Investigating mutations within the receptor binding domain (RBD) and their impact on the interaction with the ACE2 receptor using deep mutational scanning (DMS) experimental data to gain insights into their effects on viral transmissibility.
Note: Click on the mutation ID in the table to retrieve the complete annotation information for that mutation.
Mutation ID |
Gene ID |
Gene name |
Genome position |
DNA mutation |
Mutation type |
Protein mutation-1 letter |
Protein mutation-3 letter |
V3814 |
GU280_gp02 |
S |
22530 |
968C>T |
missense_variant |
T323I |
Thr323Ile |
V3815 |
GU280_gp02 |
S |
22550 |
988C>T |
missense_variant |
P330S |
Pro330Ser |
V3816 |
GU280_gp02 |
S |
22564 |
1002C>A |
missense_variant |
N334K |
Asn334Lys |
V3817 |
GU280_gp02 |
S |
22577 |
1015G>A |
missense_variant |
G339S |
Gly339Ser |
V3818 |
GU280_gp02 |
S |
22577 |
1015G>C |
missense_variant |
G339R |
Gly339Arg |
V3819 |
GU280_gp02 |
S |
22577 |
1015G>T |
missense_variant |
G339C |
Gly339Cys |
V3820 |
GU280_gp02 |
S |
22578 |
1016G>A |
missense_variant |
G339D |
Gly339Asp |
V3821 |
GU280_gp02 |
S |
22580 |
1018G>A |
missense_variant |
E340K |
Glu340Lys |
V3822 |
GU280_gp02 |
S |
22592 |
1030G>T |
missense_variant |
A344S |
Ala344Ser |
V3823 |
GU280_gp02 |
S |
22599 |
1037G>A |
missense_variant |
R346K |
Arg346Lys |
V3824 |
GU280_gp02 |
S |
22599 |
1037G>C |
missense_variant |
R346T |
Arg346Thr |
V3825 |
GU280_gp02 |
S |
22599 |
1037G>T |
missense_variant |
R346I |
Arg346Ile |
V3826 |
GU280_gp02 |
S |
22600 |
1038A>C |
missense_variant |
R346S |
Arg346Ser |
V3827 |
GU280_gp02 |
S |
22600 |
1038A>T |
missense_variant |
R346S |
Arg346Ser |
V3828 |
GU280_gp02 |
S |
22604 |
1042G>T |
missense_variant |
A348S |
Ala348Ser |
V3829 |
GU280_gp02 |
S |
22616 |
1054G>T |
missense_variant |
A352S |
Ala352Ser |
V3830 |
GU280_gp02 |
S |
22622 |
1060A>G |
missense_variant |
N354D |
Asn354Asp |
V3831 |
GU280_gp02 |
S |
22624 |
1062C>A |
missense_variant |
N354K |
Asn354Lys |
V3832 |
GU280_gp02 |
S |
22629 |
1067A>C |
missense_variant |
K356T |
Lys356Thr |
V3833 |
GU280_gp02 |
S |
22629 |
1067A>G |
missense_variant |
K356R |
Lys356Arg |
V3834 |
GU280_gp02 |
S |
22632 |
1070G>A |
missense_variant |
R357K |
Arg357Lys |
V3835 |
GU280_gp02 |
S |
22638 |
1076G>A |
missense_variant |
S359N |
Ser359Asn |
V3836 |
GU280_gp02 |
S |
22661 |
1099G>C |
missense_variant |
V367L |
Val367Leu |
V3837 |
GU280_gp02 |
S |
22661 |
1099G>T |
missense_variant |
V367F |
Val367Phe |
V3838 |
GU280_gp02 |
S |
22664 |
1102C>A |
missense_variant |
L368I |
Leu368Ile |
V3839 |
GU280_gp02 |
S |
22673 |
1111T>C |
missense_variant |
S371P |
Ser371Pro |
V3840 |
GU280_gp02 |
S |
22674 |
1112C>T |
missense_variant |
S371F |
Ser371Phe |
V3841 |
GU280_gp02 |
S |
22679 |
1117T>C |
missense_variant |
S373P |
Ser373Pro |
V3842 |
GU280_gp02 |
S |
22680 |
1118C>T |
missense_variant |
S373L |
Ser373Leu |
V3843 |
GU280_gp02 |
S |
22686 |
1124C>T |
missense_variant |
S375F |
Ser375Phe |
V3844 |
GU280_gp02 |
S |
22688 |
1126A>G |
missense_variant |
T376A |
Thr376Ala |
V3845 |
GU280_gp02 |
S |
22706 |
1144G>T |
missense_variant |
V382L |
Val382Leu |
V3846 |
GU280_gp02 |
S |
22712 |
1150C>T |
missense_variant |
P384S |
Pro384Ser |
V3847 |
GU280_gp02 |
S |
22713 |
1151C>T |
missense_variant |
P384L |
Pro384Leu |
V3848 |
GU280_gp02 |
S |
22716 |
1154C>T |
missense_variant |
T385I |
Thr385Ile |
V3849 |
GU280_gp02 |
S |
22743 |
1181A>G |
missense_variant |
N394S |
Asn394Ser |
V3850 |
GU280_gp02 |
S |
22770 |
1208G>A |
missense_variant |
R403K |
Arg403Lys |
V3851 |
GU280_gp02 |
S |
22775 |
1213G>A |
missense_variant |
D405N |
Asp405Asn |
V3852 |
GU280_gp02 |
S |
22778 |
1216G>C |
missense_variant |
E406Q |
Glu406Gln |
V3853 |
GU280_gp02 |
S |
22785 |
1223G>T |
missense_variant |
R408I |
Arg408Ile |
V3854 |
GU280_gp02 |
S |
22786 |
1224A>C |
missense_variant |
R408S |
Arg408Ser |
V3855 |
GU280_gp02 |
S |
22786 |
1224A>T |
missense_variant |
R408S |
Arg408Ser |
V3856 |
GU280_gp02 |
S |
22790 |
1228A>G |
missense_variant |
I410V |
Ile410Val |
V3857 |
GU280_gp02 |
S |
22793 |
1231G>T |
missense_variant |
A411S |
Ala411Ser |
V3858 |
GU280_gp02 |
S |
22802 |
1240C>A |
missense_variant |
Q414K |
Gln414Lys |
V3859 |
GU280_gp02 |
S |
22803 |
1241A>G |
missense_variant |
Q414R |
Gln414Arg |
V3860 |
GU280_gp02 |
S |
22812 |
1250A>C |
missense_variant |
K417T |
Lys417Thr |
V3861 |
GU280_gp02 |
S |
22813 |
1251G>T |
missense_variant |
K417N |
Lys417Asn |
V3862 |
GU280_gp02 |
S |
22820 |
1258G>A |
missense_variant |
D420N |
Asp420Asn |
V3863 |
GU280_gp02 |
S |
22841 |
1279G>A |
missense_variant |
D427N |
Asp427Asn |
V3864 |
GU280_gp02 |
S |
22851 |
1289C>T |
missense_variant |
T430I |
Thr430Ile |
V3865 |
GU280_gp02 |
S |
22862 |
1300A>G |
missense_variant |
I434V |
Ile434Val |
V3866 |
GU280_gp02 |
S |
22879 |
1317C>A |
missense_variant |
N439K |
Asn439Lys |
V3867 |
GU280_gp02 |
S |
22882 |
1320T>A |
missense_variant |
N440K |
Asn440Lys |
V3868 |
GU280_gp02 |
S |
22882 |
1320T>G |
missense_variant |
N440K |
Asn440Lys |
V3869 |
GU280_gp02 |
S |
22893 |
1331A>C |
missense_variant |
K444T |
Lys444Thr |
V3870 |
GU280_gp02 |
S |
22893 |
1331A>G |
missense_variant |
K444R |
Lys444Arg |
V3871 |
GU280_gp02 |
S |
22893 |
1331A>T |
missense_variant |
K444M |
Lys444Met |
V3872 |
GU280_gp02 |
S |
22894 |
1332G>C |
missense_variant |
K444N |
Lys444Asn |
V3873 |
GU280_gp02 |
S |
22894 |
1332G>T |
missense_variant |
K444N |
Lys444Asn |
V3874 |
GU280_gp02 |
S |
22895 |
1333G>C |
missense_variant |
V445L |
Val445Leu |
V3875 |
GU280_gp02 |
S |
22895 |
1333G>T |
missense_variant |
V445F |
Val445Phe |
V3876 |
GU280_gp02 |
S |
22896 |
1334T>C |
missense_variant |
V445A |
Val445Ala |
V3877 |
GU280_gp02 |
S |
22898 |
1336G>A |
missense_variant |
G446S |
Gly446Ser |
V3878 |
GU280_gp02 |
S |
22899 |
1337G>A |
missense_variant |
G446D |
Gly446Asp |
V3879 |
GU280_gp02 |
S |
22899 |
1337G>T |
missense_variant |
G446V |
Gly446Val |
V3880 |
GU280_gp02 |
S |
22907 |
1345T>A |
missense_variant |
Y449N |
Tyr449Asn |
V3881 |
GU280_gp02 |
S |
22907 |
1345T>C |
missense_variant |
Y449H |
Tyr449His |
V3882 |
GU280_gp02 |
S |
22910 |
1348A>G |
missense_variant |
N450D |
Asn450Asp |
V3883 |
GU280_gp02 |
S |
22912 |
1350T>G |
missense_variant |
N450K |
Asn450Lys |
V3884 |
GU280_gp02 |
S |
22916 |
1354C>A |
missense_variant |
L452M |
Leu452Met |
V3885 |
GU280_gp02 |
S |
22917 |
1355T>A |
missense_variant |
L452Q |
Leu452Gln |
V3886 |
GU280_gp02 |
S |
22917 |
1355T>G |
missense_variant |
L452R |
Leu452Arg |
V3887 |
GU280_gp02 |
S |
22920 |
1358A>T |
missense_variant |
Y453F |
Tyr453Phe |
V3888 |
GU280_gp02 |
S |
22926 |
1364T>C |
missense_variant |
L455S |
Leu455Ser |
V3889 |
GU280_gp02 |
S |
22941 |
1379A>G |
missense_variant |
N460S |
Asn460Ser |
V3890 |
GU280_gp02 |
S |
22942 |
1380T>A |
missense_variant |
N460K |
Asn460Lys |
V3891 |
GU280_gp02 |
S |
22942 |
1380T>G |
missense_variant |
N460K |
Asn460Lys |
V3892 |
GU280_gp02 |
S |
22971 |
1409C>A |
missense_variant |
T470N |
Thr470Asn |
V3893 |
GU280_gp02 |
S |
22973 |
1411G>C |
missense_variant |
E471Q |
Glu471Gln |
V3894 |
GU280_gp02 |
S |
22986 |
1424C>T |
missense_variant |
A475V |
Ala475Val |
V3895 |
GU280_gp02 |
S |
22988 |
1426G>A |
missense_variant |
G476S |
Gly476Ser |
V3896 |
GU280_gp02 |
S |
22992 |
1430G>A |
missense_variant |
S477N |
Ser477Asn |
V3897 |
GU280_gp02 |
S |
22992 |
1430G>T |
missense_variant |
S477I |
Ser477Ile |
V3898 |
GU280_gp02 |
S |
22993 |
1431C>A |
missense_variant |
S477R |
Ser477Arg |
V3899 |
GU280_gp02 |
S |
22994 |
1432A>G |
missense_variant |
T478A |
Thr478Ala |
V3900 |
GU280_gp02 |
S |
22995 |
1433C>A |
missense_variant |
T478K |
Thr478Lys |
V3901 |
GU280_gp02 |
S |
22995 |
1433C>G |
missense_variant |
T478R |
Thr478Arg |
V3902 |
GU280_gp02 |
S |
22995 |
1433C>T |
missense_variant |
T478I |
Thr478Ile |
V3903 |
GU280_gp02 |
S |
22997 |
1435C>T |
missense_variant |
P479S |
Pro479Ser |
V3904 |
GU280_gp02 |
S |
23004 |
1442A>G |
missense_variant |
N481S |
Asn481Ser |
V3905 |
GU280_gp02 |
S |
23005 |
1443T>A |
missense_variant |
N481K |
Asn481Lys |
V3906 |
GU280_gp02 |
S |
23009 |
1447G>C |
missense_variant |
V483L |
Val483Leu |
V3907 |
GU280_gp02 |
S |
23009 |
1447G>T |
missense_variant |
V483F |
Val483Phe |
V3908 |
GU280_gp02 |
S |
23010 |
1448T>C |
missense_variant |
V483A |
Val483Ala |
V3909 |
GU280_gp02 |
S |
23012 |
1450G>A |
missense_variant |
E484K |
Glu484Lys |
V3910 |
GU280_gp02 |
S |
23012 |
1450G>C |
missense_variant |
E484Q |
Glu484Gln |
V3911 |
GU280_gp02 |
S |
23013 |
1451A>C |
missense_variant |
E484A |
Glu484Ala |
V3912 |
GU280_gp02 |
S |
23013 |
1451A>G |
missense_variant |
E484G |
Glu484Gly |
V3913 |
GU280_gp02 |
S |
23016 |
1454G>A |
missense_variant |
G485D |
Gly485Asp |
V3914 |
GU280_gp02 |
S |
23018 |
1456T>A |
missense_variant |
F486I |
Phe486Ile |
V3915 |
GU280_gp02 |
S |
23018 |
1456T>C |
missense_variant |
F486L |
Phe486Leu |
V3916 |
GU280_gp02 |
S |
23018 |
1456T>G |
missense_variant |
F486V |
Phe486Val |
V3917 |
GU280_gp02 |
S |
23019 |
1457T>C |
missense_variant |
F486S |
Phe486Ser |
V3918 |
GU280_gp02 |
S |
23027 |
1465T>C |
missense_variant |
Y489H |
Tyr489His |
V3919 |
GU280_gp02 |
S |
23030 |
1468T>C |
missense_variant |
F490L |
Phe490Leu |
V3920 |
GU280_gp02 |
S |
23030 |
1468T>G |
missense_variant |
F490V |
Phe490Val |
V3921 |
GU280_gp02 |
S |
23031 |
1469T>C |
missense_variant |
F490S |
Phe490Ser |
V3922 |
GU280_gp02 |
S |
23040 |
1478A>G |
missense_variant |
Q493R |
Gln493Arg |
V3923 |
GU280_gp02 |
S |
23040 |
1478A>T |
missense_variant |
Q493L |
Gln493Leu |
V3924 |
GU280_gp02 |
S |
23042 |
1480T>C |
missense_variant |
S494P |
Ser494Pro |
V3925 |
GU280_gp02 |
S |
23048 |
1486G>A |
missense_variant |
G496S |
Gly496Ser |
V3926 |
GU280_gp02 |
S |
23055 |
1493A>G |
missense_variant |
Q498R |
Gln498Arg |
V3927 |
GU280_gp02 |
S |
23063 |
1501A>T |
missense_variant |
N501Y |
Asn501Tyr |
V3928 |
GU280_gp02 |
S |
23064 |
1502A>C |
missense_variant |
N501T |
Asn501Thr |
V3929 |
GU280_gp02 |
S |
23069 |
1507G>A |
missense_variant |
V503I |
Val503Ile |
V3930 |
GU280_gp02 |
S |
23075 |
1513T>C |
missense_variant |
Y505H |
Tyr505His |
V3931 |
GU280_gp02 |
S |
23084 |
1522T>C |
missense_variant |
Y508H |
Tyr508His |
V3932 |
GU280_gp02 |
S |
23108 |
1546G>C |
missense_variant |
E516Q |
Glu516Gln |
V3933 |
GU280_gp02 |
S |
23120 |
1558G>T |
missense_variant |
A520S |
Ala520Ser |
V3935 |
GU280_gp02 |
S |
23126 |
1564G>T |
missense_variant |
A522S |
Ala522Ser |
V3936 |
GU280_gp02 |
S |
23127 |
1565C>T |
missense_variant |
A522V |
Ala522Val |
V3937 |
GU280_gp02 |
S |
23181 |
1619A>G |
missense_variant |
N540S |
Asn540Ser |