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The current mutation

ID: V5871
DNA: 213C>T
Protein: I71I
Position: 478








COV2Var annotation categories







Summary information of mutation (213C>T)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp01_pp1a
  Gene Name   ORF1ab_pp1a
  Gene Type   protein_coding
  Genome position   478
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   synonymous_variant
  DNA Level   DNA Mutation: 213C>T
  Ref Seq: C
  Mut Seq: T
  Protein Level   Protein 1-letter Mutation: I71I
  Protein 3-letter Mutation: Ile71Ile

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (213C>T) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.1.228 12 6 5.00e-1
2020-10 B.1.177.39 12 1 8.33e-2
2020-10 B.1.177.56 12 1 8.33e-2
2020-11 B.1.1.28 15 4 2.67e-1
2020-11 B.1.1.341 15 4 2.67e-1
2020-11 B.1.1.243 15 2 1.33e-1
2020-12 B.1.2 40 14 3.50e-1
2020-12 B.1.311 40 8 2.00e-1
2020-12 B.1.177 40 6 1.50e-1
2020-03 B.1.190 23 23 1.00e+0
2020-04 B.1.190 18 12 6.67e-1
2020-04 A.2 18 2 1.11e-1
2020-04 B.1 18 2 1.11e-1
2020-06 B.1 5 5 1.00e+0
2020-07 B.1.1.228 6 2 3.33e-1
2020-07 B.1.1.25 6 1 1.67e-1
2020-07 B.1.291 6 1 1.67e-1
2020-08 B.1.177.82 9 3 3.33e-1
2020-08 B.1.1.228 9 2 2.22e-1
2020-08 B.1.1.222 9 1 1.11e-1
2020-09 B.1.177.82 19 10 5.26e-1
2020-09 B.1.612 19 4 2.11e-1
2020-09 B.1 19 2 1.05e-1
2021-01 B.1.429 62 23 3.71e-1
2021-01 B.1.2 62 13 2.10e-1
2021-01 B.1.1.7 62 12 1.94e-1
2021-10 B.1.617.2 247 53 2.15e-1
2021-10 AY.122 247 32 1.30e-1
2021-10 AY.44 247 29 1.17e-1
2021-11 AY.4 323 58 1.80e-1
2021-11 AY.122 323 41 1.27e-1
2021-11 AY.113 323 37 1.15e-1
2021-12 BA.1.17.2 352 115 3.27e-1
2021-12 AY.3 352 32 9.09e-2
2021-12 AY.103 352 24 6.82e-2
2021-02 B.1.1.7 95 26 2.74e-1
2021-02 B.1.2 95 17 1.79e-1
2021-02 B.1.478 95 9 9.47e-2
2021-03 B.1.1.7 116 36 3.10e-1
2021-03 B.1.2 116 32 2.76e-1
2021-03 B.1 116 9 7.76e-2
2021-04 B.1.1.7 90 53 5.89e-1
2021-04 P.1 90 6 6.67e-2
2021-04 B.1.2 90 5 5.56e-2
2021-05 B.1.1.7 116 69 5.95e-1
2021-05 AY.19 116 22 1.90e-1
2021-05 P.1 116 10 8.62e-2
2021-06 AY.19 160 74 4.62e-1
2021-06 P.1 160 29 1.81e-1
2021-06 B.1.1.7 160 23 1.44e-1
2021-07 AY.19 232 116 5.00e-1
2021-07 P.1 232 40 1.72e-1
2021-07 AY.4 232 17 7.33e-2
2021-08 AY.19 230 54 2.35e-1
2021-08 P.1 230 26 1.13e-1
2021-08 AY.4 230 15 6.52e-2
2021-09 B.1.617.2 196 26 1.33e-1
2021-09 AY.4 196 18 9.18e-2
2021-09 AY.103 196 16 8.16e-2
2022-01 BA.1.17.2 245 105 4.29e-1
2022-01 BA.1 245 36 1.47e-1
2022-01 BA.1.1 245 35 1.43e-1
2022-10 DA.1 107 39 3.64e-1
2022-10 BQ.1.2 107 20 1.87e-1
2022-10 BN.1.3 107 10 9.35e-2
2022-11 BQ.1.2 250 148 5.92e-1
2022-11 BA.5.2.31 250 33 1.32e-1
2022-11 DA.1 250 17 6.80e-2
2022-12 BQ.1.2 286 159 5.56e-1
2022-12 BN.1.3 286 26 9.09e-2
2022-12 BQ.1.1 286 18 6.29e-2
2022-02 BA.1.1 152 49 3.22e-1
2022-02 BA.2 152 38 2.50e-1
2022-02 BA.1 152 11 7.24e-2
2022-03 BA.2 131 69 5.27e-1
2022-03 BA.2.9 131 25 1.91e-1
2022-03 BA.1.1 131 10 7.63e-2
2022-04 BA.2 79 38 4.81e-1
2022-04 BA.2.9 79 19 2.41e-1
2022-04 BA.2.38 79 8 1.01e-1
2022-05 BA.2.38 166 86 5.18e-1
2022-05 BA.2 166 24 1.45e-1
2022-05 BA.2.9 166 21 1.27e-1
2022-06 BA.2.38 143 51 3.57e-1
2022-06 BF.3 143 40 2.80e-1
2022-06 BA.2 143 12 8.39e-2
2022-07 BF.3 130 81 6.23e-1
2022-07 BA.2.38 130 13 1.00e-1
2022-07 BA.5.6 130 9 6.92e-2
2022-08 BF.3 86 40 4.65e-1
2022-08 BA.5.5 86 8 9.30e-2
2022-08 DA.1 86 8 9.30e-2
2022-09 DA.1 100 60 6.00e-1
2022-09 BA.5.2.31 100 9 9.00e-2
2022-09 BA.5.6 100 6 6.00e-2
2023-01 BQ.1.2 183 97 5.30e-1
2023-01 BQ.1.1.18 183 14 7.65e-2
2023-01 BQ.1.1 183 13 7.10e-2
2023-02 BQ.1.2 37 21 5.68e-1
2023-02 BQ.1.1.18 37 6 1.62e-1
2023-02 BN.1.3 37 4 1.08e-1

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V5871 BQ.1.2 4.21e-2 446 2022-1-4 2023-2-21
V5871 AY.87 2.18e-2 21 2021-5-18 2022-1-22
V5871 BA.5.2.31 3.77e-2 67 2022-6-6 2023-1-27
V5871 BF.3 8.95e-2 167 2022-5-3 2022-12-27
V5871 BA.2.38 2.33e-2 164 2022-1-7 2022-10-24
V5871 AY.19 3.70e-1 146 2021-4-5 2022-5-7
V5871 B.1.1.228 1.39e-2 5 2020-5-13 2021-12-15
V5871 B.1.1.336 2.35e-2 2 2020-9-1 2021-6-21
V5871 B.1.1.341 1.18e-1 2 2020-9-14 2020-11-19
V5871 B.1.190 4.12e-1 35 2020-3-13 2020-5-6
V5871 B.1.478 7.94e-2 10 2020-5-15 2021-3-5
V5871 B.1.539 3.03e-2 2 2020-10-25 2021-3-12
V5871 CU.1 1.30e-1 7 2022-8-5 2022-12-18
V5871 DA.1 9.41e-1 127 2022-1-10 2023-1-24
V5871 XBG 1.92e-2 3 2022-7-5 2023-2-7






Examining mutation (213C>T) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID




Association between mutation (213C>T) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory -1.46e+1 9.36e+2 -1.57e-2 9.88e-1 Decrease
Deceased -1.68e+1 6.30e+3 -2.66e-3 9.98e-1 Decrease
Homebound -2.07e+1 1.13e+4 -1.83e-3 9.99e-1 Decrease
Hospitalized 3.32e+0 6.92e-1 4.79e+0 1.64e-6 Increase
Mild -2.71e+0 6.93e-1 -3.91e+0 9.40e-5 Decrease
Recovered -1.58e+1 9.39e+2 -1.68e-2 9.87e-1 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 1.98e-1 1.72e-1 1.15e+0 2.51e-1 Increase
18-39 -1.64e-1 9.37e-2 -1.75e+0 8.02e-2 Decrease
40-64 5.34e-2 9.40e-2 5.68e-1 5.70e-1 Increase
65-84 1.52e-1 1.21e-1 1.25e+0 2.10e-1 Increase
>=85 -5.96e-1 3.42e-1 -1.74e+0 8.12e-2 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male -1.88e-1 9.09e-2 -2.07e+0 3.85e-2 Decrease





Investigating natural selection at mutation (213C>T) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method




Alterations in protein physicochemical properties induced by mutation (213C>T)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY




Alterations in protein stability induced by mutation (213C>T)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition




Impact on protein function induced by mutation (213C>T)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms




Exploring mutation (213C>T) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (213C>T)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites




Impact of spike protein mutation (213C>T) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (213C>T) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

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Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

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        Show interface residues:





Impact of mutation (213C>T) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (213C>T) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V1633 7095G>T missense_variant ORF1ab_pp1a M2365I 6.40e-1 AY.3
V8467 19899A>G synonymous_variant ORF1ab_pp1ab K6633K 8.19e-1 AY.3
V3585 212C>T missense_variant S S71F 6.39e-1 BA.1.17.2
V6939 8025C>T synonymous_variant ORF1ab_pp1a L2675L 6.47e-1 P.1
V7770 14493C>T synonymous_variant ORF1ab_pp1ab H4831H 9.32e-1 P.1
V2033 10136C>T missense_variant ORF1ab_pp1a A3379V 8.93e-1 B.1.429
V7573 12996C>T synonymous_variant ORF1ab_pp1a C4332C 6.96e-1 B.1.429
V3139 18673G>T missense_variant ORF1ab_pp1ab G6225C 6.45e-1 BA.2.10
V3065 18157C>T missense_variant ORF1ab_pp1ab P6053S 7.24e-1 BA.5.6
V2004 9967C>T missense_variant ORF1ab_pp1a R3323C 1.00e+0 A.2
V4535 512C>T missense_variant ORF3a S171L 1.00e+0 A.2
V6507 4662C>T synonymous_variant ORF1ab_pp1a D1554D 8.16e-1 A.2
V1172 4487C>T missense_variant ORF1ab_pp1a T1496I 1.00e+0 A
V3663 455G>T missense_variant S W152L 7.07e-1 A
V4609 718C>T missense_variant ORF3a P240S 7.07e-1 A
V8535 20559C>T synonymous_variant ORF1ab_pp1ab N6853N 7.07e-1 A
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 7.06e-1 AU.3
V3683 530T>C missense_variant S M177T 7.07e-1 AY.104
V5402 466G>T missense_variant N A156S 1.00e+0 AY.104
V6366 3546C>T synonymous_variant ORF1ab_pp1a L1182L 7.07e-1 AY.104
V667 2011A>G missense_variant ORF1ab_pp1a I671V 1.00e+0 AY.104
V3542 65C>T missense_variant S T22I 1.00e+0 AY.105
V9106 3597T>C synonymous_variant S D1199D 1.00e+0 AY.105
V5544 812C>T missense_variant N T271I 1.00e+0 AY.108
V6182 2220C>T synonymous_variant ORF1ab_pp1a I740I 7.07e-1 AY.108
V9061 3348T>C synonymous_variant S T1116T 1.00e+0 AY.108
V3480 21032G>A missense_variant ORF1ab_pp1ab G7011D 6.66e-1 AY.116.1
V9159 129C>T synonymous_variant ORF3a F43F 8.16e-1 AY.116.1
V7887 15435C>T synonymous_variant ORF1ab_pp1ab F5145F 1.00e+0 AY.117
V6788 6774C>T synonymous_variant ORF1ab_pp1a G2258G 1.00e+0 AY.118
V7685 13923G>A synonymous_variant ORF1ab_pp1ab R4641R 6.32e-1 AY.120
V773 2525C>T missense_variant ORF1ab_pp1a T842I 1.00e+0 AY.120
V8158 17481C>T synonymous_variant ORF1ab_pp1ab N5827N 6.32e-1 AY.120
V2357 12439G>A missense_variant ORF1ab_pp1a V4147I 6.18e-1 AY.121
V9288 27C>T synonymous_variant M T9T 6.71e-1 AY.121
V2305 11948C>T missense_variant ORF1ab_pp1a S3983F 7.07e-1 AY.122.1
V2900 17021C>T missense_variant ORF1ab_pp1ab S5674L 7.07e-1 AY.122.1
V5655 1247C>T missense_variant N S416L 7.07e-1 AY.122.1
V4006 2015C>T missense_variant S A672V 1.00e+0 AY.122.5
V2692 15175G>A missense_variant ORF1ab_pp1ab V5059I 7.07e-1 AY.131
V9187 285G>A synonymous_variant ORF3a L95L 1.00e+0 AY.131
V7527 12663A>G synonymous_variant ORF1ab_pp1a K4221K 7.07e-1 AY.14
V836 2816A>G missense_variant ORF1ab_pp1a E939G 7.07e-1 AY.14
V8071 16866C>T synonymous_variant ORF1ab_pp1ab Y5622Y 1.00e+0 AY.3.1
V5695 29C>T missense_variant ORF10 P10L 1.00e+0 AY.33.2
V5629 1152G>T missense_variant N Q384H 1.00e+0 AY.34.1.1
V4446 262G>T missense_variant ORF3a V88L 7.07e-1 AY.36.1
V8957 2529T>C synonymous_variant S D843D 1.00e+0 AY.37
V9455 210C>T synonymous_variant ORF7a G70G 1.00e+0 AY.37
V2026 10075C>T missense_variant ORF1ab_pp1a P3359S 7.75e-1 AY.39.1
V9651 459C>T synonymous_variant N N153N 1.00e+0 AY.39.1
V1534 6445G>T missense_variant ORF1ab_pp1a V2149F 7.07e-1 AY.46.6
V4219 3450G>T missense_variant S E1150D 1.00e+0 AY.51
V652 1967C>T missense_variant ORF1ab_pp1a A656V 7.07e-1 AY.51
V1903 8981C>T missense_variant ORF1ab_pp1a A2994V 1.00e+0 AY.5.4
V2178 11080C>T missense_variant ORF1ab_pp1a L3694F 1.00e+0 AY.5.4
V5194 298G>T missense_variant ORF8 V100L 1.00e+0 AY.5.4
V539 1583C>T missense_variant ORF1ab_pp1a S528L 7.07e-1 AY.5.4
V6877 7569C>T synonymous_variant ORF1ab_pp1a N2523N 7.07e-1 AY.5.4
V8145 17415G>T synonymous_variant ORF1ab_pp1ab T5805T 7.07e-1 AY.5.4
V8821 1503T>C synonymous_variant S N501N 1.00e+0 AY.5.4
V932 3161C>T missense_variant ORF1ab_pp1a P1054L 7.07e-1 AY.5.4
V9369 483C>T synonymous_variant M I161I 7.07e-1 AY.5.4
V2057 10423G>T missense_variant ORF1ab_pp1a V3475F 7.07e-1 AY.57
V303 586T>C missense_variant ORF1ab_pp1a Y196H 7.07e-1 AY.57
V4478 311C>T missense_variant ORF3a P104L 7.07e-1 AY.57
V7084 9165C>T synonymous_variant ORF1ab_pp1a I3055I 7.07e-1 AY.64
V9830 102C>T synonymous_variant ORF10 N34N 7.07e-1 AY.64
V8296 18492G>T synonymous_variant ORF1ab_pp1ab P6164P 1.00e+0 AY.69
V3141 18687G>T missense_variant ORF1ab_pp1ab K6229N 7.30e-1 AY.75
V4255 3655G>T missense_variant S G1219C 1.00e+0 AY.7
V1956 9472A>G missense_variant ORF1ab_pp1a S3158G 1.00e+0 AY.81
V7950 15957G>A synonymous_variant ORF1ab_pp1ab P5319P 1.00e+0 AY.81
V1474 6235C>T missense_variant ORF1ab_pp1a P2079S 8.15e-1 AY.87
V1709 7775A>G missense_variant ORF1ab_pp1a D2592G 7.22e-1 AY.87
V184 245_253delGTCATGTTA disruptive_inframe_deletion ORF1ab_pp1a G82_M85delinsV 7.52e-1 AY.87
V2178 11080C>T missense_variant ORF1ab_pp1a L3694F 8.15e-1 AY.87
V2352 12386C>T missense_variant ORF1ab_pp1a T4129I -7.08e-1 AY.87
V2883 16892C>T missense_variant ORF1ab_pp1ab T5631I -6.45e-1 AY.87
V539 1583C>T missense_variant ORF1ab_pp1a S528L 8.63e-1 AY.87
V5410 497C>T missense_variant N T166I 7.85e-1 AY.87
V5737 *4322G>T downstream_gene_variant S None 8.99e-1 AY.87
V616 1826C>T missense_variant ORF1ab_pp1a T609I -7.47e-1 AY.87
V6655 5766C>T synonymous_variant ORF1ab_pp1a N1922N 6.16e-1 AY.87
V8145 17415G>T synonymous_variant ORF1ab_pp1ab T5805T 9.76e-1 AY.87
V8424 19551A>T synonymous_variant ORF1ab_pp1ab P6517P -6.25e-1 AY.87
V932 3161C>T missense_variant ORF1ab_pp1a P1054L 7.97e-1 AY.87
V9369 483C>T synonymous_variant M I161I 8.79e-1 AY.87
V9773 1011C>T synonymous_variant N I337I 9.76e-1 AY.87
V3530 52C>T missense_variant S L18F 6.83e-1 B.1.1.216
V4600 673G>T missense_variant ORF3a V225F 9.42e-1 B.1.1.216
V6453 4275C>T synonymous_variant ORF1ab_pp1a Y1425Y 9.42e-1 B.1.1.216
V842 2831C>T missense_variant ORF1ab_pp1a S944L 7.82e-1 B.1.1.216
V8991 2808C>T synonymous_variant S D936D 8.94e-1 B.1.1.216
V3051 18062C>T missense_variant ORF1ab_pp1ab A6021V 9.04e-1 B.1.1.222
V5847 81C>T synonymous_variant ORF1ab_pp1a L27L 7.62e-1 B.1.1.222
V1821 8468C>T missense_variant ORF1ab_pp1a T2823I 1.00e+0 B.1.1.25
V4135 2819C>T missense_variant S S940F 8.94e-1 B.1.1.28
V4436 229G>A missense_variant ORF3a V77I 7.07e-1 B.1.1.28
V5247 5C>T missense_variant N S2F 1.00e+0 B.1.1.28
V7705 14061C>T synonymous_variant ORF1ab_pp1ab H4687H 8.94e-1 B.1.1.28
V8284 18423C>T synonymous_variant ORF1ab_pp1ab C6141C 6.66e-1 B.1.1.28
V8753 936C>T synonymous_variant S I312I 6.32e-1 B.1.1.28
V9018 3015G>A synonymous_variant S Q1005Q 1.00e+0 B.1.1.28
V1848 8607G>T missense_variant ORF1ab_pp1a L2869F 7.07e-1 B.1.1.306
V5542 808G>A missense_variant N V270I 1.00e+0 B.1.1.306
V6716 6156G>T synonymous_variant ORF1ab_pp1a V2052V 7.07e-1 B.1.1.306
V7094 9237C>T synonymous_variant ORF1ab_pp1a A3079A 7.07e-1 B.1.1.306
V8850 1734T>C synonymous_variant S D578D 7.07e-1 B.1.1.306
V9696 675C>T synonymous_variant N D225D 1.00e+0 B.1.1.306
V4658 -15G>T upstream_gene_variant E None 1.00e+0 B.1.1.33
V1611 6868G>A missense_variant ORF1ab_pp1a V2290I 7.78e-1 B.1.1.519
V6245 2616C>T synonymous_variant ORF1ab_pp1a A872A 7.07e-1 B.1.1.529
V7346 11310C>T synonymous_variant ORF1ab_pp1a F3770F 7.07e-1 B.1.1.529
V3785 770G>A missense_variant S G257D 1.00e+0 B.1.177.56
V4255 3655G>T missense_variant S G1219C 7.07e-1 B.1.177.56
V716 2258C>T missense_variant ORF1ab_pp1a T753I 1.00e+0 B.1.177.56
V1057 3637C>T missense_variant ORF1ab_pp1a P1213S 6.86e-1 B.1.177.60
V4851 13C>T missense_variant ORF7a L5F 7.33e-1 B.1.177.60
V6086 1611A>G synonymous_variant ORF1ab_pp1a A537A 8.77e-1 B.1.177.60
V7168 9765C>T synonymous_variant ORF1ab_pp1a T3255T 6.19e-1 B.1.177.60
V2812 16436G>T missense_variant ORF1ab_pp1ab R5479L 1.00e+0 B.1.177.77
V6453 4275C>T synonymous_variant ORF1ab_pp1a Y1425Y 1.00e+0 B.1.177.77
V7099 9267C>T synonymous_variant ORF1ab_pp1a F3089F 1.00e+0 B.1.177.77
V7228 10242C>T synonymous_variant ORF1ab_pp1a N3414N 1.00e+0 B.1.177.77
V7247 10380C>T synonymous_variant ORF1ab_pp1a D3460D 6.65e-1 B.1.177.77
V641 1924C>T missense_variant ORF1ab_pp1a L642F 7.07e-1 B.1.177.7
V6842 7263C>T synonymous_variant ORF1ab_pp1a V2421V 1.00e+0 B.1.177.7
V3542 65C>T missense_variant S T22I 1.00e+0 B.1.177.82
V4519 439C>T missense_variant ORF3a L147F 9.66e-1 B.1.177.82
V4661 24G>T missense_variant E E8D 1.00e+0 B.1.177.82
V7226 10215T>C synonymous_variant ORF1ab_pp1a N3405N 7.07e-1 B.1.243
V903 3043G>A missense_variant ORF1ab_pp1a E1015K 7.07e-1 B.1.243
V403 1037C>T missense_variant ORF1ab_pp1a T346I 7.07e-1 B.1.36.8
V2078 10568C>T missense_variant ORF1ab_pp1a A3523V 7.07e-1 B.1.369
V8709 618G>A synonymous_variant S K206K 1.00e+0 B.1.369
V4836 165G>T missense_variant ORF6 E55D 1.00e+0 B.1.36
V7503 12513C>T synonymous_variant ORF1ab_pp1a Y4171Y 7.07e-1 B.1.36
V4633 775G>T missense_variant ORF3a V259L 7.06e-1 B.1.398
V4678 145G>T missense_variant E V49L 7.06e-1 B.1.398
V5481 626G>T missense_variant N R209I 7.06e-1 B.1.398
V9282 220C>T synonymous_variant E L74L 7.06e-1 B.1.398
V3482 21037C>T missense_variant ORF1ab_pp1ab P7013S 1.00e+0 B.1.427
V7222 10191C>T synonymous_variant ORF1ab_pp1a F3397F 7.07e-1 B.1.427
V2765 15942G>T missense_variant ORF1ab_pp1ab E5314D 7.07e-1 B.1.466.2
V6703 6099G>A synonymous_variant ORF1ab_pp1a A2033A 7.06e-1 B.1.499
V7168 9765C>T synonymous_variant ORF1ab_pp1a T3255T 7.06e-1 B.1.499
V133 88G>A missense_variant ORF1ab_pp1a G30S 7.07e-1 B.1.588
V3686 531G>T missense_variant S M177I 7.07e-1 B.1.588
V8766 1062C>T synonymous_variant S N354N 7.06e-1 B.1.612
V9105 3594C>T synonymous_variant S I1198I 6.71e-1 B.1.621
V2064 10483C>T missense_variant ORF1ab_pp1a L3495F 1.00e+0 B.1.623
V3343 20120C>T missense_variant ORF1ab_pp1ab A6707V 1.00e+0 B.40
V467 1282A>G missense_variant ORF1ab_pp1a S428G 1.00e+0 BA.1.1.14
V9400 46C>T synonymous_variant ORF6 L16L 8.16e-1 BA.1.12
V4375 127T>C missense_variant ORF3a F43L 1.00e+0 BA.1.16
V6932 7977T>C synonymous_variant ORF1ab_pp1a H2659H 1.00e+0 BA.1.16
V8881 1971C>T synonymous_variant S N657N 7.07e-1 BA.2.12
V9424 45T>C synonymous_variant ORF7a C15C 1.00e+0 BA.2.12
V4821 95T>C missense_variant ORF6 I32T 1.00e+0 BA.2.21
V6688 6018T>C synonymous_variant ORF1ab_pp1a N2006N 7.07e-1 BA.2.21
V2815 16469C>T missense_variant ORF1ab_pp1ab S5490L 6.40e-1 BA.2.24
V1876 8784G>T missense_variant ORF1ab_pp1a K2928N 6.03e-1 BA.2.3.13
V7684 13920C>T synonymous_variant ORF1ab_pp1ab T4640T 7.07e-1 BA.2.3.13
V1313 5354T>C missense_variant ORF1ab_pp1a I1785T 7.07e-1 BA.2.36
V1868 8711A>G missense_variant ORF1ab_pp1a E2904G 7.07e-1 BA.2.36
V189 248A>G missense_variant ORF1ab_pp1a H83R 7.07e-1 BA.2.36
V1921 9173C>T missense_variant ORF1ab_pp1a T3058I 7.07e-1 BA.2.36
V3626 407G>T missense_variant S C136F 7.07e-1 BA.2.36
V3630 422_433delTGGGTGTTTATT disruptive_inframe_deletion S L141_Y144del 7.07e-1 BA.2.36
V4137 2824G>A missense_variant S A942T 7.07e-1 BA.2.36
V7767 14469A>G synonymous_variant ORF1ab_pp1ab E4823E 7.07e-1 BA.2.36
V9224 618C>T synonymous_variant ORF3a Y206Y 7.07e-1 BA.2.36
V9443 141T>C synonymous_variant ORF7a H47H 7.07e-1 BA.2.36
V9612 243T>C synonymous_variant N D81D 7.07e-1 BA.2.36
V2375 12524C>T missense_variant ORF1ab_pp1a T4175I 7.73e-1 BA.2.38
V351 826C>T missense_variant ORF1ab_pp1a P276S 7.18e-1 BA.2.38
V7265 10533C>T synonymous_variant ORF1ab_pp1a D3511D 9.72e-1 BA.2.38
V8581 20943C>T synonymous_variant ORF1ab_pp1ab L6981L 9.75e-1 BA.2.38
V359 876G>T missense_variant ORF1ab_pp1a K292N 7.07e-1 BA.2.49
V8127 17238C>T synonymous_variant ORF1ab_pp1ab F5746F 7.07e-1 BA.2.49
V7704 14058C>T synonymous_variant ORF1ab_pp1ab Y4686Y 1.00e+0 BA.4.1.6
V440 1174G>A missense_variant ORF1ab_pp1a G392S 7.07e-1 BA.5.1.23
V8326 18693T>C synonymous_variant ORF1ab_pp1ab N6231N 7.07e-1 BA.5.1.23
V1126 4020G>T missense_variant ORF1ab_pp1a E1340D 1.00e+0 BA.5.1.6
V1246 4828C>T missense_variant ORF1ab_pp1a H1610Y 1.00e+0 BA.5.1.6
V2158 11008G>T missense_variant ORF1ab_pp1a V3670F 7.07e-1 BA.5.1.6
V4264 3687G>T missense_variant S M1229I 1.00e+0 BA.5.1.6
V6574 5100C>T synonymous_variant ORF1ab_pp1a Y1700Y 7.07e-1 BA.5.1.6
V5273 37C>T missense_variant N P13S 1.00e+0 BA.5.2.23
V6778 6714T>G synonymous_variant ORF1ab_pp1a V2238V 1.00e+0 BA.5.2.23
V2998 17776G>T missense_variant ORF1ab_pp1ab A5926S 1.00e+0 BA.5.2.26
V4334 71C>T missense_variant ORF3a T24I 1.00e+0 BA.5.2.26
V7464 12135C>T synonymous_variant ORF1ab_pp1a L4045L 7.07e-1 BA.5.2.26
V9654 471C>T synonymous_variant N I157I 8.16e-1 BA.5.2.26
V6905 7782C>T synonymous_variant ORF1ab_pp1a Y2594Y 1.00e+0 BA.5.2.27
V7063 8961C>T synonymous_variant ORF1ab_pp1a G2987G 1.00e+0 BA.5.2.27
V8259 18219C>T synonymous_variant ORF1ab_pp1ab H6073H 7.07e-1 BA.5.2.27
V9402 60G>A synonymous_variant ORF6 R20R 1.00e+0 BA.5.2.27
V3817 1015G>A missense_variant S G339S 1.00e+0 BA.5.2.28
V6359 3507T>C synonymous_variant ORF1ab_pp1a V1169V 1.00e+0 BA.5.2.28
V6807 6903T>C synonymous_variant ORF1ab_pp1a Y2301Y 7.07e-1 BA.5.2.28
V7489 12402T>C synonymous_variant ORF1ab_pp1a N4134N 1.00e+0 BA.5.2.28
V3349 20138C>T missense_variant ORF1ab_pp1ab S6713L 8.38e-1 BA.5.2.31
V6960 8154C>T synonymous_variant ORF1ab_pp1a F2718F 9.85e-1 BA.5.2.31
V3072 18188C>T missense_variant ORF1ab_pp1ab A6063V 6.54e-1 BA.5.3.1
V428 1127C>T missense_variant ORF1ab_pp1a S376L 7.90e-1 BA.5.3.1
V7592 13152T>C synonymous_variant ORF1ab_pp1a D4384D 6.21e-1 BA.5.3.1
V7993 16257T>C synonymous_variant ORF1ab_pp1ab N5419N 9.00e-1 BA.5.3.1
V8411 19392G>A synonymous_variant ORF1ab_pp1ab K6464K 6.54e-1 BA.5.3.1
V9762 972C>T synonymous_variant N V324V 9.00e-1 BA.5.3.1
V902 3042G>T missense_variant ORF1ab_pp1a M1014I 1.00e+0 BA.5.9
V7356 11403C>T synonymous_variant ORF1ab_pp1a N3801N 1.00e+0 BC.1
V1313 5354T>C missense_variant ORF1ab_pp1a I1785T 1.00e+0 BE.1.1.1
V1750 7982C>T missense_variant ORF1ab_pp1a S2661F 1.00e+0 BE.1.2.1
V798 2645C>T missense_variant ORF1ab_pp1a T882I 7.07e-1 BE.1.2.1
V194 252_254delTAT disruptive_inframe_deletion ORF1ab_pp1a M85del 7.06e-1 BF.16
V2804 16352C>T missense_variant ORF1ab_pp1ab T5451I 1.00e+0 BF.16
V301 577C>T missense_variant ORF1ab_pp1a P193S 1.00e+0 BF.16
V3467 20927C>T missense_variant ORF1ab_pp1ab A6976V 7.06e-1 BF.16
V4948 239G>T missense_variant ORF7a R80I 1.00e+0 BF.16
V7406 11718A>G synonymous_variant ORF1ab_pp1a E3906E 8.16e-1 BF.16
V8845 1707T>C synonymous_variant S I569I 7.06e-1 BF.16
V9523 108G>T synonymous_variant ORF8 P36P 1.00e+0 BF.16
V4470 301C>T missense_variant ORF3a L101F 1.00e+0 BF.28
V5033 73C>T missense_variant ORF7b L25F 7.07e-1 BF.28
V9368 480C>T synonymous_variant M D160D 7.07e-1 BF.28
V268 439G>A missense_variant ORF1ab_pp1a D147N 1.00e+0 BM.1.1.1
V4879 83C>T missense_variant ORF7a T28I 9.25e-1 BM.1.1.1
V8222 18003C>T synonymous_variant ORF1ab_pp1ab R6001R 7.37e-1 BM.1.1.1
V6799 6840C>T synonymous_variant ORF1ab_pp1a T2280T 8.66e-1 BN.1.2
V9407 96C>T synonymous_variant ORF6 I32I 6.71e-1 BN.1.2
V2554 13867G>A missense_variant ORF1ab_pp1ab V4623I 8.03e-1 BN.1.3
V4337 77C>T missense_variant ORF3a S26L 6.51e-1 BN.1.3
V4389 146G>T missense_variant ORF3a G49V 8.94e-1 BQ.1.1.11
V7116 9459C>T synonymous_variant ORF1ab_pp1a F3153F 8.16e-1 BQ.1.1.11
V8808 1416C>T synonymous_variant S I472I 7.56e-1 BQ.1.1.11
V9561 18C>T synonymous_variant N P6P 7.07e-1 BQ.1.1.11
V1359 5669C>T missense_variant ORF1ab_pp1a T1890I 7.07e-1 BQ.1.1.13
V6009 999G>A synonymous_variant ORF1ab_pp1a T333T 7.07e-1 BQ.1.1.13
V6940 8028C>T synonymous_variant ORF1ab_pp1a T2676T 8.16e-1 BQ.1.1.1
V4671 70G>C missense_variant E V24L 1.00e+0 BQ.1.1.4
V6057 1362C>T synonymous_variant ORF1ab_pp1a L454L 6.66e-1 BQ.1.8
V6237 2577C>T synonymous_variant ORF1ab_pp1a A859A 7.56e-1 BQ.1.8
V6777 6703C>T synonymous_variant ORF1ab_pp1a L2235L 8.16e-1 BQ.1.8
V6877 7569C>T synonymous_variant ORF1ab_pp1a N2523N 7.56e-1 BQ.1.8
V9257 816C>T synonymous_variant ORF3a S272S 7.56e-1 BQ.1.8
V1703 7750G>A missense_variant ORF1ab_pp1a A2584T 7.07e-1 BR.2.1
V2564 13931C>T missense_variant ORF1ab_pp1ab T4644I 7.07e-1 BR.2.1
V4713 -2C>T upstream_gene_variant M None 7.07e-1 BR.2.1
V7824 14916C>T synonymous_variant ORF1ab_pp1ab A4972A 7.07e-1 BR.2.1
V8147 17427A>G synonymous_variant ORF1ab_pp1ab S5809S 7.75e-1 C.37
V5350 238C>T missense_variant N P80S 7.07e-1 CL.1
V4272 3711G>C missense_variant S M1237I 8.16e-1 P.1.15
V589 1724A>G missense_variant ORF1ab_pp1a Q575R 1.00e+0 P.1.17
V3485 21040C>T missense_variant ORF1ab_pp1ab R7014C 7.07e-1 P.2
V2330 12197C>T missense_variant ORF1ab_pp1a T4066I 7.07e-1 Q.1
V5337 163G>T missense_variant N A55S 6.71e-1 Q.1
V9405 90T>C synonymous_variant ORF6 D30D 1.00e+0 Q.1
V8220 17997C>T synonymous_variant ORF1ab_pp1ab I5999I 7.07e-1 Q.4
V4116 2635G>A missense_variant S A879T 7.07e-1 XBB.2
V5616 1130A>G missense_variant N D377G 8.94e-1 XBF
V4220 3457G>T missense_variant S D1153Y 7.15e-1 AY.19
V4406 171G>T missense_variant ORF3a Q57H 7.94e-1 AY.19
V4560 555G>T missense_variant ORF3a Q185H 6.73e-1 AY.19
V4507 392G>T missense_variant ORF3a W131L 1.00e+0 AY.75.2
V4733 89C>T missense_variant M T30I 1.00e+0 AY.75.2
V5020 40_41delTT frameshift_variant ORF7b L14fs 1.00e+0 AY.75.2
V6179 2197C>T synonymous_variant ORF1ab_pp1a L733L 1.00e+0 AY.75.2
V749 2367G>A missense_variant ORF1ab_pp1a M789I 1.00e+0 AY.75.2
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 7.06e-1 AY.75.2
V885 2985G>T missense_variant ORF1ab_pp1a E995D 1.00e+0 AY.75.2
V2751 15804G>T missense_variant ORF1ab_pp1ab E5268D 8.93e-1 B.1.1.228
V5898 321T>C synonymous_variant ORF1ab_pp1a L107L 7.72e-1 B.1.1.228
V6985 8427C>T synonymous_variant ORF1ab_pp1a Y2809Y 7.72e-1 B.1.1.228
V8520 20415G>A synonymous_variant ORF1ab_pp1ab P6805P 8.93e-1 B.1.1.228
V9758 954G>T synonymous_variant N S318S 8.93e-1 B.1.1.228
V127 79C>A missense_variant ORF1ab_pp1a L27I 1.00e+0 B.1.1.243
V4549 530G>T missense_variant ORF3a S177I 1.00e+0 B.1.1.243
V4923 187T>C missense_variant ORF7a F63L 1.00e+0 B.1.1.243
V628 1877C>T missense_variant ORF1ab_pp1a P626L 1.00e+0 B.1.1.243
V1357 5642C>T missense_variant ORF1ab_pp1a T1881I 7.03e-1 B.1.1.336
V2692 15175G>A missense_variant ORF1ab_pp1ab V5059I 7.03e-1 B.1.1.336
V3388 20330C>T missense_variant ORF1ab_pp1ab T6777I 7.03e-1 B.1.1.336
V3580 203T>C missense_variant S I68T 1.00e+0 B.1.1.336
V3688 535C>A missense_variant S L179I 6.99e-1 B.1.1.336
V3752 719C>T missense_variant S T240I 6.99e-1 B.1.1.336
V474 1307C>T missense_variant ORF1ab_pp1a T436I 6.99e-1 B.1.1.336
V1974 9659C>T missense_variant ORF1ab_pp1a A3220V 1.00e+0 B.1.1.46
V2229 11331G>T missense_variant ORF1ab_pp1a Q3777H 7.05e-1 B.1.1.46
V346 811C>T missense_variant ORF1ab_pp1a P271S 7.05e-1 B.1.1.46
V4537 514G>T missense_variant ORF3a G172C 7.05e-1 B.1.1.46
V7203 10014C>T synonymous_variant ORF1ab_pp1a L3338L 7.05e-1 B.1.1.46
V7501 12504G>A synonymous_variant ORF1ab_pp1a A4168A 7.05e-1 B.1.1.46
V7766 14460C>T synonymous_variant ORF1ab_pp1ab F4820F 7.05e-1 B.1.1.46
V3051 18062C>T missense_variant ORF1ab_pp1ab A6021V 1.00e+0 B.1.153
V3156 18747C>A missense_variant ORF1ab_pp1ab D6249E 1.00e+0 B.1.153
V3667 459G>T missense_variant S M153I 1.00e+0 B.1.153
V3896 1430G>A missense_variant S S477N 1.00e+0 B.1.153
V4542 520G>T missense_variant ORF3a G174C 7.02e-1 B.1.153
V875 2965G>A missense_variant ORF1ab_pp1a G989S 1.00e+0 B.1.153
V9523 108G>T synonymous_variant ORF8 P36P 7.02e-1 B.1.153
V3694 541G>C missense_variant S G181R 1.00e+0 B.1.177.33
V891 3002C>T missense_variant ORF1ab_pp1a T1001I 1.00e+0 B.1.177.33
V6697 6082C>T synonymous_variant ORF1ab_pp1a L2028L 1.00e+0 B.1.177.39
V2116 10818G>T missense_variant ORF1ab_pp1a L3606F 1.00e+0 B.1.291
V5663 -17C>T upstream_gene_variant ORF10 None 1.00e+0 B.1.291
V7427 11850C>T synonymous_variant ORF1ab_pp1a S3950S 1.00e+0 B.1.291
V8194 17796C>T synonymous_variant ORF1ab_pp1ab L5932L 1.00e+0 B.1.291
V2688 15142G>T missense_variant ORF1ab_pp1ab A5048S 9.49e-1 B.1.478
V4320 53G>A missense_variant ORF3a G18D 9.49e-1 B.1.478
V4640 784C>T missense_variant ORF3a P262S 9.49e-1 B.1.478
V6830 7128G>T synonymous_variant ORF1ab_pp1a P2376P 1.00e+0 B.1.478
V94 -26T>C upstream_gene_variant ORF1ab_pp1a None 7.62e-1 B.1.478
V9566 45T>C synonymous_variant N I15I 7.62e-1 B.1.478
V8799 1296C>T synonymous_variant S C432C 7.02e-1 B.1.539
V377 925C>T missense_variant ORF1ab_pp1a P309S 1.00e+0 BA.2.70
V45 -93C>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 BA.2.70
V2791 16210A>G missense_variant ORF1ab_pp1ab S5404G 1.00e+0 BY.1.1
V3091 18319G>A missense_variant ORF1ab_pp1ab V6107I 1.00e+0 BY.1.1
V3534 56C>T missense_variant S T19I -6.81e-1 BY.1.1
V3818 1015G>C missense_variant S G339R -6.81e-1 BY.1.1
V3820 1016G>A missense_variant S G339D -1.00e+0 BY.1.1
V3916 1456T>G missense_variant S F486V 1.00e+0 BY.1.1
V3940 1640C>T missense_variant S T547I 1.00e+0 BY.1.1
V4154 3058G>T missense_variant S A1020S 1.00e+0 BY.1.1
V5651 1237A>C missense_variant N S413R -6.81e-1 BY.1.1
V6557 4995T>A synonymous_variant ORF1ab_pp1a T1665T 1.00e+0 BY.1.1
V6778 6714T>G synonymous_variant ORF1ab_pp1a V2238V 1.00e+0 BY.1.1
V7193 9933C>T synonymous_variant ORF1ab_pp1a D3311D -6.81e-1 BY.1.1
V8180 17649C>T synonymous_variant ORF1ab_pp1ab N5883N 1.00e+0 BY.1.1
V9446 156C>T synonymous_variant ORF7a N52N 1.00e+0 BY.1.1
V9496 52C>T synonymous_variant ORF7b L18L -1.00e+0 BY.1.1
V9569 57A>G synonymous_variant N G19G 1.00e+0 BY.1.1
V6869 7500C>T synonymous_variant ORF1ab_pp1a S2500S 1.00e+0 CU.1
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 1.00e+0 CU.1
V914 3073G>T missense_variant ORF1ab_pp1a V1025L 7.06e-1 N.4
V3977 1865T>C missense_variant S V622A 7.06e-1 Q.8
V6187 2244C>T synonymous_variant ORF1ab_pp1a P748P 7.06e-1 Q.8
V6206 2382A>G synonymous_variant ORF1ab_pp1a K794K 1.00e+0 Q.8
V6687 6009T>C synonymous_variant ORF1ab_pp1a Y2003Y 7.06e-1 Q.8
V2553 13862G>A missense_variant ORF1ab_pp1ab S4621N 6.02e-1 XBG
V7847 15129T>C synonymous_variant ORF1ab_pp1ab R5043R 1.00e+0 XBG





Manual curation of mutation (213C>T)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID