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The current mutation

ID: V6602
DNA: 5310C>T
Protein: Y1770Y
Position: 5575








COV2Var annotation categories







Summary information of mutation (5310C>T)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp01_pp1a
  Gene Name   ORF1ab_pp1a
  Gene Type   protein_coding
  Genome position   5575
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   synonymous_variant
  DNA Level   DNA Mutation: 5310C>T
  Ref Seq: C
  Mut Seq: T
  Protein Level   Protein 1-letter Mutation: Y1770Y
  Protein 3-letter Mutation: Tyr1770Tyr

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (5310C>T) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.177 255 220 8.63e-1
2020-10 B.1.1.317 255 8 3.14e-2
2020-10 C.30 255 7 2.75e-2
2020-11 B.1.177 581 532 9.16e-1
2020-11 C.30 581 15 2.58e-2
2020-11 B.1.1.67 581 6 1.03e-2
2020-12 B.1.177 500 411 8.22e-1
2020-12 B.1.160 500 23 4.60e-2
2020-12 C.30 500 8 1.60e-2
2020-03 B.1 9 5 5.56e-1
2020-03 B.1.108 9 2 2.22e-1
2020-03 B.1.1 9 1 1.11e-1
2020-04 B.1.1 7 3 4.29e-1
2020-04 A.2.2 7 1 1.43e-1
2020-04 B.1 7 1 1.43e-1
2020-05 B.1 8 3 3.75e-1
2020-05 B.1.1 8 2 2.50e-1
2020-05 B.1.210 8 1 1.25e-1
2020-06 B.1.1.33 4 1 2.50e-1
2020-06 B.1.502 4 1 2.50e-1
2020-06 B.1.547 4 1 2.50e-1
2020-07 B.1.1 12 6 5.00e-1
2020-07 B.1 12 2 1.67e-1
2020-07 B.1.416 12 1 8.33e-2
2020-08 B.1 13 4 3.08e-1
2020-08 B.1.1 13 4 3.08e-1
2020-08 B.1.1.33 13 4 3.08e-1
2020-09 B.1.177 57 31 5.44e-1
2020-09 B.1.1.67 57 6 1.05e-1
2020-09 B.1.1.37 57 4 7.02e-2
2021-01 B.1.177 395 252 6.38e-1
2021-01 B.1.2 395 19 4.81e-2
2021-01 B.1.1.7 395 18 4.56e-2
2021-10 AY.103 498 81 1.63e-1
2021-10 AY.4 498 76 1.53e-1
2021-10 AY.43 498 71 1.43e-1
2021-11 AY.43 847 264 3.12e-1
2021-11 AY.103 847 164 1.94e-1
2021-11 AY.4 847 84 9.92e-2
2021-12 AY.43 916 243 2.65e-1
2021-12 AY.103 916 222 2.42e-1
2021-12 AY.122 916 74 8.08e-2
2021-02 B.1.1.7 210 49 2.33e-1
2021-02 B.1.177 210 32 1.52e-1
2021-02 B.1.177.10 210 23 1.10e-1
2021-03 B.1.1.7 313 173 5.53e-1
2021-03 B.1.351 313 40 1.28e-1
2021-03 B.1.526 313 30 9.58e-2
2021-04 B.1.351 319 125 3.92e-1
2021-04 B.1.1.7 319 102 3.20e-1
2021-04 B.1.526 319 38 1.19e-1
2021-05 B.1.351 342 173 5.06e-1
2021-05 B.1.1.7 342 92 2.69e-1
2021-05 B.1.617.2 342 36 1.05e-1
2021-06 B.1.351 276 171 6.20e-1
2021-06 B.1.1.7 276 38 1.38e-1
2021-06 P.1 276 23 8.33e-2
2021-07 B.1.351 336 73 2.17e-1
2021-07 AY.95 336 42 1.25e-1
2021-07 AY.9.2 336 40 1.19e-1
2021-08 B.1.617.2 461 139 3.02e-1
2021-08 AY.4 461 53 1.15e-1
2021-08 AY.35 461 48 1.04e-1
2021-09 AY.4 364 79 2.17e-1
2021-09 B.1.617.2 364 60 1.65e-1
2021-09 AY.103 364 53 1.46e-1
2022-01 BA.1 744 459 6.17e-1
2022-01 BA.1.1 744 92 1.24e-1
2022-01 BA.1.17.2 744 34 4.57e-2
2022-10 BF.5 96 16 1.67e-1
2022-10 BA.5.1.10 96 13 1.35e-1
2022-10 BQ.1.1 96 9 9.38e-2
2022-11 BA.5.1.27 251 69 2.75e-1
2022-11 BQ.1.1 251 52 2.07e-1
2022-11 BQ.1.1.4 251 12 4.78e-2
2022-12 BA.5.1.27 354 109 3.08e-1
2022-12 BQ.1.1 354 61 1.72e-1
2022-12 XBB.1.5 354 36 1.02e-1
2022-02 BA.1 515 206 4.00e-1
2022-02 BA.1.1 515 165 3.20e-1
2022-02 BA.2 515 50 9.71e-2
2022-03 BA.2 460 232 5.04e-1
2022-03 BA.1.1 460 101 2.20e-1
2022-03 BA.1 460 57 1.24e-1
2022-04 BA.2 400 223 5.58e-1
2022-04 BA.1.1 400 79 1.98e-1
2022-04 BA.2.9 400 39 9.75e-2
2022-05 BA.2 229 124 5.41e-1
2022-05 BA.2.9 229 34 1.48e-1
2022-05 BA.2.3 229 20 8.73e-2
2022-06 BA.2 105 47 4.48e-1
2022-06 BA.4 105 7 6.67e-2
2022-06 BA.2.9 105 5 4.76e-2
2022-07 BA.4 90 18 2.00e-1
2022-07 BA.2 90 9 1.00e-1
2022-07 BA.4.1 90 6 6.67e-2
2022-08 BA.5.1.22 87 12 1.38e-1
2022-08 BF.10 87 10 1.15e-1
2022-08 BE.1 87 8 9.20e-2
2022-09 BA.4.6 96 11 1.15e-1
2022-09 BE.1.1 96 11 1.15e-1
2022-09 BF.5 96 10 1.04e-1
2023-01 XBB.1.5 375 201 5.36e-1
2023-01 BQ.1.18 375 35 9.33e-2
2023-01 BA.5.1.27 375 27 7.20e-2
2023-02 XBB.1.5 195 128 6.56e-1
2023-02 BQ.1.1 195 18 9.23e-2
2023-02 BQ.1.1.28 195 12 6.15e-2

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V6602 B.1.351 1.90e-2 593 2020-2-18 2022-10-26
V6602 AY.35 1.60e-2 72 2020-8-21 2022-5-20
V6602 AY.95 6.23e-2 90 2021-1-7 2022-1-24
V6602 B.1.177.10 3.54e-2 39 2020-9-2 2021-5-4
V6602 B.1.404 1.18e-2 10 2020-7-6 2021-5-30
V6602 BA.2.43 1.15e-2 6 2022-3-10 2022-7-21
V6602 C.30 6.23e-2 34 2020-8-4 2021-2-6
V6602 CR.1 2.60e-2 17 2022-8-17 2023-2-15
V6602 AY.74 1.42e-2 84 2020-9-19 2022-2-1
V6602 BA.5.1.27 1.08e-1 215 2022-7-8 2023-2-17
V6602 B.1.177 2.08e-2 1490 2020-2-2 2022-5-25
V6602 B.1.1.236 2.34e-2 3 2020-9-1 2021-3-8
V6602 B.1.1.389 1.22e-2 2 2020-6-18 2021-4-7
V6602 B.1.1.47 2.99e-2 5 2020-7-1 2021-12-10
V6602 B.1.1.67 7.96e-2 18 2020-3-15 2021-3-18
V6602 B.1.466.1 1.45e-2 2 2020-6-9 2021-4-3
V6602 B.1.469 3.46e-2 9 2020-8-21 2021-10-8
V6602 B.1.502 1.05e-1 2 2020-6-7 2020-8-17
V6602 B.1.547 3.45e-2 2 2020-3-13 2021-1-12
V6602 B.1.597 1.36e-2 2 2020-3-19 2021-5-11
V6602 B.1.637.1 4.00e-2 3 2021-9-21 2022-1-12
V6602 BQ.1.1.9 1.76e-2 4 2022-8-1 2023-2-12
V6602 CG.1 1.01e-2 5 2022-6-27 2023-2-7






Examining mutation (5310C>T) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID




Association between mutation (5310C>T) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory -1.02e+0 1.04e+0 -9.78e-1 3.28e-1 Decrease
Deceased -1.27e+0 5.92e-1 -2.14e+0 3.20e-2 Decrease
Homebound -1.26e+1 5.25e+2 -2.40e-2 9.81e-1 Decrease
Hospitalized 6.44e-1 1.76e-1 3.65e+0 2.58e-4 Increase
Mild -1.89e+0 7.26e-1 -2.61e+0 9.14e-3 Decrease
Recovered 8.07e-1 1.84e-1 4.38e+0 1.17e-5 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 4.74e-2 1.25e-1 3.79e-1 7.04e-1 Increase
18-39 -6.77e-2 6.87e-2 -9.85e-1 3.25e-1 Decrease
40-64 9.58e-3 6.87e-2 1.39e-1 8.89e-1 Increase
65-84 5.14e-2 9.16e-2 5.61e-1 5.75e-1 Increase
>=85 9.93e-2 1.58e-1 6.30e-1 5.28e-1 Increase

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male -7.62e-2 6.61e-2 -1.15e+0 2.49e-1 Decrease





Investigating natural selection at mutation (5310C>T) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method




Alterations in protein physicochemical properties induced by mutation (5310C>T)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY




Alterations in protein stability induced by mutation (5310C>T)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition




Impact on protein function induced by mutation (5310C>T)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms




Exploring mutation (5310C>T) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (5310C>T)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites




Impact of spike protein mutation (5310C>T) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (5310C>T) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

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Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

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        Show interface residues:





Impact of mutation (5310C>T) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (5310C>T) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V3233 19391A>G missense_variant ORF1ab_pp1ab K6464R 9.62e-1 B.1.177
V522 1493C>T missense_variant ORF1ab_pp1a A498V 8.76e-1 B.1.177
V8132 17286C>T synonymous_variant ORF1ab_pp1ab L5762L 6.55e-1 AY.43
V2841 16679G>T missense_variant ORF1ab_pp1ab S5560I 6.87e-1 AY.5
V7778 14526C>T synonymous_variant ORF1ab_pp1ab I4842I 6.39e-1 AY.4.2
V6818 7014C>T synonymous_variant ORF1ab_pp1a F2338F 8.52e-1 XBB.1.5
V7239 10329C>T synonymous_variant ORF1ab_pp1a N3443N 6.19e-1 XBB.1.5
V4545 521G>T missense_variant ORF3a G174V 6.83e-1 A.23.1
V6014 1023C>T synonymous_variant ORF1ab_pp1a C341C 7.20e-1 A.23.1
V8799 1296C>T synonymous_variant S C432C 6.66e-1 A.23.1
V9047 3237T>C synonymous_variant S P1079P 6.83e-1 A.23.1
V5941 570C>T synonymous_variant ORF1ab_pp1a F190F 1.00e+0 AY.108
V1704 7751C>T missense_variant ORF1ab_pp1a A2584V 7.18e-1 AY.112.2
V2771 16025C>T missense_variant ORF1ab_pp1ab A5342V 6.67e-1 AY.112.2
V4320 53G>A missense_variant ORF3a G18D 6.71e-1 AY.112.2
V4448 266C>T missense_variant ORF3a T89I 8.32e-1 AY.112.2
V5726 *4304G>T downstream_gene_variant S None 7.28e-1 AY.112.2
V9151 102G>T synonymous_variant ORF3a T34T 7.92e-1 AY.112.2
V6440 4158C>T synonymous_variant ORF1ab_pp1a R1386R 7.45e-1 AY.116
V7319 11079C>T synonymous_variant ORF1ab_pp1a I3693I 6.19e-1 AY.116
V9801 1176G>T synonymous_variant N V392V 6.74e-1 AY.116
V1263 4919C>T missense_variant ORF1ab_pp1a P1640L 1.00e+0 AY.120.2
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 1.00e+0 AY.120.2
V1982 9764C>T missense_variant ORF1ab_pp1a T3255I -7.07e-1 AY.120.2
V2189 11153T>C missense_variant ORF1ab_pp1a V3718A 1.00e+0 AY.120.2
V2207 11249C>T missense_variant ORF1ab_pp1a T3750I 7.07e-1 AY.120.2
V359 876G>T missense_variant ORF1ab_pp1a K292N 1.00e+0 AY.120.2
V4332 68C>T missense_variant ORF3a A23V 7.07e-1 AY.120.2
V5525 727G>A missense_variant N G243S 1.00e+0 AY.120.2
V5926 480C>T synonymous_variant ORF1ab_pp1a N160N 1.00e+0 AY.120.2
V6187 2244C>T synonymous_variant ORF1ab_pp1a P748P 1.00e+0 AY.120.2
V6604 5319A>G synonymous_variant ORF1ab_pp1a T1773T 1.00e+0 AY.120.2
V8133 17298G>T synonymous_variant ORF1ab_pp1ab R5766R 7.07e-1 AY.120.2
V561 1648C>T missense_variant ORF1ab_pp1a R550C 8.16e-1 AY.121.1
V5841 48C>T synonymous_variant ORF1ab_pp1a L16L 6.66e-1 AY.121.1
V622 1856C>T missense_variant ORF1ab_pp1a T619I 8.16e-1 AY.121.1
V893 3011C>T missense_variant ORF1ab_pp1a T1004I 6.66e-1 AY.121.1
V3138 18664C>T missense_variant ORF1ab_pp1ab P6222S 7.07e-1 AY.122.1
V2514 13619C>T missense_variant ORF1ab_pp1ab T4540I 8.37e-1 AY.127
V3449 20835G>T missense_variant ORF1ab_pp1ab E6945D 6.36e-1 AY.127
V6292 2988C>T synonymous_variant ORF1ab_pp1a D996D 8.08e-1 AY.127
V5027 43G>T missense_variant ORF7b A15S 8.16e-1 AY.13
V891 3002C>T missense_variant ORF1ab_pp1a T1001I 7.07e-1 AY.13
V9191 300C>T synonymous_variant ORF3a G100G 1.00e+0 AY.13
V3440 20746G>T missense_variant ORF1ab_pp1ab V6916L 6.23e-1 AY.23
V3779 758A>C missense_variant S D253A 7.07e-1 AY.24
V2329 12194C>T missense_variant ORF1ab_pp1a T4065I 8.16e-1 AY.25.3
V4549 530G>T missense_variant ORF3a S177I 1.00e+0 AY.25.3
V5652 1238G>T missense_variant N S413I 1.00e+0 AY.30
V8615 21225A>G synonymous_variant ORF1ab_pp1ab K7075K 7.75e-1 AY.34
V2279 11802G>T missense_variant ORF1ab_pp1a M3934I 1.00e+0 AY.36
V4488 334G>T missense_variant ORF3a V112F 1.00e+0 AY.36
V451 1204C>T missense_variant ORF1ab_pp1a R402C 1.00e+0 AY.36
V7660 13752C>T synonymous_variant ORF1ab_pp1ab F4584F 7.07e-1 AY.36
V6166 2136C>T synonymous_variant ORF1ab_pp1a H712H 7.07e-1 AY.38
V9320 264A>G synonymous_variant M V88V 1.00e+0 AY.39.1.4
V3206 19123A>G missense_variant ORF1ab_pp1ab S6375G 1.00e+0 AY.39.1
V5763 *4352G>A downstream_gene_variant S None 1.00e+0 AY.46.1
V4269 3704G>T missense_variant S C1235F 6.25e-1 AY.46.5
V7923 15693G>T synonymous_variant ORF1ab_pp1ab G5231G 1.00e+0 AY.48
V4198 3350C>T missense_variant S T1117I 7.07e-1 AY.4.9
V2269 11755C>T missense_variant ORF1ab_pp1a L3919F 7.40e-1 AY.54
V3393 20352G>T missense_variant ORF1ab_pp1ab W6784C 7.68e-1 AY.54
V4942 232C>T missense_variant ORF7a R78C 6.70e-1 AY.57
V4483 322C>T missense_variant ORF3a L108F 6.11e-1 AY.59
V6123 1845C>T synonymous_variant ORF1ab_pp1a N615N 9.26e-1 AY.59
V7333 11214C>T synonymous_variant ORF1ab_pp1a I3738I 1.00e+0 AY.59
V372 913C>T missense_variant ORF1ab_pp1a P305S 7.75e-1 AY.69
V1073 3690G>T missense_variant ORF1ab_pp1a K1230N 1.00e+0 AY.74
V3393 20352G>T missense_variant ORF1ab_pp1ab W6784C 8.78e-1 AY.74
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 9.49e-1 AY.74
V4312 37G>T missense_variant ORF3a V13L 9.94e-1 AY.74
V5990 885C>T synonymous_variant ORF1ab_pp1a G295G 1.00e+0 AY.74
V6327 3246C>T synonymous_variant ORF1ab_pp1a A1082A 9.63e-1 AY.74
V1347 5557C>T missense_variant ORF1ab_pp1a L1853F 7.06e-1 AY.77
V1499 6308C>T missense_variant ORF1ab_pp1a S2103F 7.06e-1 AY.77
V1726 7844C>T missense_variant ORF1ab_pp1a T2615I 7.06e-1 AY.77
V1893 8915C>T missense_variant ORF1ab_pp1a S2972F 7.06e-1 AY.77
V2434 13091C>T missense_variant ORF1ab_pp1a T4364I 7.06e-1 AY.77
V2629 14522C>T missense_variant ORF1ab_pp1ab A4841V 7.06e-1 AY.77
V2751 15804G>T missense_variant ORF1ab_pp1ab E5268D 7.06e-1 AY.77
V3119 18539G>T missense_variant ORF1ab_pp1ab S6180I 7.06e-1 AY.77
V328 679G>A missense_variant ORF1ab_pp1a G227S 7.06e-1 AY.77
V6011 1002C>T synonymous_variant ORF1ab_pp1a G334G 7.06e-1 AY.77
V6237 2577C>T synonymous_variant ORF1ab_pp1a A859A 7.06e-1 AY.77
V7528 12681T>C synonymous_variant ORF1ab_pp1a Y4227Y 7.06e-1 AY.77
V7884 15405T>C synonymous_variant ORF1ab_pp1ab N5135N 7.06e-1 AY.77
V3807 896C>T missense_variant S T299I 7.07e-1 AY.79
V7169 9771C>T synonymous_variant ORF1ab_pp1a I3257I 7.07e-1 AY.79
V2901 17024C>T missense_variant ORF1ab_pp1ab T5675I 1.00e+0 AY.91
V3751 725_733delTTGCTTTAC disruptive_inframe_deletion S L242_L244del 1.00e+0 AY.91
V3754 725T>A missense_variant S L242H 1.00e+0 AY.91
V5792 *4370C>T downstream_gene_variant S None 1.00e+0 AY.91
V6252 2682C>T synonymous_variant ORF1ab_pp1a G894G 7.07e-1 AY.91
V7704 14058C>T synonymous_variant ORF1ab_pp1ab Y4686Y 1.00e+0 AY.91
V8938 2427A>G synonymous_variant S P809P 1.00e+0 AY.91
V9445 153T>C synonymous_variant ORF7a D51D 1.00e+0 AY.91
V1406 6020C>T missense_variant ORF1ab_pp1a T2007I 1.00e+0 AY.92
V5719 113C>T missense_variant ORF10 T38I 8.01e-1 AY.95
V7264 10524C>T synonymous_variant ORF1ab_pp1a D3508D 8.21e-1 AY.95
V7894 15499C>T synonymous_variant ORF1ab_pp1ab L5167L 9.60e-1 AY.95
V8849 1728C>T synonymous_variant S V576V 8.85e-1 AY.9
V9736 871C>T synonymous_variant N L291L 8.58e-1 AY.9
V343 801T>A missense_variant ORF1ab_pp1a N267K 1.00e+0 B.1.110.3
V970 3298G>A missense_variant ORF1ab_pp1a G1100S 1.00e+0 B.1.110.3
V5866 180T>C synonymous_variant ORF1ab_pp1a V60V 1.00e+0 B.1.1.1
V1495 6290C>T missense_variant ORF1ab_pp1a A2097V 1.00e+0 B.1.1.207
V4021 2041C>T missense_variant S P681S 7.07e-1 B.1.1.207
V7476 12208C>T synonymous_variant ORF1ab_pp1a L4070L 1.00e+0 B.1.1.207
V1764 8083A>G missense_variant ORF1ab_pp1a S2695G 7.07e-1 B.1.1.222
V5179 241G>T missense_variant ORF8 V81F 1.00e+0 B.1.1.263
V1185 4550C>T missense_variant ORF1ab_pp1a S1517F 8.65e-1 B.1.126
V9061 3348T>C synonymous_variant S T1116T 8.65e-1 B.1.126
V8073 16875T>A synonymous_variant ORF1ab_pp1ab S5625S 7.07e-1 B.1.1.298
V1044 3606G>T missense_variant ORF1ab_pp1a K1202N 8.94e-1 B.1.1.317
V1265 4941G>T missense_variant ORF1ab_pp1a M1647I 8.16e-1 B.1.1.317
V1763 8069C>T missense_variant ORF1ab_pp1a A2690V 7.73e-1 B.1.1.317
V4158 3080C>T missense_variant S T1027I 7.37e-1 B.1.1.317
V6657 5775C>T synonymous_variant ORF1ab_pp1a F1925F 7.73e-1 B.1.1.317
V759 2435C>T missense_variant ORF1ab_pp1a T812I 6.79e-1 B.1.1.317
V8744 870C>T synonymous_variant S D290D 6.91e-1 B.1.1.317
V9665 519A>T synonymous_variant N A173A 7.73e-1 B.1.1.317
V1427 6088T>C missense_variant ORF1ab_pp1a S2030P 1.00e+0 B.1.1.372
V1694 7664A>G missense_variant ORF1ab_pp1a K2555R 1.00e+0 B.1.1.372
V4466 298G>T missense_variant ORF3a G100C 7.07e-1 B.1.1.372
V4478 311C>T missense_variant ORF3a P104L 1.00e+0 B.1.1.372
V4535 512C>T missense_variant ORF3a S171L 7.07e-1 B.1.1.372
V7360 11439C>T synonymous_variant ORF1ab_pp1a Y3813Y 1.00e+0 B.1.1.372
V7877 15336C>T synonymous_variant ORF1ab_pp1ab V5112V 1.00e+0 B.1.1.372
V8808 1416C>T synonymous_variant S I472I 1.00e+0 B.1.1.372
V2431 13064C>T missense_variant ORF1ab_pp1a T4355I 1.00e+0 B.1.1.39
V4103 2537C>T missense_variant S A846V 7.07e-1 B.1.1.434
V1290 5160G>T missense_variant ORF1ab_pp1a K1720N 1.00e+0 B.1.1.50
V4095 2501T>C missense_variant S I834T 1.00e+0 B.1.1.50
V5660 -20A>T upstream_gene_variant ORF10 None 1.00e+0 B.1.1.50
V7869 15279G>T synonymous_variant ORF1ab_pp1ab T5093T 1.00e+0 B.1.1.50
V1972 9626C>T missense_variant ORF1ab_pp1a A3209V 7.78e-1 B.1.1.529
V2189 11153T>C missense_variant ORF1ab_pp1a V3718A 6.87e-1 B.1.1.529
V2207 11249C>T missense_variant ORF1ab_pp1a T3750I 7.23e-1 B.1.1.529
V2737 15649_15651dupGAT conservative_inframe_insertion ORF1ab_pp1ab D5217dup 7.58e-1 B.1.1.529
V2789 16202C>T missense_variant ORF1ab_pp1ab P5401L 7.40e-1 B.1.1.529
V2804 16352C>T missense_variant ORF1ab_pp1ab T5451I 6.92e-1 B.1.1.529
V3549 73C>T missense_variant S P25S 7.78e-1 B.1.1.529
V3723 626C>T missense_variant S P209L 7.22e-1 B.1.1.529
V3730 635T>C missense_variant S L212S 7.42e-1 B.1.1.529
V3739 643G>C missense_variant S D215H 7.42e-1 B.1.1.529
V3755 727_732delGCTTTA conservative_inframe_deletion S A243_L244del 7.51e-1 B.1.1.529
V3783 767C>T missense_variant S S256L 7.51e-1 B.1.1.529
V3884 1354C>A missense_variant S L452M 7.05e-1 B.1.1.529
V3915 1456T>C missense_variant S F486L 6.85e-1 B.1.1.529
V3917 1457T>C missense_variant S F486S 6.85e-1 B.1.1.529
V4044 2108A>T missense_variant S N703I 7.78e-1 B.1.1.529
V4866 41C>T missense_variant ORF7a T14I 7.77e-1 B.1.1.529
V4987 325T>C missense_variant ORF7a F109L 8.00e-1 B.1.1.529
V5000 359C>T missense_variant ORF7a T120I 7.64e-1 B.1.1.529
V5020 40_41delTT frameshift_variant ORF7b L14fs 8.13e-1 B.1.1.529
V5061 -4G>T upstream_gene_variant ORF8 None 7.87e-1 B.1.1.529
V5063 5A>C missense_variant ORF8 K2T 7.87e-1 B.1.1.529
V6057 1362C>T synonymous_variant ORF1ab_pp1a L454L 6.40e-1 B.1.1.529
V7035 8808C>T synonymous_variant ORF1ab_pp1a T2936T 6.85e-1 B.1.1.529
V7538 12754C>T synonymous_variant ORF1ab_pp1a L4252L 7.40e-1 B.1.1.529
V7808 14766T>C synonymous_variant ORF1ab_pp1ab Y4922Y 7.78e-1 B.1.1.529
V7829 14973C>T synonymous_variant ORF1ab_pp1ab H4991H 7.23e-1 B.1.1.529
V9209 462C>T synonymous_variant ORF3a Y154Y 7.78e-1 B.1.1.529
V9324 297T>C synonymous_variant M S99S 8.23e-1 B.1.1.529
V2021 10058A>G missense_variant ORF1ab_pp1a K3353R 1.00e+0 B.1.177.10
V2381 12532G>T missense_variant ORF1ab_pp1a G4178C 9.87e-1 B.1.177.10
V1921 9173C>T missense_variant ORF1ab_pp1a T3058I 7.07e-1 B.1.177.17
V1538 6458C>T missense_variant ORF1ab_pp1a T2153I 1.00e+0 B.1.177.21
V6087 1614A>G synonymous_variant ORF1ab_pp1a S538S 1.00e+0 B.1.177.21
V9539 228C>T synonymous_variant ORF8 I76I 7.07e-1 B.1.177.73
V1260 4913C>T missense_variant ORF1ab_pp1a T1638I 7.07e-1 B.1.177.77
V1928 9214G>T missense_variant ORF1ab_pp1a G3072C 1.00e+0 B.1.177.77
V2002 9937C>T missense_variant ORF1ab_pp1a L3313F 7.07e-1 B.1.177.77
V3611 289A>G missense_variant S K97E 7.07e-1 B.1.177.77
V3638 432_434delTTA disruptive_inframe_deletion S Y145del 7.07e-1 B.1.177.77
V3646 433T>C missense_variant S Y145H 1.00e+0 B.1.177.77
V4058 2203T>G missense_variant S S735A 1.00e+0 B.1.177.77
V4775 373C>T missense_variant M H125Y 1.00e+0 B.1.177.77
V5129 152C>T missense_variant ORF8 A51V 1.00e+0 B.1.177.77
V6178 2190C>T synonymous_variant ORF1ab_pp1a L730L 1.00e+0 B.1.177.77
V7802 14700A>G synonymous_variant ORF1ab_pp1ab K4900K 1.00e+0 B.1.177.77
V8189 17763G>A synonymous_variant ORF1ab_pp1ab V5921V 1.00e+0 B.1.177.77
V8303 18550C>T synonymous_variant ORF1ab_pp1ab L6184L 1.00e+0 B.1.177.77
V9652 462T>C synonymous_variant N N154N 1.00e+0 B.1.177.77
V5759 *4349C>T downstream_gene_variant S None 1.00e+0 B.1.177.83
V3234 19392G>T missense_variant ORF1ab_pp1ab K6464N 6.92e-1 B.1.177.86
V7052 8901C>T synonymous_variant ORF1ab_pp1a T2967T 7.35e-1 B.1.177.86
V8190 17763G>T synonymous_variant ORF1ab_pp1ab V5921V 9.64e-1 B.1.177.86
V6621 5451G>A synonymous_variant ORF1ab_pp1a K1817K 1.00e+0 B.1.232
V2224 11300C>T missense_variant ORF1ab_pp1a P3767L 1.00e+0 B.1.240
V4610 719C>T missense_variant ORF3a P240L 1.00e+0 B.1.240
V6114 1783C>T synonymous_variant ORF1ab_pp1a L595L 1.00e+0 B.1.240
V4415 188T>C missense_variant ORF3a I63T 7.07e-1 B.1.241
V947 3218G>A missense_variant ORF1ab_pp1a G1073E 6.32e-1 B.1.243
V6585 5214T>C synonymous_variant ORF1ab_pp1a H1738H 1.00e+0 B.1.258.17
V6703 6099G>A synonymous_variant ORF1ab_pp1a A2033A 1.00e+0 B.1.258.17
V9077 3441A>G synonymous_variant S S1147S 1.00e+0 B.1.258.17
V1175 4498C>T missense_variant ORF1ab_pp1a H1500Y 7.07e-1 B.1.265
V3084 18262C>T missense_variant ORF1ab_pp1ab R6088C 1.00e+0 B.1.265
V6173 2166A>G synonymous_variant ORF1ab_pp1a K722K 7.07e-1 B.1.265
V6413 3942G>T synonymous_variant ORF1ab_pp1a A1314A 7.07e-1 B.1.265
V8411 19392G>A synonymous_variant ORF1ab_pp1ab K6464K 8.16e-1 B.1.265
V9347 381T>C synonymous_variant M T127T 7.07e-1 B.1.265
V3678 488C>T missense_variant S A163V 7.07e-1 B.1.351.2
V7959 15996C>T synonymous_variant ORF1ab_pp1ab C5332C 7.07e-1 B.1.351.2
V5299 83A>G missense_variant N Q28R 7.74e-1 B.1.351
V7209 10104C>T synonymous_variant ORF1ab_pp1a R3368R 6.46e-1 B.1.351
V7346 11310C>T synonymous_variant ORF1ab_pp1a F3770F 8.94e-1 B.1.351
V2536 13729G>T missense_variant ORF1ab_pp1ab A4577S 1.00e+0 B.1.36.29
V5634 1167G>T missense_variant N Q389H 1.00e+0 B.1.36.29
V6541 4902C>T synonymous_variant ORF1ab_pp1a Y1634Y 7.07e-1 B.1.36.29
V3340 20092G>T missense_variant ORF1ab_pp1ab G6698C 1.00e+0 B.1.36.31
V3996 1960G>C missense_variant S E654Q 1.00e+0 B.1.36.31
V4079 2386G>T missense_variant S D796Y 7.06e-1 B.1.36.31
V4608 717G>T missense_variant ORF3a E239D 7.06e-1 B.1.36.31
V5411 501G>T missense_variant N L167F 1.00e+0 B.1.36.31
V569 1666C>A missense_variant ORF1ab_pp1a Q556K 1.00e+0 B.1.36.31
V9688 642C>T synonymous_variant N G214G 1.00e+0 B.1.36.31
V4922 186A>T missense_variant ORF7a Q62H 6.47e-1 B.1.36
V5259 22A>T missense_variant N N8Y 6.02e-1 B.1.36
V7412 11754G>A synonymous_variant ORF1ab_pp1a L3918L 6.23e-1 B.1.36
V1058 3638C>T missense_variant ORF1ab_pp1a P1213L 6.30e-1 B.1.404
V5810 *4389G>T downstream_gene_variant S None 8.35e-1 B.1.404
V7477 12219C>T synonymous_variant ORF1ab_pp1a V4073V 6.96e-1 B.1.404
V4406 171G>T missense_variant ORF3a Q57H 7.07e-1 B.1.416
V5526 727G>T missense_variant N G243C 7.07e-1 B.1.466.2
V2046 10345G>T missense_variant ORF1ab_pp1a V3449F 7.07e-1 B.1.470
V1847 8602G>A missense_variant ORF1ab_pp1a G2868S 1.00e+0 B.1.497
V1348 5561C>T missense_variant ORF1ab_pp1a T1854I 7.07e-1 B.1.499
V1746 7943C>T missense_variant ORF1ab_pp1a T2648I 7.07e-1 B.1.499
V309 617C>T missense_variant ORF1ab_pp1a A206V 7.07e-1 B.1.499
V3954 1718C>T missense_variant S T573I 1.00e+0 B.1.499
V4745 196G>T missense_variant M V66L 1.00e+0 B.1.499
V6320 3207A>G synonymous_variant ORF1ab_pp1a G1069G 1.00e+0 B.1.499
V6729 6273C>T synonymous_variant ORF1ab_pp1a G2091G 7.07e-1 B.1.499
V4773 327G>T missense_variant M M109I 1.00e+0 B.1.517
V7533 12709C>T synonymous_variant ORF1ab_pp1a L4237L 1.00e+0 B.1.517
V8227 18048C>T synonymous_variant ORF1ab_pp1ab V6016V 7.07e-1 B.1.517
V9707 747A>G synonymous_variant N K249K 1.00e+0 B.1.517
V2015 10031C>T missense_variant ORF1ab_pp1a S3344F 7.07e-1 B.1.525
V3763 733C>T missense_variant S H245Y 7.07e-1 B.1.525
V5981 825T>C synonymous_variant ORF1ab_pp1a F275F 7.07e-1 B.1.525
V990 3369C>A missense_variant ORF1ab_pp1a N1123K 7.07e-1 B.1.525
V2734 15642G>T missense_variant ORF1ab_pp1ab Q5214H 7.95e-1 B.1.526
V9393 633C>T synonymous_variant M S211S 7.07e-1 B.1.596
V3172 18853G>T missense_variant ORF1ab_pp1ab A6285S 1.00e+0 B.1.609
V3597 234G>T missense_variant S R78S 7.07e-1 B.1.609
V1064 3659C>T missense_variant ORF1ab_pp1a P1220L 8.16e-1 B.1.617.1
V4497 375G>T missense_variant ORF3a M125I 1.00e+0 B.1.617.1
V4317 48G>T missense_variant ORF3a K16N 1.00e+0 B.4
V5029 55T>C missense_variant ORF7b F19L 1.00e+0 B.4
V6941 8034C>T synonymous_variant ORF1ab_pp1a N2678N 1.00e+0 B.4
V6943 8055C>T synonymous_variant ORF1ab_pp1a P2685P 7.07e-1 B.4
V8161 17502C>T synonymous_variant ORF1ab_pp1ab V5834V 7.07e-1 B.4
V9773 1011C>T synonymous_variant N I337I 7.07e-1 B.4
V1796 8332C>T missense_variant ORF1ab_pp1a L2778F 1.00e+0 BA.1.1.11
V5733 *4318G>A downstream_gene_variant S None 1.00e+0 BA.1.1.11
V7230 10260C>T synonymous_variant ORF1ab_pp1a V3420V 1.00e+0 BA.1.1.11
V4332 68C>T missense_variant ORF3a A23V 7.07e-1 BA.1.1.13
V9199 339C>T synonymous_variant ORF3a Y113Y 7.07e-1 BA.1.1.16
V4030 2059G>A missense_variant S V687I 7.07e-1 BA.1.13.1
V7302 10887C>T synonymous_variant ORF1ab_pp1a V3629V 7.07e-1 BA.1.13.1
V870 2948A>G missense_variant ORF1ab_pp1a D983G 7.07e-1 BA.1.13.1
V9366 466C>T synonymous_variant M L156L 1.00e+0 BA.1.14.1
V218 319C>T missense_variant ORF1ab_pp1a L107F 1.00e+0 BA.1.14.2
V9217 582A>G synonymous_variant ORF3a E194E 1.00e+0 BA.1.1.4
V4966 280C>A missense_variant ORF7a Q94K 8.16e-1 BA.1.16
V7052 8901C>T synonymous_variant ORF1ab_pp1a T2967T 1.00e+0 BA.1.1.7
V963 3275C>T missense_variant ORF1ab_pp1a A1092V 1.00e+0 BA.1.1.7
V1607 6848C>T missense_variant ORF1ab_pp1a T2283I 7.07e-1 BA.1.1.9
V1173 4489C>T missense_variant ORF1ab_pp1a P1497S 7.07e-1 BA.1.19
V2582 14029C>T missense_variant ORF1ab_pp1ab R4677C 1.00e+0 BA.1.19
V3411 20495C>T missense_variant ORF1ab_pp1ab A6832V 1.00e+0 BA.1.19
V797 2638A>G missense_variant ORF1ab_pp1a I880V 7.07e-1 BA.1.19
V9319 246C>T synonymous_variant M I82I 1.00e+0 BA.1.19
V5628 1148C>T missense_variant N P383L 7.07e-1 BA.1.21
V8837 1641A>G synonymous_variant S T547T 7.07e-1 BA.2.10.1
V2997 17768C>T missense_variant ORF1ab_pp1ab T5923I 8.16e-1 BA.2.10.2
V6235 2562T>C synonymous_variant ORF1ab_pp1a N854N 8.16e-1 BA.2.10.2
V5279 52G>A missense_variant N G18S 1.00e+0 BA.2.13
V610 1804A>G missense_variant ORF1ab_pp1a T602A 7.07e-1 BA.2.1
V6396 3825C>T synonymous_variant ORF1ab_pp1a D1275D 9.68e-1 BA.2.29
V371 905C>T missense_variant ORF1ab_pp1a S302F 7.07e-1 BA.2.3.11
V8144 17412C>T synonymous_variant ORF1ab_pp1ab I5804I 7.07e-1 BA.2.3.11
V8158 17481C>T synonymous_variant ORF1ab_pp1ab N5827N 1.00e+0 BA.2.3.11
V900 3041T>C missense_variant ORF1ab_pp1a M1014T 1.00e+0 BA.2.3.11
V4100 2533G>T missense_variant S A845S 8.16e-1 BA.2.3.2
V531 1555G>A missense_variant ORF1ab_pp1a G519S 8.16e-1 BA.2.3.2
V7290 10743C>T synonymous_variant ORF1ab_pp1a H3581H 6.32e-1 BA.2.3.2
V997 3419A>G missense_variant ORF1ab_pp1a Q1140R 1.00e+0 BA.2.3.2
V5638 1192G>T missense_variant N A398S 1.00e+0 BA.2.3.9
V6832 7152C>T synonymous_variant ORF1ab_pp1a Y2384Y 1.00e+0 BA.2.3.9
V3022 17911C>T missense_variant ORF1ab_pp1ab P5971S 8.45e-1 BA.2.40.1
V3800 805T>C missense_variant S Y269H 8.64e-1 BA.2.43
V441 1174G>T missense_variant ORF1ab_pp1a G392C 8.64e-1 BA.2.43
V4525 467A>G missense_variant ORF3a Y156C 8.64e-1 BA.2.43
V6419 3990G>A synonymous_variant ORF1ab_pp1a P1330P 7.21e-1 BA.2.5
V3495 21108G>T missense_variant ORF1ab_pp1ab Q7036H 1.00e+0 BA.2.68
V378 926C>A missense_variant ORF1ab_pp1a P309Q 1.00e+0 BA.2.68
V2034 10151C>T missense_variant ORF1ab_pp1a S3384L 7.07e-1 BA.2.6
V5807 *4385C>T downstream_gene_variant S None 7.07e-1 BA.2.72
V7682 13914C>T synonymous_variant ORF1ab_pp1ab T4638T 6.32e-1 BA.2.72
V547 1612T>C missense_variant ORF1ab_pp1a S538P 1.00e+0 BA.2.74
V202 257T>A missense_variant ORF1ab_pp1a V86D 7.07e-1 BA.2.75.1
V4886 106T>C missense_variant ORF7a S36P 1.00e+0 BA.2.7
V1509 6362C>T missense_variant ORF1ab_pp1a T2121I 8.16e-1 BA.2.8
V6846 7299C>T synonymous_variant ORF1ab_pp1a S2433S 1.00e+0 BA.4.1.4
V2400 12659C>T missense_variant ORF1ab_pp1a P4220L 1.00e+0 BA.4.6.5
V7189 9918C>T synonymous_variant ORF1ab_pp1a I3306I 8.16e-1 BA.4.7
V8892 2025G>A synonymous_variant S Q675Q 1.00e+0 BA.4.7
V9636 408G>A synonymous_variant N E136E 7.07e-1 BA.4.7
V3528 42G>T missense_variant S Q14H 6.30e-1 BA.5.1.10
V4273 3711G>T missense_variant S M1237I 8.83e-1 BA.5.1.10
V5072 22G>A missense_variant ORF8 G8R 8.02e-1 BA.5.1.10
V8161 17502C>T synonymous_variant ORF1ab_pp1ab V5834V 8.61e-1 BA.5.1.10
V7494 12445C>T synonymous_variant ORF1ab_pp1a L4149L 6.29e-1 BA.5.1.22
V2023 10069G>A missense_variant ORF1ab_pp1a A3357T 1.00e+0 BA.5.1.25
V2587 14054C>T missense_variant ORF1ab_pp1ab T4685I 6.32e-1 BA.5.1.25
V476 1321G>A missense_variant ORF1ab_pp1a E441K 8.16e-1 BA.5.1.25
V4030 2059G>A missense_variant S V687I 9.82e-1 BA.5.1.27
V8766 1062C>T synonymous_variant S N354N 9.48e-1 BA.5.1.27
V9677 576C>T synonymous_variant N N192N 9.37e-1 BA.5.1.27
V4029 2054G>T missense_variant S R685L 1.00e+0 BA.5.2.12
V310 619C>T missense_variant ORF1ab_pp1a R207C 7.07e-1 BA.5.2.16
V3665 458T>C missense_variant S M153T 1.00e+0 BA.5.2.16
V8158 17481C>T synonymous_variant ORF1ab_pp1ab N5827N 7.07e-1 BA.5.2.16
V8300 18540C>T synonymous_variant ORF1ab_pp1ab S6180S 1.00e+0 BA.5.2.16
V8626 60C>T synonymous_variant S T20T 1.00e+0 BA.5.2.16
V8659 240T>C synonymous_variant S D80D 1.00e+0 BA.5.2.16
V9282 220C>T synonymous_variant E L74L 1.00e+0 BA.5.2.16
V3000 17815G>T missense_variant ORF1ab_pp1ab V5939L 9.26e-1 BA.5.2.21
V5186 272A>T missense_variant ORF8 Q91L 9.26e-1 BA.5.2.21
V9390 612T>C synonymous_variant M Y204Y 8.45e-1 BA.5.2.21
V2294 11888C>T missense_variant ORF1ab_pp1a A3963V 7.07e-1 BA.5.2.26
V6910 7809C>T synonymous_variant ORF1ab_pp1a N2603N 7.07e-1 BA.5.2.31
V8411 19392G>A synonymous_variant ORF1ab_pp1ab K6464K 7.07e-1 BA.5.2.31
V5644 1204G>T missense_variant N D402Y 7.87e-1 BA.5.2.34
V5937 558C>T synonymous_variant ORF1ab_pp1a V186V 8.25e-1 BA.5.2.34
V6397 3828C>T synonymous_variant ORF1ab_pp1a I1276I 7.44e-1 BA.5.2.34
V6417 3981C>T synonymous_variant ORF1ab_pp1a T1327T 9.68e-1 BA.5.2.34
V6507 4662C>T synonymous_variant ORF1ab_pp1a D1554D 9.39e-1 BA.5.2.34
V8836 1629C>T synonymous_variant S F543F 7.10e-1 BA.5.2.34
V2560 13922G>A missense_variant ORF1ab_pp1ab R4641K 1.00e+0 BA.5.2.36
V388 965A>G missense_variant ORF1ab_pp1a K322R 6.31e-1 BA.5.2.36
V5228 361delA frameshift_variant ORF8 I121fs 6.16e-1 BA.5.2.36
V6703 6099G>A synonymous_variant ORF1ab_pp1a A2033A 1.00e+0 BA.5.2.36
V9195 318C>T synonymous_variant ORF3a L106L 6.11e-1 BA.5.2.44
V1538 6458C>T missense_variant ORF1ab_pp1a T2153I 1.00e+0 BA.5.2.47
V1255 4892C>T missense_variant ORF1ab_pp1a A1631V 1.00e+0 BA.5.2.7
V157 161_163delTAG disruptive_inframe_deletion ORF1ab_pp1a V54del 1.00e+0 BA.5.3.2
V3721 623C>T missense_variant S T208M 7.07e-1 BA.5.3.2
V5315 98G>A missense_variant N S33N 1.00e+0 BA.5.3.4
V9395 9T>C synonymous_variant ORF6 H3H 1.00e+0 BA.5.3.4
V6630 5547C>T synonymous_variant ORF1ab_pp1a D1849D 6.14e-1 BA.5.5.1
V7416 11778C>T synonymous_variant ORF1ab_pp1a D3926D 9.13e-1 BA.5.5.1
V4430 214G>T missense_variant ORF3a A72S 7.07e-1 BC.1
V6945 8061C>T synonymous_variant ORF1ab_pp1a D2687D 1.00e+0 BE.1.2.1
V8522 20439C>T synonymous_variant ORF1ab_pp1ab Y6813Y 1.00e+0 BE.1.2.1
V9296 84C>T synonymous_variant M F28F 7.50e-1 BE.3
V6630 5547C>T synonymous_variant ORF1ab_pp1a D1849D 7.07e-1 BE.9
V7778 14526C>T synonymous_variant ORF1ab_pp1ab I4842I 7.07e-1 BE.9
V3363 20188T>C missense_variant ORF1ab_pp1ab Y6730H 8.66e-1 BF.21
V564 1652C>T missense_variant ORF1ab_pp1a T551I 8.66e-1 BF.21
V6941 8034C>T synonymous_variant ORF1ab_pp1a N2678N 1.00e+0 BF.24
V7352 11385C>T synonymous_variant ORF1ab_pp1a G3795G 1.00e+0 BF.24
V8098 17061G>A synonymous_variant ORF1ab_pp1ab L5687L 7.07e-1 BF.24
V8118 17178T>C synonymous_variant ORF1ab_pp1ab P5726P 7.07e-1 BF.26
V195 253_255delATG conservative_inframe_deletion ORF1ab_pp1a M85del 6.37e-1 BF.7.4.2
V2694 15187G>A missense_variant ORF1ab_pp1ab G5063S 9.35e-1 BF.7.4.2
V3354 20147A>G missense_variant ORF1ab_pp1ab E6716G 6.57e-1 BF.7.4.2
V4759 244A>G missense_variant M I82V 1.00e+0 BF.7.4.2
V6273 2826G>A synonymous_variant ORF1ab_pp1a E942E 6.57e-1 BF.7.4.2
V7093 9222C>T synonymous_variant ORF1ab_pp1a Y3074Y 6.01e-1 BF.7.4.2
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 9.25e-1 BF.7.4.2
V9776 1023C>T synonymous_variant N D341D 1.00e+0 BF.7.4.2
V5175 229G>A missense_variant ORF8 G77S 7.07e-1 BF.7.4
V5178 241G>A missense_variant ORF8 V81I 1.00e+0 BF.7.5
V7345 11307C>T synonymous_variant ORF1ab_pp1a F3769F 7.07e-1 BF.7.5
V9491 39T>C synonymous_variant ORF7b F13F 1.00e+0 BF.7.5
V6172 2163T>C synonymous_variant ORF1ab_pp1a V721V 1.00e+0 BG.5
V6819 7026A>G synonymous_variant ORF1ab_pp1a G2342G 8.16e-1 BL.1
V1203 4628C>T missense_variant ORF1ab_pp1a T1543I 6.66e-1 BM.1.1.3
V5129 152C>T missense_variant ORF8 A51V 8.16e-1 BM.1.1.3
V9314 213C>T synonymous_variant M Y71Y 8.16e-1 BM.1.1.3
V1 -245C>T upstream_gene_variant ORF1ab_pp1a None 1.00e+0 BM.4.1.1
V9378 537C>T synonymous_variant M Y179Y 7.07e-1 BM.4.1.1
V2187 11152G>A missense_variant ORF1ab_pp1a V3718I 7.07e-1 BN.1.1
V6041 1251T>C synonymous_variant ORF1ab_pp1a H417H 7.07e-1 BN.1.1
V6293 2991T>C synonymous_variant ORF1ab_pp1a N997N 7.07e-1 BN.1.1
V143 119C>T missense_variant ORF1ab_pp1a S40L 7.07e-1 BQ.1.1.15
V4852 16T>C missense_variant ORF7a F6L 8.16e-1 BQ.1.1.16
V7130 9546C>T synonymous_variant ORF1ab_pp1a T3182T 8.16e-1 BQ.1.1.16
V377 925C>T missense_variant ORF1ab_pp1a P309S 1.00e+0 BQ.1.1.25
V4758 241G>T missense_variant M A81S 1.00e+0 BQ.1.1.25
V326 671C>T missense_variant ORF1ab_pp1a T224I 7.06e-1 BQ.1.1.27
V4817 80G>T missense_variant ORF6 W27L 1.00e+0 BQ.1.1.27
V6895 7719T>C synonymous_variant ORF1ab_pp1a D2573D 1.00e+0 BQ.1.1.27
V8354 18900C>T synonymous_variant ORF1ab_pp1ab D6300D 7.06e-1 BQ.1.1.27
V1798 8341C>T missense_variant ORF1ab_pp1a L2781F 1.00e+0 BQ.1.1.28
V3081 18247C>T missense_variant ORF1ab_pp1ab P6083S 6.45e-1 BQ.1.1.31
V7698 14004G>A synonymous_variant ORF1ab_pp1ab T4668T 8.45e-1 BQ.1.1.5
V1561 6600G>T missense_variant ORF1ab_pp1a K2200N 1.00e+0 BQ.1.1.7
V6391 3792T>C synonymous_variant ORF1ab_pp1a H1264H 1.00e+0 BQ.1.1.7
V8823 1524C>T synonymous_variant S Y508Y 1.00e+0 BQ.1.1.7
V2850 16729T>C missense_variant ORF1ab_pp1ab Y5577H 6.77e-1 BQ.1.18
V85 -44C>T upstream_gene_variant ORF1ab_pp1a None 6.86e-1 BQ.1.18
V4817 80G>T missense_variant ORF6 W27L 7.07e-1 BQ.1.24
V2172 11057C>T missense_variant ORF1ab_pp1a A3686V 9.85e-1 C.30
V6890 7671G>T synonymous_variant ORF1ab_pp1a A2557A 7.23e-1 C.30
V1708 7766A>G missense_variant ORF1ab_pp1a K2589R 7.07e-1 C.36.3
V1724 7837G>T missense_variant ORF1ab_pp1a V2613F 1.00e+0 C.36
V4498 377G>T missense_variant ORF3a R126M 1.00e+0 C.36
V5080 32C>A missense_variant ORF8 T11K 7.07e-1 C.36
V6998 8535T>C synonymous_variant ORF1ab_pp1a Y2845Y 1.00e+0 C.36
V8578 20925T>C synonymous_variant ORF1ab_pp1ab N6975N 1.00e+0 C.36
V9511 51C>T synonymous_variant ORF8 H17H 1.00e+0 C.36
V403 1037C>T missense_variant ORF1ab_pp1a T346I 6.67e-1 CH.1.1.1
V3895 1426G>A missense_variant S G476S 7.07e-1 CL.1
V7819 14877C>T synonymous_variant ORF1ab_pp1ab T4959T 7.07e-1 CL.1
V3000 17815G>T missense_variant ORF1ab_pp1ab V5939L 7.07e-1 CN.1
V4460 293C>T missense_variant ORF3a A98V 7.07e-1 CN.1
V5186 272A>T missense_variant ORF8 Q91L 7.07e-1 CN.1
V9390 612T>C synonymous_variant M Y204Y 7.07e-1 CN.1
V7021 8682C>T synonymous_variant ORF1ab_pp1a N2894N 6.77e-1 CR.1
V6029 1176C>T synonymous_variant ORF1ab_pp1a G392G 1.00e+0 D.2
V5085 46T>C missense_variant ORF8 F16L 1.00e+0 DR.1
V7560 12942C>T synonymous_variant ORF1ab_pp1a A4314A 7.55e-1 DR.1
V7174 9786G>A synonymous_variant ORF1ab_pp1a L3262L 7.75e-1 P.1.14
V4480 316C>T missense_variant ORF3a L106F 7.07e-1 P.1.1
V7063 8961C>T synonymous_variant ORF1ab_pp1a G2987G 1.00e+0 P.1.4
V7550 12850C>T synonymous_variant ORF1ab_pp1a L4284L 1.00e+0 P.1.4
V9693 666G>T synonymous_variant N L222L 1.00e+0 P.1.4
V4429 214G>A missense_variant ORF3a A72T 1.00e+0 P.1.6
V2289 11851C>T missense_variant ORF1ab_pp1a L3951F 6.67e-1 R.1
V1553 6548C>T missense_variant ORF1ab_pp1a T2183I 7.07e-1 XBB.1.1
V8521 20415G>T synonymous_variant ORF1ab_pp1ab P6805P 7.07e-1 XBB.1.1
V2485 13448A>G missense_variant ORF1ab_pp1ab K4483R 7.06e-1 AY.76
V4486 329C>T missense_variant ORF3a A110V 8.15e-1 AY.76
V9345 372C>T synonymous_variant M L124L 8.15e-1 AY.76
V5151 193G>T missense_variant ORF8 A65S 1.00e+0 B.1.1.128
V5467 611G>T missense_variant N G204V 7.05e-1 B.1.1.128
V6941 8034C>T synonymous_variant ORF1ab_pp1a N2678N 1.00e+0 B.1.1.128
V7464 12135C>T synonymous_variant ORF1ab_pp1a L4045L 1.00e+0 B.1.1.128
V2975 17558C>T missense_variant ORF1ab_pp1ab P5853L 1.00e+0 B.1.1.236
V3298 19796G>T missense_variant ORF1ab_pp1ab S6599I 8.13e-1 B.1.1.236
V3475 20956G>T missense_variant ORF1ab_pp1ab A6986S 1.00e+0 B.1.1.236
V3561 98C>T missense_variant S T33I 1.00e+0 B.1.1.236
V5133 161C>G stop_gained ORF8 S54* 8.13e-1 B.1.1.236
V531 1555G>A missense_variant ORF1ab_pp1a G519S 8.13e-1 B.1.1.236
V776 2565G>T missense_variant ORF1ab_pp1a E855D 1.00e+0 B.1.1.236
V957 3249G>T missense_variant ORF1ab_pp1a M1083I 1.00e+0 B.1.1.236
V9748 927C>T synonymous_variant N P309P 1.00e+0 B.1.1.236
V3454 20873A>G missense_variant ORF1ab_pp1ab K6958R 8.14e-1 B.1.1.389
V2511 13586G>T missense_variant ORF1ab_pp1ab G4529V 1.00e+0 B.1.1.47
V2801 16316C>T missense_variant ORF1ab_pp1ab T5439I 8.92e-1 B.1.1.47
V3099 18383C>T missense_variant ORF1ab_pp1ab P6128L 7.36e-1 B.1.1.47
V6395 3819C>T synonymous_variant ORF1ab_pp1a D1273D 9.10e-1 B.1.1.47
V8002 16332C>T synonymous_variant ORF1ab_pp1ab Y5444Y 7.83e-1 B.1.1.47
V5847 81C>T synonymous_variant ORF1ab_pp1a L27L 9.71e-1 B.1.1.67
V2196 11191A>G missense_variant ORF1ab_pp1a I3731V 1.00e+0 B.1.177.23
V680 2069C>T missense_variant ORF1ab_pp1a A690V 1.00e+0 B.1.177.23
V1539 6461C>T missense_variant ORF1ab_pp1a T2154I 7.06e-1 B.1.408
V1958 9484A>G missense_variant ORF1ab_pp1a K3162E 1.00e+0 B.1.415
V3686 531G>T missense_variant S M177I 1.00e+0 B.1.415
V9229 636C>T synonymous_variant ORF3a Y212Y 1.00e+0 B.1.415
V5737 *4322G>T downstream_gene_variant S None 1.00e+0 B.1.417
V6116 1797C>T synonymous_variant ORF1ab_pp1a A599A 1.00e+0 B.1.417
V9304 159C>T synonymous_variant M F53F 1.00e+0 B.1.417
V9509 30C>T synonymous_variant ORF8 I10I 1.00e+0 B.1.417
V3242 19420G>T missense_variant ORF1ab_pp1ab V6474L 6.60e-1 B.1.469
V3454 20873A>G missense_variant ORF1ab_pp1ab K6958R -8.61e-1 B.1.469
V3628 412G>T missense_variant S D138Y 8.12e-1 B.1.469
V5734 *4321G>T downstream_gene_variant S None 9.41e-1 B.1.469
V9617 261C>T synonymous_variant N Y87Y 1.00e+0 B.1.469
V1543 6476G>A missense_variant ORF1ab_pp1a R2159Q 1.00e+0 B.1.503
V2825 16531G>T missense_variant ORF1ab_pp1ab V5511L 1.00e+0 B.1.503
V2828 16582G>T missense_variant ORF1ab_pp1ab D5528Y 1.00e+0 B.1.503
V3304 19838G>T missense_variant ORF1ab_pp1ab S6613I 1.00e+0 B.1.503
V3530 52C>T missense_variant S L18F 1.00e+0 B.1.503
V3610 288G>T missense_variant S E96D 1.00e+0 B.1.503
V4535 512C>T missense_variant ORF3a S171L 1.00e+0 B.1.503
V4599 671G>T missense_variant ORF3a G224V 1.00e+0 B.1.503
V5236 -5C>T upstream_gene_variant N None 1.00e+0 B.1.503
V5759 *4349C>T downstream_gene_variant S None 1.00e+0 B.1.503
V5906 357C>T synonymous_variant ORF1ab_pp1a R119R 1.00e+0 B.1.503
V7371 11493C>T synonymous_variant ORF1ab_pp1a P3831P 1.00e+0 B.1.503
V7416 11778C>T synonymous_variant ORF1ab_pp1a D3926D 1.00e+0 B.1.503
V7840 15060C>T synonymous_variant ORF1ab_pp1ab N5020N 1.00e+0 B.1.503
V7842 15078C>T synonymous_variant ORF1ab_pp1ab A5026A 1.00e+0 B.1.503
V8624 33C>T synonymous_variant S V11V 1.00e+0 B.1.503
V8835 1626C>T synonymous_variant S N542N 1.00e+0 B.1.503
V9090 3513C>T synonymous_variant S G1171G 1.00e+0 B.1.503
V2048 10361C>T missense_variant ORF1ab_pp1a A3454V 7.01e-1 B.1.547
V3836 1099G>C missense_variant S V367L 7.01e-1 B.1.547
V1077 3701C>T missense_variant ORF1ab_pp1a A1234V 1.00e+0 B.1.597
V1237 4775A>G missense_variant ORF1ab_pp1a Q1592R 1.00e+0 B.1.597
V2858 16766A>G missense_variant ORF1ab_pp1ab N5589S 1.00e+0 B.1.597
V3523 24G>T missense_variant S L8F 1.00e+0 B.1.597
V4035 2066G>T missense_variant S S689I 1.00e+0 B.1.597
V5727 *4306G>T downstream_gene_variant S None 1.00e+0 B.1.597
V7892 15474C>T synonymous_variant ORF1ab_pp1ab F5158F 1.00e+0 B.1.597
V7397 11676C>T synonymous_variant ORF1ab_pp1a V3892V 8.60e-1 B.1.637.1
V1456 6178G>T missense_variant ORF1ab_pp1a D2060Y 1.00e+0 B.1.91
V5508 687G>T missense_variant N Q229H 1.00e+0 B.1.91
V192 253_258delATGGTT conservative_inframe_deletion ORF1ab_pp1a M85_V86del 8.16e-1 BA.1.3
V7557 12930T>C synonymous_variant ORF1ab_pp1a V4310V -8.16e-1 BA.1.3
V8556 20709T>C synonymous_variant ORF1ab_pp1ab S6903S 7.06e-1 BA.1.3
V2565 13938G>T missense_variant ORF1ab_pp1ab E4646D 8.15e-1 BA.2.3.5
V4511 401G>A missense_variant ORF3a R134H 1.00e+0 BA.2.3.5
V6229 2523C>T synonymous_variant ORF1ab_pp1a I841I 1.00e+0 BA.2.38.3
V6921 7875C>T synonymous_variant ORF1ab_pp1a S2625S 1.00e+0 BA.2.78
V1556 6578C>T missense_variant ORF1ab_pp1a S2193F 1.00e+0 BA.5.2.30
V3750 697A>G missense_variant S I233V 1.00e+0 BA.5.2.30
V4513 418C>T missense_variant ORF3a L140F 1.00e+0 BA.5.2.30
V9338 351C>T synonymous_variant M N117N 1.00e+0 BG.4
V6676 5931C>T synonymous_variant ORF1ab_pp1a P1977P 1.00e+0 BL.3
V1219 4700C>T missense_variant ORF1ab_pp1a T1567I 1.00e+0 BM.2.1
V3709 553A>T missense_variant S N185Y 1.00e+0 BM.2.1
V184 245_253delGTCATGTTA disruptive_inframe_deletion ORF1ab_pp1a G82_M85delinsV 7.51e-1 BQ.1.1.9
V7672 13833C>T synonymous_variant ORF1ab_pp1ab F4611F 7.01e-1 BQ.1.1.9
V999 3421C>A missense_variant ORF1ab_pp1a H1141N 7.04e-1 BQ.1.1.9
V3765 740G>A missense_variant S S247N 1.00e+0 XAM





Manual curation of mutation (5310C>T)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID