2021 34312390
1450G>A E484K Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants Res Sq 2021 33851150
1450G>A E484K Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K Front Med (Lausanne) 2021 34262921
1450G>A E484K Novel Lateral Flow-Based Assay for Simple and Visual Detection of SARS-CoV-2 Mutations Front Cell Infect Microbiol 2022 35909973
1450G>A E484K Novel SARS-CoV-2 variants: the pandemics within the pandemic Clin Microbiol Infect 2021 34015535
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1450G>A E484K Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies Front Immunol 2021 35140714
1450G>A E484K Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model Vaccine 2022 35101265
1450G>A E484K Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera iScience 2021 34723159
1450G>A E484K Performance evaluation of Novaplex SARS-CoV-2 variants assay kit series for SARS-CoV-2 detection using single nucleotide polymorphisms Access Microbiol 2022 36415740
1450G>A E484K Pervasive transmission of E484K and emergence of VUI-NP13L with evidence of SARS-CoV-2 co-infection events by two different lineages in Rio Grande do Sul, Brazil. Virus Res 2021 33631222
1450G>A E484K Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms Microb Genom 2021 34846283
1450G>A E484K Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concern. Virology 2022 35580380
1450G>A E484K Polysulfates Block SARS-CoV-2 Uptake through Electrostatic Interactions* Angew Chem Int Ed Engl 2021 33860605
1450G>A E484K Post-Vaccination Coronavirus Disease 2019: A Case-Control Study and Genomic Analysis of 119 Breakthrough Infections in Partially Vaccinated Individuals Clin Infect Dis 2022 34410361
1450G>A E484K Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study Microbiol Spectr 2021 34787439
1450G>A E484K Post-vaccination SARS-CoV-2 infections and incidence of the B.1.427/B.1.429 variant among healthcare personnel at a northern California academic medical center medRxiv 2021 33907767
1450G>A E484K Post-Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections and Incidence of the Presumptive B.1.427/B.1.429 Variant Among Healthcare Personnel at a Northern California Academic Medical Center Clin Infect Dis 2022 34137815
1450G>A E484K Potential inhibitor for blocking binding between ACE2 and SARS-CoV-2 spike protein with mutations Biomed Pharmacother 2022 35279013
1450G>A E484K Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants Nat Commun 2021 34728625
1450G>A E484K Prediction of SARS-CoV-2 Variant Lineages Using the S1-Encoding Region Sequence Obtained by PacBio Single-Molecule Real-Time Sequencing Viruses 2021 34960813
1450G>A E484K Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California. Nat Microbiol 2022 35013591
1450G>A E484K Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021. Pathogens 2021 34451453
1450G>A E484K Prenol, but Not Vitamin C, of Fruit Binds to SARS-CoV-2 Spike S1 to Inhibit Viral Entry: Implications for COVID-19. J Immunol 2023 37144841
1450G>A E484K Probing the mutational landscape of the SARS-CoV-2 spike protein via quantum mechanical modeling of crystallographic structures PNAS Nexus 2022 36712320
1450G>A E484K Prolonged SARS-CoV-2 RNA shedding in a young man recovering from traumatic pneumothorax S Afr Med J 2022 35139987
1450G>A E484K Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect Phytother Res 2021 34472141
1450G>A E484K Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients Commun Biol 2022 35505237
1450G>A E484K Rapid and Accurate Identification of SARS-CoV-2 Variants Using Real Time PCR Assays Front Cell Infect Microbiol 2022 35619652
1450G>A E484K Rapid and Flexible RT-qPCR Surveillance Platforms To Detect SARS-CoV-2 Mutations Microbiol Spectr 2023 36625603
1450G>A E484K Rapid and qualitative identification of SARS-CoV-2 mutations associated with variants of concern using a multiplex RT-PCR assay coupled with melting analysis Int J Infect Dis 2022 35760381
1450G>A E484K Rapid and simultaneous identification of three mutations by the Novaplex�?SARS-CoV-2 variants I assay kit J Clin Virol 2021 34134034
1450G>A E484K Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection Diagnostics (Basel) 2021 34679517
1450G>A E484K Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assays Diagn Microbiol Infect Dis 2022 36122486
1450G>A E484K Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant - New York City, New York, January 1-April 5, 2021. MMWR Morb Mortal Wkly Rep 2021 33983915
1450G>A E484K Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display bioRxiv 2021 34545362
1450G>A E484K Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display Cell Rep 2022 35114110
1450G>A E484K [Rapid identification of SARS-CoV-2 main variants using real-time quantitative PCR assay] Sheng Wu Gong Cheng Xue Bao 2022 35786474
1450G>A E484K Rapid Identification of SARS-CoV-2 Variants of Concern Using a Portable peakPCR Platform Anal Chem 2021 34852455
1450G>A E484K Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021 mSystems 2021 34128696
1450G>A E484K RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 Receptor Viruses 2021 35062205
1450G>A E484K RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge Transl Res 2022 35489692
1450G>A E484K Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic Infect Genet Evol 2021 34146731
1450G>A E484K Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants. J Biol Chem 2021 34543625
1450G>A E484K Recognition through GRP78 is enhanced in the UK, South African, and Brazilian variants of SARS-CoV-2; An in silico perspective. Biochem Biophys Res Commun 2021 34049205
1450G>A E484K Recombinant SARS-CoV-2 genomes are currently circulating at low levels bioRxiv 2021 33758853
1450G>A E484K Recombinant SARS-CoV-2 genomes circulated at low levels over the first year of the pandemic Virus Evol 2021 36793768
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1450G>A E484K Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies Nat Med 2021 33664494
1450G>A E484K Retrospective review of re-positive qPCR tests for SARS-CoV: do they indicate presence of reinfection? Eur Rev Med Pharmacol Sci 2022 35916828
1450G>A E484K Review of the mechanisms of SARS-CoV-2 evolution and transmission ArXiv 2021 34545334
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1450G>A E484K SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape Cell 2021 33735608
1450G>A E484K SARS-CoV-2 B.1.1.7 and B.1.351 Spike variants bind human ACE2 with increased affinity bioRxiv 2021 33655251
1450G>A E484K SARS-CoV-2 B.1.1.7 lineage rapidly spreads and replaces R.1 lineage in Japan: Serial and stationary observation in a community Infect Genet Evol 2021 34560289
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1450G>A E484K SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression Microorganisms 2022 35056592
1450G>A E484K SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes Nat Commun 2021 33976134
1450G>A E484K SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys Lancet Respir Med 2022 35085490
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1450G>A E484K SARS-CoV-2 spike E484K mutation reduces antibody neutralisation Lancet Microbe 2021 33846703
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1450G>A E484K SARS-CoV-2 testing and sequencing for international arrivals reveals significant cross border transmission of high risk variants into the United Kingdom EClinicalMedicine 2021 34278277
1450G>A E484K SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact Cell Signal 2023 37423342
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1450G>A E484K SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution Nat Microbiol 2021 34400835
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1450G>A E484K SARS-CoV-2 Variants: Mutations and Effective Changes Biotechnol Bioprocess Eng 2021 34975266
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1450G>A E484K Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Mutational Pattern in the Fourth Pandemic Phase in Greece Curr Issues Mol Biol 2022 35723403
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1450G>A E484K Stay-At-Home Orders Are Associated With Emergence of Novel SARS-CoV-2 Variants Cureus 2021 33728228
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1450G>A E484K Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants bioRxiv 2021 33619487
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1450G>A E484K Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex J Biomol Struct Dyn 2022 33583326
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1450G>A E484K Synthetic proteins for COVID-19 diagnostics Peptides 2021 34087220
1450G>A E484K Targeted Sanger sequencing to recover key mutations in SARS-CoV-2 variant genome assemblies produced by next-generation sequencing Microb Genom 2022 35294336
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1450G>A E484K Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization. Commun Biol 2021 34645933
1450G>A E484K The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants Cell Host Microbe 2022 34921776
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1450G>A E484K The Biological Properties of the SARS-CoV-2 Cameroon Variant Spike: An Intermediate between the Alpha and Delta Variants Pathogens 2022 35890058
1450G>A E484K The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another J Virol Methods 2021 34332998
1450G>A E484K The Development of SARS-CoV-2 Variants: The Gene Makes the Disease J Dev Biol 2021 34940505
1450G>A E484K The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera medRxiv 2021 33532796
1450G>A E484K The E484K Substitution in a SARS-CoV-2 Spike Protein Subunit Vaccine Resulted in Limited Cross-Reactive Neutralizing Antibody Responses in Mice Viruses 2022 35632595
1450G>A E484K The effect of the E484K mutation of SARS-CoV-2 on the neutralizing activity of antibodies from BNT162b2 vaccinated individuals Vaccine 2022 35183387
1450G>A E484K The Emergence and Spread of Novel SARS-CoV-2 Variants Front Public Health 2021 34409009
1450G>A E484K The emerging SARS-CoV-2 variants of concern Ther Adv Infect Dis 2021 34211709
1450G>A E484K The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum EBioMedicine 2021 34419925
1450G>A E484K The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus Viruses 2021 33917138
1450G>A E484K The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD medRxiv 2021 33758878
1450G>A E484K The Prevalence of Protein S Variant in Patients Diagnosed with COVID-19 Clin Lab 2022 36250839
1450G>A E484K Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant Biochem Biophys Res Commun 2021 34119826
1450G>A E484K The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants. Front Public Health 2021 35047474
1450G>A E484K Thermodynamics and kinetics in antibody resistance of the 501Y.V2 SARS-CoV-2 variant RSC Adv 2021 35497518
1450G>A E484K The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction Perspective Chembiochem 2022 34529328
1450G>A E484K The SARS-CoV-2 B.1.618 variant slightly alters the spike RBD-ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective RSC Adv 2021 35480256
1450G>A E484K Tracking SARS-CoV-2 variants through pandemic waves using RT-PCR testing in low-resource settings PLOS Glob Public Health 2023 37262051
1450G>A E484K Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences. Am J Pathol 2021 34303698
1450G>A E484K Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS-CoV-2, MERS-CoV, Ebola, Zika, HIV-1, and influenza A virus. J Med Virol 2022 35655326
1450G>A E484K Two-Period Study Results from a Large Italian Hospital Laboratory Attesting SARS-CoV-2 Variant PCR Assay Evolution Microbiol Spectr 2022 36409091
1450G>A E484K Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants bioRxiv 2021 33821267
1450G>A E484K Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice bioRxiv 2021 33688650
1450G>A E484K Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease Cell Host Microbe 2021 34192518
1450G>A E484K Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis Viruses 2023 37112836
1450G>A E484K Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2) J Biomol Struct Dyn 2022 34495817
1450G>A E484K Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells Front Neurosci 2023 36875642
1450G>A E484K Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDs. Diagnostics (Basel) 2021 34208912
1450G>A E484K Vaccination using mutated receptor binding domains of SARS-CoV-2: Evidence for partial immune escape but not serotype formation Front Immunol 2023 36845100
1450G>A E484K Vaccine Breakthrough Infections with SARS-CoV-2 Variants N Engl J Med 2021 33882219
1450G>A E484K Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries. Genomics 2021 34004284
1450G>A E484K Validation and advantages of using novel RT-qPCR melting curve analysis assays for the identification of SARS-CoV-2 variants Sci Rep 2022 35906388
1450G>A E484K Variable neutralizing antibody responses to 10 SARS-CoV-2 variants in natural infection with wild- type (B.1) virus, Kappa (B.1.617.1), and Delta (B.1.617.2) variants and COVISHIELD vaccine immunization in India: utility of the MSD platform. Front Immunol 2023 37342350
1450G>A E484K Variants of SARS-CoV-2, their effects on infection, transmission and neutralization by vaccine-induced antibodies. Eur Rev Med Pharmacol Sci 2021 34604978
1450G>A E484K Variation in the prevalence of cough symptoms 4-5 days after infection with SARS-CoV-2 between seasons with different prevalent strains J Gen Fam Med 2022 35600908
1450G>A E484K Wastewater surveillance of SARS-CoV-2 genomic populations on a country-wide scale through targeted sequencing PLoS One 2023 37083889
1450G>A E484K Whole Sequencing and Detailed Analysis of SARS-CoV-2 Genomes in Southeast Spain: Identification of Recurrent Mutations in the 20E (EU1) Variant with Some Clinical Implications Diseases 2023 37092436
1450G>A E484K Wild type and variants of SARS-COV-2 in Parisian sewage: presence in raw water and through processes in wastewater treatment plants Environ Sci Pollut Res Int 2022 36029443
1450G>A E484K Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines? J Korean Med Sci 2021 33975397