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The current mutation

ID: V4863
DNA: 37G>A
Protein: A13T
Position: 27430








COV2Var annotation categories







Summary information of mutation (37G>A)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp07
  Gene Name   ORF7a
  Gene Type   protein_coding
  Genome position   27430
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   missense_variant
  DNA Level   DNA Mutation: 37G>A
  Ref Seq: G
  Mut Seq: A
  Protein Level   Protein 1-letter Mutation: A13T
  Protein 3-letter Mutation: Ala13Thr

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (37G>A) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.1.284 17 6 3.53e-1
2020-10 B.1.2 17 4 2.35e-1
2020-10 B.1.324 17 3 1.76e-1
2020-11 B.1.1 15 2 1.33e-1
2020-11 B.1.1.1 15 2 1.33e-1
2020-11 B.1.1.312 15 2 1.33e-1
2020-12 B.1.177 47 9 1.91e-1
2020-12 B.1.1 47 8 1.70e-1
2020-12 B.1.1.158 47 8 1.70e-1
2020-03 B.1.1 19 17 8.95e-1
2020-03 B.1 19 1 5.26e-2
2020-03 B.1.356 19 1 5.26e-2
2020-04 B.1.1 4 2 5.00e-1
2020-04 B.1 4 1 2.50e-1
2020-04 B.1.93 4 1 2.50e-1
2020-05 B.1 1 1 1.00e+0
2020-06 B.1.1.158 8 6 7.50e-1
2020-06 B.1 8 2 2.50e-1
2020-07 B.1.1.158 23 14 6.09e-1
2020-07 B.1.1 23 6 2.61e-1
2020-07 B.1.206 23 1 4.35e-2
2020-08 B.1.1.158 22 8 3.64e-1
2020-08 B.1.1 22 5 2.27e-1
2020-08 B.1.1.284 22 5 2.27e-1
2020-09 B.1.1.284 12 7 5.83e-1
2020-09 B.1.1.158 12 2 1.67e-1
2020-09 B.1 12 1 8.33e-2
2021-01 B.1.1.158 29 6 2.07e-1
2021-01 B.1.1.7 29 6 2.07e-1
2021-01 B.1.2 29 4 1.38e-1
2021-10 AY.122 869 731 8.41e-1
2021-10 AY.64 869 43 4.95e-2
2021-10 AY.4 869 15 1.73e-2
2021-11 AY.122 843 537 6.37e-1
2021-11 AY.64 843 89 1.06e-1
2021-11 AY.4 843 81 9.61e-2
2021-12 AY.122 588 336 5.71e-1
2021-12 AY.44 588 54 9.18e-2
2021-12 AY.4 588 47 7.99e-2
2021-02 B.1.177.67 71 22 3.10e-1
2021-02 B.1.177 71 8 1.13e-1
2021-02 B.1.2 71 7 9.86e-2
2021-03 B.1.2 90 29 3.22e-1
2021-03 P.2 90 19 2.11e-1
2021-03 B.1.1.7 90 11 1.22e-1
2021-04 B.1.1.7 110 78 7.09e-1
2021-04 P.2 110 11 1.00e-1
2021-04 B.1.1.519 110 5 4.55e-2
2021-05 B.1.1.7 41 25 6.10e-1
2021-05 B.1.1.519 41 4 9.76e-2
2021-05 P.1 41 3 7.32e-2
2021-06 B.1.1.7 34 10 2.94e-1
2021-06 AY.122 34 6 1.76e-1
2021-06 B.1.635 34 4 1.18e-1
2021-07 AY.122 477 344 7.21e-1
2021-07 AY.7 477 91 1.91e-1
2021-07 B.1.617.2 477 12 2.52e-2
2021-08 AY.122 1017 799 7.86e-1
2021-08 AY.7 1017 118 1.16e-1
2021-08 AY.103 1017 17 1.67e-2
2021-09 AY.122 1019 905 8.88e-1
2021-09 AY.7 1019 21 2.06e-2
2021-09 AY.103 1019 16 1.57e-2
2022-01 BA.2 393 187 4.76e-1
2022-01 BA.1.17.2 393 83 2.11e-1
2022-01 BA.1.1 393 21 5.34e-2
2022-10 BQ.1.1.2 206 105 5.10e-1
2022-10 BE.1 206 66 3.20e-1
2022-10 DU.1 206 10 4.85e-2
2022-11 BQ.1.1.2 388 297 7.65e-1
2022-11 DU.1 388 25 6.44e-2
2022-11 BE.1 388 10 2.58e-2
2022-12 BQ.1.1.2 1156 781 6.76e-1
2022-12 DU.1 1156 274 2.37e-1
2022-12 BQ.1.1.31 1156 14 1.21e-2
2022-02 BA.2 653 429 6.57e-1
2022-02 BA.2.10 653 76 1.16e-1
2022-02 BA.1.17.2 653 40 6.13e-2
2022-03 BA.2 597 482 8.07e-1
2022-03 BA.2.10 597 82 1.37e-1
2022-03 BA.1.1 597 14 2.35e-2
2022-04 BA.2 388 325 8.38e-1
2022-04 BA.2.10 388 37 9.54e-2
2022-04 BA.1.1.2 388 13 3.35e-2
2022-05 BA.2 169 125 7.40e-1
2022-05 BA.2.10 169 25 1.48e-1
2022-05 BA.1.1 169 4 2.37e-2
2022-06 BE.1 116 68 5.86e-1
2022-06 BA.2 116 17 1.47e-1
2022-06 BA.2.9 116 17 1.47e-1
2022-07 BE.1 312 275 8.81e-1
2022-07 BA.5.3.1 312 11 3.53e-2
2022-07 BA.2 312 5 1.60e-2
2022-08 BE.1 262 236 9.01e-1
2022-08 BA.5.3.1 262 4 1.53e-2
2022-08 BA.5.5 262 3 1.15e-2
2022-09 BE.1 168 135 8.04e-1
2022-09 BA.4.6 168 6 3.57e-2
2022-09 BF.10 168 5 2.98e-2
2023-01 BQ.1.1.2 920 475 5.16e-1
2023-01 DU.1 920 357 3.88e-1
2023-01 BA.5.2.6 920 11 1.20e-2
2023-02 DU.1 428 189 4.42e-1
2023-02 BQ.1.1.2 428 184 4.30e-1
2023-02 XBB.1.5 428 39 9.11e-2

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V4863 AY.122 1.78e-2 3670 2020-7-16 2022-9-9
V4863 AY.64 8.48e-2 157 2021-4-4 2021-12-29
V4863 AY.7 4.51e-2 234 2021-5-1 2022-1-15
V4863 B.1.1.158 2.50e-1 22 2020-6-1 2021-1-13
V4863 B.1.1.243 1.48e-2 4 2020-4-24 2021-4-26
V4863 B.1.177.67 1.92e-1 24 2020-11-5 2021-4-22
V4863 B.1.635 7.55e-2 4 2021-1-16 2021-6-18
V4863 BA.1.1.6 1.13e-2 9 2021-12-5 2022-7-11
V4863 BA.1.1.8 1.83e-2 18 2021-11-26 2022-3-29
V4863 BE.1 2.84e-2 798 2022-1-5 2023-2-16
V4863 BE.1.3 1.83e-2 18 2022-5-18 2023-2-16
V4863 BL.2 2.45e-2 16 2022-6-9 2023-1-30
V4863 BQ.1.1.2 8.86e-1 1845 2022-8-10 2023-2-21
V4863 DU.1 7.22e-1 855 2022-10-4 2023-2-23
V4863 P.7 1.93e-2 5 2020-7-1 2021-5-30






Examining mutation (37G>A) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID




Association between mutation (37G>A) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory 1.76e-1 4.25e-1 4.14e-1 6.79e-1 Increase
Deceased -8.23e-3 5.31e-1 -1.55e-2 9.88e-1 Decrease
Homebound -1.42e+1 1.54e+3 -9.22e-3 9.93e-1 Decrease
Hospitalized -3.34e+0 5.15e-1 -6.47e+0 9.57e-11 Decrease
Mild -8.57e-1 4.67e-1 -1.84e+0 6.64e-2 Decrease
Recovered 2.47e+0 2.66e-1 9.28e+0 1.76e-20 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 1.83e-1 6.12e-2 2.99e+0 2.82e-3 Increase
18-39 -1.16e-1 3.76e-2 -3.07e+0 2.15e-3 Decrease
40-64 -8.27e-2 3.80e-2 -2.17e+0 2.97e-2 Decrease
65-84 3.56e-2 5.19e-2 6.85e-1 4.93e-1 Increase
>=85 3.91e-1 8.55e-2 4.58e+0 4.75e-6 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male 2.46e-2 3.60e-2 6.82e-1 4.95e-1 Increase





Investigating natural selection at mutation (37G>A) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method
ORF7a 27394 27759 121 13 5.00e-2 BA.2.7 MEME
ORF7a 27394 27759 121 13 4.00e-2 BE.8 MEME

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method
ORF7a 27394 27759 121 13 11.75 0.00 2.00e-2 BQ.1.5 FEL
ORF7a 27394 27759 121 13 6.14 0.00 3.00e-2 XBF FEL
ORF7a 27394 27759 121 13 0.00 10.80 5.00e-2 AY.7 FEL
ORF7a 27394 27759 121 13 5.72 0.48 1.00e-2 BQ.1 FEL

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method
ORF7a 27394 27759 121 13 9.60e-1 2.00e-2 BQ.1.5 FUBAR
ORF7a 27394 27759 121 13 0.00e+0 9.90e-1 AY.7 FUBAR
ORF7a 27394 27759 121 13 9.90e-1 1.00e-2 BQ.1 FUBAR




Alterations in protein physicochemical properties induced by mutation (37G>A)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY
Mutation ORF7a 13774.2 8.23 7450 99.92 0.298
Reference ORF7a 13744.17 8.23 7450 100.74 0.318




Alterations in protein stability induced by mutation (37G>A)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition
A13T ORF7a Point 13 -1.37 Decrease 7 25 Environment
A13T ORF7a Point 13 -1.35 Decrease 7.4 37 Internal




Impact on protein function induced by mutation (37G>A)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms
A13T ORF7a Point 0.068 Loss of Helix (Pr = 0.28 | P = 0.03)
Altered Cytoplasmic_loop (Pr = 0.27 | P = 6.0e-04)
Altered PPI_hotspot (Pr = 0.23 | P = 0.06)
Altered Signal_helix (Pr = 0.04 | P = 4.7e-03)




Exploring mutation (37G>A) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (37G>A)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites
A13T ORF7a 27430 Thermolysin NA
 LITLATCELY (pos: 12)




Impact of spike protein mutation (37G>A) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (37G>A) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

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Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

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        Show interface residues:





Impact of mutation (37G>A) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (37G>A) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V7765 14454G>A synonymous_variant ORF1ab_pp1ab K4818K 7.03e-1 B.1.177
V3774 754G>A missense_variant S G252S 6.76e-1 AY.5
V1488 6271G>A missense_variant ORF1ab_pp1a G2091S 7.73e-1 AY.103
V4117 2635G>T missense_variant S A879S 8.05e-1 AY.122
V7299 10830C>T synonymous_variant ORF1ab_pp1a A3610A 6.04e-1 AY.44
V1441 6136C>T missense_variant ORF1ab_pp1a P2046S 8.85e-1 BA.2.10
V7224 10206A>G synonymous_variant ORF1ab_pp1a S3402S 7.07e-1 AY.102
V2744 15718G>A missense_variant ORF1ab_pp1ab V5240I 1.00e+0 AY.113
V3256 19552G>T missense_variant ORF1ab_pp1ab V6518L 8.16e-1 AY.113
V1017 3472C>T missense_variant ORF1ab_pp1a P1158S 9.63e-1 AY.116
V4842 -5C>T upstream_gene_variant ORF7a None 7.76e-1 AY.116
V5770 *4353G>T downstream_gene_variant S None 8.15e-1 AY.116
V7995 16275T>C synonymous_variant ORF1ab_pp1ab D5425D 6.81e-1 AY.116
V9201 399C>T synonymous_variant ORF3a C133C 9.63e-1 AY.116
V8840 1668C>T synonymous_variant S N556N 1.00e+0 AY.27
V7861 15216C>T synonymous_variant ORF1ab_pp1ab T5072T 7.07e-1 AY.29.1
V6748 6408T>C synonymous_variant ORF1ab_pp1a D2136D 7.07e-1 AY.30
V4391 148G>T missense_variant ORF3a V50F 1.00e+0 AY.34.1
V1231 4760C>T missense_variant ORF1ab_pp1a S1587L 7.07e-1 AY.34
V9413 159T>C synonymous_variant ORF6 D53D 7.07e-1 AY.34
V2038 10184C>T missense_variant ORF1ab_pp1a P3395L 1.00e+0 AY.36
V5410 497C>T missense_variant N T166I 1.00e+0 AY.36
V4020 2039C>T missense_variant S S680F 8.45e-1 AY.42
V571 1675G>A missense_variant ORF1ab_pp1a V559M 7.07e-1 AY.42
V9432 105C>T synonymous_variant ORF7a C35C 1.00e+0 AY.42
V3536 59C>T missense_variant S T20I 1.00e+0 AY.4.7
V5167 209C>T missense_variant ORF8 P70L 1.00e+0 AY.4.7
V3053 18073G>T missense_variant ORF1ab_pp1ab A6025S 7.01e-1 AY.64
V5484 630G>T missense_variant N M210I 9.86e-1 AY.64
V5885 264G>A synonymous_variant ORF1ab_pp1a L88L 8.81e-1 AY.64
V6014 1023C>T synonymous_variant ORF1ab_pp1a C341C 1.00e+0 AY.7.2
V6824 7056C>T synonymous_variant ORF1ab_pp1a S2352S 8.16e-1 AY.7.2
V8039 16651C>T synonymous_variant ORF1ab_pp1ab L5551L 1.00e+0 AY.7.2
V6014 1023C>T synonymous_variant ORF1ab_pp1a C341C 8.38e-1 AY.7
V6824 7056C>T synonymous_variant ORF1ab_pp1a S2352S 8.76e-1 AY.7
V8369 18999C>T synonymous_variant ORF1ab_pp1ab N6333N 7.07e-1 AY.85
V1435 6103G>A missense_variant ORF1ab_pp1a G2035R 1.00e+0 AY.88
V3582 205C>T missense_variant S H69Y 1.00e+0 AY.88
V4091 2485G>A missense_variant S A829T 1.00e+0 AY.88
V4117 2635G>T missense_variant S A879S 1.00e+0 AY.88
V4208 3398T>C missense_variant S V1133A 1.00e+0 AY.88
V6803 6888T>C synonymous_variant ORF1ab_pp1a D2296D 1.00e+0 AY.88
V9035 3186C>T synonymous_variant S F1062F 1.00e+0 AY.88
V2466 13304C>T missense_variant ORF1ab_pp1ab A4435V 8.16e-1 AY.98.1
V1467 6211G>T missense_variant ORF1ab_pp1a V2071F 7.55e-1 B.1.1.216
V3627 412G>C missense_variant S D138H 7.96e-1 B.1.1.216
V5116 116T>C missense_variant ORF8 I39T 8.35e-1 B.1.1.216
V5496 643G>T missense_variant N G215C 8.44e-1 B.1.1.216
V6415 3969C>T synonymous_variant ORF1ab_pp1a D1323D 8.56e-1 B.1.1.216
V7102 9294C>T synonymous_variant ORF1ab_pp1a Y3098Y 8.44e-1 B.1.1.216
V7403 11697C>T synonymous_variant ORF1ab_pp1a L3899L 1.00e+0 B.1.1.216
V9002 2880C>T synonymous_variant S N960N 9.25e-1 B.1.1.216
V9112 3645C>T synonymous_variant S Y1215Y 6.52e-1 B.1.1.216
V1750 7982C>T missense_variant ORF1ab_pp1a S2661F 9.73e-1 B.1.1.284
V5437 572G>T missense_variant N R191L 8.82e-1 B.1.1.284
V5858 117A>G synonymous_variant ORF1ab_pp1a L39L 6.23e-1 B.1.1.284
V1708 7766A>G missense_variant ORF1ab_pp1a K2589R 7.07e-1 B.1.1.317
V6629 5541C>T synonymous_variant ORF1ab_pp1a C1847C 7.07e-1 B.1.1.318
V1354 5621C>T missense_variant ORF1ab_pp1a T1874I 7.07e-1 B.1.1.33
V4664 31A>G missense_variant E T11A 1.00e+0 B.1.1.33
V6920 7872G>T synonymous_variant ORF1ab_pp1a V2624V 7.07e-1 B.1.1.33
V7884 15405T>C synonymous_variant ORF1ab_pp1ab N5135N 1.00e+0 B.1.1.33
V3737 641G>T missense_variant S R214L 1.00e+0 B.1.1.39
V5847 81C>T synonymous_variant ORF1ab_pp1a L27L 1.00e+0 B.1.1.39
V9553 333T>C synonymous_variant ORF8 Y111Y 6.12e-1 B.1.160
V1696 7689G>T missense_variant ORF1ab_pp1a Q2563H 1.00e+0 B.1.177.60
V3434 20727G>T missense_variant ORF1ab_pp1ab L6909F 1.00e+0 B.1.177.60
V3735 638T>G missense_variant S V213G 1.00e+0 B.1.177.60
V3884 1354C>A missense_variant S L452M 1.00e+0 B.1.177.60
V3940 1640C>T missense_variant S T547I 7.07e-1 B.1.177.60
V7355 11400C>T synonymous_variant ORF1ab_pp1a L3800L 1.00e+0 B.1.177.60
V9335 339T>C synonymous_variant M N113N 7.07e-1 B.1.177.60
V1730 7858C>T missense_variant ORF1ab_pp1a L2620F 7.07e-1 B.1.221
V1805 8372C>T missense_variant ORF1ab_pp1a T2791I 7.07e-1 B.1.221
V4811 57G>T missense_variant ORF6 M19I 7.07e-1 B.1.221
V4818 85C>T missense_variant ORF6 L29F 7.07e-1 B.1.221
V615 1825A>G missense_variant ORF1ab_pp1a T609A 7.07e-1 B.1.221
V6272 2811A>G synonymous_variant ORF1ab_pp1a E937E 7.07e-1 B.1.221
V7909 15631C>T synonymous_variant ORF1ab_pp1ab L5211L 7.07e-1 B.1.221
V1938 9296C>T missense_variant ORF1ab_pp1a S3099L 1.00e+0 B.1.320
V2550 13856C>T missense_variant ORF1ab_pp1ab P4619L 7.07e-1 B.1.320
V3265 19630G>A missense_variant ORF1ab_pp1ab A6544T 1.00e+0 B.1.320
V4992 340T>C missense_variant ORF7a F114L 1.00e+0 B.1.320
V9519 102T>C synonymous_variant ORF8 D34D 1.00e+0 B.1.320
V8929 2367C>T synonymous_variant S Y789Y 1.00e+0 B.1.356
V2154 11001G>T missense_variant ORF1ab_pp1a L3667F 1.00e+0 B.1.36.29
V3864 1289C>T missense_variant S T430I 7.07e-1 B.1.36.29
V3960 1747G>C missense_variant S E583Q 1.00e+0 B.1.36.29
V5216 352T>G missense_variant ORF8 L118V 1.00e+0 B.1.36.29
V5222 357_358insCTG conservative_inframe_insertion ORF8 D119_F120insL 7.07e-1 B.1.36.29
V6573 5091T>C synonymous_variant ORF1ab_pp1a D1697D 7.07e-1 B.1.36.29
V9301 103C>T synonymous_variant M L35L 1.00e+0 B.1.36.29
V5600 1093C>T missense_variant N P365S 9.48e-1 B.1.517
V4194 3337C>A missense_variant S Q1113K 1.00e+0 B.1.525
V7272 10603C>T synonymous_variant ORF1ab_pp1a L3535L 1.00e+0 B.1.596
V4693 214G>T missense_variant E D72Y 1.00e+0 B.1.637
V6944 8058T>C synonymous_variant ORF1ab_pp1a R2686R 1.00e+0 B.1.637
V3081 18247C>T missense_variant ORF1ab_pp1ab P6083S 1.00e+0 B.1.93
V8964 2568C>T synonymous_variant S N856N 1.00e+0 B.1.93
V5435 568A>G missense_variant N S190G 1.00e+0 BA.1.1.12
V3748 665C>T missense_variant S A222V 7.07e-1 BA.1.13
V1021 3478C>T missense_variant ORF1ab_pp1a H1160Y 1.00e+0 BA.1.1.8
V3109 18434C>T missense_variant ORF1ab_pp1ab A6145V 8.80e-1 BA.1.1.8
V7799 14673C>T synonymous_variant ORF1ab_pp1ab D4891D 7.07e-1 BA.1.21
V6354 3430C>T synonymous_variant ORF1ab_pp1a L1144L 1.00e+0 BA.1.6
V5711 83C>T missense_variant ORF10 A28V 7.07e-1 BA.2.29
V6968 8271G>A synonymous_variant ORF1ab_pp1a K2757K 1.00e+0 BA.2.29
V4284 3755C>T missense_variant S S1252F 7.07e-1 BA.2.3.1
V803 2668C>T missense_variant ORF1ab_pp1a L890F 1.00e+0 BA.2.3.7
V7647 13656G>A synonymous_variant ORF1ab_pp1ab K4552K 1.00e+0 BA.2.56
V4888 110C>T missense_variant ORF7a S37F 1.00e+0 BA.2.57
V5151 193G>T missense_variant ORF8 A65S 1.00e+0 BA.2.57
V2202 11206C>T missense_variant ORF1ab_pp1a L3736F 7.07e-1 BA.2.5
V1568 6661C>T missense_variant ORF1ab_pp1a P2221S 7.07e-1 BA.2.74
V9783 1080C>T synonymous_variant N Y360Y 7.07e-1 BA.2.74
V1203 4628C>T missense_variant ORF1ab_pp1a T1543I 1.00e+0 BA.2.75.1
V2889 16943A>G missense_variant ORF1ab_pp1ab Y5648C 7.07e-1 BA.2.75.1
V3825 1037G>T missense_variant S R346I 7.07e-1 BA.2.75.1
V3918 1465T>C missense_variant S Y489H 1.00e+0 BA.2.75.1
V5254 16C>A missense_variant N P6T 1.00e+0 BA.2.75.1
V7986 16179C>T synonymous_variant ORF1ab_pp1ab S5393S 1.00e+0 BA.2.75.1
V537 1570G>A missense_variant ORF1ab_pp1a G524S 8.94e-1 BA.4.1.8
V602 1771G>T missense_variant ORF1ab_pp1a A591S 7.07e-1 BA.4.1.8
V7613 13290C>T synonymous_variant ORF1ab_pp1ab Y4430Y 8.66e-1 BA.4.1.8
V7676 13854G>A synonymous_variant ORF1ab_pp1ab T4618T 6.66e-1 BA.4.1.8
V8230 18054G>T synonymous_variant ORF1ab_pp1ab G6018G 1.00e+0 BA.4.1.8
V347 812C>T missense_variant ORF1ab_pp1a P271L 1.00e+0 BA.5.1.3
V6977 8340C>T synonymous_variant ORF1ab_pp1a F2780F 7.07e-1 BA.5.2.12
V4417 191C>T missense_variant ORF3a T64I 8.66e-1 BA.5.2.20
V2466 13304C>T missense_variant ORF1ab_pp1ab A4435V 1.00e+0 BA.5.2.23
V2147 10978G>T missense_variant ORF1ab_pp1a V3660L 1.00e+0 BA.5.2.26
V377 925C>T missense_variant ORF1ab_pp1a P309S 7.07e-1 BA.5.2.26
V7742 14319C>T synonymous_variant ORF1ab_pp1ab H4773H 7.07e-1 BA.5.2.26
V4144 2862A>T missense_variant S Q954H -7.07e-1 BA.5.2.29
V4146 2907T>A missense_variant S N969K -7.07e-1 BA.5.2.29
V4586 650C>T missense_variant ORF3a T217I 7.07e-1 BA.5.2.29
V9448 168G>T synonymous_variant ORF7a L56L 1.00e+0 BA.5.2.29
V9170 186C>T synonymous_variant ORF3a I62I 6.70e-1 BA.5.2.2
V7456 12051A>G synonymous_variant ORF1ab_pp1a R4017R 7.63e-1 BA.5.2.6
V7356 11403C>T synonymous_variant ORF1ab_pp1a N3801N 7.07e-1 BA.5.3.1
V8809 1419T>C synonymous_variant S Y473Y 7.74e-1 BA.5.3.1
V7356 11403C>T synonymous_variant ORF1ab_pp1a N3801N 7.30e-1 BA.5.3
V3493 21101C>T missense_variant ORF1ab_pp1ab P7034L 6.32e-1 BA.5.9
V5811 *4390C>T downstream_gene_variant S None 7.07e-1 BA.5.9
V4213 3427C>T missense_variant S P1143S 1.00e+0 BC.1
V2241 11485C>T missense_variant ORF1ab_pp1a L3829F 6.97e-1 BE.1.3
V2576 13993T>C missense_variant ORF1ab_pp1ab Y4665H 6.39e-1 BE.1.3
V2860 16775A>G missense_variant ORF1ab_pp1ab N5592S 6.82e-1 BE.1.3
V341 783G>T missense_variant ORF1ab_pp1a K261N 6.53e-1 BE.1.3
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 6.27e-1 BE.1.3
V3780 758A>G missense_variant S D253G 8.80e-1 BE.1.3
V3824 1037G>C missense_variant S R346T 6.97e-1 BE.1.3
V3869 1331A>C missense_variant S K444T 6.67e-1 BE.1.3
V3890 1380T>A missense_variant S N460K 6.53e-1 BE.1.3
V6254 2689T>C synonymous_variant ORF1ab_pp1a L897L 6.39e-1 BE.1.3
V9564 39C>T synonymous_variant N P13P 6.15e-1 BE.1.3
V4154 3058G>T missense_variant S A1020S 7.07e-1 BE.1.4
V8649 201T>C synonymous_variant S A67A 1.00e+0 BE.1.4
V7356 11403C>T synonymous_variant ORF1ab_pp1a N3801N 9.76e-1 BE.1
V8036 16623C>T synonymous_variant ORF1ab_pp1ab Y5541Y 6.89e-1 BE.1
V8809 1419T>C synonymous_variant S Y473Y 8.41e-1 BE.1
V2513 13598C>T missense_variant ORF1ab_pp1ab T4533I 8.94e-1 BF.31
V3343 20120C>T missense_variant ORF1ab_pp1ab A6707V 1.00e+0 BF.31
V6717 6159A>G synonymous_variant ORF1ab_pp1a E2053E 1.00e+0 BF.31
V6866 7467C>T synonymous_variant ORF1ab_pp1a Y2489Y 7.06e-1 BF.31
V4562 569C>T missense_variant ORF3a T190I 1.00e+0 BF.7.6
V1244 4814C>T missense_variant ORF1ab_pp1a T1605I 7.07e-1 BF.8
V4535 512C>T missense_variant ORF3a S171L 7.07e-1 BF.8
V2889 16943A>G missense_variant ORF1ab_pp1ab Y5648C 1.00e+0 BL.1
V5254 16C>A missense_variant N P6T 1.00e+0 BL.1
V5815 *4397G>T downstream_gene_variant S None 7.07e-1 BL.1
V6080 1560C>T synonymous_variant ORF1ab_pp1a A520A 1.00e+0 BL.1
V6680 5961T>C synonymous_variant ORF1ab_pp1a H1987H 7.07e-1 BL.1
V6794 6816C>T synonymous_variant ORF1ab_pp1a N2272N 1.00e+0 BL.1
V7986 16179C>T synonymous_variant ORF1ab_pp1ab S5393S 7.07e-1 BL.1
V8508 20289A>G synonymous_variant ORF1ab_pp1ab L6763L 1.00e+0 BL.1
V1887 8871G>A missense_variant ORF1ab_pp1a M2957I 6.57e-1 BL.2
V2889 16943A>G missense_variant ORF1ab_pp1ab Y5648C 7.03e-1 BL.2
V5254 16C>A missense_variant N P6T 7.63e-1 BL.2
V6680 5961T>C synonymous_variant ORF1ab_pp1a H1987H 6.38e-1 BL.2
V7986 16179C>T synonymous_variant ORF1ab_pp1ab S5393S 7.03e-1 BL.2
V1305 5288A>G missense_variant ORF1ab_pp1a K1763R 1.00e+0 BM.1.1.1
V1887 8871G>A missense_variant ORF1ab_pp1a M2957I 1.00e+0 BM.1.1.1
V5254 16C>A missense_variant N P6T 1.00e+0 BM.1.1.1
V6680 5961T>C synonymous_variant ORF1ab_pp1a H1987H 1.00e+0 BM.1.1.1
V8508 20289A>G synonymous_variant ORF1ab_pp1ab L6763L 1.00e+0 BM.1.1.1
V2366 12476C>T missense_variant ORF1ab_pp1a T4159I 7.07e-1 BN.1.2
V3819 1015G>T missense_variant S G339C 7.07e-1 BN.1.2
V5988 861G>A synonymous_variant ORF1ab_pp1a R287R 7.07e-1 BN.1.2
V7336 11232C>T synonymous_variant ORF1ab_pp1a Y3744Y 8.16e-1 BN.1.3
V32 -126C>T upstream_gene_variant ORF1ab_pp1a None 7.07e-1 BQ.1.1.11
V2375 12524C>T missense_variant ORF1ab_pp1a T4175I 9.13e-1 BQ.1.1.15
V3780 758A>G missense_variant S D253G 1.00e+0 BQ.1.1.15
V6890 7671G>T synonymous_variant ORF1ab_pp1a A2557A 1.00e+0 BQ.1.1.15
V7164 9738T>C synonymous_variant ORF1ab_pp1a S3246S 9.13e-1 BQ.1.1.15
V8095 17022A>G synonymous_variant ORF1ab_pp1ab S5674S 1.00e+0 BQ.1.1.15
V3272 19687C>T missense_variant ORF1ab_pp1ab P6563S 6.71e-1 BQ.1.1.18
V4973 286C>T missense_variant ORF7a L96F 1.00e+0 BQ.1.1.20
V8521 20415G>T synonymous_variant ORF1ab_pp1ab P6805P 7.74e-1 BQ.1.1.20
V341 783G>T missense_variant ORF1ab_pp1a K261N 1.00e+0 BQ.1.1.24
V3780 758A>G missense_variant S D253G 7.07e-1 BQ.1.1.24
V7964 16044C>T synonymous_variant ORF1ab_pp1ab F5348F 1.00e+0 BQ.1.1.25
V1021 3478C>T missense_variant ORF1ab_pp1a H1160Y 8.99e-1 BQ.1.1.31
V1300 5261C>T missense_variant ORF1ab_pp1a T1754I 9.46e-1 BQ.1.1.31
V3780 758A>G missense_variant S D253G 9.46e-1 BQ.1.1.31
V6770 6618C>T synonymous_variant ORF1ab_pp1a V2206V 1.00e+0 BQ.1.1.31
V9227 630C>T synonymous_variant ORF3a D210D 8.66e-1 BQ.1.13.1
V1568 6661C>T missense_variant ORF1ab_pp1a P2221S 7.07e-1 BQ.1.1.3
V7589 13119C>T synonymous_variant ORF1ab_pp1a C4373C 7.07e-1 BQ.1.13
V6122 1837C>T synonymous_variant ORF1ab_pp1a L613L 8.70e-1 BQ.1.14
V1232 4763T>A missense_variant ORF1ab_pp1a M1588K 1.00e+0 BQ.1.1.6
V5033 73C>T missense_variant ORF7b L25F 1.00e+0 BQ.1.1.6
V53 -80C>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 BQ.1.1.6
V5692 27delT frameshift_variant ORF10 P10fs 1.00e+0 BQ.1.1.6
V7623 13362T>C synonymous_variant ORF1ab_pp1ab D4454D 1.00e+0 BQ.1.1.6
V8981 2754G>A synonymous_variant S E918E 1.00e+0 BQ.1.1.6
V150 140A>G missense_variant ORF1ab_pp1a K47R 7.74e-1 BQ.1.1.8
V2782 16129C>T missense_variant ORF1ab_pp1ab P5377S 7.74e-1 BQ.1.1.8
V3780 758A>G missense_variant S D253G 9.26e-1 BQ.1.1.8
V403 1037C>T missense_variant ORF1ab_pp1a T346I 1.00e+0 BQ.1.1.8
V5368 307G>T missense_variant N D103Y 9.13e-1 BQ.1.1.8
V5454 599G>A missense_variant N G200D 1.00e+0 BQ.1.1.8
V6098 1662T>C synonymous_variant ORF1ab_pp1a T554T 1.00e+0 BQ.1.1.8
V6137 1899G>A synonymous_variant ORF1ab_pp1a E633E 1.00e+0 BQ.1.1.8
V8369 18999C>T synonymous_variant ORF1ab_pp1ab N6333N 9.26e-1 BQ.1.1.8
V9623 330C>T synonymous_variant N F110F 7.14e-1 BQ.1.2
V9737 876C>T synonymous_variant N I292I 8.78e-1 BQ.1.2
V7578 13032C>T synonymous_variant ORF1ab_pp1a D4344D 7.07e-1 BW.1.1
V5976 792C>T synonymous_variant ORF1ab_pp1a D264D 7.07e-1 CM.2
V5017 33G>T missense_variant ORF7b L11F 1.00e+0 CM.8.1
V1397 5948C>T missense_variant ORF1ab_pp1a A1983V 1.00e+0 DR.1
V7472 12174C>T synonymous_variant ORF1ab_pp1a P4058P 1.00e+0 DR.1
V3780 758A>G missense_variant S D253G 6.84e-1 DU.1
V1424 6077A>G missense_variant ORF1ab_pp1a D2026G 1.00e+0 P.1.15
V757 2410C>T missense_variant ORF1ab_pp1a P804S 1.00e+0 P.1.15
V87 -42T>C upstream_gene_variant ORF1ab_pp1a None 1.00e+0 P.1.15
V8268 18312C>T synonymous_variant ORF1ab_pp1ab D6104D 7.58e-1 P.2
V8297 18513A>G synonymous_variant ORF1ab_pp1ab Q6171Q 7.58e-1 P.2
V9243 732C>T synonymous_variant ORF3a V244V 7.75e-1 P.2
V6462 4320T>C synonymous_variant ORF1ab_pp1a D1440D 1.00e+0 Q.4
V9170 186C>T synonymous_variant ORF3a I62I 1.00e+0 Q.4
V2875 16871C>T missense_variant ORF1ab_pp1ab P5624L 8.16e-1 B.1.1.158
V5616 1130A>G missense_variant N D377G 7.21e-1 B.1.1.158
V7269 10569C>T synonymous_variant ORF1ab_pp1a A3523A 8.16e-1 B.1.1.158
V2961 17482C>T missense_variant ORF1ab_pp1ab P5828S 8.64e-1 B.1.1.243
V3292 19769G>A missense_variant ORF1ab_pp1ab R6590H 7.04e-1 B.1.1.243
V4619 760G>A missense_variant ORF3a G254R 1.00e+0 B.1.1.243
V5047 115G>T stop_gained ORF7b E39* 7.46e-1 B.1.1.243
V5634 1167G>T missense_variant N Q389H 7.04e-1 B.1.1.243
V6019 1077C>T synonymous_variant ORF1ab_pp1a Y359Y 8.64e-1 B.1.1.243
V6038 1230G>T synonymous_variant ORF1ab_pp1a V410V 8.64e-1 B.1.1.243
V6453 4275C>T synonymous_variant ORF1ab_pp1a Y1425Y 8.64e-1 B.1.1.243
V6546 4927C>T synonymous_variant ORF1ab_pp1a L1643L 8.64e-1 B.1.1.243
V6637 5613C>T synonymous_variant ORF1ab_pp1a N1871N 8.64e-1 B.1.1.243
V6714 6144T>C synonymous_variant ORF1ab_pp1a S2048S 7.04e-1 B.1.1.243
V6760 6516C>T synonymous_variant ORF1ab_pp1a F2172F 8.64e-1 B.1.1.243
V7464 12135C>T synonymous_variant ORF1ab_pp1a L4045L 7.04e-1 B.1.1.243
V7781 14541C>T synonymous_variant ORF1ab_pp1ab Y4847Y 7.04e-1 B.1.1.243
V758 2411C>T missense_variant ORF1ab_pp1a P804L 7.06e-1 B.1.1.312
V8876 1944C>T synonymous_variant S G648G 1.00e+0 B.1.1.312
V1265 4941G>T missense_variant ORF1ab_pp1a M1647I 1.00e+0 B.1.146
V2538 13764G>T missense_variant ORF1ab_pp1ab M4588I 1.00e+0 B.1.146
V4403 164T>G missense_variant ORF3a V55G 1.00e+0 B.1.177.28
V5244 -1A>T upstream_gene_variant N None 1.00e+0 B.1.177.28
V8092 17004T>C synonymous_variant ORF1ab_pp1ab D5668D 1.00e+0 B.1.177.28
V1721 7825C>T missense_variant ORF1ab_pp1a L2609F 9.29e-1 B.1.177.67
V5940 567C>T synonymous_variant ORF1ab_pp1a N189N 9.51e-1 B.1.177.67
V8964 2568C>T synonymous_variant S N856N 1.00e+0 B.1.177.67
V3909 1450G>A missense_variant S E484K -6.55e-1 B.1.351.1
V3927 1501A>T missense_variant S N501Y -6.55e-1 B.1.351.1
V4488 334G>T missense_variant ORF3a V112F 1.00e+0 B.1.351.1
V4560 555G>T missense_variant ORF3a Q185H 1.00e+0 B.1.351.1
V5677 -3C>T upstream_gene_variant ORF10 None 1.00e+0 B.1.351.1
V5775 *4357C>T downstream_gene_variant S None 1.00e+0 B.1.351.1
V9557 360C>T synonymous_variant ORF8 F120F -6.55e-1 B.1.351.1
V2771 16025C>T missense_variant ORF1ab_pp1ab A5342V 1.00e+0 B.1.596.1
V4687 184G>T missense_variant E V62F 1.00e+0 B.1.596.1
V8293 18483C>T synonymous_variant ORF1ab_pp1ab V6161V 1.00e+0 B.1.596.1
V8761 1029C>T synonymous_variant S N343N 1.00e+0 B.1.596.1
V8899 2046G>T synonymous_variant S R682R 1.00e+0 B.1.596.1
V9647 444C>T synonymous_variant N T148T 1.00e+0 B.1.596.1
V7531 12705C>T synonymous_variant ORF1ab_pp1a N4235N 1.00e+0 B.1.625
V1763 8069C>T missense_variant ORF1ab_pp1a A2690V 6.78e-1 B.1.635
V2021 10058A>G missense_variant ORF1ab_pp1a K3353R 7.32e-1 B.1.635
V3884 1354C>A missense_variant S L452M 1.00e+0 B.1.635
V4960 268C>T stop_gained ORF7a Q90* 6.78e-1 B.1.635
V7220 10185C>T synonymous_variant ORF1ab_pp1a P3395P 6.93e-1 B.1.635
V9345 372C>T synonymous_variant M L124L 7.32e-1 B.1.635
V5129 152C>T missense_variant ORF8 A51V 1.00e+0 BA.2.61
V6102 1708C>T synonymous_variant ORF1ab_pp1a L570L 1.00e+0 BA.2.61
V198 257_259delTTG disruptive_inframe_deletion ORF1ab_pp1a V86del 1.00e+0 BE.8
V3663 455G>T missense_variant S W152L 1.00e+0 BE.8
V3999 1973A>G missense_variant S N658S 1.00e+0 BE.8
V8809 1419T>C synonymous_variant S Y473Y 1.00e+0 BE.8
V9598 159C>T synonymous_variant N F53F 1.00e+0 BE.8
V2870 16840C>T missense_variant ORF1ab_pp1ab H5614Y 1.00e+0 BF.7.9
V3161 18799C>T missense_variant ORF1ab_pp1ab P6267S 1.00e+0 BF.7.9
V4604 686C>T missense_variant ORF3a T229I 7.06e-1 BF.7.9
V8766 1062C>T synonymous_variant S N354N 1.00e+0 BF.7.9
V1197 4603G>A missense_variant ORF1ab_pp1a V1535I 1.00e+0 BQ.1.27
V3146 18720G>A missense_variant ORF1ab_pp1ab M6240I 1.00e+0 BQ.1.27
V3308 19868C>T missense_variant ORF1ab_pp1ab A6623V 1.00e+0 BQ.1.27
V3580 203T>C missense_variant S I68T 1.00e+0 BQ.1.27
V3589 218C>T missense_variant S T73I 1.00e+0 BQ.1.27
V5559 898C>T missense_variant N H300Y 1.00e+0 BQ.1.27
V8173 17595T>C synonymous_variant ORF1ab_pp1ab Y5865Y 1.00e+0 BQ.1.27
V9223 612C>T synonymous_variant ORF3a H204H 1.00e+0 BQ.1.27
V2191 11174A>G missense_variant ORF1ab_pp1a N3725S 6.29e-1 P.7
V4173 3219G>T missense_variant S K1073N 6.29e-1 P.7
V8964 2568C>T synonymous_variant S N856N 6.29e-1 P.7
V25 -160C>T upstream_gene_variant ORF1ab_pp1a None 7.05e-1 XBC.1.1





Manual curation of mutation (37G>A)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID