Back to top

The current mutation

ID: V7093
DNA: 9222C>T
Protein: Y3074Y
Position: 9487








COV2Var annotation categories







Summary information of mutation (9222C>T)

Basic Information about Mutation.

  Gene Information   Gene ID   GU280_gp01_pp1a
  Gene Name   ORF1ab_pp1a
  Gene Type   protein_coding
  Genome position   9487
  Reference genome   GenBank ID: NC_045512.2
  Mutation type   synonymous_variant
  DNA Level   DNA Mutation: 9222C>T
  Ref Seq: C
  Mut Seq: T
  Protein Level   Protein 1-letter Mutation: Y3074Y
  Protein 3-letter Mutation: Tyr3074Tyr

Overview of the genomic positions of Mutation.
Note: The annotated 12 genes were retrieved from GeneBank (Accession: NC_045512.2). "MP" represents genomic position of mutation.





Analyzing the distribution of mutation (9222C>T) across geographic regions, temporal trends, and lineages

The count of genome sequences harboring this mutation and its distribution across global regions offer insights into regional variations.
Note: The distribution of mutation across 218 geographical regions. Color representation of genome sequence counts. The data is obtained from GISAID's metadata, specifically capturing the regional distribution of genomic sequences.



The dynamic count of genome sequences containing this mutation over time.
Note: Clicking the "Count" or "Cumulative Count" button toggles the view. Count represents the number of genome sequences per month. Cumulative count represents the accumulated total count up to the respective month. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.



For every time point represented in the graph above, identifying the top 3 lineages with the highest count of genome sequences carrying this mutation aids in pinpointing noteworthy lineages for further analysis.
Note: Users can filter the lineages by entering a "Year-Month" term in the search box. For example, entering 2020-01 will display lineages that appeared in January 2020. The data is obtained from GISAID's metadata, specifically capturing the collection date of genomic sequences.

Collection date Lineage Total lineage monthly counts Lineage-specific monthly counts Lineage-specific monthly frequency
2020-10 B.1.453 20 6 3.00e-1
2020-10 B.1.160 20 3 1.50e-1
2020-10 B.1 20 2 1.00e-1
2020-11 B.1.36.8 17 5 2.94e-1
2020-11 B.1.177 17 3 1.76e-1
2020-11 B.1.160 17 2 1.18e-1
2020-12 AA.5 90 62 6.89e-1
2020-12 B.1.160 90 5 5.56e-2
2020-12 B.1.2 90 5 5.56e-2
2020-03 B.1 7 7 1.00e+0
2020-04 B.1 1 1 1.00e+0
2020-05 B.1 2 1 5.00e-1
2020-05 B.1.1 2 1 5.00e-1
2020-06 B.1.453 1 1 1.00e+0
2020-07 B.1.313 9 5 5.56e-1
2020-07 B.1.36.8 9 2 2.22e-1
2020-07 B.1.2 9 1 1.11e-1
2020-08 B.1 3 2 6.67e-1
2020-08 B.6.8 3 1 3.33e-1
2020-09 B.1.36.8 11 4 3.64e-1
2020-09 B.1.1.28 11 2 1.82e-1
2020-09 B.1.1 11 1 9.09e-2
2021-01 AA.5 92 38 4.13e-1
2021-01 B.1.1.7 92 10 1.09e-1
2021-01 B.1.2 92 10 1.09e-1
2021-10 AY.4 302 83 2.75e-1
2021-10 AY.3 302 74 2.45e-1
2021-10 AY.80 302 33 1.09e-1
2021-11 AY.4 292 147 5.03e-1
2021-11 AY.44 292 30 1.03e-1
2021-11 AY.3 292 16 5.48e-2
2021-12 BA.1.15.1 2572 2154 8.37e-1
2021-12 BA.1 2572 127 4.94e-2
2021-12 AY.4 2572 102 3.97e-2
2021-02 B.1.1.7 111 48 4.32e-1
2021-02 AA.5 111 22 1.98e-1
2021-02 B.1.177.83 111 7 6.31e-2
2021-03 B.1.1.7 116 83 7.16e-1
2021-03 B.1.1.1 116 16 1.38e-1
2021-03 B.1.2 116 7 6.03e-2
2021-04 B.1.1.7 146 124 8.49e-1
2021-04 B.1.160 146 7 4.79e-2
2021-04 AT.1 146 2 1.37e-2
2021-05 B.1.1.7 102 83 8.14e-1
2021-05 B.1.351 102 9 8.82e-2
2021-05 P.1 102 3 2.94e-2
2021-06 B.1.1.7 50 31 6.20e-1
2021-06 B.1.617.2 50 3 6.00e-2
2021-06 AY.125 50 2 4.00e-2
2021-07 AZ.1 69 16 2.32e-1
2021-07 P.1 69 8 1.16e-1
2021-07 AY.44 69 6 8.70e-2
2021-08 AY.124 121 29 2.40e-1
2021-08 AY.4 121 15 1.24e-1
2021-08 AY.122 121 13 1.07e-1
2021-09 AY.4 210 49 2.33e-1
2021-09 AY.124 210 38 1.81e-1
2021-09 AY.3 210 20 9.52e-2
2022-01 BA.1.15.1 3042 2675 8.79e-1
2022-01 BA.1 3042 160 5.26e-2
2022-01 BA.1.1 3042 122 4.01e-2
2022-10 BE.1.1.1 140 29 2.07e-1
2022-10 BF.25 140 21 1.50e-1
2022-10 BA.5.1.25 140 17 1.21e-1
2022-11 BE.1.1.1 371 147 3.96e-1
2022-11 BE.1.1 371 42 1.13e-1
2022-11 BA.5.1.25 371 41 1.11e-1
2022-12 BQ.1.1.32 202 39 1.93e-1
2022-12 BE.1.1.1 202 37 1.83e-1
2022-12 BQ.1.1 202 17 8.42e-2
2022-02 BA.1.15.1 1468 1119 7.62e-1
2022-02 BA.1.1 1468 208 1.42e-1
2022-02 BA.1 1468 67 4.56e-2
2022-03 BA.1.15.1 303 114 3.76e-1
2022-03 BA.1.1 303 79 2.61e-1
2022-03 BA.2 303 56 1.85e-1
2022-04 BA.2 128 76 5.94e-1
2022-04 BA.1.1 128 11 8.59e-2
2022-04 BA.2.3 128 8 6.25e-2
2022-05 BA.2 82 51 6.22e-1
2022-05 BA.2.3 82 9 1.10e-1
2022-05 BA.2.29 82 6 7.32e-2
2022-06 BA.2 87 30 3.45e-1
2022-06 BA.2.29 87 16 1.84e-1
2022-06 BA.2.9.6 87 10 1.15e-1
2022-07 BA.2.29 90 36 4.00e-1
2022-07 BA.5.1.21 90 9 1.00e-1
2022-07 BA.4.1 90 6 6.67e-2
2022-08 BF.5 29 8 2.76e-1
2022-08 BA.5.5 29 4 1.38e-1
2022-08 BA.2.29 29 2 6.90e-2
2022-09 BA.5.1.25 36 4 1.11e-1
2022-09 BF.25 36 4 1.11e-1
2022-09 BA.5.1.21 36 3 8.33e-2
2023-01 BQ.1.1.32 107 23 2.15e-1
2023-01 XBB.1.5 107 21 1.96e-1
2023-01 BQ.1.1 107 11 1.03e-1
2023-02 XBB.1.5 24 11 4.58e-1
2023-02 BQ.1.1 24 4 1.67e-1
2023-02 BQ.1.1.32 24 2 8.33e-2

The count of genome sequences and the frequency of this mutation in each lineage.
Note: Displaying mutation frequencies (>0.01) among 2,735 lineages. Mutation Count represents the count of sequences carrying this mutation. Users can filter the lineages by entering a search term in the search box. For example, entering "A.1" will display A.1 lineages. The data is obtained from GISAID's metadata, specifically capturing the lineage of genomic sequences. Mutation count: Count of sequences carrying this mutation.

Mutation ID Lineage Mutation frequency Mutation count Earliest lineage emergence Latest lineage emergence
V7093 BA.1.15.1 1.57e-1 6064 2021-11-18 2022-9-2
V7093 AY.80 3.23e-2 40 2021-6-2 2022-1-8
V7093 B.1.177.83 1.31e-2 8 2020-8-25 2021-6-8
V7093 B.1.36.8 1.66e-2 15 2020-4-11 2022-5-5
V7093 BA.5.1.21 2.02e-2 26 2022-2-8 2023-1-5
V7093 BE.1.1.1 7.78e-2 220 2022-2-6 2023-2-14
V7093 BF.25 4.32e-2 52 2022-4-25 2023-2-11
V7093 BF.7.4.2 1.86e-2 14 2022-7-23 2023-2-7
V7093 BA.5.1.25 1.58e-2 76 2022-5-11 2023-2-7
V7093 AA.5 1.00e+0 62 2020-12-5 2021-3-2
V7093 AZ.1 1.83e-2 8 2021-1-22 2021-7-29
V7093 B.1.313 3.01e-2 5 2020-4-1 2021-8-5
V7093 B.1.453 3.95e-2 14 2020-3-17 2021-2-8
V7093 B.1.478 2.38e-2 3 2020-5-15 2021-3-5
V7093 BA.2.9.6 2.52e-2 12 2022-3-16 2022-8-7
V7093 BQ.1.27 2.71e-2 7 2022-10-7 2023-2-11






Examining mutation (9222C>T) found in abundant sequences of non-human animal hosts

Exploring mutation presence across 35 non-human animal hosts for cross-species transmission.
Note: We retained the mutation that appear in at least three non-human animal hosts' sequences. The data is obtained from GISAID's metadata, specifically capturing the host of genomic sequences.

Animal host Lineage Source region Collection date Accession ID
Odocoileus virginianus AY.118 USA 2021-11-19 EPI_ISL_16366935
Odocoileus virginianus AY.103 USA 2021-11-27 EPI_ISL_13658815
Odocoileus virginianus AY.103 USA 2021-12-9 EPI_ISL_16366931
Odocoileus virginianus AY.103 USA 2021-11-20 EPI_ISL_16297250
Gorilla gorilla gorilla B.1.1.7 Czech Republic 2021-3-3 EPI_ISL_1497615
Gorilla gorilla gorilla B.1.1.7 Czech Republic 2021-3-17 EPI_ISL_1497617
Odocoileus virginianus B.1.1.7 USA 2021-10-3 EPI_ISL_13610593
Odocoileus virginianus B.1.2 USA 2021-11-7 EPI_ISL_13610658
Odocoileus virginianus B.1 Canada 2021-11-3 EPI_ISL_10175390
Odocoileus virginianus P.1 USA 2021-11-6 EPI_ISL_13610643
Odocoileus virginianus P.1 USA 2021-10-31 EPI_ISL_13610619




Association between mutation (9222C>T) and patients of different ages, genders, and statuses

Note: The logistic regression model was employed to examine changes in patient data before and after the mutation. The logistic regression model was conducted using the glm function in R. The data is obtained from GISAID's metadata, specifically capturing the patient status, gender, and age of genomic sequences.

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient statuses (ambulatory, deceased, homebound, hospitalized, mild, and recovered) based on GISAID classifications. In the analysis exploring the association between mutation and patient status, the model included mutation, patient status, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient status Ambulatory -1.35e-1 1.00e+0 -1.35e-1 8.93e-1 Decrease
Deceased -1.42e+1 9.80e+2 -1.45e-2 9.88e-1 Decrease
Homebound -3.66e+1 6.59e+4 -5.56e-4 1.00e+0 Decrease
Hospitalized 4.49e-1 7.26e-1 6.18e-1 5.37e-1 Increase
Mild 1.20e+0 1.11e+0 1.07e+0 2.82e-1 Increase
Recovered -2.28e-1 7.95e-1 -2.87e-1 7.74e-1 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient age (0-17, 18-39, 40-64, 65-84, and 85+). In the analysis exploring the association between mutation and patient age, the model included mutation, patient age, gender, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient age, years 0-17 2.36e-1 1.53e-1 1.54e+0 1.22e-1 Increase
18-39 2.67e-1 8.10e-2 3.30e+0 9.68e-4 Increase
40-64 -2.13e-1 8.52e-2 -2.51e+0 1.22e-2 Decrease
65-84 -2.62e-1 1.26e-1 -2.08e+0 3.75e-2 Decrease
>=85 -5.12e-3 2.12e-1 -2.42e-2 9.81e-1 Decrease

Analyzing the association between mutation and patient status.
Note: we categorized the data into different patient gender (male and female). In the analysis exploring the association between mutation and patient gender, the model included mutation, patient gender, patient age, sequence region of origin, and sequence collection time point. In the 'increase' direction of the mutation, it means that when this mutation occurs, it increases the corresponding effect proportion. In the 'decrease' direction of the mutation, it means that when this mutation occurs, it decreases the corresponding effect proportion. A p-value lower than 0.001 signifies a notable differentiation between the population with and without the mutation.

Attribute Effect Estimate SE Z-value P-value Direction
Patient gender Male 2.82e-2 8.04e-2 3.51e-1 7.25e-1 Increase





Investigating natural selection at mutation (9222C>T) site for genetic adaptation and diversity

Note: Investigating the occurrence of positive selection or negative selection at this mutation site reveals implications for genetic adaptation and diversity.

The MEME method within the HyPhy software was employed to analyze positive selection. MEME: episodic selection.
Note: List of sites found to be under episodic selection by MEME (p < 0.05). "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site P-value Lineage Method

The FEL method within the HyPhy software was employed to analyze both positive and negative selection. FEL: pervasive selection on samll datasets.
Note: List of sites found to be under pervasive selection by FEL (p < 0.05). A beta value greater than alpha signifies positive selection, while a beta value smaller than alpha signifies negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Alpha Beta P-value Lineage Method

The FUBAR method within the HyPhy software was employed to analyze both positive and negative selection. FUBAR: pervasive selection on large datasets.
Note: List of sites found to be under pervasive selection by FUBAR (prob > 0.95). A prob[alpha < beta] value exceeding 0.95 indicates positive selection, while a prob[alpha > beta] value exceeding 0.95 indicates negative selection. "Protein Start" corresponds to the protein's starting genomic position. "Protein End" corresponds to the protein's ending genomic position. The term 'site' represents a selection site within the protein.

Protein name Protein start Protein end Protein length Site Prob[alpha>beta] Prob[alpha<beta] Lineage Method




Alterations in protein physicochemical properties induced by mutation (9222C>T)

Understanding the alterations in protein physicochemical properties can reveal the evolutionary processes and adaptive changes of viruses
Note: ProtParam software was used for the analysis of physicochemical properties. Significant change threshold: A change exceeding 10% compared to the reference is considered a significant change. "GRAVY" is an abbreviation for "grand average of hydropathicity".

Group Protein name Molecular weight Theoretical PI Extinction coefficients Aliphatic index GRAVY




Alterations in protein stability induced by mutation (9222C>T)

The impact of mutations on protein stability directly or indirectly affects the biological characteristics, adaptability, and transmission capacity of the virus
Note: iMutant 2.0 was utilized to analyze the effects of mutations on protein stability. pH 7 and a temperature of 25°C are employed to replicate the in vitro environment. pH 7.4 and a temperature of 37°C are utilized to simulate the in vivo environment.

Mutation Protein name Mutation type Position ΔDDG Stability pH Temperature Condition




Impact on protein function induced by mutation (9222C>T)

The impact of mutations on protein function
Note: The MutPred2 software was used to predict the pathogenicity of a mutation and gives the molecular mechanism of pathogenicity. A score above 0.5 indicates an increased likelihood of pathogenicity. "Pr" is the abbreviation for "proportion. P" is the abbreviation for "p-value.

Mutation Protein name Mutation type Score Molecular mechanisms




Exploring mutation (9222C>T) distribution within intrinsically disordered protein regions

Intrinsically Disordered Proteins (IDPs) which refers to protein regions that have no unique 3D structure. In viral proteins, mutations in the disordered regions s are critical for immune evasion and antibody escape, suggesting potential additional implications for vaccines and monoclonal therapeutic strategies.
Note: The iupred3 software was utilized for analyzing IDPs. A score greater than 0.5 is considered indicative of an IDP. In the plot, "POS" represents the position of the mutation.





Alterations in enzyme cleavage sites induced by mutation (9222C>T)

Exploring the impact of mutations on the cleavage sites of 28 enzymes.
Note: The PeptideCutter software was used for detecting enzymes cleavage sites. The increased enzymes cleavage sites refer to the cleavage sites in the mutated protein that are added compared to the reference protein. Conversely, the decreased enzymes cleavage sites indicate the cleavage sites in the mutated protein that are reduced compared to the reference protein.

Mutation Protein name Genome position Enzyme name Increased cleavage sites Decreased cleavage sites




Impact of spike protein mutation (9222C>T) on antigenicity and immunogenicity

Investigating the impact of mutations on antigenicity and immunogenicity carries important implications for vaccine design and our understanding of immune responses.
Note: An absolute change greater than 0.0102 (three times the median across sites) in antigenicity score is considered significant. An absolute changegreater than 0.2754 (three times the median across sites) in immunogenicity score is considered significant. The VaxiJen tool was utilized for antigenicity analysis. The IEDB tool was used for immunogenicity analysis. Antigens with a prediction score of more than 0.4 for this tool are considered candidate antigens. MHC I immunogenicity score >0, indicating a higher probability to stimulate an immune response.

Group Protein name Protein region Antigenicity score Immunogenicity score




Impact of mutation (9222C>T) on viral transmissibility by the affinity between RBD and ACE2 receptor

Unraveling the impact of mutations on the interaction between the receptor binding domain (RBD) and ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: The ΔBinding affinity represents the disparity between the binding affinity of a mutation and the reference binding affinity. A positive Δbinding affinity value (Δlog10(KD,app) > 0) signifies an increased affinity between RBD and ACE2 receptor due to the mutation. Conversely, a negative value (Δlog10(KD,app) < 0) indicates a reduced affinity between RBD and ACE2 receptor caused by the mutation. A p-value smaller than 0.05 indicates significance. "Ave mut bind" represents the average binding affinity of this mutation. "Ave ref bind" refers to the average binding affinity at a site without any mutation (reference binding affinity).

;
Mutation Protein name Protein region Mutation Position Ave mut bind Ave ref bind ΔBinding affinity P-value Image


The interface between the receptor binding domain (RBD) and ACE2 receptor is depicted in the crystal structure 6JM0.
Note: The structure 6M0J encompasses the RBD range of 333 to 526. The binding sites (403-406, 408, 417, 439, 445-447, 449, 453, 455-456, 473-478, 484-498, and 500-506) on the RBD that interface with ACE2 are indicated in magenta. The binding sites on the RBD that have been identified through the interface footprints experiment. The ACE2 binding sites within the interface are shown in cyan, representing residues within 5Å proximity to the RBD binding sites. The mutation within the RBD range of 333 to 526 is depicted in red.

        Show as:

        Show interface residues:





Impact of mutation (9222C>T) on immune escape by the affinity between RBD and antibody/serum

By utilizing experimental data from deep mutational scanning (DMS), we can uncover how mutations affect the interaction between the receptor binding domain (RBD) and antibodies/serum. This approach provides valuable insights into strategies for evading the host immune response.
Note: We considered a mutation to mediate strong escape if the escape score exceeded 0.1 (10% of the maximum score of 1). A total of 1,504 antibodies/serum data were collected for this analysis. "Condition name" refers to the name of the antibodies/serum. "Mut escape score" represents the escape score of the mutation in that specific condition. "Avg mut escape score" indicates the average escape score of the mutation site in that condition, considering the occurrence of this mutation and other mutations. Class 1 antibodies bind to an epitope only in the RBD “up” conformation, and are the most abundant. Class 2 antibodies bind to the RBD both in “up” and “down” conformations. Class 3 and class 4 antibodies both bind outside the ACE2 binding site. Class 3 antibodies bind the RBD in both the open and closed conformation, while class 4 antibodies bind only in the open conformation.

Mutation Condition name Condition type Condition subtype Condition year Mut escape score Avg mut escape score




Investigating the co-mutation patterns of mutation (9222C>T) across 2,735 viral lineages

Investigating the co-mutation patterns of SARS-CoV-2 across 2,735 viral lineages to unravel the cooperative effects of different mutations. In biological research, correlation analysis of mutation sites helps us understand whether there is a close relationship or interaction between certain mutations.
Note: The Spearman correlation coefficient is used to calculate the correlation between two mutations within each Pango lineage. Holm–Bonferroni method was used for multiple test adjustment. We retained mutation pairs with correlation values greater than 0.6 or less than -0.6 and Holm–Bonferroni corrected p-values less than 0.05.

Associated mutation ID DNA mutation Mutation type Protein name Protein mutation correlation coefficient Lineage
V5966 693C>T synonymous_variant ORF1ab_pp1a C231C 6.17e-1 BE.1.1
V7669 13812C>T synonymous_variant ORF1ab_pp1ab L4604L 6.61e-1 BQ.1.1
V943 3206G>A missense_variant ORF1ab_pp1a G1069E 7.46e-1 P.1
V5584 1028A>G missense_variant N D343G 7.56e-1 AY.126
V8701 534C>T synonymous_variant S D178D 7.07e-1 AY.98
V4322 56A>G missense_variant ORF3a E19G 7.07e-1 AY.102
V1174 4490C>T missense_variant ORF1ab_pp1a P1497L 1.00e+0 AY.104
V1665 7484C>T missense_variant ORF1ab_pp1a T2495I 7.07e-1 AY.104
V2857 16755G>T missense_variant ORF1ab_pp1ab E5585D 1.00e+0 AY.104
V8956 2520C>T synonymous_variant S C840C 1.00e+0 AY.104
V3932 1546G>C missense_variant S E516Q 8.16e-1 AY.119
V182 244_252delGGTCATGTT conservative_inframe_deletion ORF1ab_pp1a G82_V84del 1.00e+0 AY.122.1
V6237 2577C>T synonymous_variant ORF1ab_pp1a A859A 7.07e-1 AY.123
V1165 4394A>G missense_variant ORF1ab_pp1a Y1465C 9.94e-1 AY.124
V4990 329T>C missense_variant ORF7a I110T 9.88e-1 AY.124
V5659 -21C>T upstream_gene_variant ORF10 None 1.00e+0 AY.129
V497 1351C>T missense_variant ORF1ab_pp1a L451F 8.89e-1 AY.13
V8535 20559C>T synonymous_variant ORF1ab_pp1ab N6853N 6.46e-1 AY.13
V1352 5584C>T missense_variant ORF1ab_pp1a P1862S 7.07e-1 AY.14
V8848 1725T>C synonymous_variant S A575A 1.00e+0 AY.14
V2038 10184C>T missense_variant ORF1ab_pp1a P3395L 1.00e+0 AY.3.3
V3737 641G>T missense_variant S R214L 8.66e-1 AY.3.3
V5087 52C>T stop_gained ORF8 Q18* 1.00e+0 AY.3.3
V9319 246C>T synonymous_variant M I82I 8.94e-1 AY.3.3
V2450 13187C>T missense_variant ORF1ab_pp1a A4396V 9.70e-1 AY.34.1
V2942 17351A>G missense_variant ORF1ab_pp1ab K5784R 9.17e-1 AY.34.1
V4339 79G>T missense_variant ORF3a D27Y 9.70e-1 AY.34.1
V4549 530G>T missense_variant ORF3a S177I 9.70e-1 AY.34.1
V5767 *4353G>A downstream_gene_variant S None 8.84e-1 AY.34.1
V6411 3927T>C synonymous_variant ORF1ab_pp1a T1309T 7.07e-1 AY.34.1
V6732 6303C>T synonymous_variant ORF1ab_pp1a D2101D 1.00e+0 AY.34.1
V6755 6471T>C synonymous_variant ORF1ab_pp1a V2157V 9.70e-1 AY.34.1
V6913 7827C>T synonymous_variant ORF1ab_pp1a L2609L 8.52e-1 AY.34.1
V9463 237C>T synonymous_variant ORF7a A79A 7.07e-1 AY.34.1
V3997 1963C>T missense_variant S H655Y 1.00e+0 AY.4.13
V5557 887C>T missense_variant N T296I 8.66e-1 AY.4.13
V1978 9697C>T missense_variant ORF1ab_pp1a H3233Y 1.00e+0 AY.4.2.3
V7583 13101C>T synonymous_variant ORF1ab_pp1a N4367N 1.00e+0 AY.42
V2592 14134G>T missense_variant ORF1ab_pp1ab V4712L 6.54e-1 AY.45
V4567 583T>C missense_variant ORF3a S195P 1.00e+0 AY.46.3
V4884 101C>T missense_variant ORF7a P34L 7.07e-1 AY.46.4
V1583 6764C>T missense_variant ORF1ab_pp1a S2255F 1.00e+0 AY.46.6
V773 2525C>T missense_variant ORF1ab_pp1a T842I 1.00e+0 AY.46.6
V9071 3414T>C synonymous_variant S Y1138Y 1.00e+0 AY.46.6
V432 1138C>T missense_variant ORF1ab_pp1a P380S 1.00e+0 AY.4.7
V4203 3371G>T missense_variant S G1124V 1.00e+0 AY.48
V1134 4134G>T missense_variant ORF1ab_pp1a M1378I 1.00e+0 AY.57
V832 2801G>A missense_variant ORF1ab_pp1a G934D 1.00e+0 AY.57
V2485 13448A>G missense_variant ORF1ab_pp1ab K4483R 7.07e-1 AY.58
V3492 21100C>T missense_variant ORF1ab_pp1ab P7034S 9.35e-1 AY.7.1
V1048 3611C>T missense_variant ORF1ab_pp1a A1204V 7.07e-1 AY.78
V231 341T>C missense_variant ORF1ab_pp1a I114T 6.85e-1 AY.80
V5532 754G>T missense_variant N A252S 7.13e-1 AY.80
V9303 123C>T synonymous_variant M N41N 9.00e-1 AY.80
V2188 11152G>T missense_variant ORF1ab_pp1a V3718F 6.66e-1 AY.94
V7135 9591G>T synonymous_variant ORF1ab_pp1a V3197V 7.07e-1 AY.98.1
V2065 10490C>T missense_variant ORF1ab_pp1a A3497V 6.82e-1 B.1.1.1
V2430 13061C>T missense_variant ORF1ab_pp1a T4354I 8.12e-1 B.1.1.1
V310 619C>T missense_variant ORF1ab_pp1a R207C 7.79e-1 B.1.1.1
V4200 3352G>T missense_variant S D1118Y 8.07e-1 B.1.1.1
V5114 112C>T missense_variant ORF8 P38S 6.82e-1 B.1.1.1
V5443 581C>T missense_variant N S194L 7.58e-1 B.1.1.1
V6419 3990G>A synonymous_variant ORF1ab_pp1a P1330P 6.99e-1 B.1.1.1
V6534 4839T>C synonymous_variant ORF1ab_pp1a H1613H 8.07e-1 B.1.1.1
V6958 8124C>T synonymous_variant ORF1ab_pp1a N2708N 8.38e-1 B.1.1.1
V7073 9054C>T synonymous_variant ORF1ab_pp1a F3018F 7.65e-1 B.1.1.1
V8522 20439C>T synonymous_variant ORF1ab_pp1ab Y6813Y 9.21e-1 B.1.1.1
V8836 1629C>T synonymous_variant S F543F 6.99e-1 B.1.1.1
V9078 3444C>T synonymous_variant S F1148F 6.69e-1 B.1.1.1
V9324 297T>C synonymous_variant M S99S 8.94e-1 B.1.1.1
V3138 18664C>T missense_variant ORF1ab_pp1ab P6222S 7.06e-1 B.1.1.232
V4083 2429C>T missense_variant S S810L 1.00e+0 B.1.1.232
V8902 2073C>T synonymous_variant S S691S 7.74e-1 B.1.1.25
V2458 13235C>T missense_variant ORF1ab_pp1ab T4412I 8.16e-1 B.1.1.28
V4783 486G>T missense_variant M K162N 8.16e-1 B.1.1.28
V3047 18034A>G missense_variant ORF1ab_pp1ab I6012V 1.00e+0 B.1.1.306
V824 2777C>T missense_variant ORF1ab_pp1a P926L 7.07e-1 B.1.1.306
V4485 328G>T missense_variant ORF3a A110S 7.07e-1 B.1.1.348
V4979 296C>T missense_variant ORF7a P99L 1.00e+0 B.1.1.348
V8690 432T>C synonymous_variant S Y144Y 1.00e+0 B.1.1.348
V137 100T>A missense_variant ORF1ab_pp1a S34T 1.00e+0 B.1.1.372
V1971 9605C>T missense_variant ORF1ab_pp1a T3202M 1.00e+0 B.1.1.372
V2065 10490C>T missense_variant ORF1ab_pp1a A3497V 7.07e-1 B.1.1.372
V2430 13061C>T missense_variant ORF1ab_pp1a T4354I 1.00e+0 B.1.1.372
V2592 14134G>T missense_variant ORF1ab_pp1ab V4712L 1.00e+0 B.1.1.372
V3114 18472T>C missense_variant ORF1ab_pp1ab F6158L 1.00e+0 B.1.1.372
V5250 8A>T missense_variant N D3V 1.00e+0 B.1.1.372
V5251 9T>A missense_variant N D3E 1.00e+0 B.1.1.372
V5443 581C>T missense_variant N S194L 1.00e+0 B.1.1.372
V5978 798C>T synonymous_variant ORF1ab_pp1a F266F 1.00e+0 B.1.1.372
V6419 3990G>A synonymous_variant ORF1ab_pp1a P1330P 1.00e+0 B.1.1.372
V6546 4927C>T synonymous_variant ORF1ab_pp1a L1643L 7.07e-1 B.1.1.372
V7184 9888T>C synonymous_variant ORF1ab_pp1a D3296D 1.00e+0 B.1.1.372
V891 3002C>T missense_variant ORF1ab_pp1a T1001I 1.00e+0 B.1.1.372
V9324 297T>C synonymous_variant M S99S 7.07e-1 B.1.1.372
V9737 876C>T synonymous_variant N I292I 1.00e+0 B.1.1.372
V9741 894C>T synonymous_variant N Y298Y 1.00e+0 B.1.1.372
V7673 13836T>C synonymous_variant ORF1ab_pp1ab G4612G 6.32e-1 B.1.160
V7828 14958C>T synonymous_variant ORF1ab_pp1ab F4986F 7.02e-1 B.1.177.83
V5838 27C>T synonymous_variant ORF1ab_pp1a N9N 7.07e-1 B.1.258.11
V7586 13110T>C synonymous_variant ORF1ab_pp1a C4370C 1.00e+0 B.1.258.11
V6251 2679G>A synonymous_variant ORF1ab_pp1a L893L 6.42e-1 B.1.351
V3211 19138C>T missense_variant ORF1ab_pp1ab H6380Y 8.57e-1 B.1.36.8
V4775 373C>T missense_variant M H125Y 7.12e-1 B.1.36.8
V576 1682T>C missense_variant ORF1ab_pp1a V561A 8.36e-1 B.1.36.8
V6969 8283G>A synonymous_variant ORF1ab_pp1a K2761K 6.39e-1 B.1.36.8
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 8.64e-1 B.1.36.8
V5636 1174G>T missense_variant N V392L 7.07e-1 B.1.561
V827 2783A>G missense_variant ORF1ab_pp1a D928G 7.07e-1 B.1.561
V8825 1539T>C synonymous_variant S L513L 1.00e+0 B.1.561
V1044 3606G>T missense_variant ORF1ab_pp1a K1202N 1.00e+0 B.1.575
V303 586T>C missense_variant ORF1ab_pp1a Y196H 7.07e-1 B.1.596
V5725 *4302C>T downstream_gene_variant S None 7.07e-1 B.1.619
V1426 6087G>T missense_variant ORF1ab_pp1a K2029N 1.00e+0 B.1.620
V2241 11485C>T missense_variant ORF1ab_pp1a L3829F 1.00e+0 B.1.620
V4433 221C>T missense_variant ORF3a S74F 6.03e-1 BA.1.1.14
V6001 939C>T synonymous_variant ORF1ab_pp1a N313N 1.00e+0 BA.1.19
V608 1796C>T missense_variant ORF1ab_pp1a A599V 7.07e-1 BA.1.19
V7206 10071C>T synonymous_variant ORF1ab_pp1a A3357A 1.00e+0 BA.2.21
V1349 5567C>T missense_variant ORF1ab_pp1a S1856F 9.14e-1 BA.2.29
V464 1277G>T missense_variant ORF1ab_pp1a R426L 7.07e-1 BA.2.3.13
V260 421_429delAAGTCATTT conservative_inframe_deletion ORF1ab_pp1a K141_F143del 1.00e+0 BA.2.38.2
V294 550C>T missense_variant ORF1ab_pp1a R184C 1.00e+0 BA.2.38.2
V7624 13383C>T synonymous_variant ORF1ab_pp1ab Y4461Y 7.06e-1 BA.2.38.2
V1474 6235C>T missense_variant ORF1ab_pp1a P2079S 8.16e-1 BA.2.50
V6818 7014C>T synonymous_variant ORF1ab_pp1a F2338F 7.07e-1 BA.2.50
V8154 17469C>T synonymous_variant ORF1ab_pp1ab F5823F 1.00e+0 BA.2.51
V1041 3593A>G missense_variant ORF1ab_pp1a Q1198R 1.00e+0 BA.2.72
V1806 8374C>T missense_variant ORF1ab_pp1a P2792S 1.00e+0 BA.2.72
V223 331G>A missense_variant ORF1ab_pp1a V111M 1.00e+0 BA.2.72
V2679 15088C>T missense_variant ORF1ab_pp1ab L5030F 1.00e+0 BA.2.72
V3785 770G>A missense_variant S G257D 1.00e+0 BA.2.72
V6318 3192C>T synonymous_variant ORF1ab_pp1a Y1064Y 1.00e+0 BA.2.72
V6637 5613C>T synonymous_variant ORF1ab_pp1a N1871N 1.00e+0 BA.2.72
V7287 10728C>T synonymous_variant ORF1ab_pp1a I3576I 7.07e-1 BA.2.72
V7393 11649A>G synonymous_variant ORF1ab_pp1a S3883S 1.00e+0 BA.2.72
V7796 14664C>T synonymous_variant ORF1ab_pp1ab N4888N 1.00e+0 BA.2.72
V8479 20046T>C synonymous_variant ORF1ab_pp1ab Y6682Y 1.00e+0 BA.2.72
V889 2996C>T missense_variant ORF1ab_pp1a T999I 1.00e+0 BA.2.72
V9018 3015G>A synonymous_variant S Q1005Q 1.00e+0 BA.2.72
V9759 957C>T synonymous_variant N R319R 1.00e+0 BA.2.72
V1445 6143C>T missense_variant ORF1ab_pp1a S2048F 1.00e+0 BA.2.75.2
V1768 8102C>T missense_variant ORF1ab_pp1a A2701V 7.07e-1 BA.2.75.2
V7506 12528G>A synonymous_variant ORF1ab_pp1a K4176K 1.00e+0 BA.2.75.4
V439 1172C>T missense_variant ORF1ab_pp1a S391F 1.00e+0 BA.2.75
V6102 1708C>T synonymous_variant ORF1ab_pp1a L570L 1.00e+0 BA.4.2
V8064 16815G>A synonymous_variant ORF1ab_pp1ab Q5605Q 1.00e+0 BA.4.2
V6828 7125C>T synonymous_variant ORF1ab_pp1a A2375A 8.82e-1 BA.4.6.5
V8445 19698G>A synonymous_variant ORF1ab_pp1ab T6566T 9.26e-1 BA.4.6.5
V4922 186A>T missense_variant ORF7a Q62H 6.18e-1 BA.5.1.21
V3313 19912G>A missense_variant ORF1ab_pp1ab V6638I 7.07e-1 BA.5.1.22
V5569 956G>A missense_variant N R319H 7.07e-1 BA.5.1.22
V3364 20197A>G missense_variant ORF1ab_pp1ab T6733A 7.14e-1 BA.5.1.24
V3586 214G>A missense_variant S G72R 7.14e-1 BA.5.1.24
V7423 11811C>T synonymous_variant ORF1ab_pp1a N3937N 6.30e-1 BA.5.1.24
V8573 20892C>T synonymous_variant ORF1ab_pp1ab S6964S 6.17e-1 BA.5.1.24
V8897 2046G>A synonymous_variant S R682R 6.76e-1 BA.5.1.24
V933 3163A>G missense_variant ORF1ab_pp1a T1055A 7.14e-1 BA.5.1.24
V3824 1037G>C missense_variant S R346T 6.74e-1 BA.5.1.25
V8315 18613C>T synonymous_variant ORF1ab_pp1ab L6205L 6.15e-1 BA.5.1.25
V8561 20772C>T synonymous_variant ORF1ab_pp1ab L6924L 6.90e-1 BA.5.1.25
V5848 90C>T synonymous_variant ORF1ab_pp1a G30G 1.00e+0 BA.5.1.26
V9443 141T>C synonymous_variant ORF7a H47H 7.07e-1 BA.5.1.3
V7426 11835C>T synonymous_variant ORF1ab_pp1a A3945A 7.07e-1 BA.5.2.20
V3542 65C>T missense_variant S T22I 7.07e-1 BA.5.2.2
V46 -92G>A upstream_gene_variant ORF1ab_pp1a None 7.07e-1 BA.5.2.31
V7744 14335C>T synonymous_variant ORF1ab_pp1ab L4779L 6.70e-1 BA.5.2.31
V8290 18459T>C synonymous_variant ORF1ab_pp1ab H6153H 7.07e-1 BA.5.2.31
V9046 3234T>C synonymous_variant S A1078A 1.00e+0 BA.5.2.43
V144 127C>T missense_variant ORF1ab_pp1a R43C 7.07e-1 BA.5.2.47
V4264 3687G>T missense_variant S M1229I 7.07e-1 BA.5.2.47
V9653 468A>T synonymous_variant N A156A 1.00e+0 BA.5.2.47
V5966 693C>T synonymous_variant ORF1ab_pp1a C231C 7.71e-1 BE.1.1.1
V5134 161C>T missense_variant ORF8 S54L 6.32e-1 BE.1.1.2
V8954 2514T>C synonymous_variant S G838G 7.07e-1 BE.1.1.2
V7103 9300C>T synonymous_variant ORF1ab_pp1a F3100F 1.00e+0 BE.5
V558 1640T>C missense_variant ORF1ab_pp1a I547T 7.07e-1 BE.9
V3461 20893G>A missense_variant ORF1ab_pp1ab V6965M 1.00e+0 BF.13
V4610 719C>T missense_variant ORF3a P240L 6.66e-1 BF.13
V9057 3300A>G synonymous_variant S T1100T 1.00e+0 BF.14
V856 2891C>T missense_variant ORF1ab_pp1a A964V 7.78e-1 BF.1
V123 70C>T missense_variant ORF1ab_pp1a R24C 9.38e-1 BF.25
V4638 780G>A missense_variant ORF3a M260I 7.66e-1 BF.25
V5797 *4375G>T downstream_gene_variant S None 6.74e-1 BF.26
V1561 6600G>T missense_variant ORF1ab_pp1a K2200N 7.07e-1 BF.27
V195 253_255delATG conservative_inframe_deletion ORF1ab_pp1a M85del 9.06e-1 BF.7.4.2
V3354 20147A>G missense_variant ORF1ab_pp1ab E6716G 9.34e-1 BF.7.4.2
V4759 244A>G missense_variant M I82V 6.01e-1 BF.7.4.2
V6273 2826G>A synonymous_variant ORF1ab_pp1a E942E 9.34e-1 BF.7.4.2
V6602 5310C>T synonymous_variant ORF1ab_pp1a Y1770Y 6.01e-1 BF.7.4.2
V8370 19005C>T synonymous_variant ORF1ab_pp1ab N6335N 6.51e-1 BF.7.4.2
V9776 1023C>T synonymous_variant N D341D 6.01e-1 BF.7.4.2
V127 79C>A missense_variant ORF1ab_pp1a L27I 1.00e+0 BN.1.3.1
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 7.07e-1 BQ.1.1.10
V2778 16111C>T missense_variant ORF1ab_pp1ab P5371S 7.07e-1 BQ.1.1.11
V7669 13812C>T synonymous_variant ORF1ab_pp1ab L4604L 7.07e-1 BQ.1.1.11
V992 3373G>T missense_variant ORF1ab_pp1a G1125C 7.07e-1 BQ.1.1.11
V4470 301C>T missense_variant ORF3a L101F 6.81e-1 BQ.1.1.16
V7669 13812C>T synonymous_variant ORF1ab_pp1ab L4604L 9.35e-1 BQ.1.1.16
V8359 18922C>T synonymous_variant ORF1ab_pp1ab L6308L 8.81e-1 BQ.1.1.16
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 1.00e+0 BQ.1.1.24
V4531 494C>T missense_variant ORF3a S165F 7.07e-1 BQ.1.1.25
V7414 11760C>T synonymous_variant ORF1ab_pp1a S3920S 8.16e-1 BQ.1.1.25
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 8.16e-1 BQ.1.1.25
V4900 134C>T missense_variant ORF7a P45L 7.07e-1 BQ.1.12
V1724 7837G>T missense_variant ORF1ab_pp1a V2613F 1.00e+0 BQ.1.1.31
V4365 118T>C missense_variant ORF3a S40P 1.00e+0 BQ.1.1.31
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 9.47e-1 BQ.1.1.32
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 8.58e-1 BQ.1.18
V7257 10476C>T synonymous_variant ORF1ab_pp1a D3492D 6.71e-1 BQ.1.2
V327 677G>A missense_variant ORF1ab_pp1a R226K 1.00e+0 C.16
V8336 18768C>T synonymous_variant ORF1ab_pp1ab D6256D 1.00e+0 CK.1
V2568 13952C>T missense_variant ORF1ab_pp1ab T4651I 1.00e+0 CL.1
V6676 5931C>T synonymous_variant ORF1ab_pp1a P1977P 1.00e+0 CL.1
V7422 11808C>T synonymous_variant ORF1ab_pp1a D3936D 1.00e+0 CL.1
V842 2831C>T missense_variant ORF1ab_pp1a S944L 8.66e-1 CL.1
V188 247C>T missense_variant ORF1ab_pp1a H83Y 1.00e+0 CP.1
V3370 20213G>T missense_variant ORF1ab_pp1ab G6738V 1.00e+0 CP.1
V6942 8046C>T synonymous_variant ORF1ab_pp1a N2682N 7.07e-1 DL.1
V5103 91T>C missense_variant ORF8 Y31H 1.00e+0 DN.1
V5348 214G>C missense_variant N V72L 1.00e+0 DN.1
V7799 14673C>T synonymous_variant ORF1ab_pp1ab D4891D 1.00e+0 DN.1
V8001 16311C>T synonymous_variant ORF1ab_pp1ab D5437D 1.00e+0 DN.1
V9408 99A>T synonymous_variant ORF6 I33I 1.00e+0 DN.1
V4380 131G>A missense_variant ORF3a G44E 1.00e+0 P.1.12
V6139 1911A>G synonymous_variant ORF1ab_pp1a E637E 1.00e+0 P.1.12
V6833 7155C>T synonymous_variant ORF1ab_pp1a I2385I 1.00e+0 P.1.12
V8790 1239G>T synonymous_variant S G413G 1.00e+0 P.1.12
V943 3206G>A missense_variant ORF1ab_pp1a G1069E 1.00e+0 P.1.12
V943 3206G>A missense_variant ORF1ab_pp1a G1069E 1.00e+0 P.1.14
V2513 13598C>T missense_variant ORF1ab_pp1ab T4533I 7.07e-1 P.1.15
V2980 17675C>T missense_variant ORF1ab_pp1ab A5892V 1.00e+0 P.1.15
V533 1556G>A missense_variant ORF1ab_pp1a G519D 6.54e-1 P.1.15
V7353 11388C>T synonymous_variant ORF1ab_pp1a L3796L 6.12e-1 P.1.15
V6972 8325A>G synonymous_variant ORF1ab_pp1a K2775K 7.07e-1 P.1.17
V9633 384C>T synonymous_variant N D128D 1.00e+0 P.1.4
V1187 4559C>T missense_variant ORF1ab_pp1a S1520F 1.00e+0 XBB.1.2
V745 2345C>T missense_variant ORF1ab_pp1a P782L 1.00e+0 XBB.2
V7666 13800T>C synonymous_variant ORF1ab_pp1ab D4600D 7.07e-1 XBB.2
V3211 19138C>T missense_variant ORF1ab_pp1ab H6380Y 8.36e-1 XBB
V311 620G>T missense_variant ORF1ab_pp1a R207L 1.00e+0 XB
V3411 20495C>T missense_variant ORF1ab_pp1ab A6832V 7.07e-1 XB
V5372 359G>T missense_variant N G120V 7.07e-1 XB
V5899 324C>T synonymous_variant ORF1ab_pp1a V108V 1.00e+0 XB
V6285 2919A>G synonymous_variant ORF1ab_pp1a E973E 1.00e+0 XB
V9811 1236C>T synonymous_variant N S412S 1.00e+0 XB
V1733 7874C>T missense_variant ORF1ab_pp1a S2625F 7.06e-1 AY.23.2
V8659 240T>C synonymous_variant S D80D 1.00e+0 AY.23.2
V4401 163G>T missense_variant ORF3a V55F 1.00e+0 AY.25.1.2
V180 241C>T missense_variant ORF1ab_pp1a H81Y 8.92e-1 AZ.1
V2623 14477C>T missense_variant ORF1ab_pp1ab S4826F 8.50e-1 AZ.1
V3109 18434C>T missense_variant ORF1ab_pp1ab A6145V 8.92e-1 AZ.1
V3310 19870G>T missense_variant ORF1ab_pp1ab V6624L 8.50e-1 AZ.1
V5780 *4360G>A downstream_gene_variant S None 6.62e-1 AZ.1
V6385 3753A>G synonymous_variant ORF1ab_pp1a E1251E 1.00e+0 AZ.1
V6929 7914G>T synonymous_variant ORF1ab_pp1a R2638R 7.88e-1 AZ.1
V2303 11926G>T missense_variant ORF1ab_pp1a V3976F 8.16e-1 B.1.177.33
V5038 92C>T missense_variant ORF7b S31L 8.16e-1 B.1.177.33
V7304 10908C>T synonymous_variant ORF1ab_pp1a L3636L 8.16e-1 B.1.177.33
V7601 13194G>A synonymous_variant ORF1ab_pp1a S4398S 8.16e-1 B.1.177.33
V842 2831C>T missense_variant ORF1ab_pp1a S944L 7.06e-1 B.1.177.33
V2996 17765C>T missense_variant ORF1ab_pp1ab A5922V 6.65e-1 B.1.313
V1278 5045C>T missense_variant ORF1ab_pp1a T1682I 8.15e-1 B.1.36.7
V1371 5762C>T missense_variant ORF1ab_pp1a P1921L 7.96e-1 B.1.453
V2804 16352C>T missense_variant ORF1ab_pp1ab T5451I 7.49e-1 B.1.453
V3442 20770C>T missense_variant ORF1ab_pp1ab L6924F 9.62e-1 B.1.453
V5144 184G>T missense_variant ORF8 V62L 9.65e-1 B.1.453
V652 1967C>T missense_variant ORF1ab_pp1a A656V 1.00e+0 B.1.453
V7766 14460C>T synonymous_variant ORF1ab_pp1ab F4820F 9.62e-1 B.1.453
V7833 15000T>C synonymous_variant ORF1ab_pp1ab D5000D 1.00e+0 B.1.453
V1629 7069C>T missense_variant ORF1ab_pp1a H2357Y 1.00e+0 B.1.478
V1799 8347G>T missense_variant ORF1ab_pp1a V2783F 1.00e+0 B.1.478
V2085 10617G>T missense_variant ORF1ab_pp1a M3539I 1.00e+0 B.1.478
V2684 15116G>T missense_variant ORF1ab_pp1ab S5039I 8.62e-1 B.1.478
V5144 184G>T missense_variant ORF8 V62L 1.00e+0 B.1.478
V6402 3873T>C synonymous_variant ORF1ab_pp1a V1291V 1.00e+0 B.1.478
V7532 12708C>T synonymous_variant ORF1ab_pp1a N4236N 1.00e+0 B.1.478
V8868 1872T>C synonymous_variant S I624I 1.00e+0 B.1.478
V7881 15390C>T synonymous_variant ORF1ab_pp1ab D5130D 1.00e+0 BA.4.6.3
V8764 1038A>G synonymous_variant S R346R 1.00e+0 BA.4.6.3
V2015 10031C>T missense_variant ORF1ab_pp1a S3344F 9.34e-1 BQ.1.27
V631 1879G>T missense_variant ORF1ab_pp1a V627F 9.34e-1 BQ.1.27
V6371 3609C>T synonymous_variant ORF1ab_pp1a I1203I 7.91e-1 BQ.1.27
V6480 4455G>A synonymous_variant ORF1ab_pp1a A1485A 9.34e-1 BQ.1.27
V6638 5619C>T synonymous_variant ORF1ab_pp1a Y1873Y 8.78e-1 BQ.1.27
V1414 6047C>T missense_variant ORF1ab_pp1a T2016I 7.06e-1 C.14
V1625 7031C>T missense_variant ORF1ab_pp1a A2344V 1.00e+0 C.14
V2524 13681C>T missense_variant ORF1ab_pp1ab P4561S 7.06e-1 C.14
V5382 404C>T missense_variant N T135I 7.06e-1 C.14
V6040 1248C>T synonymous_variant ORF1ab_pp1a C416C 7.06e-1 C.14
V6180 2205C>T synonymous_variant ORF1ab_pp1a A735A 1.00e+0 C.14
V890 2999C>T missense_variant ORF1ab_pp1a T1000I 1.00e+0 C.14
V9665 519A>T synonymous_variant N A173A 7.06e-1 C.14
V9771 999C>T synonymous_variant N Y333Y 7.05e-1 C.14
V8759 1008C>T synonymous_variant S C336C 1.00e+0 P.1.8
V2791 16210A>G missense_variant ORF1ab_pp1ab S5404G 7.06e-1 XAG
V6125 1848C>T synonymous_variant ORF1ab_pp1a I616I 7.06e-1 XAG
V7467 12147C>T synonymous_variant ORF1ab_pp1a I4049I 1.00e+0 XAG





Manual curation of mutation (9222C>T)-related literature from PubMed

The pubmed.mineR and pubmed-mapper were utilized for extracting literature from PubMed, followed by manual filtering.
Note: PubMed: (COVID-19 [Title/Abstract] OR SARS-COV-2 [Title/Abstract]) AND (DNA mutation [Title/Abstract] OR Protein mutation-1 letter [Title/Abstract] OR Protein mutation-3 letter [Title/Abstract]).

DNA level Protein level Paper title Journal name Publication year Pubmed ID