Back to top

The current mutation

ID: V4880
DNA: 85G>T
Protein: V29L
Position: 27478








COV2Var annotation categories







Summary information of mutation (85G>T)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp07
  Gene Name   ORF7a
  Gene Type   protein_coding
  Genome position   27478
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   missense_variant
  DNA Level   DNA Mutation: 85G>T
  Ref Seq: G
  Mut Seq: T
  Protein Level   Protein 1-letter Mutation: V29L
  Protein 3-letter Mutation: Val29Leu

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (85G>T) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 AK.2 37 16 4.32e-1
2020-10 B.1.177 37 5 1.35e-1
2020-10 B.1.1.516 37 4 1.08e-1
2020-11 B.1.2 42 10 2.38e-1
2020-11 AK.2 42 8 1.90e-1
2020-11 B.1.177.16 42 6 1.43e-1
2020-12 AK.2 56 14 2.50e-1
2020-12 B.1 56 5 8.93e-2
2020-12 B.1.438.1 56 5 8.93e-2
2020-02 B.1 1 1 1.00e+0
2020-03 C.14 10 5 5.00e-1
2020-03 B.1 10 2 2.00e-1
2020-03 B.40 10 2 2.00e-1
2020-04 C.14 16 10 6.25e-1
2020-04 B.1 16 4 2.50e-1
2020-04 B.1.1 16 1 6.25e-2
2020-05 C.14 27 20 7.41e-1
2020-05 A 27 3 1.11e-1
2020-05 B.1.1 27 2 7.41e-2
2020-06 C.14 24 15 6.25e-1
2020-06 B.1.3 24 8 3.33e-1
2020-06 B.1.1.1 24 1 4.17e-2
2020-07 C.14 12 4 3.33e-1
2020-07 B.1.3 12 3 2.50e-1
2020-07 AE.1 12 2 1.67e-1
2020-08 C.14 38 12 3.16e-1
2020-08 B.1.36 38 9 2.37e-1
2020-08 B.1.1.302 38 8 2.11e-1
2020-09 B.1.2 19 5 2.63e-1
2020-09 C.14 19 4 2.11e-1
2020-09 B.1.1.1 19 2 1.05e-1
2021-01 B.1.480 119 27 2.27e-1
2021-01 B.1.429 119 12 1.01e-1
2021-01 B.1.2 119 11 9.24e-2
2021-10 AY.122 447 95 2.13e-1
2021-10 AY.4 447 88 1.97e-1
2021-10 AY.121 447 59 1.32e-1
2021-11 AY.121 536 123 2.29e-1
2021-11 AY.4 536 76 1.42e-1
2021-11 AY.122 536 61 1.14e-1
2021-12 AY.103 319 66 2.07e-1
2021-12 AY.121 319 54 1.69e-1
2021-12 AY.25 319 29 9.09e-2
2021-02 B.1.480 95 17 1.79e-1
2021-02 B.1.1.159 95 16 1.68e-1
2021-02 B.1.1.7 95 11 1.16e-1
2021-03 B.1.1.7 107 48 4.49e-1
2021-03 B.1.429 107 27 2.52e-1
2021-03 B.1.2 107 7 6.54e-2
2021-04 B.1.1.7 172 105 6.10e-1
2021-04 B.1.429 172 19 1.10e-1
2021-04 B.1.351.5 172 13 7.56e-2
2021-05 B.1.1.7 137 98 7.15e-1
2021-05 P.1 137 6 4.38e-2
2021-05 B.1.526 137 4 2.92e-2
2021-06 B.1.619.1 116 43 3.71e-1
2021-06 B.1.1.7 116 34 2.93e-1
2021-06 AY.4 116 6 5.17e-2
2021-07 AY.71 233 28 1.20e-1
2021-07 AY.4 233 26 1.12e-1
2021-07 B.1.619.1 233 21 9.01e-2
2021-08 AY.122 460 114 2.48e-1
2021-08 AY.4 460 54 1.17e-1
2021-08 AY.25 460 50 1.09e-1
2021-09 AY.122 593 167 2.82e-1
2021-09 AY.4 593 118 1.99e-1
2021-09 AY.25 593 63 1.06e-1
2022-01 BA.1.1 83 20 2.41e-1
2022-01 AY.121 83 9 1.08e-1
2022-01 AY.122 83 8 9.64e-2
2022-10 BE.6 78 44 5.64e-1
2022-10 BF.14 78 7 8.97e-2
2022-10 BE.1.1 78 5 6.41e-2
2022-11 BE.6 74 33 4.46e-1
2022-11 BA.5.1.5 74 7 9.46e-2
2022-11 BQ.1 74 5 6.76e-2
2022-12 BE.6 69 22 3.19e-1
2022-12 BA.4.6 69 5 7.25e-2
2022-12 BA.5.1.5 69 5 7.25e-2
2022-02 BA.1.1 86 31 3.60e-1
2022-02 BA.1 86 17 1.98e-1
2022-02 BA.2 86 15 1.74e-1
2022-03 BA.2 75 43 5.73e-1
2022-03 BA.1.1 75 11 1.47e-1
2022-03 BA.2.9 75 8 1.07e-1
2022-04 BA.2 81 54 6.67e-1
2022-04 BA.2.9 81 15 1.85e-1
2022-04 BA.1.1.2 81 4 4.94e-2
2022-05 BA.2 40 31 7.75e-1
2022-05 BA.2.49 40 5 1.25e-1
2022-05 BA.2.9 40 2 5.00e-2
2022-06 BA.2 26 4 1.54e-1
2022-06 BA.2.13 26 2 7.69e-2
2022-06 BA.2.3 26 2 7.69e-2
2022-07 BE.1.1 36 7 1.94e-1
2022-07 BE.3 36 4 1.11e-1
2022-07 BA.4 36 3 8.33e-2
2022-08 BE.1.1 54 13 2.41e-1
2022-08 BA.5.2.7 54 10 1.85e-1
2022-08 BA.4.6 54 3 5.56e-2
2022-09 BE.6 101 30 2.97e-1
2022-09 BA.5.2.7 101 18 1.78e-1
2022-09 BV.1 101 8 7.92e-2
2023-01 BE.6 41 7 1.71e-1
2023-01 BA.5.2.48 41 6 1.46e-1
2023-01 BF.5 41 4 9.76e-2
2023-02 BE.6 11 3 2.73e-1
2023-02 BA.5.3.1 11 2 1.82e-1
2023-02 CH.1.1.3 11 2 1.82e-1

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V4880 AB.1 1.83e-2 2 2020-12-1 2021-2-15
V4880 AK.2 9.05e-1 19 2020-9-19 2020-12-6
V4880 AY.119.1 3.72e-2 28 2020-11-9 2022-2-23
V4880 AY.71 1.28e-2 30 2021-3-9 2021-12-23
V4880 B.1.1.159 5.56e-2 11 2020-8-15 2021-6-26
V4880 B.1.1.516 1.30e-1 3 2020-4-14 2021-2-15
V4880 B.1.1.58 1.37e-2 2 2020-4-8 2021-7-16
V4880 B.1.177.48 1.29e-2 4 2020-9-24 2021-1-27
V4880 B.1.3 2.15e-2 12 2020-3-30 2021-5-11
V4880 B.1.480 1.10e-1 49 2020-7-3 2021-7-21
V4880 B.1.619.1 4.58e-2 74 2021-2-22 2021-9-21
V4880 BA.5.2.7 1.06e-2 31 2022-1-26 2023-2-17
V4880 BE.6 4.20e-1 140 2022-8-5 2023-2-15
V4880 BV.1 4.95e-2 11 2022-7-1 2022-12-5
V4880 C.14 2.57e-1 77 2020-3-20 2022-4-27
V4880 C.4 1.49e-2 2 2020-5-19 2021-8-18
V4880 CY.1 1.75e-2 2 2022-9-7 2023-1-16






Examining mutation (85G>T) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID




Association between mutation (85G>T) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory -1.69e+1 2.34e+3 -7.22e-3 9.94e-1 Decrease
Deceased -7.81e-2 1.18e+0 -6.61e-2 9.47e-1 Decrease
Homebound 3.00e-15 5.52e+4 5.43e-20 1.00e+0 Increase
Hospitalized 1.77e+0 5.56e-1 3.19e+0 1.45e-3 Increase
Mild 3.02e+0 9.36e-1 3.22e+0 1.27e-3 Increase
Recovered -1.49e+0 4.94e-1 -3.02e+0 2.53e-3 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 -4.55e-1 2.89e-1 -1.57e+0 1.16e-1 Decrease
18-39 -4.04e-1 1.31e-1 -3.09e+0 1.97e-3 Decrease
40-64 1.56e-1 1.20e-1 1.30e+0 1.95e-1 Increase
65-84 1.71e-1 1.66e-1 1.03e+0 3.05e-1 Increase
>=85 8.88e-1 2.18e-1 4.08e+0 4.56e-5 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male -3.23e-2 1.20e-1 -2.70e-1 7.87e-1 Decrease





Investigating natural selection at mutation (85G>T) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method
ORF7a 27394 27759 121 29 0.00e+0 AY.3 MEME

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method
ORF7a 27394 27759 121 29 11.53 0.00 2.00e-2 BD.1 FEL
ORF7a 27394 27759 121 29 20.20 0.00 2.00e-2 BE.7 FEL
ORF7a 27394 27759 121 29 89.69 0.00 2.00e-2 BR.2 FEL
ORF7a 27394 27759 121 29 26.61 0.00 4.00e-2 P.1.12 FEL
ORF7a 27394 27759 121 29 6.43 0.00 1.00e-2 AY.46.4 FEL
ORF7a 27394 27759 121 29 34.20 0.00 5.00e-2 AY.93 FEL
ORF7a 27394 27759 121 29 10.85 0.87 2.00e-2 BA.5.2.9 FEL

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method
ORF7a 27394 27759 121 29 9.60e-1 3.00e-2 BD.1 FUBAR
ORF7a 27394 27759 121 29 9.90e-1 1.00e-2 BE.7 FUBAR
ORF7a 27394 27759 121 29 9.80e-1 1.00e-2 BA.5.2.9 FUBAR




Alterations in protein physicochemical properties induced by mutation (85G>T)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY
Mutation ORF7a 13758.2 8.23 7450 101.57 0.315
Reference ORF7a 13744.17 8.23 7450 100.74 0.318




Alterations in protein stability induced by mutation (85G>T)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition
V29L ORF7a Point 29 -0.64 Decrease 7 25 Environment
V29L ORF7a Point 29 -0.64 Decrease 7.4 37 Internal




Impact on protein function induced by mutation (85G>T)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms
V29L ORF7a Point 0.138 Loss of Strand (Pr = 0.27 | P = 0.02)
Altered Cytoplasmic_loop (Pr = 0.27 | P = 8.2e-04)
Altered PPI_hotspot (Pr = 0.24 | P = 0.04)
Gain of Zinc_binding at E33 (Pr = 0.17 | P = 0.09)
Gain of Sodium_binding at E33 (Pr = 0.14 | P = 0.09)




Exploring mutation (85G>T) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (85G>T)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites
V29L ORF7a 27478 Pepsin (pH1.3) RGTTLLLKEP (pos: 28)
 NA
V29L ORF7a 27478 Chymotrypsin-low specificity GTTLLLKEPC (pos: 29)
 NA
V29L ORF7a 27478 Pepsin (pH>2) RGTTLLLKEP (pos: 28)
 NA




Impact of spike protein mutation (85G>T) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (85G>T) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

;
Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

        Show as:

        Show interface residues:





Impact of mutation (85G>T) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (85G>T) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V1600 6818C>T missense_variant ORF1ab_pp1a S2273F 8.33e-1 BA.1.18
V1548 6497C>T missense_variant ORF1ab_pp1a T2166I 6.45e-1 AY.122
V5347 214G>A missense_variant N V72I 6.50e-1 AY.122
V5685 11T>C missense_variant ORF10 I4T 6.43e-1 AY.122
V789 2618G>A missense_variant ORF1ab_pp1a C873Y 7.52e-1 B.1.429
V8524 20455C>T synonymous_variant ORF1ab_pp1ab L6819L 6.51e-1 B.1.429
V1113 3916G>T missense_variant ORF1ab_pp1a A1306S 7.07e-1 A.2.5
V1816 8419A>G missense_variant ORF1ab_pp1a I2807V 1.00e+0 A.2.5
V4948 239G>T missense_variant ORF7a R80I 1.00e+0 A.2.5
V5046 115G>C missense_variant ORF7b E39Q 8.16e-1 A.2.5
V5094 77C>T missense_variant ORF8 T26I 7.07e-1 A.2.5
V6565 5040G>A synonymous_variant ORF1ab_pp1a L1680L 7.07e-1 A.2.5
V3559 86C>T missense_variant S T29I 7.07e-1 AD.2
V7388 11601C>T synonymous_variant ORF1ab_pp1a C3867C 7.07e-1 AD.2
V6419 3990G>A synonymous_variant ORF1ab_pp1a P1330P 1.00e+0 A
V7564 12960C>T synonymous_variant ORF1ab_pp1a S4320S 7.74e-1 A
V4284 3755C>T missense_variant S S1252F 7.07e-1 AY.102
V8257 18210A>G synonymous_variant ORF1ab_pp1ab Q6070Q 7.07e-1 AY.102
V60 -73C>T upstream_gene_variant ORF1ab_pp1a None 7.27e-1 AY.110
V9469 258G>T synonymous_variant ORF7a L86L 1.00e+0 AY.111
V5739 *4326T>A downstream_gene_variant S None 6.12e-1 AY.113
V5574 974C>T missense_variant N T325I 7.07e-1 AY.114
V1044 3606G>T missense_variant ORF1ab_pp1a K1202N 7.07e-1 AY.116
V375 920C>T missense_variant ORF1ab_pp1a A307V 7.07e-1 AY.116
V6655 5766C>T synonymous_variant ORF1ab_pp1a N1922N 7.07e-1 AY.116
V7369 11487C>T synonymous_variant ORF1ab_pp1a L3829L 7.07e-1 AY.116
V8012 16386C>T synonymous_variant ORF1ab_pp1ab L5462L 7.07e-1 AY.116
V9286 12C>T synonymous_variant M S4S 7.07e-1 AY.116
V4294 3788C>T missense_variant S P1263L 9.23e-1 AY.119.1
V4492 352A>G missense_variant ORF3a I118V 6.20e-1 AY.119.1
V6720 6174G>A synonymous_variant ORF1ab_pp1a Q2058Q 8.83e-1 AY.119.1
V8704 552T>C synonymous_variant S G184G 1.00e+0 AY.119.1
V9373 513T>C synonymous_variant M A171A 9.62e-1 AY.119.1
V4254 3647T>C missense_variant S I1216T 8.16e-1 AY.119.2
V1580 6751G>A missense_variant ORF1ab_pp1a G2251S 7.07e-1 AY.121.1
V3196 19009C>T missense_variant ORF1ab_pp1ab P6337S 1.00e+0 AY.121.1
V3753 724C>T missense_variant S L242F 7.59e-1 AY.121
V6538 4879C>T synonymous_variant ORF1ab_pp1a L1627L 6.17e-1 AY.121
V2441 13156C>T missense_variant ORF1ab_pp1a L4386F 7.07e-1 AY.122.1
V1513 6373C>T missense_variant ORF1ab_pp1a H2125Y 7.07e-1 AY.124.1
V1302 5279C>T missense_variant ORF1ab_pp1a T1760I 6.72e-1 AY.129
V471 1293A>G missense_variant ORF1ab_pp1a I431M 6.53e-1 AY.129
V9200 390C>T synonymous_variant ORF3a C130C 8.77e-1 AY.129
V1153 4289C>A missense_variant ORF1ab_pp1a T1430N 8.16e-1 AY.14
V5025 42A>T missense_variant ORF7b L14F 1.00e+0 AY.14
V854 2887G>T missense_variant ORF1ab_pp1a G963C 1.00e+0 AY.14
V9565 42C>T synonymous_variant N R14R 8.16e-1 AY.14
V4203 3371G>T missense_variant S G1124V 1.00e+0 AY.15
V4942 232C>T missense_variant ORF7a R78C 7.07e-1 AY.15
V3483 21038C>T missense_variant ORF1ab_pp1ab P7013L 8.16e-1 AY.16
V3392 20347C>T missense_variant ORF1ab_pp1ab L6783F 7.07e-1 AY.23
V1052 3620C>T missense_variant ORF1ab_pp1a P1207L 8.16e-1 AY.25.3
V5995 912T>C synonymous_variant ORF1ab_pp1a Y304Y 8.16e-1 AY.25.3
V7755 14385C>T synonymous_variant ORF1ab_pp1ab N4795N 7.07e-1 AY.25.3
V8570 20877A>G synonymous_variant ORF1ab_pp1ab L6959L 7.07e-1 AY.25.3
V8904 2079T>A synonymous_variant S I693I 7.07e-1 AY.25.3
V5286 61T>C missense_variant N S21P 6.32e-1 AY.3.1
V1037 3573G>T missense_variant ORF1ab_pp1a L1191F 1.00e+0 AY.32
V5402 466G>T missense_variant N A156S 1.00e+0 AY.35
V3162 18806C>T missense_variant ORF1ab_pp1ab A6269V 7.07e-1 AY.36
V7126 9538C>T synonymous_variant ORF1ab_pp1a L3180L 7.07e-1 AY.38
V7716 14136G>T synonymous_variant ORF1ab_pp1ab V4712V 6.70e-1 AY.38
V9340 360C>T synonymous_variant M L120L 7.49e-1 AY.38
V2825 16531G>T missense_variant ORF1ab_pp1ab V5511L 8.82e-1 AY.39.1.4
V9706 741T>C synonymous_variant N T247T 9.35e-1 AY.39.1.4
V2512 13594G>T missense_variant ORF1ab_pp1ab D4532Y 7.07e-1 AY.4.11
V3101 18388C>T missense_variant ORF1ab_pp1ab R6130C 7.07e-1 AY.4.11
V5559 898C>T missense_variant N H300Y 7.07e-1 AY.4.11
V5727 *4306G>T downstream_gene_variant S None 7.07e-1 AY.4.11
V6580 5157T>C synonymous_variant ORF1ab_pp1a N1719N 7.07e-1 AY.4.11
V9469 258G>T synonymous_variant ORF7a L86L 7.07e-1 AY.4.11
V2912 17080A>G missense_variant ORF1ab_pp1ab I5694V 7.07e-1 AY.4.13
V4408 173G>T missense_variant ORF3a S58I 7.07e-1 AY.4.13
V5628 1148C>T missense_variant N P383L 1.00e+0 AY.4.13
V7171 9774C>T synonymous_variant ORF1ab_pp1a T3258T 8.16e-1 AY.4.13
V2819 16486C>T missense_variant ORF1ab_pp1ab P5496S 7.07e-1 AY.4.2.1
V1555 6575C>T missense_variant ORF1ab_pp1a A2192V 6.31e-1 AY.42
V2123 10852A>G missense_variant ORF1ab_pp1a I3618V 6.19e-1 AY.42
V5088 55G>T stop_gained ORF8 E19* 6.18e-1 AY.42
V294 550C>T missense_variant ORF1ab_pp1a R184C 8.16e-1 AY.43.3
V7181 9873C>T synonymous_variant ORF1ab_pp1a N3291N 8.16e-1 AY.43.3
V7901 15546C>T synonymous_variant ORF1ab_pp1ab N5182N 8.00e-1 AY.4.5
V8121 17202A>G synonymous_variant ORF1ab_pp1ab T5734T 8.59e-1 AY.46
V8656 219C>T synonymous_variant S T73T 8.42e-1 AY.46
V8818 1485T>C synonymous_variant S Y495Y 8.91e-1 AY.46
V7116 9459C>T synonymous_variant ORF1ab_pp1a F3153F 1.00e+0 AY.53
V7389 11613C>T synonymous_variant ORF1ab_pp1a V3871V 1.00e+0 AY.53
V8067 16855C>T synonymous_variant ORF1ab_pp1ab L5619L 1.00e+0 AY.53
V5167 209C>T missense_variant ORF8 P70L 6.32e-1 AY.54
V2279 11802G>T missense_variant ORF1ab_pp1a M3934I 8.16e-1 AY.61
V5489 634G>T missense_variant N G212C 8.16e-1 AY.61
V6069 1473G>T synonymous_variant ORF1ab_pp1a V491V 1.00e+0 AY.7.2
V9485 348C>T synonymous_variant ORF7a L116L 1.00e+0 AY.8
V1085 3737C>T missense_variant ORF1ab_pp1a T1246I 1.00e+0 B.1.1.10
V1630 7075A>G missense_variant ORF1ab_pp1a I2359V 1.00e+0 B.1.1.10
V3303 19819G>A missense_variant ORF1ab_pp1ab V6607I 1.00e+0 B.1.1.10
V3400 20445G>T missense_variant ORF1ab_pp1ab M6815I 1.00e+0 B.1.1.10
V5317 100G>T missense_variant N G34W 7.07e-1 B.1.1.10
V7429 11856A>G synonymous_variant ORF1ab_pp1a P3952P 1.00e+0 B.1.1.10
V7693 13971C>T synonymous_variant ORF1ab_pp1ab Y4657Y 1.00e+0 B.1.1.10
V8911 2169C>T synonymous_variant S T723T 1.00e+0 B.1.1.10
V9744 906G>T synonymous_variant N P302P 1.00e+0 B.1.1.10
V4240 3573G>T missense_variant S K1191N 1.00e+0 B.1.1.153
V4342 85G>T missense_variant ORF3a V29F 7.06e-1 B.1.1.153
V5017 33G>T missense_variant ORF7b L11F 7.55e-1 B.1.1.153
V8449 19719C>T synonymous_variant ORF1ab_pp1ab V6573V 6.65e-1 B.1.1.153
V1702 7738G>T missense_variant ORF1ab_pp1a V2580F 1.00e+0 B.1.1.277
V2080 10581G>T missense_variant ORF1ab_pp1a M3527I 1.00e+0 B.1.1.277
V9756 948A>G synonymous_variant N G316G 7.07e-1 B.1.1.28
V2073 10525C>T missense_variant ORF1ab_pp1a H3509Y 8.16e-1 B.1.1.294
V2961 17482C>T missense_variant ORF1ab_pp1ab P5828S 1.00e+0 B.1.1.294
V3574 192G>T missense_variant S W64C 1.00e+0 B.1.1.294
V4291 3787C>T missense_variant S P1263S 1.00e+0 B.1.1.294
V5916 418C>T synonymous_variant ORF1ab_pp1a L140L 6.65e-1 B.1.1.294
V4497 375G>T missense_variant ORF3a M125I 1.00e+0 B.1.1.311
V9145 81T>C synonymous_variant ORF3a D27D 7.07e-1 B.1.1.311
V3660 452G>T missense_variant S S151I 1.00e+0 B.1.1.318
V4485 328G>T missense_variant ORF3a A110S 1.00e+0 B.1.1.318
V7122 9513C>T synonymous_variant ORF1ab_pp1a S3171S 7.07e-1 B.1.1.318
V7215 10143C>T synonymous_variant ORF1ab_pp1a Y3381Y 1.00e+0 B.1.1.318
V9123 3753A>G synonymous_variant S G1251G 1.00e+0 B.1.1.318
V3645 433T>A missense_variant S Y145N 7.07e-1 B.1.1.348
V7695 13995T>C synonymous_variant ORF1ab_pp1ab Y4665Y 7.07e-1 B.1.1.348
V9304 159C>T synonymous_variant M F53F 9.04e-1 B.1.177.16
V7545 12825T>C synonymous_variant ORF1ab_pp1a D4275D 1.00e+0 B.1.177.21
V9301 103C>T synonymous_variant M L35L 7.07e-1 B.1.177.21
V5462 608G>T missense_variant N R203M 1.00e+0 B.1.177.80
V9217 582A>G synonymous_variant ORF3a E194E 1.00e+0 B.1.177.80
V7518 12603A>G synonymous_variant ORF1ab_pp1a G4201G 7.56e-1 B.1.243
V8283 18417C>T synonymous_variant ORF1ab_pp1ab A6139A 7.07e-1 B.1.243
V4794 -6C>T upstream_gene_variant ORF6 None 7.07e-1 B.1.258.17
V8441 19671T>C synonymous_variant ORF1ab_pp1ab T6557T 1.00e+0 B.1.258.17
V2537 13730C>T missense_variant ORF1ab_pp1ab A4577V 1.00e+0 B.1.36.17
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 1.00e+0 B.1.36.17
V870 2948A>G missense_variant ORF1ab_pp1a D983G 1.00e+0 B.1.36.17
V9630 348G>T synonymous_variant N G116G 1.00e+0 B.1.36.17
V5153 194C>T missense_variant ORF8 A65V 6.54e-1 B.1.36.18
V2537 13730C>T missense_variant ORF1ab_pp1ab A4577V 1.00e+0 B.1.36.22
V3327 20011G>T missense_variant ORF1ab_pp1ab D6671Y 1.00e+0 B.1.36.22
V6653 5751C>T synonymous_variant ORF1ab_pp1a N1917N 1.00e+0 B.1.36.22
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 1.00e+0 B.1.36.22
V870 2948A>G missense_variant ORF1ab_pp1a D983G 1.00e+0 B.1.36.22
V1093 3803C>T missense_variant ORF1ab_pp1a A1268V 1.00e+0 B.1.36.29
V2211 11256G>T missense_variant ORF1ab_pp1a M3752I 7.07e-1 B.1.36.8
V7051 8898C>T synonymous_variant ORF1ab_pp1a N2966N 1.00e+0 B.1.36.8
V7574 12999C>T synonymous_variant ORF1ab_pp1a H4333H 1.00e+0 B.1.36.8
V2537 13730C>T missense_variant ORF1ab_pp1ab A4577V 6.23e-1 B.1.36
V6880 7579C>T synonymous_variant ORF1ab_pp1a L2527L 8.32e-1 B.1.36
V2217 11275G>T missense_variant ORF1ab_pp1a V3759F 1.00e+0 B.1.375
V7684 13920C>T synonymous_variant ORF1ab_pp1ab T4640T 1.00e+0 B.1.375
V2202 11206C>T missense_variant ORF1ab_pp1a L3736F 1.00e+0 B.1.398
V4078 2386G>C missense_variant S D796H 1.00e+0 B.1.398
V4451 275C>T missense_variant ORF3a S92L 1.00e+0 B.1.398
V6933 7983T>C synonymous_variant ORF1ab_pp1a S2661S 1.00e+0 B.1.398
V8790 1239G>T synonymous_variant S G413G 1.00e+0 B.1.398
V721 2269G>A missense_variant ORF1ab_pp1a V757I 8.14e-1 B.1.3
V7154 9699T>C synonymous_variant ORF1ab_pp1a H3233H 8.16e-1 B.1.427
V8203 17853C>T synonymous_variant ORF1ab_pp1ab H5951H 7.07e-1 B.1.466.2
V8872 1908T>C synonymous_variant S Y636Y 7.07e-1 B.1.466.2
V1513 6373C>T missense_variant ORF1ab_pp1a H2125Y 7.07e-1 B.1.499
V1965 9583A>G missense_variant ORF1ab_pp1a S3195G 1.00e+0 B.1.499
V2669 14993A>G missense_variant ORF1ab_pp1ab Y4998C 1.00e+0 B.1.499
V3005 17841G>T missense_variant ORF1ab_pp1ab Q5947H 1.00e+0 B.1.499
V3697 542G>T missense_variant S G181V 1.00e+0 B.1.499
V4441 249G>T missense_variant ORF3a L83F 1.00e+0 B.1.499
V7453 12039T>C synonymous_variant ORF1ab_pp1a Y4013Y 1.00e+0 B.1.499
V8011 16383G>T synonymous_variant ORF1ab_pp1ab T5461T 1.00e+0 B.1.499
V8296 18492G>T synonymous_variant ORF1ab_pp1ab P6164P 1.00e+0 B.1.499
V5760 *4350G>A downstream_gene_variant S None 6.66e-1 B.1.575
V5729 *4312C>T downstream_gene_variant S None 7.71e-1 B.1.619.1
V7696 13998C>T synonymous_variant ORF1ab_pp1ab D4666D 7.95e-1 B.1.619.1
V8609 21144T>C synonymous_variant ORF1ab_pp1ab F7048F 8.16e-1 B.1.619.1
V1574 6725C>T missense_variant ORF1ab_pp1a S2242F 7.07e-1 B.1.623
V5369 337C>A missense_variant N L113I 1.00e+0 BA.1.1.13
V5694 28C>T missense_variant ORF10 P10S 1.00e+0 BA.1.1.13
V2294 11888C>T missense_variant ORF1ab_pp1a A3963V 8.16e-1 BA.1.1.4
V8296 18492G>T synonymous_variant ORF1ab_pp1ab P6164P 1.00e+0 BA.1.1.4
V3534 56C>T missense_variant S T19I 1.00e+0 BA.1.15.2
V2787 16193C>T missense_variant ORF1ab_pp1ab S5398L 8.16e-1 BA.2.13
V5894 291C>T synonymous_variant ORF1ab_pp1a Y97Y 1.00e+0 BA.2.3.2
V9112 3645C>T synonymous_variant S Y1215Y 6.32e-1 BA.2.49
V4884 101C>T missense_variant ORF7a P34L 7.07e-1 BA.2.75.1
V8605 21114T>C synonymous_variant ORF1ab_pp1ab S7038S 1.00e+0 BA.4.4
V8264 18270G>A synonymous_variant ORF1ab_pp1ab K6090K 6.55e-1 BA.4
V2522 13659C>A missense_variant ORF1ab_pp1ab D4553E 7.07e-1 BA.5.1.1
V996 3410A>G missense_variant ORF1ab_pp1a N1137S 7.07e-1 BA.5.1.1
V3939 1640C>A missense_variant S T547K 7.07e-1 BA.5.1.5
V6112 1779C>T synonymous_variant ORF1ab_pp1a N593N 1.00e+0 BA.5.1.5
V7472 12174C>T synonymous_variant ORF1ab_pp1a P4058P 9.79e-1 BA.5.1.5
V2699 15271G>T missense_variant ORF1ab_pp1ab A5091S 1.00e+0 BA.5.1.8
V7209 10104C>T synonymous_variant ORF1ab_pp1a R3368R 1.00e+0 BA.5.1.8
V8332 18747C>T synonymous_variant ORF1ab_pp1ab D6249D 1.00e+0 BA.5.1.8
V6002 948C>T synonymous_variant ORF1ab_pp1a C316C 7.07e-1 BA.5.2.23
V6095 1647C>T synonymous_variant ORF1ab_pp1a S549S 7.23e-1 BA.5.2.48
V6853 7359T>C synonymous_variant ORF1ab_pp1a V2453V 1.00e+0 BA.5.2.48
V7269 10569C>T synonymous_variant ORF1ab_pp1a A3523A 8.56e-1 BA.5.2.48
V714 2245A>G missense_variant ORF1ab_pp1a T749A 6.32e-1 BA.5.2.6
V1577 6740C>T missense_variant ORF1ab_pp1a T2247I 6.51e-1 BA.5.2.7
V1422 6071C>T missense_variant ORF1ab_pp1a S2024L 7.06e-1 BA.5.3.5
V3775 755G>A missense_variant S G252D 1.00e+0 BA.5.3.5
V3827 1038A>T missense_variant S R346S 1.00e+0 BA.5.3
V5610 1113C>A missense_variant N D371E 6.74e-1 BA.5.9
V5969 723C>T synonymous_variant ORF1ab_pp1a Y241Y 6.74e-1 BA.5.9
V8559 20751T>C synonymous_variant ORF1ab_pp1ab H6917H 6.74e-1 BA.5.9
V2478 13403C>T missense_variant ORF1ab_pp1ab T4468I 1.00e+0 BE.2
V6891 7680C>T synonymous_variant ORF1ab_pp1a Y2560Y 8.66e-1 BE.3
V2986 17713C>T missense_variant ORF1ab_pp1ab L5905F 1.00e+0 BE.5
V6421 3996G>A synonymous_variant ORF1ab_pp1a Q1332Q 1.00e+0 BE.5
V5855 111G>A synonymous_variant ORF1ab_pp1a E37E 7.07e-1 BF.10
V4338 79G>C missense_variant ORF3a D27H 7.07e-1 BF.28
V9527 132A>G synonymous_variant ORF8 K44K 1.00e+0 BF.3
V9188 288C>T synonymous_variant ORF3a L96L 1.00e+0 BF.4
V7094 9237C>T synonymous_variant ORF1ab_pp1a A3079A 8.16e-1 BF.7.4.1
V8979 2721T>C synonymous_variant S N907N 7.07e-1 BF.7.4.1
V4076 2372C>T missense_variant S T791I 7.07e-1 BF.7.4
V2707 15349C>T missense_variant ORF1ab_pp1ab H5117Y 1.00e+0 BN.1.2.1
V4082 2426C>T missense_variant S P809L 1.00e+0 BN.1.2.1
V1347 5557C>T missense_variant ORF1ab_pp1a L1853F 7.07e-1 BQ.1.11
V1230 4758G>T missense_variant ORF1ab_pp1a M1586I 7.07e-1 BQ.1.1.25
V567 1661C>T missense_variant ORF1ab_pp1a T554I 1.00e+0 BQ.1.1.28
V7740 14307C>T synonymous_variant ORF1ab_pp1ab D4769D 1.00e+0 BQ.1.13.1
V1230 4758G>T missense_variant ORF1ab_pp1a M1586I 7.07e-1 BQ.1.1.32
V5937 558C>T synonymous_variant ORF1ab_pp1a V186V 7.07e-1 BQ.1.25
V247 395G>A missense_variant ORF1ab_pp1a G132D 7.07e-1 BQ.1.28
V6087 1614A>G synonymous_variant ORF1ab_pp1a S538S 7.07e-1 BQ.1.28
V8094 17016G>T synonymous_variant ORF1ab_pp1ab V5672V 7.07e-1 C.36
V9341 363C>T synonymous_variant M N121N 1.00e+0 C.36
V7057 8925G>T synonymous_variant ORF1ab_pp1a V2975V 8.42e-1 C.37
V7074 9066T>C synonymous_variant ORF1ab_pp1a D3022D 8.53e-1 C.37
V7969 16074C>T synonymous_variant ORF1ab_pp1ab V5358V 8.86e-1 C.37
V2337 12248C>T missense_variant ORF1ab_pp1a T4083M 8.16e-1 CH.1.1.1
V6400 3849T>C synonymous_variant ORF1ab_pp1a A1283A 7.07e-1 CH.1.1.1
V7550 12850C>T synonymous_variant ORF1ab_pp1a L4284L 1.00e+0 CH.1.1.1
V7974 16113G>T synonymous_variant ORF1ab_pp1ab P5371P 6.66e-1 P.1.15
V2202 11206C>T missense_variant ORF1ab_pp1a L3736F 1.00e+0 P.1.7
V5575 976C>T missense_variant N P326S 1.00e+0 Q.4
V9338 351C>T synonymous_variant M N117N 7.07e-1 XBB.3
V7266 10537C>T synonymous_variant ORF1ab_pp1a L3513L 8.16e-1 XB
V1708 7766A>G missense_variant ORF1ab_pp1a K2589R 1.00e+0 A.29
V4486 329C>T missense_variant ORF3a A110V 1.00e+0 A.29
V4872 66G>T missense_variant ORF7a E22D 1.00e+0 A.29
V4916 182C>T missense_variant ORF7a T61I 1.00e+0 A.29
V6384 3747C>T synonymous_variant ORF1ab_pp1a L1249L 1.00e+0 A.29
V6481 4455G>T synonymous_variant ORF1ab_pp1a A1485A 1.00e+0 A.29
V8096 17040C>T synonymous_variant ORF1ab_pp1ab V5680V 1.00e+0 A.29
V9139 24C>T synonymous_variant ORF3a F8F 1.00e+0 A.29
V9648 447C>T synonymous_variant N R149R 1.00e+0 A.29
V9485 348C>T synonymous_variant ORF7a L116L 7.04e-1 AB.1
V1665 7484C>T missense_variant ORF1ab_pp1a T2495I 1.00e+0 AE.1
V5641 1195G>C missense_variant N D399H 1.00e+0 AE.1
V6817 7002C>T synonymous_variant ORF1ab_pp1a F2334F 1.00e+0 AE.1
V8496 20172C>T synonymous_variant ORF1ab_pp1ab D6724D 1.00e+0 AE.1
V9037 3195G>T synonymous_variant S V1065V 1.00e+0 AE.1
V3896 1430G>A missense_variant S S477N 1.00e+0 B.1.1.159
V4878 80C>T missense_variant ORF7a T27I 1.00e+0 B.1.1.159
V5332 122G>A missense_variant N R41Q 1.00e+0 B.1.1.159
V5766 *4352G>T downstream_gene_variant S None 9.51e-1 B.1.1.159
V7108 9375T>C synonymous_variant ORF1ab_pp1a H3125H 9.00e-1 B.1.1.159
V7291 10755C>T synonymous_variant ORF1ab_pp1a L3585L 1.00e+0 B.1.1.159
V4746 202G>T missense_variant M A68S 1.00e+0 B.1.1.397
V677 2041C>T missense_variant ORF1ab_pp1a L681F 7.73e-1 B.1.1.397
V6936 8001C>T synonymous_variant ORF1ab_pp1a G2667G 8.16e-1 B.1.1.397
V9503 126C>T synonymous_variant ORF7b H42H 1.00e+0 B.1.1.397
V5047 115G>T stop_gained ORF7b E39* 1.00e+0 B.1.1.404
V5219 355G>T missense_variant ORF8 D119Y 1.00e+0 B.1.1.404
V531 1555G>A missense_variant ORF1ab_pp1a G519S 1.00e+0 B.1.1.404
V7176 9813C>T synonymous_variant ORF1ab_pp1a F3271F 1.00e+0 B.1.1.404
V8267 18306C>T synonymous_variant ORF1ab_pp1ab L6102L 1.00e+0 B.1.1.404
V9056 3282C>T synonymous_variant S V1094V 1.00e+0 B.1.1.404
V9585 111A>T synonymous_variant N S37S 1.00e+0 B.1.1.404
V1064 3659C>T missense_variant ORF1ab_pp1a P1220L 1.00e+0 B.1.1.516
V2116 10818G>T missense_variant ORF1ab_pp1a L3606F 1.00e+0 B.1.1.516
V3061 18133G>T missense_variant ORF1ab_pp1ab V6045L 1.00e+0 B.1.1.516
V6600 5289G>A synonymous_variant ORF1ab_pp1a K1763K 1.00e+0 B.1.1.516
V7514 12576A>G synonymous_variant ORF1ab_pp1a K4192K 1.00e+0 B.1.1.516
V560 1646C>T missense_variant ORF1ab_pp1a S549F 1.00e+0 B.1.1.525
V9182 252G>T synonymous_variant ORF3a L84L 1.00e+0 B.1.1.525
V9210 480C>T synonymous_variant ORF3a Y160Y 1.00e+0 B.1.1.525
V9470 261C>T synonymous_variant ORF7a F87F 1.00e+0 B.1.1.525
V6655 5766C>T synonymous_variant ORF1ab_pp1a N1922N 1.00e+0 B.1.1.58
V1561 6600G>T missense_variant ORF1ab_pp1a K2200N 7.06e-1 B.1.160.26
V3061 18133G>T missense_variant ORF1ab_pp1ab V6045L 7.06e-1 B.1.160.26
V5766 *4352G>T downstream_gene_variant S None 1.00e+0 B.1.177.48
V3009 17851C>T missense_variant ORF1ab_pp1ab H5951Y 1.00e+0 B.1.36.10
V2821 16498C>T missense_variant ORF1ab_pp1ab L5500F 1.00e+0 B.1.36.38
V4240 3573G>T missense_variant S K1191N 1.00e+0 B.1.36.38
V4381 131G>T missense_variant ORF3a G44V 1.00e+0 B.1.36.38
V6342 3339C>T synonymous_variant ORF1ab_pp1a H1113H 1.00e+0 B.1.36.38
V6788 6774C>T synonymous_variant ORF1ab_pp1a G2258G 1.00e+0 B.1.36.38
V7293 10785C>T synonymous_variant ORF1ab_pp1a V3595V 1.00e+0 B.1.36.38
V9308 168G>T synonymous_variant M L56L 7.06e-1 B.1.36.38
V9753 939G>T synonymous_variant N A313A 1.00e+0 B.1.36.38
V1142 4190C>T missense_variant ORF1ab_pp1a A1397V 1.00e+0 B.1.459
V1670 7499C>T missense_variant ORF1ab_pp1a S2500F 1.00e+0 B.1.459
V1801 8355delT frameshift_variant ORF1ab_pp1a I2786fs 1.00e+0 B.1.459
V4545 521G>T missense_variant ORF3a G174V 7.06e-1 B.1.459
V4971 283G>C missense_variant ORF7a E95Q 1.00e+0 B.1.459
V576 1682T>C missense_variant ORF1ab_pp1a V561A 7.06e-1 B.1.459
V6941 8034C>T synonymous_variant ORF1ab_pp1a N2678N 7.06e-1 B.1.459
V6948 8079C>T synonymous_variant ORF1ab_pp1a D2693D 1.00e+0 B.1.459
V7051 8898C>T synonymous_variant ORF1ab_pp1a N2966N 7.06e-1 B.1.459
V8325 18684G>T synonymous_variant ORF1ab_pp1ab L6228L 7.06e-1 B.1.459
V8843 1686C>T synonymous_variant S F562F 1.00e+0 B.1.459
V4546 524C>T missense_variant ORF3a T175I 6.00e-1 B.1.480
V5382 404C>T missense_variant N T135I 1.00e+0 B.1.480
V5418 535G>A missense_variant N G179S 9.05e-1 B.1.480
V7157 9708G>A synonymous_variant ORF1ab_pp1a K3236K 1.00e+0 B.1.480
V81 -47G>T upstream_gene_variant ORF1ab_pp1a None 6.00e-1 B.1.480
V766 2480A>G missense_variant ORF1ab_pp1a D827G 1.00e+0 B.1.586
V471 1293A>G missense_variant ORF1ab_pp1a I431M 1.00e+0 B.1.625
V5197 305G>T missense_variant ORF8 C102F 7.06e-1 B.1.625
V5511 702G>A missense_variant N M234I 7.06e-1 B.1.625
V9572 63A>T synonymous_variant N S21S 1.00e+0 B.1.625
V1061 3652A>G missense_variant ORF1ab_pp1a S1218G 1.00e+0 B.1.9.4
V7791 14643T>C synonymous_variant ORF1ab_pp1ab N4881N 7.05e-1 B.1.9.4
V2425 13004A>G missense_variant ORF1ab_pp1a D4335G 1.00e+0 BL.4
V5971 729A>G synonymous_variant ORF1ab_pp1a E243E 7.90e-1 BV.1
V1072 3686A>G missense_variant ORF1ab_pp1a D1229G 1.00e+0 C.4
V1512 6371C>T missense_variant ORF1ab_pp1a T2124I 1.00e+0 C.4
V4549 530G>T missense_variant ORF3a S177I 1.00e+0 C.4
V5296 74G>T missense_variant N G25V 1.00e+0 C.4
V5762 *4350G>T downstream_gene_variant S None 1.00e+0 C.4
V6265 2772C>T synonymous_variant ORF1ab_pp1a F924F -7.04e-1 C.4
V7073 9054C>T synonymous_variant ORF1ab_pp1a F3018F 1.00e+0 C.4
V9078 3444C>T synonymous_variant S F1148F 8.13e-1 C.4
V1 -245C>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 L.3
V2277 11788C>T missense_variant ORF1ab_pp1a L3930F 7.06e-1 L.3
V2588 14071G>T missense_variant ORF1ab_pp1ab V4691F 1.00e+0 L.3
V3059 18130G>T missense_variant ORF1ab_pp1ab A6044S 1.00e+0 L.3





Manual curation of mutation (85G>T)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID