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The current mutation

ID: V5017
DNA: 33G>T
Protein: L11F
Position: 27788








COV2Var annotation categories







Summary information of mutation (33G>T)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp08
  Gene Name   ORF7b
  Gene Type   protein_coding
  Genome position   27788
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   missense_variant
  DNA Level   DNA Mutation: 33G>T
  Ref Seq: G
  Mut Seq: T
  Protein Level   Protein 1-letter Mutation: L11F
  Protein 3-letter Mutation: Leu11Phe

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (33G>T) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.1.448 5 2 4.00e-1
2020-10 B.1.177 5 2 4.00e-1
2020-10 B.1.1.311 5 1 2.00e-1
2020-11 B.1.1 5 1 2.00e-1
2020-11 B.1.1.306 5 1 2.00e-1
2020-11 B.1.1.37 5 1 2.00e-1
2020-12 B.1.1 13 5 3.85e-1
2020-12 B.1.1.28 13 2 1.54e-1
2020-12 B.1.1.464 13 2 1.54e-1
2020-03 B.4 4 4 1.00e+0
2020-04 B.1 9 6 6.67e-1
2020-04 B.1.1 9 1 1.11e-1
2020-04 B.1.1.1 9 1 1.11e-1
2020-05 B.1 27 25 9.26e-1
2020-05 B.1.1.306 27 1 3.70e-2
2020-05 B.1.210 27 1 3.70e-2
2020-06 B.1 4 4 1.00e+0
2020-07 B.1 7 3 4.29e-1
2020-07 B.1.1.291 7 3 4.29e-1
2020-07 B.1.369 7 1 1.43e-1
2020-08 B.1.1.291 4 3 7.50e-1
2020-08 B.1.369 4 1 2.50e-1
2020-09 B.1 2 1 5.00e-1
2020-09 B.1.1.307 2 1 5.00e-1
2021-01 B.1.177 37 9 2.43e-1
2021-01 B.1 37 8 2.16e-1
2021-01 B.1.1.464 37 6 1.62e-1
2021-10 AY.20 172 25 1.45e-1
2021-10 AY.25 172 20 1.16e-1
2021-10 AY.103 172 19 1.10e-1
2021-11 AY.25.1 285 51 1.79e-1
2021-11 AY.103 285 50 1.75e-1
2021-11 AY.25 285 29 1.02e-1
2021-12 AY.25.1 186 30 1.61e-1
2021-12 AY.103 186 28 1.51e-1
2021-12 AY.4 186 25 1.34e-1
2021-02 B.1.177.21 33 11 3.33e-1
2021-02 B.1.1.7 33 6 1.82e-1
2021-02 B.1.1.464 33 3 9.09e-2
2021-03 B.1.1.7 43 15 3.49e-1
2021-03 B.1.36.29 43 9 2.09e-1
2021-03 B.1.1.153 43 6 1.40e-1
2021-04 B.1.1.7 38 21 5.53e-1
2021-04 P.1.17 38 6 1.58e-1
2021-04 B.1.36.29 38 5 1.32e-1
2021-05 P.1.17 85 55 6.47e-1
2021-05 B.1.1.7 85 14 1.65e-1
2021-05 P.1 85 12 1.41e-1
2021-06 P.1.17 81 69 8.52e-1
2021-06 AY.4 81 3 3.70e-2
2021-06 B.1.1.7 81 2 2.47e-2
2021-07 P.1.17 82 46 5.61e-1
2021-07 AY.103 82 6 7.32e-2
2021-07 AY.107 82 4 4.88e-2
2021-08 AY.47 145 39 2.69e-1
2021-08 AY.20 145 20 1.38e-1
2021-08 AY.126 145 19 1.31e-1
2021-09 AY.6 187 46 2.46e-1
2021-09 AY.43 187 24 1.28e-1
2021-09 AY.47 187 24 1.28e-1
2022-01 BA.1.1 141 88 6.24e-1
2022-01 AY.25.1 141 5 3.55e-2
2022-01 BA.1.15 141 5 3.55e-2
2022-10 BA.4.6 11745 8445 7.19e-1
2022-10 BA.4.6.5 11745 752 6.40e-2
2022-10 BA.4.1 11745 472 4.02e-2
2022-11 BA.4.6 5514 4015 7.28e-1
2022-11 BA.4.6.5 5514 335 6.08e-2
2022-11 BA.4.6.4 5514 213 3.86e-2
2022-12 BA.4.6 1967 1254 6.38e-1
2022-12 BA.4.6.3 1967 141 7.17e-2
2022-12 BA.4.6.5 1967 98 4.98e-2
2022-02 BA.1.1 147 109 7.41e-1
2022-02 BA.2 147 15 1.02e-1
2022-02 BA.1 147 7 4.76e-2
2022-03 BA.4 308 155 5.03e-1
2022-03 BA.1.1 308 62 2.01e-1
2022-03 BA.4.1 308 42 1.36e-1
2022-04 BA.4 1814 845 4.66e-1
2022-04 BA.4.1 1814 674 3.72e-1
2022-04 BA.4.1.1 1814 97 5.35e-2
2022-05 BA.4.1 10121 5007 4.95e-1
2022-05 BA.4 10121 3319 3.28e-1
2022-05 BA.4.4 10121 589 5.82e-2
2022-06 BA.4.1 45529 21598 4.74e-1
2022-06 BA.4 45529 14425 3.17e-1
2022-06 BA.4.4 45529 2349 5.16e-2
2022-07 BA.4.1 48749 19866 4.08e-1
2022-07 BA.4 48749 12105 2.48e-1
2022-07 BA.4.6 48749 7243 1.49e-1
2022-08 BA.4.6 26131 11240 4.30e-1
2022-08 BA.4.1 26131 6748 2.58e-1
2022-08 BA.4 26131 3063 1.17e-1
2022-09 BA.4.6 18907 12815 6.78e-1
2022-09 BA.4.1 18907 1750 9.26e-2
2022-09 BA.4.6.5 18907 1086 5.74e-2
2023-01 BA.4.6 472 217 4.60e-1
2023-01 BA.4.6.3 472 56 1.19e-1
2023-01 BA.4.1 472 45 9.53e-2
2023-02 BA.4.6 57 18 3.16e-1
2023-02 BA.4.1 57 12 2.11e-1
2023-02 BA.4.6.3 57 10 1.75e-1

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V5017 AY.48 3.19e-2 59 2021-3-5 2022-1-3
V5017 B.1.1.464 1.21e-2 12 2020-4-1 2021-7-7
V5017 B.1.160.26 1.03e-2 4 2020-9-25 2021-4-8
V5017 BA.4 9.67e-1 35035 2021-12-22 2023-1-25
V5017 BA.4.1 9.70e-1 56442 2021-6-30 2023-2-17
V5017 BA.4.1.1 9.53e-1 4819 2022-1-1 2023-1-21
V5017 BA.4.1.10 9.54e-1 308 2022-6-30 2022-12-26
V5017 BA.4.1.2 9.88e-1 237 2022-4-19 2022-8-15
V5017 BA.4.1.3 9.92e-1 396 2022-1-15 2022-10-25
V5017 BA.4.1.4 9.95e-1 829 2022-5-12 2022-10-28
V5017 BA.4.1.5 9.91e-1 630 2022-4-24 2022-10-11
V5017 BA.4.1.6 9.77e-1 1362 2022-5-7 2022-11-29
V5017 BA.4.1.7 9.87e-1 76 2022-5-22 2022-8-22
V5017 BA.4.1.8 4.06e-2 80 2022-1-17 2023-2-16
V5017 BA.4.1.9 9.64e-1 537 2021-12-22 2023-1-24
V5017 BA.4.2 9.74e-1 4219 2022-1-19 2022-12-5
V5017 BA.4.3 9.83e-1 117 2022-4-19 2022-8-17
V5017 BA.4.4 9.80e-1 6980 2021-11-17 2023-1-23
V5017 BA.4.5 6.99e-1 707 2022-3-25 2022-11-15
V5017 BA.4.6 9.72e-1 47306 2022-1-3 2023-2-15
V5017 BA.4.6.1 9.57e-1 972 2022-6-9 2023-2-13
V5017 BA.4.6.2 9.63e-1 207 2022-8-11 2023-1-30
V5017 BA.4.6.3 9.82e-1 444 2022-8-2 2023-2-11
V5017 BA.4.6.4 9.69e-1 1605 2022-5-29 2023-1-31
V5017 BA.4.6.5 9.70e-1 4065 2022-5-19 2023-2-2
V5017 BA.4.7 9.74e-1 1629 2022-4-13 2023-1-16
V5017 BA.4.8 6.56e-2 8 2022-3-8 2022-9-17
V5017 BA.5 2.77e-2 993 2021-11-15 2023-2-20
V5017 BA.5.1.5 1.23e-2 116 2022-4-26 2023-2-14
V5017 BY.1 1.04e-2 14 2022-1-1 2023-2-20
V5017 CS.1 1.00e+0 11 2022-8-15 2022-10-28
V5017 DC.1 9.73e-1 214 2022-8-8 2023-1-9
V5017 P.1.17 2.95e-2 181 2021-2-23 2021-11-19
V5017 XAJ 9.20e-2 8 2022-5-18 2022-9-10






Examining mutation (33G>T) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID




Association between mutation (33G>T) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory 2.31e-2 1.15e-1 2.01e-1 8.41e-1 Increase
Deceased 1.45e-1 3.17e-1 4.56e-1 6.49e-1 Increase
Homebound 3.53e-1 8.03e-1 4.40e-1 6.60e-1 Increase
Hospitalized 3.69e-2 9.61e-2 3.84e-1 7.01e-1 Increase
Mild -2.03e-1 2.40e-1 -8.48e-1 3.96e-1 Decrease
Recovered -8.62e-2 1.09e-1 -7.90e-1 4.29e-1 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 1.09e-1 2.92e-2 3.72e+0 1.98e-4 Increase
18-39 6.84e-2 1.45e-2 4.71e+0 2.45e-6 Increase
40-64 -1.32e-2 1.42e-2 -9.29e-1 3.53e-1 Decrease
65-84 -6.32e-2 1.88e-2 -3.36e+0 7.68e-4 Decrease
>=85 -1.56e-2 3.64e-2 -4.29e-1 6.68e-1 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male -4.33e-2 1.39e-2 -3.12e+0 1.82e-3 Decrease





Investigating natural selection at mutation (33G>T) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method




Alterations in protein physicochemical properties induced by mutation (33G>T)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY
Mutation ORF7b 5214.29 4.17 6990 147.44 1.426
Reference ORF7b 5180.27 4.17 6990 156.51 1.449




Alterations in protein stability induced by mutation (33G>T)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition
L11F ORF7b Point 11 -0.8 Decrease 7 25 Environment
L11F ORF7b Point 11 -0.85 Decrease 7.4 37 Internal




Impact on protein function induced by mutation (33G>T)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms
L11F ORF7b Point 0.043 Altered PPI_hotspot (Pr = 0.33 | P = 1.5e-03)
Gain of Strand (Pr = 0.28 | P = 9.0e-03)
Altered Cytoplasmic_loop (Pr = 0.27 | P = 8.4e-04)
Loss of Helix (Pr = 0.27 | P = 0.06)
Loss of Sulfation at Y10 (Pr = 0.05 | P = 8.2e-03)
Loss of Disulfide_linkage at C12 (Pr = 0.04 | P = 0.09)
Altered N-terminal_signal (Pr = 0.03 | P = 4.4e-03)




Exploring mutation (33G>T) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (33G>T)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites
L11F ORF7b 27788 Chymotrypsin-high specificity DFYFCFLAFL (pos: 11)
 NA




Impact of spike protein mutation (33G>T) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (33G>T) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

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Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

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        Show interface residues:





Impact of mutation (33G>T) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (33G>T) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V3255 19549C>T missense_variant ORF1ab_pp1ab P6517S 8.36e-1 AY.25.1
V9496 52C>T synonymous_variant ORF7b L18L 7.92e-1 BA.4.1
V9496 52C>T synonymous_variant ORF7b L18L 7.79e-1 BA.4.6
V813 2708C>T missense_variant ORF1ab_pp1a A903V 6.71e-1 AY.125
V1798 8341C>T missense_variant ORF1ab_pp1a L2781F 7.09e-1 AY.126
V5502 652G>T missense_variant N A218S 6.79e-1 AY.126
V8404 19326T>C synonymous_variant ORF1ab_pp1ab Y6442Y 8.80e-1 AY.20
V4167 3202G>T missense_variant S V1068F 6.68e-1 AY.44
V5724 *4301T>G downstream_gene_variant S None 7.55e-1 AY.47
V8006 16362C>T synonymous_variant ORF1ab_pp1ab L5454L 9.81e-1 AY.47
V3392 20347C>T missense_variant ORF1ab_pp1ab L6783F 1.00e+0 A.2.5
V3903 1435C>T missense_variant S P479S 7.74e-1 A.2.5
V6400 3849T>C synonymous_variant ORF1ab_pp1a A1283A 9.13e-1 A.2.5
V7570 12984G>T synonymous_variant ORF1ab_pp1a L4328L 1.00e+0 A.2.5
V773 2525C>T missense_variant ORF1ab_pp1a T842I 8.66e-1 A.2.5
V507 1416G>T missense_variant ORF1ab_pp1a E472D 9.23e-1 AY.107
V1721 7825C>T missense_variant ORF1ab_pp1a L2609F 1.00e+0 AY.120.2
V2038 10184C>T missense_variant ORF1ab_pp1a P3395L 1.00e+0 AY.120.2
V2366 12476C>T missense_variant ORF1ab_pp1a T4159I 1.00e+0 AY.120.2
V3091 18319G>A missense_variant ORF1ab_pp1ab V6107I 1.00e+0 AY.120.2
V4220 3457G>T missense_variant S D1153Y 1.00e+0 AY.120.2
V5197 305G>T missense_variant ORF8 C102F 1.00e+0 AY.120.2
V7130 9546C>T synonymous_variant ORF1ab_pp1a T3182T 1.00e+0 AY.120.2
V7490 12408T>C synonymous_variant ORF1ab_pp1a A4136A 1.00e+0 AY.120.2
V8067 16855C>T synonymous_variant ORF1ab_pp1ab L5619L 1.00e+0 AY.120.2
V9548 306T>C synonymous_variant ORF8 C102C 1.00e+0 AY.120.2
V1916 9142G>A missense_variant ORF1ab_pp1a V3048I 1.00e+0 AY.121.1
V5632 1160A>G missense_variant N K387R 1.00e+0 AY.121.1
V8639 156G>A synonymous_variant S Q52Q 7.07e-1 AY.121.1
V2378 12529G>A missense_variant ORF1ab_pp1a G4177R 7.07e-1 AY.122.1
V6958 8124C>T synonymous_variant ORF1ab_pp1a N2708N 7.07e-1 AY.122.1
V2111 10817dupT frameshift_variant ORF1ab_pp1a L3606fs 7.07e-1 AY.122.2
V2403 12721A>G missense_variant ORF1ab_pp1a M4241V 7.07e-1 AY.122.2
V3340 20092G>T missense_variant ORF1ab_pp1ab G6698C 1.00e+0 AY.13
V4736 118G>T missense_variant M A40S 1.00e+0 AY.34.1
V6682 5985C>T synonymous_variant ORF1ab_pp1a N1995N 1.00e+0 AY.34.1
V7869 15279G>T synonymous_variant ORF1ab_pp1ab T5093T 1.00e+0 AY.34.1
V5391 430G>T missense_variant N D144Y 7.07e-1 AY.36
V1796 8332C>T missense_variant ORF1ab_pp1a L2778F 1.00e+0 AY.4.2.3
V2202 11206C>T missense_variant ORF1ab_pp1a L3736F 1.00e+0 AY.4.2.3
V2904 17061G>T missense_variant ORF1ab_pp1ab L5687F 7.07e-1 AY.42
V3735 638T>G missense_variant S V213G 1.00e+0 AY.45
V4839 181G>C missense_variant ORF6 D61H 7.07e-1 AY.45
V4841 182A>T missense_variant ORF6 D61V 7.07e-1 AY.45
V7437 11895G>A synonymous_variant ORF1ab_pp1a E3965E 7.07e-1 AY.45
V773 2525C>T missense_variant ORF1ab_pp1a T842I 1.00e+0 AY.45
V2337 12248C>T missense_variant ORF1ab_pp1a T4083M 6.66e-1 AY.4.8
V389 973C>T missense_variant ORF1ab_pp1a H325Y 8.53e-1 AY.4.8
V6993 8499T>C synonymous_variant ORF1ab_pp1a D2833D 6.32e-1 AY.4.8
V3680 519G>T missense_variant S Q173H 9.64e-1 AY.48
V4569 584C>T missense_variant ORF3a S195F 9.18e-1 AY.48
V4869 49C>T missense_variant ORF7a L17F 9.18e-1 AY.48
V7797 14667C>T synonymous_variant ORF1ab_pp1ab N4889N 9.91e-1 AY.48
V7933 15750G>A synonymous_variant ORF1ab_pp1ab R5250R 9.83e-1 AY.48
V8060 16773A>T synonymous_variant ORF1ab_pp1ab A5591A 9.74e-1 AY.48
V1606 6839C>T missense_variant ORF1ab_pp1a T2280I 1.00e+0 AY.74
V1486 6267G>T missense_variant ORF1ab_pp1a E2089D 6.32e-1 AY.94
V9755 945C>T synonymous_variant N F315F 7.07e-1 AY.94
V4240 3573G>T missense_variant S K1191N 7.55e-1 B.1.1.153
V4342 85G>T missense_variant ORF3a V29F 9.35e-1 B.1.1.153
V4880 85G>T missense_variant ORF7a V29L 7.55e-1 B.1.1.153
V8449 19719C>T synonymous_variant ORF1ab_pp1ab V6573V 8.81e-1 B.1.1.153
V2714 15408G>T missense_variant ORF1ab_pp1ab E5136D 7.07e-1 B.1.1.28
V646 1942A>G missense_variant ORF1ab_pp1a I648V 6.32e-1 B.1.1.28
V3616 293C>T missense_variant S S98F 9.13e-1 B.1.1.291
V6386 3756C>T synonymous_variant ORF1ab_pp1a N1252N 1.00e+0 B.1.1.291
V6420 3990G>T synonymous_variant ORF1ab_pp1a P1330P 7.70e-1 B.1.1.291
V9341 363C>T synonymous_variant M N121N 1.00e+0 B.1.1.291
V9123 3753A>G synonymous_variant S G1251G 7.07e-1 B.1.1.306
V9366 466C>T synonymous_variant M L156L 7.07e-1 B.1.1.306
V1185 4550C>T missense_variant ORF1ab_pp1a S1517F 1.00e+0 B.1.1.37
V4275 3730C>T missense_variant S L1244F 8.65e-1 B.1.1.464
V9406 93C>T synonymous_variant ORF6 Y31Y 8.65e-1 B.1.1.464
V377 925C>T missense_variant ORF1ab_pp1a P309S 7.07e-1 B.1.1.50
V4658 -15G>T upstream_gene_variant E None 1.00e+0 B.1.1.50
V7712 14118T>C synonymous_variant ORF1ab_pp1ab N4706N 1.00e+0 B.1.1.50
V3242 19420G>T missense_variant ORF1ab_pp1ab V6474L 7.07e-1 B.1.1.529
V5396 451C>T missense_variant N P151S 1.00e+0 B.1.1.529
V629 1879G>A missense_variant ORF1ab_pp1a V627I 1.00e+0 B.1.1.529
V8290 18459T>C synonymous_variant ORF1ab_pp1ab H6153H 1.00e+0 B.1.1.529
V8256 18207T>C synonymous_variant ORF1ab_pp1ab D6069D 1.00e+0 B.1.177.60
V8679 348C>T synonymous_variant S S116S 7.07e-1 B.1.177.60
V3061 18133G>T missense_variant ORF1ab_pp1ab V6045L 1.00e+0 B.1.234
V2997 17768C>T missense_variant ORF1ab_pp1ab T5923I 8.07e-1 B.1.36.29
V4011 2025G>T missense_variant S Q675H 8.49e-1 B.1.36.29
V4764 251T>C missense_variant M M84T 1.00e+0 B.1.36.29
V8903 2076C>T synonymous_variant S I692I 6.95e-1 B.1.36.29
V4131 2806G>T missense_variant S D936Y 1.00e+0 B.1.36.31
V4316 48G>C missense_variant ORF3a K16N 1.00e+0 B.1.36.31
V6716 6156G>T synonymous_variant ORF1ab_pp1a V2052V 7.07e-1 B.1.369
V3793 782G>T missense_variant S G261V 7.07e-1 B.1.36
V4935 217C>T missense_variant ORF7a H73Y 7.07e-1 B.1.36
V1755 8022G>T missense_variant ORF1ab_pp1a M2674I 7.07e-1 B.1.466.2
V3542 65C>T missense_variant S T22I 7.07e-1 B.1.575
V8369 18999C>T synonymous_variant ORF1ab_pp1ab N6333N 7.07e-1 B.1.575
V6559 5010A>G synonymous_variant ORF1ab_pp1a A1670A 7.07e-1 B.1.621
V195 253_255delATG conservative_inframe_deletion ORF1ab_pp1a M85del 8.65e-1 B.4
V2901 17024C>T missense_variant ORF1ab_pp1ab T5675I 1.00e+0 B.4
V8265 18291C>T synonymous_variant ORF1ab_pp1ab D6097D 1.00e+0 B.4
V2182 11114C>T missense_variant ORF1ab_pp1a A3705V 1.00e+0 BA.2.23
V425 1114G>A missense_variant ORF1ab_pp1a A372T 1.00e+0 BA.2.23
V8584 20955C>T synonymous_variant ORF1ab_pp1ab F6985F 7.07e-1 BA.2.23
V2099 10732G>A missense_variant ORF1ab_pp1a G3578S 7.07e-1 BA.2.3.14
V5939 564C>T synonymous_variant ORF1ab_pp1a N188N 7.07e-1 BA.2.3.14
V7613 13290C>T synonymous_variant ORF1ab_pp1ab Y4430Y 7.07e-1 BA.2.3.14
V6520 4743G>A synonymous_variant ORF1ab_pp1a T1581T 1.00e+0 BA.2.38.1
V8344 18849C>T synonymous_variant ORF1ab_pp1ab D6283D 1.00e+0 BA.2.38.1
V2180 11090C>T missense_variant ORF1ab_pp1a A3697V 1.00e+0 BA.2.40.1
V9496 52C>T synonymous_variant ORF7b L18L 8.56e-1 BA.4.1.1
V9496 52C>T synonymous_variant ORF7b L18L 7.06e-1 BA.4.1.4
V9496 52C>T synonymous_variant ORF7b L18L 9.12e-1 BA.4.1.5
V9496 52C>T synonymous_variant ORF7b L18L 8.51e-1 BA.4.1.6
V9496 52C>T synonymous_variant ORF7b L18L 7.35e-1 BA.4.1.9
V9496 52C>T synonymous_variant ORF7b L18L 7.39e-1 BA.4.2
V9496 52C>T synonymous_variant ORF7b L18L 7.30e-1 BA.4.4
V1114 3919G>A missense_variant ORF1ab_pp1a G1307S 9.62e-1 BA.4.5
V2037 10184C>A missense_variant ORF1ab_pp1a P3395H 9.74e-1 BA.4.5
V249 405T>G missense_variant ORF1ab_pp1a S135R 7.74e-1 BA.4.5
V260 421_429delAAGTCATTT conservative_inframe_deletion ORF1ab_pp1a K141_F143del 9.16e-1 BA.4.5
V2918 17146C>T missense_variant ORF1ab_pp1ab R5716C 9.65e-1 BA.4.5
V3578 204_209delACATGT disruptive_inframe_deletion S H69_V70del 8.60e-1 BA.4.5
V3635 425G>A missense_variant S G142D 9.74e-1 BA.4.5
V3695 542G>A missense_variant S G181E 9.12e-1 BA.4.5
V3735 638T>G missense_variant S V213G 9.55e-1 BA.4.5
V3820 1016G>A missense_variant S G339D 9.60e-1 BA.4.5
V3840 1112C>T missense_variant S S371F 9.58e-1 BA.4.5
V3841 1117T>C missense_variant S S373P 9.60e-1 BA.4.5
V3843 1124C>T missense_variant S S375F 9.60e-1 BA.4.5
V3844 1126A>G missense_variant S T376A 9.60e-1 BA.4.5
V3851 1213G>A missense_variant S D405N 9.49e-1 BA.4.5
V3854 1224A>C missense_variant S R408S 9.14e-1 BA.4.5
V4144 2862A>T missense_variant S Q954H 9.13e-1 BA.4.5
V4146 2907T>A missense_variant S N969K 9.11e-1 BA.4.5
V4729 55C>G missense_variant M Q19E 8.35e-1 BA.4.5
V5241 -3A>T upstream_gene_variant N None 9.39e-1 BA.4.5
V5651 1237A>C missense_variant N S413R 9.37e-1 BA.4.5
V6064 1419C>T synonymous_variant ORF1ab_pp1a I473I 9.39e-1 BA.4.5
V6426 4056C>T synonymous_variant ORF1ab_pp1a A1352A 8.44e-1 BA.4.5
V7193 9933C>T synonymous_variant ORF1ab_pp1a D3311D 9.79e-1 BA.4.5
V7219 10182G>A synonymous_variant ORF1ab_pp1a R3394R 9.74e-1 BA.4.5
V7888 15450C>T synonymous_variant ORF1ab_pp1ab L5150L 9.62e-1 BA.4.5
V8457 19791A>G synonymous_variant ORF1ab_pp1ab E6597E 8.87e-1 BA.4.5
V9076 3438C>T synonymous_variant S D1146D 9.58e-1 BA.4.5
V9496 52C>T synonymous_variant ORF7b L18L 9.91e-1 BA.4.5
V97 -25C>T upstream_gene_variant ORF1ab_pp1a None 7.91e-1 BA.4.5
V9496 52C>T synonymous_variant ORF7b L18L 6.73e-1 BA.4.6.1
V9496 52C>T synonymous_variant ORF7b L18L 8.79e-1 BA.4.6.4
V9496 52C>T synonymous_variant ORF7b L18L 7.12e-1 BA.4.6.5
V9496 52C>T synonymous_variant ORF7b L18L 8.43e-1 BA.4.7
V9496 52C>T synonymous_variant ORF7b L18L 7.57e-1 BA.4
V1641 7166C>T missense_variant ORF1ab_pp1a S2389L 1.00e+0 BA.5.1.15
V7074 9066T>C synonymous_variant ORF1ab_pp1a D3022D 1.00e+0 BA.5.1.17
V8289 18450C>T synonymous_variant ORF1ab_pp1ab A6150A 7.07e-1 BA.5.1.17
V1942 9346C>T missense_variant ORF1ab_pp1a L3116F 7.07e-1 BA.5.11
V3999 1973A>G missense_variant S N658S 7.07e-1 BA.5.11
V5396 451C>T missense_variant N P151S 1.00e+0 BA.5.11
V5951 630A>G synonymous_variant ORF1ab_pp1a K210K 1.00e+0 BA.5.1.30
V7921 15688C>T synonymous_variant ORF1ab_pp1ab L5230L 7.07e-1 BA.5.1.30
V260 421_429delAAGTCATTT conservative_inframe_deletion ORF1ab_pp1a K141_F143del 6.55e-1 BA.5.1.5
V3697 542G>T missense_variant S G181V 9.61e-1 BA.5.1.5
V3882 1348A>G missense_variant S N450D 6.91e-1 BA.5.1.5
V6804 6897C>T synonymous_variant ORF1ab_pp1a D2299D 9.25e-1 BA.5.1.5
V9424 45T>C synonymous_variant ORF7a C15C -7.31e-1 BA.5.1.5
V6371 3609C>T synonymous_variant ORF1ab_pp1a I1203I 6.32e-1 BA.5.1.6
V9783 1080C>T synonymous_variant N Y360Y 1.00e+0 BA.5.1.6
V1022 3503C>T missense_variant ORF1ab_pp1a T1168I 1.00e+0 BA.5.1.9
V1328 5439G>T missense_variant ORF1ab_pp1a Q1813H 7.06e-1 BA.5.1.9
V1758 8053C>A missense_variant ORF1ab_pp1a P2685T 1.00e+0 BA.5.1.9
V8342 18828T>C synonymous_variant ORF1ab_pp1ab Y6276Y 7.07e-1 BA.5.1.9
V4041 2093C>T missense_variant S S698L 1.00e+0 BA.5.2.16
V540 1586T>C missense_variant ORF1ab_pp1a I529T 7.07e-1 BA.5.2.16
V5396 451C>T missense_variant N P151S 8.66e-1 BA.5.2.28
V3154 18745G>T missense_variant ORF1ab_pp1ab D6249Y 1.00e+0 BA.5.2.3
V1145 4210C>T missense_variant ORF1ab_pp1a R1404C 6.66e-1 BA.5.3.4
V4839 181G>C missense_variant ORF6 D61H 1.00e+0 BA.5.3.5
V3999 1973A>G missense_variant S N658S 6.17e-1 BA.5
V5402 466G>T missense_variant N A156S 6.40e-1 BA.5
V5396 451C>T missense_variant N P151S 7.07e-1 BE.2
V6040 1248C>T synonymous_variant ORF1ab_pp1a C416C 7.07e-1 BE.3
V8888 1998T>C synonymous_variant S I666I 7.07e-1 BE.3
V5396 451C>T missense_variant N P151S 1.00e+0 BF.12
V9696 675C>T synonymous_variant N D225D 1.00e+0 BF.12
V4544 521G>A missense_variant ORF3a G174D 1.00e+0 BF.21
V7749 14355T>C synonymous_variant ORF1ab_pp1ab T4785T 7.07e-1 BF.21
V1637 7122G>A missense_variant ORF1ab_pp1a M2374I 6.92e-1 BF.26
V590 1727A>G missense_variant ORF1ab_pp1a Y576C 6.92e-1 BF.26
V4250 3615G>T missense_variant S K1205N 7.07e-1 BF.7.4.1
V5410 497C>T missense_variant N T166I 7.07e-1 BF.7.4.1
V9718 804C>T synonymous_variant N Y268Y 1.00e+0 BK.1
V5396 451C>T missense_variant N P151S 1.00e+0 BQ.1.1.13
V3879 1337G>T missense_variant S G446V 1.00e+0 BQ.1.1.1
V5396 451C>T missense_variant N P151S 1.00e+0 BQ.1.11
V5627 1147C>T missense_variant N P383S 1.00e+0 BQ.1.1.22
V5846 78G>T synonymous_variant ORF1ab_pp1a V26V 1.00e+0 BQ.1.1.22
V9422 25C>T synonymous_variant ORF7a L9L 8.16e-1 BQ.1.1.32
V6001 939C>T synonymous_variant ORF1ab_pp1a N313N 8.16e-1 BQ.1.18
V3733 638T>A missense_variant S V213E 6.47e-1 BY.1
V4012 2027C>T missense_variant S T676I 7.31e-1 BY.1
V6158 2079C>T synonymous_variant ORF1ab_pp1a I693I 1.00e+0 BY.1
V7726 14214C>T synonymous_variant ORF1ab_pp1ab Y4738Y 1.00e+0 BY.1
V5316 98G>T missense_variant N S33I 7.07e-1 C.37
V2374 12521C>T missense_variant ORF1ab_pp1a T4174I 1.00e+0 CA.3
V3954 1718C>T missense_variant S T573I 7.07e-1 CA.3
V7203 10014C>T synonymous_variant ORF1ab_pp1a L3338L 1.00e+0 CA.3
V7684 13920C>T synonymous_variant ORF1ab_pp1ab T4640T 1.00e+0 CA.3
V6440 4158C>T synonymous_variant ORF1ab_pp1a R1386R 9.27e-1 CH.1.1.3
V4863 37G>A missense_variant ORF7a A13T 1.00e+0 CM.8.1
V1736 7891T>C missense_variant ORF1ab_pp1a S2631P 7.50e-1 P.1.17
V7650 13680C>T synonymous_variant ORF1ab_pp1ab N4560N 1.00e+0 R.1
V5039 94C>T missense_variant ORF7b L32F 1.00e+0 XBB
V141 111G>T missense_variant ORF1ab_pp1a E37D 1.00e+0 B.1.1.448
V1486 6267G>T missense_variant ORF1ab_pp1a E2089D 7.06e-1 B.1.1.448
V3059 18130G>T missense_variant ORF1ab_pp1ab A6044S 1.00e+0 B.1.1.448
V6725 6207C>T synonymous_variant ORF1ab_pp1a T2069T 1.00e+0 B.1.1.448
V7307 10959C>T synonymous_variant ORF1ab_pp1a V3653V 7.06e-1 B.1.1.448
V7323 11109T>C synonymous_variant ORF1ab_pp1a D3703D 1.00e+0 B.1.1.448
V4009 2024A>G missense_variant S Q675R 6.62e-1 B.1.160.26
V4807 39G>T missense_variant ORF6 E13D 8.93e-1 B.1.160.26
V4825 122C>T missense_variant ORF6 S41F 8.93e-1 B.1.160.26
V8651 210C>T synonymous_variant S V70V 1.00e+0 B.1.160.26
V8662 249C>T synonymous_variant S V83V 1.00e+0 B.1.160.26
V7269 10569C>T synonymous_variant ORF1ab_pp1a A3523A 1.00e+0 B.38
V9496 52C>T synonymous_variant ORF7b L18L 9.08e-1 BA.4.1.10
V4955 251C>T missense_variant ORF7a P84L 6.62e-1 BA.4.1.2
V9496 52C>T synonymous_variant ORF7b L18L 8.64e-1 BA.4.1.2
V9496 52C>T synonymous_variant ORF7b L18L 8.65e-1 BA.4.1.3
V1114 3919G>A missense_variant ORF1ab_pp1a G1307S 7.02e-1 BA.4.1.7
V1383 5819A>G missense_variant ORF1ab_pp1a D1940G 1.00e+0 BA.4.1.7
V2037 10184C>A missense_variant ORF1ab_pp1a P3395H 1.00e+0 BA.4.1.7
V249 405T>G missense_variant ORF1ab_pp1a S135R 1.00e+0 BA.4.1.7
V260 421_429delAAGTCATTT conservative_inframe_deletion ORF1ab_pp1a K141_F143del 1.00e+0 BA.4.1.7
V2918 17146C>T missense_variant ORF1ab_pp1ab R5716C 1.00e+0 BA.4.1.7
V3635 425G>A missense_variant S G142D 7.02e-1 BA.4.1.7
V3735 638T>G missense_variant S V213G 7.02e-1 BA.4.1.7
V4144 2862A>T missense_variant S Q954H 1.00e+0 BA.4.1.7
V4146 2907T>A missense_variant S N969K 1.00e+0 BA.4.1.7
V4729 55C>G missense_variant M Q19E 1.00e+0 BA.4.1.7
V7219 10182G>A synonymous_variant ORF1ab_pp1a R3394R 1.00e+0 BA.4.1.7
V7888 15450C>T synonymous_variant ORF1ab_pp1ab L5150L 1.00e+0 BA.4.1.7
V8116 17175C>T synonymous_variant ORF1ab_pp1ab D5725D 1.00e+0 BA.4.1.7
V9076 3438C>T synonymous_variant S D1146D 1.00e+0 BA.4.1.7
V9496 52C>T synonymous_variant ORF7b L18L 1.00e+0 BA.4.1.7
V5396 451C>T missense_variant N P151S 7.04e-1 BA.4.3
V6878 7575C>T synonymous_variant ORF1ab_pp1a D2525D -7.04e-1 BA.4.3
V9496 52C>T synonymous_variant ORF7b L18L 1.00e+0 BA.4.3
V3999 1973A>G missense_variant S N658S 1.00e+0 BA.5.2.10
V5396 451C>T missense_variant N P151S 1.00e+0 BA.5.2.10
V9123 3753A>G synonymous_variant S G1251G 7.06e-1 BA.5.2.10
V9401 58A>C synonymous_variant ORF6 R20R 7.06e-1 BA.5.2.10
V6338 3318C>T synonymous_variant ORF1ab_pp1a S1106S 7.06e-1 BM.2
V6440 4158C>T synonymous_variant ORF1ab_pp1a R1386R 1.00e+0 BM.2
V7108 9375T>C synonymous_variant ORF1ab_pp1a H3125H 1.00e+0 BM.2
V4160 3135G>T missense_variant S K1045N 1.00e+0 BT.1
V5548 835C>T missense_variant N P279S 1.00e+0 BT.1
V7933 15750G>A synonymous_variant ORF1ab_pp1ab R5250R 1.00e+0 BT.1
V6440 4158C>T synonymous_variant ORF1ab_pp1a R1386R 1.00e+0 CH.1
V4839 181G>C missense_variant ORF6 D61H 6.70e-1 DC.1
V4841 182A>T missense_variant ORF6 D61V 6.70e-1 DC.1
V5396 451C>T missense_variant N P151S 6.04e-1 DC.1
V9418 183T>C synonymous_variant ORF6 D61D 6.70e-1 DC.1
V3999 1973A>G missense_variant S N658S -7.76e-1 XAJ
V4045 2111C>T missense_variant S S704L -6.76e-1 XAJ
V5396 451C>T missense_variant N P151S 8.55e-1 XAJ
V8640 159C>T synonymous_variant S D53D 6.90e-1 XAJ
V9139 24C>T synonymous_variant ORF3a F8F -8.55e-1 XAJ





Manual curation of mutation (33G>T)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID